• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.148-160
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• 2023

Depression is a neuropsychiatric disorder associated with persistent stress and disruption of neuronal function. Persistent stress causes neuronal atrophy, including loss of synapses and reduced size of the hippocampus and prefrontal cortex. These alterations are associated with neural dysfunction, including mood disturbances, cognitive impairment, and behavioral changes. Synaptic plasticity is the fundamental function of neural networks in response to various stimuli and acts by reorganizing neuronal structure, function, and connections from the molecular to the behavioral level. In this review, we describe the alterations in synaptic plasticity as underlying pathological mechanisms for depression in animal models and humans. We further elaborate on the significance of phytochemicals as bioactive agents that can positively modulate stress-induced, aberrant synaptic activity. Bioactive agents, including flavonoids, terpenes, saponins, and lignans, have been reported to upregulate brain-derived neurotrophic factor expression and release, suppress neuronal loss, and activate the relevant signaling pathways, including TrkB, ERK, Akt, and mTOR pathways, resulting in increased spine maturation and synaptic numbers in the neuronal cells and in the brains of stressed animals. In clinical trials, phytochemical usage is regarded as safe and well-tolerated for suppressing stress-related parameters in patients with depression. Thus, intake of phytochemicals with safe and active effects on synaptic plasticity may be a strategy for preventing neuronal damage and alleviating depression in a stressful life.

• Applied Microscopy
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• v.45 no.2
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• pp.52-57
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• 2015

Bulk metallic glass (BMG) shows higth strength, high elastic limit, corrosion resistance and good wear resistance and soft magnetic properties and has been considering as a candidate for new structural materials. But they show limited macroscopic plasticity and lack of tensile ductility due to highly localized shear deformation, which should be solved for real structural application. In this paper researches on the enhancement of plasticity of BMG were reviewed briefly. Introducing heterogeneous structure in glass is effective to induce more shear transformation zones (STZs) active for multiple shear band initiation and also to block the propagating shear band. Several methods such as BMG alloy design for high Poisson's ratio, addition of alloying element having positive heat of mixing, pre-straining BMG and variety of BMG composites have been developed for homogenous distribution of locally weak region, where local strain can be initiated. Therefore enhancement of plasticity of BMG is normally accompanied with some penalty of strength loss.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.101-104
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• 2004

The application of rubber produt is a quite extensive field and has several problems in point of mass-production. The inhibitive factors at the general rubber mold are occurrence of flash, loss of raw material by curing for sprue and runner, environmental pollution by scrap junked after extraction of product and the unavailable mold structure for automation. The existence of flash at the rubber mold requires extra-process for removing or finishing it. As the reason, we can't help avoiding deterioration of quality and rising of cost. Hence we promptly need to research fur the efficient structure of mold and the preventive transforming technique of the flash without any loss of raw material in advance. This monograph is a study for Wasteless rubber mold that give us a solution for several problems happened at the general rubber mold.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1999.08a
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• pp.438-446
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• 1999

Crop minimization of the top and bottom ends of hot rolled plate, in a plate, in a plate mill, has been investigated. The existing model to determine the edging pattern at the finishing rolling pass was not reasonable to get high width accuracy and rolling yields. New models including width prediction have been formulated by using neural network model of back propagation learning algorithm and statistical analysis based on the actual production rolling data to give the optimal pattern for minimizing trimming loss. Using these models, at a given rolling condition of broadside pass and finishing pass and the permissible condition of width variation, it was possible to minimize crip at the top and bottom ends according to optimum procedure in plate mill. An application to improve the plan view pattern reduced width variation by 23% and crop length by 30% on average with an effective fishtail crop shape.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.203-208
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• 2005

In this paper, an automated adaptive mesh generation scheme, based on an advancing-front-Delaunay method, is developed for finite element simulation of three dimensional bulk metal forming processes. During the simulation, the finite element mesh system is adaptively remeshed whenever the mesh is unacceptable. Several schemes are developed such as curvature compensation scheme to minimize volume loss, optimal smoothing scheme to improve element quality, etc. The presented approach is evaluated and applied to automatic forging simulation in order to demonstrate the effect of the developed schemes.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.10a
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• pp.408-411
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• 2009

The plastic working process is a well-known molding method to produce products with good mechanical properties whilst reducing material loss and production time at the same time. Among those methods, the nosing process is commonly used for valves, tubes and ammunition which require high mechanical properties since it provides change in shape without additional mechanical process, minimum material loss during the post-process and superior properties. However, high manufacturing cost and time are required for the large-size tubes due to the multi-step nosing processes. In addition, there are some potential risks due to the buckling and property variation caused by the nosing process, too. Therefore, the shell nosing process is investigated and used in this study in order to resolve the problems described previously. Thus, we could obtain the process with lower cost and improved efficiency by means of the shell nosing process.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2006.05a
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• pp.226-229
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• 2006

