• Journal of Microbiology and Biotechnology
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• v.31 no.6
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• pp.890-901
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• 2021

The 11α-hydroxylation of canrenone can be catalyzed by Aspergillus ochraceus in bioreactors, where the geometry of the impeller greatly influences the biotransformation. In this study, the effects of the blade number and impeller diameter of a Rushton turbine on the 11α-hydroxylation of canrenone were considered. The results of fermentation experiments using a 50 mm four-blade impeller showed that 3.40% and 11.43% increases in the conversion ratio were achieved by increasing the blade number and impeller diameter, respectively. However, with an impeller diameter of 60 mm, the conversion ratio with a six-blade impeller was 14.42% lower than that with a four-blade impeller. Data from cold model experiments with a large-diameter six-blade impeller indicated that the serious leakage of inclusions and a 22.08% enzyme activity retention led to a low conversion ratio. Numerical simulations suggested that there was good gas distribution and high fluid flow velocity when the fluid was stirred by large-diameter impellers, resulting in a high dissolved oxygen content and good bulk circulation, which positively affected hyphal growth and metabolism. However, a large-diameter six-blade impeller created overly high shear compared to a large-diameter four-blade impeller, thereby decreasing the conversion ratio. The average shear rates of the former and latter cases were 43.25 s^-1 and 35.31 s^-1, respectively. We therefore concluded that appropriate shear should be applied in the 11α-hydroxylation of canrenone. Overall, this study provides basic data for the scaled-up production of 11α-hydroxycanrenone.

• Smart Structures and Systems
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• v.23 no.2
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• pp.141-153
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• 2019

This research deals with wave propagation of the functionally graded (FG) nano-beams based on the nonlocal elasticity theory considering surface and flexoelectric effects. The FG nano-beam is resting in Winkler-Pasternak foundation. It is assumed that the material properties of the nano-beam changes continuously along the thickness direction according to simple power-law form. In order to include coupling of strain gradients and electrical polarizations in governing equations of motion, the nonlocal non-classical nano-beam model containg flexoelectric effect is used. Also, the effects of surface elasticity, dielectricity and piezoelectricity as well as bulk flexoelectricity are all taken into consideration. The governing equations of motion are derived using Hamilton principle based on first shear deformation beam theory (FSDBT) and also considering residual surface stresses. The analytical method is used to calculate phase velocity of wave propagation in FG nano-beam as well as cut-off frequency. After verification with validated reference, comprehensive numerical results are presented to investigate the influence of important parameters such as flexoelectric coefficients of the surface, bulk and residual surface stresses, Winkler and shear coefficients of foundation, power gradient index of FG material, and geometric dimensions on the wave propagation characteristics of FG nano-beam. The numerical results indicate that considering surface effects/flexoelectric property caused phase velocity increases/decreases in low wave number range, respectively. The influences of aforementioned parameters on the occurrence cut-off frequency point are very small.

• Journal of the Korean Geotechnical Society
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• v.34 no.11
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• pp.43-55
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• 2018

AGF (Artificial Ground Freezing) method is a temporary ground improvement method which can apply to all types of soil with the purpose of high stiffness and low hydraulic conductivity. However, the groundwater flow and the heterogeneity of the ground increase the uncertainty of the ice-column formation which hinders the reliability of this method. The effects of groundwater flow and layered heterogeneity on ice-wall integrity by AGF method were analyzed using finite element analysis program for a coupled thermo-hydro phenomena in the freezing ground. Groundwater flow changes circular ice-column into elliptical shapes and increases the time required for the formation of ice walls. The previous theoretical formula overestimated the completion time of the ice wall and the critical groundwater velocity by neglecting the thermal interaction between adjacent ice-columns. Numerical results presented the corrected formula and verified the proposed equation for the dimensionless ice-wall completion time. In the layered heterogeneous ground, the thickness of the layer with higher hydraulic conductivity and its relative magnitude were found to be important factors in the ice-wall completion time and critical velocity.

