• 제목/요약/키워드: low fertility society

검색결과 293건 처리시간 0.025초

Voltage Dependent N Type Calcium Channel in Mouse Egg Fertilization

  • Eum, Jin Hee;Park, Miseon;Yoon, Jung Ah;Yoon, Sook Young
    • 한국발생생물학회지:발생과생식
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    • 제24권4호
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    • pp.297-306
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    • 2020
  • Repetitive changes in the intracellular calcium concentration ([Ca2+]i) triggers egg activation, including cortical granule exocytosis, resumption of second meiosis, block to polyspermy, and initiating embryonic development. [Ca2+]i oscillations that continue for several hours, are required for the early events of egg activation and possibly connected to further development to the blastocyst stage. The sources of Ca2+ ion elevation during [Ca2+]i oscillations are Ca2+ release from endoplasmic reticulum through inositol 1,4,5 tri-phosphate receptor and Ca2+ ion influx through Ca2+ channel on the plasma membrane. Ca2+ channels have been characterized into voltage-dependent Ca2+ channels (VDCCs), ligand-gated Ca2+ channel, and leak-channel. VDCCs expressed on muscle cell or neuron is specified into L, T, N, P, Q, and R type VDCs by their activation threshold or their sensitivity to peptide toxins isolated from cone snails and spiders. The present study was aimed to investigate the localization pattern of N and P/Q type voltage-dependent calcium channels in mouse eggs and the role in fertilization. [Ca2+]i oscillation was observed in a Ca2+ contained medium with sperm factor or adenophostin A injection but disappeared in Ca2+ free medium. Ca2+ influx was decreased by Lat A. N-VDCC specific inhibitor, ω-Conotoxin CVIIA induced abnormal [Ca2+]i oscillation profiles in SrCl2 treatment. N or P/Q type VDC were distributed on the plasma membrane in cortical cluster form, not in the cytoplasm. Ca2+ influx is essential for [Ca2+]i oscillation during mammalian fertilization. This Ca2+ influx might be controlled through the N or P/Q type VDCCs. Abnormal VDCCs expression of eggs could be tested in fertilization failure or low fertilization eggs in subfertility women.

일-가정 양립을 위한 가족친화경영정책 연구 (A Study on Policies towards Reconciling Work and Family Life)

  • 손주영
    • 가족자원경영과 정책
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    • 제12권3호
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    • pp.81-101
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    • 2008
  • The purpose of this study is to examine support policies regarding work and family reconciliation, to suggest plans to improve workplace policies, and to suggest directions for further studies. This study looks at OECD's work-life reconciliation policies as well as family friendly workplace policies in Korea to find a way to enhance business' receptiveness and implementation of the policies. By examining women's labor conditions, this study finds that family friendly workplace policies are necessarily imminent in our society of low fertility and ageing. Along with the evaluation of benefit level and the effectiveness of current policies, this study uses data from interviews with working mothers who have had the experience of family friendly benefits. The results of the analyses suggest that the government should focus on improving the workplace environment in companies that do not show bias against the use of family friendly policies. In order to farm more successful policies, future studies are needed to analyze the changes of fertility, working conditions, support programs, and benefits.

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New strategies for germ cell cryopreservation: Cryoinjury modulation

  • Sang-Eun Jung;Buom-Yong Ryu
    • Clinical and Experimental Reproductive Medicine
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    • 제50권4호
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    • pp.213-222
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    • 2023
  • Cryopreservation is an option for the preservation of pre- or post-pubertal female or male fertility. This technique not only is beneficial for human clinical applications, but also plays a crucial role in the breeding of livestock and endangered species. Unfortunately, frozen germ cells, including oocytes, sperm, embryos, and spermatogonial stem cells, are subject to cryoinjury. As a result, various cryoprotective agents and freezing techniques have been developed to mitigate this damage. Despite extensive research aimed at reducing apoptotic cell death during freezing, a low survival rate and impaired cell function are still observed after freeze-thawing. In recent decades, several cell death pathways other than apoptosis have been identified. However, the relationship between these pathways and cryoinjury is not yet fully understood, although necroptosis and autophagy appear to be linked to cryoinjury. Therefore, gaining a deeper understanding of the molecular mechanisms of cryoinjury could aid in the development of new strategies to enhance the effectiveness of the freezing of reproductive tissues. In this review, we focus on the pathways through which cryoinjury leads to cell death and propose novel approaches to enhance freezing efficacy based on signaling molecules.

