• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.12
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• pp.1701-1707
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• 2016

The present study investigated the anti-obesity effect of pine cone (PC, Pinus koraiensis) supercritical extract in high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice were treated with HFD, HFD+catechin, and HFD+PC [two different doses, 20 mg/kg body weight (b.w.) and 100 mg/kg b.w.] in each AIN93G supplement for 8 weeks. Treatment of HFD mice with both low and high doses of PC significantly reduced body weight gain compared to HFD mice. Liver weight of mice was reduced in both the low and high dose PC-supplemented groups (24.19% and 19.83%, respectively). Total adipose tissue weight of mice was reduced in both the low and high dose PC-supplemented groups (45.54% and 62.66%, respectively). Serum total cholesterol, triglyceride, LDL cholesterol, and HDL cholesterol were reduced in the low and high dose PC-supplemented groups, and ratios of HDL cholesterol to LDL cholesterol increased by 94.55% in the high dose PC-supplemented group. Serum leptin was significantly reduced in the low and high dose PC-supplemented groups (28.14% and 62.72%, respectively). These results were supported by genetic expression of protein and enzymes related to lipid metabolism assessed by real-time PCR. There was significant reduction of lipid regulatory transcription factors such as $PPAR-{\gamma}$, C/EBP, and SREBP and lipid enzymes such as fatty acid synthesis and lipoprotein lipase in the low and high dose PC-supplemented groups. However, there was no statistical difference between low and high dose PC treatments. These results suggest that pine cone supercritical extract supplementation is able to regulate serum lipid profiles by reducing total cholesterol, triglyceride, and LDL cholesterol levels, followed by regulation of expression of lipid metabolic factors, resulting in reduction of weight gain in HFD-induced obese mice.

• Journal of Nutrition and Health
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• v.30 no.3
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• pp.307-317
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• 1997

To determine the effects of endogenous and exogenous strogen on serum lipid levels, twenty nonsmoking healthy Korean women were participated in this experiment for 12 weeks. They were assigned to three groups : (1) eight women aged 22 to 30(yr) for the premenopausal(Pre) group, (2) eight, aged 49 to 60(yr) for the postmenoparusal(Pst) group, (3) four, aged 23 to 30(yr) for the oral contraceptive(OC) group which used triphasic OC formulation. Fasting blood samples representing every phase of the hormonal levels were obtained from the subjects of the Pre and the OC group. From the subjects of the Pst group, fasting blood samples were obtained once per three weeks for 12 weeks. All the serum data were adjusted for dietary effects, exercise, personality type and body mass index(BMI) by using analysis of covariation(ANCOVA). Serum lipid levels of the three groups were significantly different. While serum levels of triglycerides(TG)(p<0.0001), low density lipoprotein-chloesterol(LDL-C)/high density liporotein-cholesterol(HDL-C) ratio (LDC-C/HDL-C)(P<0.01) and total cholesterol (TC)/HDL-C ratio (TC/HDL-C)(P<0.001) were significatnly high in the Pst group, serum HDL-C(P0.001) level was significantly high in the Pre group. The OC group showed significantly low serum TC(P<0.0001) and LDL-C(P<0.0001) levels. There was no signidicant difference in the fluictuation of serum lipid levels during the menstrual cycle of the Pre group. However, in the OC group, serum TG level was significantly increased at phase 2(P<0.05) where exogenous estrogen administration was highest. Even though other serum lipid levels of the OC group were not significantly fluctuated according to the exogenous estrogen administration, there was a trend of increased levels of serum TC, LDL-C, LDL-C/HDL-C and TC/HDL-C and decreased level of HDL-C during the menstruation period. Also, serum TC level was high(P<0.005) and serum TG level was low (P<0.005) at the baseline of the OC group compared with the periods of OC administration. When screening and counseling the female population at risk for coronary heart disease(CHD), the result of this study suggest that in may be desirable to divide the population into several groups according to their personal physiological characteristics, such as age, OC administration, menstrual cycle and menopause, as well as general risk factors for CHD.

• Korean Journal of Plant Resources
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• v.29 no.4
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• pp.355-362
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• 2016

We investigated the effects of Acorus gramineus water extract on the blood lipid levels in high fat diet-fed obese male mice. We divided thirty-five C57BL/6 mice into 5 groups: normal group, control group, and groups treated with Acorus gramineus water extract at concentrations of 20, 100, and 500 ㎎/㎏. We inoculated Acorus gramineus water extract per orally once a day for 6 weeks respectively. The results revealed that Acorus gramineus water extracts had positive effects on the total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels.