• Computers and Concrete
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• v.24 no.3
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• pp.193-206
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• 2019

Although concrete is the most widely used construction material, its deficiency in shrinkage and low tensile resistance is undeniable. However, the aforementioned defects can be partially modified by addition of fibers. On the other hand, possibility of adding waste materials in concrete has provided a new ground for use of recycled concrete aggregates in the construction industry. In this study, a constant combination of recyclable coarse and fine concrete aggregates was used to replace the corresponding aggregates at 50% substitution percentage. Moreover, in order to investigate the effects of fibers on mechanical and durability properties of recycled aggregate concrete, the amounts of 0.5%, 1%, and 1.5% steel fibers (ST) and 0.05%, 0.1% and 0.15% polypropylene (PP) fibers by volumes were used individually and in hybrid forms. Compressive strength, tensile strength, flexural strength, ultrasonic pulse velocity (UPV), water absorption, toughness, elastic modulus and shrinkage of samples were investigated. The results of mechanical properties showed that PP fibers reduced the compressive strength while positive impact of steel fibers was evident both in single and hybrid forms. Tensile and flexural strength of samples were improved and the energy absorption of samples containing fibers increased substantially before and after crack presence. Growth in toughness especially in hybrid fiber-reinforced specimens retarded the propagation of cracks. Modulus of elasticity was decreased by the addition of PP fibers while the contrary trend was observed with the addition of steel fibers. PP fibers decreased the ultrasonic pulse velocity slightly and had undesirable effect on water absorption. However, steel fiber caused negligible decline in UPV and a small impact on water absorption. Steel fibers reduce the drying shrinkage by up to 35% when was applied solely. Using fibers also resulted in increasing the ductility of samples in failure. In addition, mechanical properties changes were also evaluated by statistical analysis of MATLAB software and smoothing spline interpolation on compressive, flexural, and indirect tensile strength. Using shell interpolation, the optimization process in areas without laboratory results led to determining optimal theoretical points in a two-parameter system including steel fibers and polypropylene.

• Economic and Environmental Geology
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• v.54 no.3
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• pp.311-330
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• 2021

The Sinseongri site contains at least eleven theropod trackways, three sauropod trackways, and one or more ornithopod walkways of dinosaur footprints. The host rock at the site is primarily siltstone and mudstone, but thermal alterations have metamorphosed it into hornfels. Except for micro cracks and exfoliations, joint systems in various directions appeared on the surface of the fossils site and showed a low share of all damage factors. The host rocks in the fossils site demonstrated relatively high physical properties as a result of ultrasonic velocity and were classified as stable. More than half of the fossils required reinforcement to control the progression of cracks if the type of conservation treatment was subdivided according to the damage type of dinosaur footprint fossils. The white paint used to visualize the footprints seems to deteriorate, allowing rock debris to spill out and causing damage to the fossil site, and alternative visualization schemes should be considered.

• Journal of Korea Water Resources Association
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• v.54 no.3
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• pp.203-215
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• 2021

In the present study, hydrologic data and topographical data from 2010 to 2019 were collected from three gauging stations placed in the watershed of Naeseong stream to determine changes and rates of changes in rainfall, water level & mean velocity, and water level & discharge, together with changes in rates of erosion and deposition at cross-sections of the river. Besides, effects of regulated and non-regulated rivers according to the presence of artificial regulation of flow rate of the river via artificial structure located at Seo stream (Yeongju si (Wolhogyo) station), the tributary free from construction of dams, were compared and analyzed. Results of analyses conducted in the present study revealed vegetational establishment and landforming due to increasing area of vegetational sandbar evolved in the flood plain (intermediate- or high- water level) by the drought sustained from 2013 to 2015. Continuous erosion of river bed was appeared because of narrowed flow area with low water level and increased velocity and tractive force on river bed.

• Journal of Powder Materials
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• v.29 no.3
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• pp.240-246
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• 2022

Novel Ni- and Fe-based alloys are developed to impart improved mechanical properties and corrosion resistance. The designed alloys are manufactured as a powder and deposited on a steel substrate using a high-velocity oxygen-fuel process. The coating layer demonstrates good corrosion resistance, and the thus-formed passive film is beneficial because of the Cr contained in the alloy system. Furthermore, during low-temperature heat treatment, factors that deteriorate the properties and which may arise during high-temperature heat treatment, are avoided. For the heattreated coating layers, the hardness increases by up to 32% and the corrosion resistance improves. The influence of the heat treatment is investigated through various methods and is considered to enhance the mechanical properties and corrosion resistance of the coating layer.