Process design has been performed for the warm hydroforming of light weight alloy tubes. For the heating of tubes, specially designed induction heating system has been adopted to ensure rapid heating of tubes. The induction heating system uses 30kHz frequency induction coil in order to concentrate the energy in the tube and prevent the energy loss. But the induced heat by the integrated heating system, consisting of induction coil, tube, pressure oil and dies, was normally not equally distributed over the length and circumference of the tube specimen, and consequent temperature distribution was non-uniform. So additional heating element has been inserted into the inside of the tube to maintain the forming temperature and reduce temperature drop due to heat loss to the molds. And for that heat loss, a heat insulation system has also been installed. The drop in flow stress at elevated temperatures results in lower internal pressure for hydroforming and lower clamping forces. The proposed warm hydroforming process has been successfully implemented when applying 6061 aluminum extruded tubes.

• Geomechanics and Engineering
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• v.10 no.6
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• pp.827-836
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• 2016

The rate of softening is an important factor to determine whether the failure occurs along localized shear band or in a more diffused manner. In this paper, strength loss and softening rate effect depending on sensitivity are investigated for weakly cemented clays, for both artificially cemented high plasticity San Francisco Bay Mud and low plasticity Yolo Loam. Destructuration and softening behavior for weakly cemented sensitive clays are demonstrated and discussed through multiple vane shear tests. Artificial sensitive clays are prepared in the laboratory for physical modeling or constitutive modeling using a small amount of cement (2 to 5%) with controlled initial water content and curing period. Through test results, shear band thickness is theoretically computed and the rate of softening is represented as a newly introduced parameter, ${\omega}_{80%}$. Consequently, it is found that the softening rate increases with sensitivity for weakly cemented sensitive clays. Increased softening rate represents faster strength loss to residual state and faster minimizing of shear band thickness. Uncemented clay has very low softening rate to 80% strength drop. Also, it is found that higher brittleness index ($I_b$) relatively shows faster softening rate. The result would be beneficial to study of physical modeling for sensitive clays in that artificially constructed high sensitivity (up to $S_t=23$) clay exhibits faster strain softening, which results in localized shear band failure once it is remolded.

• Molecules and Cells
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• v.37 no.11
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• pp.767-776
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• 2014

Alzheimer's disease (AD) is clinically characterized with progressive memory loss and cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to neurodegeneration and memory dysfunction. Mounting evidence suggests that aggregation of amyloid-${\alpha}$ ($A{\alpha}$) and hyperphosphorylated tau leads to synaptic deficits and neurodegeneration, thereby to memory loss. Among the established genetic risk factors for AD, the ${\varepsilon}4$ allele of apolipoprotein E (APOE) is the strongest genetic risk factor. We and others previously demonstrated that apoE regulates $A{\alpha}$ aggregation and clearance in an isoform-dependent manner. While the effect of apoE on $A{\alpha}$ may explain how apoE isoforms differentially affect AD pathogenesis, there are also other underexplored pathogenic mechanisms. They include differential effects of apoE on cerebral energy metabolism, neuroinflammation, neurovascular function, neurogenesis, and synaptic plasticity. ApoE is a major carrier of cholesterols that are required for neuronal activity and injury repair in the brain. Although there are a few conflicting findings and the underlying mechanism is still unclear, several lines of studies demonstrated that apoE4 leads to synaptic deficits and impairment in long-term potentiation, memory and cognition. In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.05a
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• pp.266-269
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• 2009

Iron-based soft magnetic materials are widely used as cores, such as transformer transformers, motors, and generators. Reducing losses generated from soft magnetic materials of these applications results in improving energy conversion efficiency. Recently, the new P/M soft magnetic material realized an energy loss of 68 W/kg with a drive magnetic flux of 1 T, at a frequency of 1 kHz, rivaling general-purpose electromagnetic steel sheet in the low frequency range of 200 Hz to 1 kHz. In this research, the effect of rolling parameters on soft magnetic properties of Fe-based powder cores was investigated. The Fe-based soft magnetic plates were produced by the hot powder rolling process after both pure Fe and Fe-4%Si powders were canned, evacuated, and sealed in Cu can. The soft magnetic properties such as energy loss and coercive power were measured by B-H curve analyzer. The soft magnetic properties of rolled sheets were measured under conditions of a magnetic flux density of 1 T at a frequency of 200 kHz. It was found that rolling reduction ratio is the most effective parameter on reducing both energy loss and coercivity because of increasing aspect ratio with reduction ratio. By increasing aspect ratio from 1 to 9 through hot rolling of pure Fe powder, a significant loss reduction of one-third that of SPS sample was achieved.