• The Korean Journal of Food And Nutrition
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• v.26 no.4
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• pp.670-677
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• 2013

In this study, the effects of the intake of Prunus sargentii R. seed oil on the lipid levels of mouse blood were compared to the effects of commercially available corn oils. Mice from the same purchase lot were separated into 3 groups [control (n=5), corn oil-treated group (n=5), and Prunus sargentii R. seed's oil-treated group (n=5)] of equal size. The oil-treated groups of mice were fed their respective supplemented diets for a total of 8 weeks. Prunus sargentii R. seed oil is high in palmitic acid, oleic acid, and linoleic acid. The kidney weights of mice fed Prunus sargentii R. seed oil were higher than those fed corn oil (p<0.05). The HDL-cholesterol (high density lipoprotein cholesterol) levels in mice fed Prunus sargentii R. seed oil ($124.40{\pm}20.19$mg/dl) were higher than those of mice fed corn oil (p<0.05). The total cholesterol level was highest in mice fed Prunus sargentii R. seed oil, but the LDL-cholesterol (low density lipoprotein cholesterol) level was lowest in mice fed Prunus sargentii R. seed oil. Therefore, Prunus sargentii R. seed oil may be a good resource as a natural oil material.

• Journal of Ginseng Research
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• v.20 no.2
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• pp.125-132
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• 1996

To investigate the effect of Korean red ginseng (KRG) on male sexual function and serum lipid level, the results of KRG treatments were compared to placebo group. A total of 35 patients with psychogenic impotence were assigned to medication group with KRG (n=28) and placebo (n=7). KRG and placebo were given to each group for 2 months. Changes in symptoms such as frequency of coitus, morning erection, penile rigidity and tumescence were significantly higher in the group receiving KRG than placebo group. The overall therapeutic efficacies on erectile function were 67% for KRG group and 28% for placebo group (p <0.05). In the group treated with 9 tablets of KRG, there was tendency of better efficacy as compared to the group treated with 6 tablets of KRG. The level of serum high density lipid- cholesterol (HDL-cholesterol) was significantly elevated (p < 0.05) while the other serum lipid such as total cholesterol, tiglyceride and low density lipid-cholesterol (LDL-cholesterol) , were not changed after administration of KRG. This effect was observed significantly in the group in which KRG exerted its effect on sexual function(p < 0.05). From the above results, the administration of Korean red ginseng has shown to have superior of facts as compared to the placebo. The tendency of good effect was increased when a large amount of KRG was administered. The mechanism of KRG in improving sexual function would be the result of elevating the level of geum HDL-cholesterol in impotent patients. The effect of KRG was produced when the level of cholesterol was high before starting KRG medication. Therefore, the effect of KRG could be observed more intensively when the patients have high serum cholesterol level.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.8
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• pp.1273-1278
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• 2004

The change of tissue lipid levels and fatty acid compositions in alloxan-induced diabetes was studied in rats (SD, male) in order to examine the pathway of diabetic complications. Rats were injected with alloxan 20 mg/kg BW or 40 mg/kg BW to induce diabetes. In rats injected with alloxan (40 mg/kg BW), the body weight was significantly decreased, food intake and liver weight per 100 g (BW) were significantly increased, compared with other groups. The blood glucose levels were apparently elevated as about 2 times in rats injected with alloxan (40 mg/kg BW) than the other groups. The concentrations of serum total cholesterol, triglyceride and HDL-cholesterol were not significantly different among the groups. However, the levels of serum triglyceride tended to increase according to amount of alloxan injected. Liver cholesterol levels were significantly decreased in rats injected with alloxan (40 mg/kg BW) compared with other groups, but triglyceride levels of those were not significantly different among groups. Concerning the fatty acid compositions of serum, liver, kidney, spleen phosphatidylcholine, the percentage of linoleic acid in rats injected with alloxan (40 mg/kg BW) was significantly increased, while that of arachidonic acid was significantly decreased compared with the other groups. Therefore, the ratios of arachidonic/linoleic acid in tissue phosphatidylcholine tended to be low in rats injected with alloxan (40 mg/kg BW) and especially significant low levels were found in serum and spleen. Thus, it was suggested that insulin deficiency can affect on fatty acid biosynthesis and induce diabetic complications.

• Journal of Nutrition and Health
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• v.20 no.4
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• pp.237-245
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• 1987

Young male rats were fed for 10 and 20 days on different low-fat experimental diets ; 4% lard + 4% soybean oil, 4% sardine oil + 4% lard, 4% sardine oil with vitamin E+ 4% lard, 4% sardine oil with vitamin E+ 4% soybean oil. Lipid peroxide levels in liver were significantly higher in the sardine oil groups but the addition of vitamin Ehad no effects on the lipid peroxide values. Serum total cholesterol showed no significant difference among the groups but HDL-cholesterol in serum was increased in the sardine oil groups. However, the contents of serum triglyceride and phospholipid were unaffected by the replacement with sardine oil.