닭의 인공수정에 있어서 적정주입간격에 관한 연구 (A Study on Optimum Interval between Inseminations in Artificial Insemination)

  • 이재근;송해범;이상호
    • 한국가축번식학회지
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    • 제5권1호
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    • pp.36-42
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    • 1981
  • This experiment was carried out to determine the optimum interval between inseminations in artifical insemination of hens. Two hundred and forty hens of Hisex commercial stock at 25 weeks of age and 20 cocks of the Rhode Island Red at 40 weeks of age were used for the experiment, and a total of 6,784 eggs were obtained. The intervals between inseminations compared in this study were: 3 days (T1), 5 days (T2), and 7 days(T3). Mixed raw semen was inseminated and the semen does was 0.03ml per insemination per hen. The inseminations were conducted at 15:00 at each time. The total number of insemination performed was 9 for the T1, 6 for the T2 and 5 for the T3, and eggs were collected over a period of 31 days, 32 days and 35 dyas, respectively. The average egg production of the hens during the experiment was 85.9% and the average temperature during the experiment was around 30$^{\circ}C$. The average sperm count was 3.69 billion per ml. The results obtained in this experiment can be summarized as follows: The fertility over the entire experimental period bythe treatment was 91.7% for the T1, 84.4% for the T2, and 75.2% for the T3. The difference between T1 and T3 in fertility was significant at 5% level. The average fertility on the second, third and fourth day after the insemination in the T2 and T3 was maintained at a relatively high level, but it tended to decline rapidly from the fifth day after the insemination. The average fertility for one week after the last insemination was 88.8% for the T1, 88.8% for the T2 and 78.6% for the T3, and none of the differences among the treatments were statistically significant. On the basis of the results from this study, it is recommended to adjust the insemination intervals within the range from the 3 to 5 days in order to maintain a highest level of fertility in the hens at an early stage of egg production as in the case of the hens used in this experiment. An insemination interval of 3 days is recommended, especially at an initial stage of insemination. For the hens with a low fertility, shortening, of the insemination interval to 3 or 2 days is desirable.

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미혼 남녀의 출산의도 영향요인 - 계획적 행위이론(Theory of Planned Behavior: TPB) 적용 (Factors influencing Fertility intentions of unmarried men and women - Application of theory of planned behavior)

  • 김정연;김영주
    • 산업융합연구
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    • 제20권5호
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    • pp.93-100
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    • 2022
  • 본 연구는 미혼 남녀의 출산의도에 영향을 주는 요인을 파악하기 위해 계획된 행위이론을 적용한 서술적 조사연구이다. 자료 수집은 미혼 남녀 168명을 대상으로 2021년 4월 5일부터 4월23일까지 이루어졌다. 연구결과 일반적 특성에서 남성이 여성보다 출산의도가 통계적으로 유의하게 높았으며, 연령과 학력이 높을수록, 직업이 있는 경우, 비정규직인 대상자의 출산의도가 통계적으로 유의하게 높았다. 계획적 행위이론(TPB)을 구성하는 변수 간의 상관관계를 살펴 본 결과, 출산에 대한 태도가 긍정적일수록, 주관적 규범이 클수록, 지각된 행위통제가 클수록 출산의도가 높은 것으로 나타났다. 츨신의도에 미치는 요인을 남성, 여성으로 나누어 분석한 결과, 남성의 경우 출산 태도만이 출산의도에 통계적으로 유의한 영향을 미치는 것으로 나타났으며 출산의도에 대한 설명력은 62.2%이었다. 여성의 경우 출산 태도와 지각된 행위통제가 출산의도에 통계적으로 유의한 영향을 미치며 이들 변수들의 출산의도에 대한 설명력은 69.0%이었다. 미혼남녀의 출산의도를 높이기 위해서는 장기적이며 포괄적인 접근이 필요하고, 향후 저출산 관련 정책 및 교육 프로그램 개발에 있어 본 연구결과가 기초자료를 제공하였다는 점에서 연구의 의의가 있다고 본다.