• Clean Technology
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• v.15 no.4
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• pp.245-252
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• 2009

Profiles development of melt spinning process of poly(lactic acid) (PLA) was simulated via a numerical method and the radial temperature distribution was calculated using finite difference method. The spinning speed ranged from 1 km/min to 5 km/min was analyzed and the effect of spinning conditions on the radial temperature distribution was investigated. At low spinning speed, the difference between PLA and poly(ethylene terephthalate) (PET) was relatively small. As the spinning speed increased, the difference in velocity profile became prominent. PLA showed a slower spinning speed than PET and solidified more slowly. The temperature difference between the core and surface of the PLA filament reached 4.6 K, which was less than that of PET filament with a difference of 10.4 K. The radial temperature difference increased with increasing the cooling-air velocity and the spinning temperature.

• Journal of applied mathematics & informatics
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• v.41 no.1
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• pp.51-70
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• 2023

The flow of an incompressible Ellis fluid in an inclined asymmetric channel, driven by peristaltic waves was studied under low Reynolds number and long wavelength assumptions. The wave on each side of the channel are assumed to be an infinite train of sinusoidal waves, both having the same constant wave speed and wavelength however, they vary in wave amplitude, channel half width and phase angle. We derived expressions for the axial and transverse velocities, volume flow rate, pressure rise per unit wavelength and streamlines. The effects of varying the wave amplitudes, the phase angle, the channel width, the angle of inclination of the channel as well as the fluid parameters on the flow were analyzed. Trapping conditions were determined and the presence of reflux highlighted using the streamlines for the necessary channel and fluid conditions. By varying the fluid parameters, changes in the fluid that deviated from the Newtonian case resulted in a reduction in the axial velocity in the neighborhood of the center of the channel and a simultaneous increase in the velocity at the periphery of the channel. A nonlinear relation was observed with the pressure rise and the volume flow rate. This nonlinear relation is more pronounced with an increase in the absolute value of the volume flow rate. For Newtonian fluids a linear relation exists between these two variables. The fluid parameters had little effects on the streamlines. However, variations of the wave amplitudes, volume flow, channel width and phase angle had greater effects on the streamlines and hence the trapped region.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.60-60
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• 2021

Investigating Backward-Facing Step(BFS) flow is important in that it is a representative case for separation flows in various engineering flow systems. There have been a wide range of experimental, theoretical, and numerical studies to investigate the flow characteristics over BFS, such as flow separation, reattachment length and recirculation zone. However, most of such previous studies were concentrated only on the perpendicular step angle. In this study, several numerical investigations on the flow pattern over BFS with various step angles (10° ~ 90°) and expansion ratios (1.48, 2 and 3.27) under different Reynolds numbers (5000 ~ 64000) were carried out, mainly focused on the reattachment length. The numerical simulations were performed using an open source 3D CFD software, OpenFOAM, in which the velocity profiles and turbulence intensities are calculated by RANS (Reynolds Averaged Navier-Stokes equation) and 3D LES (Large Eddy Simulation) turbulence models. Overall, it shows a good agreement between simulations and the experimental data by Ruck and Makiola (1993). In comparison with the results obtained from RANS and 3D LES, it was shown that 3D LES model can capture much better and more details on the velocity profiles, turbulence intensities, and reattachment length behind the step for relatively low Reynolds number(Re < 11000) cases. However, the simulation results by both of RANS and 3D LES showed very good agreement with the experimental data for the high Reynolds number cases(Re > 11000). For Re > 11000, the reattachment length is no longer dependent on the Reynolds number, and it tends to be nearly constant for the step angles larger than 30°.) Based on the calibrated and validated numerical simulations, several additional numerical simulations were also conducted with higher Reynolds number and another expansion ratio which were not considered in the experiments by Ruck and Makiola (1993).