• BMB Reports
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• v.36 no.5
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• pp.499-504
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• 2003

There has been increasing interest in studying the various effects of organophosphate insecticides in humans and experimental animals. Only a few data are available on the effect of the organophosphate insecticide, diazinon, on lipid metabolism. The aim of this study was to evaluate the effect of diazinon on plasma lipid constituents in mammalian animals. The plasma levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and phospholipids (PL) were measured in albino rats that were orally treated with a single dose of diazinon at a level of $LD_{50}$ or with repeated daily doses at the levels of $\frac{1}{2}$, $\frac{1}{8}$, and $\frac{1}{32}$ $LD_{50}$ for 2, 8, and 32 days, respectively. After a 24 h post-treatment with a single $LD_{50}$ dose of diazinon, TC was not significantly changed, the HDL-C and PL levels were significantly decreased, but the LDL-C and TG levels were significantly increased. Separate daily oral administrations of diazinon at $\frac{1}{2}$ $LD_{50}$, $\frac{1}{8}$ $LD_{50}$, and $\frac{1}{32}$ $LD_{50}$ doses resulted in a significant decrease in HDL-C and PL, with no significant change in TG. The LDL-C levels were significantly increased and TC showed no significant change with $\frac{1}{2}$ $LD_{50}$ and $\frac{1}{32}$$LD_{50}$ doses of diazinon, whereas a significant decrease in the levels of TC, HDL-C, as well as LDL-C, was observed with the $\frac{1}{8}$ $LD_{50}$ dose. These data suggest that diazinon may interfere with lipid metabolism in mammals.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.202-218
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• 1998

In order to evaluate the effects of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG(Xinnao-Tong, Jiangzhiyanshou-Dan and Qingxintiaoqi-Tang) on hyperlipidemia, the experimental study was performed in rats without or with hyperlipidemia induced by 2% cholesterol fed-diet or Triton WR-1339. And the levels of serum total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid were measured. The results are summarized as follows : In the model of hyperlipidemia induced by 2% cholesterol Fed-diet 1. Both low & highly concentrated GANGJIYOUNSOODAN showed significantly decreasing effects on the level of serum total cholesterol while SIMNETONG & CHUNGSIMJOKlTANG didn't. 2. GANGJIYOUNSOODAN, SIMINETONG and CHUNGSIMJOKITANG showed decreasing effects on the level of serum triglyceride with no statistical significance. 3. Only highly concentrated GANGJIYOUNSOODAN showed increasing effects on the level of serum HDL-cholesterol while the others had no effects. 4. Only highly concentrated GANGJIYOUNSOODAN had decreasing effects on the level of serum LDL-cholesterol while the others had no effects. 5. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed significantly decreasing effects on the level of serum phospholipid while the other had no effects. In the model of hyperlipidemia induced by Triton WR-1339 6. SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed slightly decreasing effects on the levels of serum total cholesterol and triglyceride with no statistical significance. 7. None of SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed any effects on the level of serum HDL-cholesterol. 8. Highly concentrated GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum LDL-cholesterol but the other had no effects. 9. All of highly concentrated SIMNETONG, GANGJIYOUNSOODAN and CHUNGSIMJOKITANG showed decreasing effects on the level of serum phospholipid with statistical significance. These results show that GANGJIYOUNSOODAN and CHUNGSIMJOKITANG, in orders, have antihyperlipidemic effects. Further study on the mechanism and on the herb screening of these prescription should be followed.

• Journal of Korean society of Dental Hygiene
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• v.12 no.6
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• pp.1173-1182
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• 2012

Objectives : The purpose of this study was to examine the factors related to the dental caries and periodontal diseases of Korean elderly people in terms of demographic characteristics, oral health promotion behavior and systemic diseases in an effort to provide information on national policy setting and policy evaluation about the prevention of tooth loss resulting from severe oral diseases and the promotion of elderly people's oral health. Methods : The first-, second- and third-year raw data of the 4th National Health and Nutrition Survey were utilized, and the data of 3,882 elderly people who got a dental checkup were analyzed. The statistical package SPSS WIN 19.0 was employed to make a logistic regression analysis. Results : The senior citizens who did toothbrushing less frequently were more likely to have dental caries. As for periodontal diseases, the men were 1.34-fold more likely to have periodontal diseases than the women, and the respondents whose self-rated health state was worse were 1.40-fold more likely to have periodontal diseases than the others whose self-rated health state was better. The senior citizens who ever received treatment from unqualified people were 1.30-fold more likely to have peridontal diseases, and those who took neither vitamin compound nor minerals were 1.30-fold more likely to have periodontal diseases. Those who suffered from low High-density Lipoprotein cholesterol(HDL) were 1.35-fold more likely to have periodontal diseases than the others who didn't. Conclusions : Those whose self-rated health status is worse should especially be concerned about periodontal diseases. Specifically, it's needed to pay attention to the low-income classes, and the government should take measures to provide quality welfare services for elderly people not to receive treatment from unqualified people. Besides, research efforts should be made to determine the relationship between periodontal diseases and low HDL-cholesterolemia.