한국(韓國) 답토양(畓土壤)의 생산력(生産力) 평가방법에 관한 연구 -2 보(報)·비옥도(肥沃度) 구성인자(構成因子) 및 기타(其他) 특성(特性)에 의(依)한 쌀수확량(收穫量)의 추정(推定) (A METHOD OF CAPABILITY EVALUATION FOR KOREAN PADDY SOILS -Part 2. The rice yield prediction by soil fertility constituents and other characters)

  • Hong, Ki-Chang;Maeng, Do-Won;Kazutake, Kyuma;Hisao, Furukawa;Suh, Yoon-Soo
    • 한국토양비료학회지
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    • 제12권1호
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    • pp.15-23
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    • 1979
  • 본(本) 연구의 제(第)1보(報)에서 추출(抽出)된 비옥도(肥沃度) 구성인자(構成因子)의 인자평점(因子評点) 및 현지조사(現地調査)에서 얻은 기타(其他) 환경인자(環境因子)를, 설명변수(說明變數)로 취(取)하고, 현지(現地)에서 청취조사(聽取調査)로부터 얻어진 쌀 수확량(收穫量)을 목적변수(目的變數)로 하여 다중회귀(多重回歸) 분석(分析)과 하야시의 수량화(數量化) 이론(理論) I (Hayashi's theory of quantification No.1)를 적용(適用)하여 생산력을 추정(推定)한 결과(結果)는 다음과 같다. (1) 시료(試料) 개체(個體)에 대하여 얻어진 다섯개의 인자평점(因子評点)을 설명변수(說明變數)로 하여 다중회귀분석(多重回歸分析)을 행(行)한 결과(結果) 중상관계수(重相關係數)가 0.43으로 추정(推定) 정도(程度)가 낮았다. (2) 비옥도(肥沃度) 인자간(因子間)의 상호작용(相互作用)을 고려(考慮)하여 직선회귀(直線回歸) 모델을 이차방정식(二次方程式)으로 변형(變形)시켜 생산력(生産力)을 추정(推定)한 결과(結果) 중상관계수(重相關係數)가 0.59로써 추정정도(推定精度)는 약간 높아졌으나 만족할 수 있는 추정식(推定式)은 얻지 못하였다. (3) 답(畓) 토양(土壤)에서 쌀의 생산력(生産力)을 지배(支配)하는 인자(因子)로서 비옥도(肥沃度)는 물론(勿論) 중요(重要)하지만 다른 환경인자(環境因子)의 영향(影響)도 받을 것으로 사료(思料)되어 비옥도군(肥沃度群), 수분공급(水分供給)의 양부(良否), 토양배수(土壤排水)의 양부(良否), 기후대(氣候帶), 표토(表土)의 점착성(粘着性), 표토(表士)의 결시성(結持性), 토성(土性) 및 하층토(下層土)의 구조발달정도(構造發達程度) 등(等)을 설명변수(說明變數)도 취(取)하여 하야시의 수량화(數量化) 이론(理論) 1을 적용(適用)하여 생산력(生産力)을 추정(推定)한 결과(結果) 중상관계수(重相關係數)가 0.9였고, 이들 인자(因子)들 중(中) 비옥도군(肥沃度群), 수분공급(水分供給) 및 기후대(氣候帶) 인자(因子)가 생산력(生産力)에 크게 기여(寄與)하고 있는 것으로 나타났다.

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한국 3개 지역의 결혼, 결혼년령 및 출산력에 관한 연구 (AGE AT MARRIAGE AND FERTILITY OF WOMEN IN THREE SELECTED AREAS IN KOREA, 1970)

  • 김모임
    • 대한간호학회지
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    • 제3권3호
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    • pp.1-14
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    • 1973
  • This study is designed to meet the following objectives: (1) To study attitude and behavior regarding marriage and age at marriage, (2) To learn correlates of age at marriage and to examine their relations, (3) To measure relative importance of the correlates of age at marriage, and (4) To study relations of age at marriage and family planning practice to fertility and their relative importance as correlates of fertility. The data are obtained by an independent cross-sectional survey in three study areas purposively selected to represent metropolitan. semihuman. rural population. The study population is confined to women age 17-50 as of survey. The overall response rate is 90%. Reliability of data is measured by . individual and aggregate inconsistency based upon a 15% subsample of the original interviews. The individual inconsistency (31%) is found to be high compared to the aggregate inconsistency (6%) for all 85 variables. However, the magnitude of differences between means is small, and the mean absolute shifts and proportional shifts are also small on the whole. In a word respondents did not change their answers too extremely or radically. The study populations of each study area are compared on some basic characteristics. It is found that the three study populations have more dissimilarities than similarities. The findings on seven different attitudinal positions of women toward marriage indicate that there have been tremendous changes in all study areas Iron "traditional" attitudes which have been prevalent for a long time in Korean society to "liberalized" or "modernized" attitudes. An apparent tendency is that women generally take a position of a "golden mean" attitude by not preferring either extreme of marriage attitudes. Nevertheless, the young, single, educated, and urbanite appears more "liberalized. " There has been some increase in ideal age at marriage from 1958 to 1970 for both sexes. No age group, marital status, or study area differentials in ideal age at marriage are found, the average ideal age at marriage in every sub-group being 24-25. Awareness of existing legal marriageable ages is low; only 4.4% are aware that "with parental permission: minimum age for males is 18 years and for females 16 years,"and only 3.7% are aware that "without parental permission: 27 years for males and 23 years for females." People in Korra tend to marry spouses who are in various social ways like themselves: the similarities include (a) education, occupational status of father, (c) economic status, (d) usual residence before marriage, and (e) religion. Both singulars and actual mean ages at marriage in this study confirm the trend of rising age at marriage previously established by other independent studies. The urban-rural differential in age at marriage is observed, but the differential narrows down gradually from 1935 to 1970. All socio-economic, demographic, and other variables pertaining to wife before and at first marriage, excluding (a) religion, (b) father′s of occupation, and (c) as: of menarche, are correlated with respondent's age at first marriage, whereas only three variables out of all socio-economic variables relating to husband before and at wife′s first marriage, viz., (a) education, (b) usual residence, and (c) economic level of his old home, are correlated with respondent′s age at marriage. Among socio-economic and modernity variables related to either husband or wife at the time of survey, only education and duration of residence are correlated with wife′s age at first marriage. Among the correlates of respondent′age at first marriage, education is in general the most important variable. However, it is found that wife′s education is more important than husband′s. The combined effects or the correlates studied explain no more than about 40% of variance for any of the selected groups of variables. Points which might counteract the effects of late marriage on fertility are not serious in Korea. For each of the correlates of the three fertility indices chosen for this study. namely, (a) number of living children, (b) number of live births, and (c) number of pregnancies, age at marriage is the major contributor to the variance in all age groups except the age group of 20-29 in which the index of family planning practice is the major contributor. The proportion of variability in fertility indices accounted for by the correlates is never more than 40% of the total variance in any age group. Based upon the findings from this study, it could be concluded that in the foreseeable future (a) celibate group will no! be increased to a point that would slow down population growth rate in Korea, (b) age at marriage will not increase continually, (c) although education stands out as the major contributing variable which independently explains the variation in age at marriage, it seems probable that education may not be the major variable in the near future, and (d) despite the fact found by this study that age at marriages has been the major contributor to the variance of each of the fertility indices used, family planning practice will play a more important role in the reduction of fertility in the Korean society. Therefore, factors interrupting practice of family planning must be eliminated and family planning program should be strengthened if further fertility reduction is needed.

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결혼 책임주의와 싱가포르 Social Development Network의 역할과 위상 (The Marriage Stewardship and the Role and Status of Social Development Network in Singapore)

  • 김명희
    • 한국융합학회논문지
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    • 제9권1호
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    • pp.143-149
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    • 2018
  • 이 논문은 싱가포르가 저출산 해결을 위해 '결혼장려정책'을 도입하고 실행주체인 'Social Development Network'(사회개발네트워크)를 어떻게 활용하여 저출산 문제에 대처해왔는지에 초점을 맞춘다. Social Development Network는 결혼에 대한 싱가포르의 국가 책임주의를 잘 드러내는 조직으로서 출범부터 고학력 여성의 독신 증가와 출산력 저하라는 사회현상과 맞물려 발전해왔다. Social Development Network의 전신은'Social Development Unit'(SDU)이며 이후에 발족한 'Social Development Service'(SDS)를 흡수하여 2009년 Social Development Network로 재탄생했다. 출범 시 Social Development Network는 상업적 결혼대행기관들의 도움 없이 자체적으로 회원을 모집하고 조직적인 활동을 추진해오다가 2006년부터는 민간업체들에게 데이트와 중매 서비스 활동을 위임하고 프로젝트를 지원하는데 집중해왔다. 이 논문은 문헌분석을 활용하여 싱가포르 결혼장려정책의 지원주체로서 결혼에 관한 책임주의 이론적 관점에서 출범 이후 현재에 이르는 Social Development Network의 위상과 역할을 분석하고 동일한 사회적 경험을 하고 있는 한국에 의미 있는 시사점을 제시하는데 목적을 둔다.

수도권 한방난임치료지원 조례 제정의 정책 확산 영향 요인 분석 (Analysis of the Influencing Factors of the Ordinance Enactment for Supporting Korean Medicine Infertility Treatment in the Metropolitan Area)

  • 김윤환;임병묵
    • 대한예방한의학회지
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    • 제25권3호
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    • pp.117-124
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    • 2021
  • Objectives : The purpose of this study is to analyze the factors affecting the enactment of local municipalities' ordinance for supporting Korean Medicine infertility treatment in the metropolitan area. Methods : For Seoul, Incheon, and Gyeonggi Province, data on the enactment of Korean Medicine infertility treatment and socio-demographic data of the local municipalities were collected through the Enhanced Local laws and regulations Information System and on-line statistical database. Logistic regression analysis was performed to analyze the factors affecting the enactment of the ordinance, The enactment of the ordinance was dependent variable, and the budgeting of local municipalities, the number of population, the number of births, the number of Korean Medicine doctors, and the total fertility rate were used as independent variables. Results : Up to 2000, the ordinances for supporting Korean Medicine infertility treatment were enacted in 16 local municipalities and the budget for that was supported by 18 local municipalities. Regarding the effect on the enactment of the ordinances, it was found that budgeting of Korean Medicine infertility treatment had a positive (+) effect, and the metropolitan government's budgeting and the total fertility rate had a negative (-) effect. Conclusions : This study suggests that the ordinance for Korean Medicine infertility treatment is a policy tool derived based on the problem of low fertility faced by each local municipality rather than the political influence of health provider's groups.

대소맥에 있어서 소수 및 소화의 분화, 발육정도가 임성 및 립중에 미치는 영향 (Relation of the Fertility and Grain Weight of Wheat and Barley to their Spike Differentiation and Development)

  • 남윤일;하용웅
    • 한국작물학회지
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    • 제27권2호
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    • pp.116-122
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    • 1982
  • 1. 소맥의 1소수당 립수는 수축의 기부로부터 제6~8단에 착생된 소수에서 가장 많이 임실되었으며, 수축의 양단에 가까워짐에 따라 감소하였다. 2. 소맥 농림6001의 수축 최하부의 소수에 임실된 립중은 25~27mg, 최상부는 26~28mg으로 가볍고, 수축의 기부로부터 제5,7,9단의 소수에 착생된 제2소화의 립중은 45~46mg, 제 1,3번째 소화의 립중은 36~43mg, 제4소화는 26~29mg으로, 제2소화에 착생된 립이 가장 무겁고 다음은 제1소화 > 제3소화 > 제4소화의 순으로 가벼웠다. 3. 파종밀도가 200립/$m^2$인 표준구에서는, 수축의 제5. 7. 9단에 착생된 소수의 각 소화별 평균 임실율은 제1소화가 97%, 제2소화 93%, 제3소화 88%, 제4소화는 15%로 제4소화의 임실율은 매우 나았으나, 이에 비하여 100립/$m^2$ 파종인 소식구에서는 표준구에 비하여, 임실율이 낮은 제1소수 및 제4소화의 임실율이 상대적으로 매우 높았으며 립중도 무거웠다. 4. 유수내의 소수 및 소화는 착생위치에 따라 분화 정도가 크게 달랐으며 분화소수 및 소화의 약 반수가 불임 또는 퇴화하였다. 5. 대맥에 있어서 출수 25일전에 X기에 달한 소수는 임실되었으나 Ⅸ후기의 소수는 불임으로, IX중기 이전의 수수는 퇴화하였다. 6. 출수 15-20일전에 분화정도가 X기 이상된 소맥의 소화는 임실되었으나 Ⅸ기 이전의 소화는 영양적인 생장은 보였으나 화기의 분화는 정지한채 불임 또는 퇴화하였다. 7. 이상의 결과로부터, 수의 양단, 소수내 선단소화의 립중 및 임성을 높이며, 분화된 소수 및 소화의 불임, 퇴화를 감소시킴으로서 1수립중의 개량여지는 많은 것으로 본다.

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