• Nuclear Engineering and Technology
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• 제28권5호
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• pp.431-439
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• 1996

In the process of simplifying the complex fate of the plant into a binary state, the information loss is inevitable. To minimize the information loss, the quantification of plant safety status has been formulated through the combination of the probability density function arising from the sensor measurement and the membership function representing the expectation of the state of the system. Therefore, in this context, the safety index is introduced in an attempt to quantify the plant status from the perspective of safety. The combination of probability density function and membership function is achieved through the integration of the fuzzy intersection of the two functions, and it often is not a simple task to integrate the fuzzy intersection due to the complexity that is the result of the fuzzy intersection. Therefore, a methodology based on the Algebra of Logic is used to express the fuzzy intersection and the fuzzy union of the arbitrary functions analytically. These exact analytical expressions are then numerically integrated by the application of Monte Carlo method. The benchmark tests for rectangular area and both fuzzy intersection and union of two normal distribution functions have been performed. Lastly, the safety index was determined for the Core Reactivity Control of Yonggwang 3&4 using the presented methodology.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집 Vol.14 No.1
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of a 1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of a 1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of a 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• E2M - 전기 전자와 첨단 소재
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• 제14권12호
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• pp.3-6
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• 2001

In common globular proteins, the native form is n its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, ad internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of $\alpha$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of $\alpha$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of $\alpha$1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these Proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of ${\alpha}$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of ${\alpha}$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of e 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제28권1호
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• pp.33-58
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• 2024

This paper reviews basic concepts for Physics-Informed Neural Networks (PINN) applied to the initial value problems for ordinary differential equations. In particular, using only basic calculus, we derive the error estimates where the error functions (the differences between the true solution and the approximations expressed by neural networks) are dominated by training loss functions. Numerical experiments are conducted to validate our error estimates, visualizing the relationship between the error and the training loss for various first-order differential equations and a second-order linear equation.

• 품질경영학회지
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• 제21권2호
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• pp.61-70
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• 1993

The concept of producer's tolerance, in contrast to the consumer's tolerance, is a natural consequence of continuous loss functions. It is based on the premise that any unit product whose quality characteristic deviated from its traget value inflicts a loss, and that this less is a continuous monotonically increasing function of the magnitude of deviation. This concept of the emphasis on loss function to improve quality of products on the side of customer is introduced by Taguchi. This paper considers the problem of determining the optimum producer's tolerance by continous loss fuction of Taguchi and proposes a probablistic model for the problem. The difference between the proposed probablistic approach and the approach taken in Taguchi is also pointed out.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 춘계학술대회논문집
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• pp.901-904
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• 2007

The power flow analysis (PFA) can be effectively used to predict structural vibration in medium-to-high frequency ranges. In this paper, vibration experiments have been performed to observe the analytical characteristics of the power flow analysis of the vibration of various coupled plates. Those plates include two plates coupled with angles of $90^{\circ}$\;and\;30^{\circ}$, respectively. In the experiment, the loss factor and the input mobility at a source point on each coupled plate have been measured. The data for the loss factors have been used as the input data to predict the vibration of the coupled plates with PFA. The frequency response functions have been measured over the surface of the coupled plates. The comparison between the experimental results and the predicted PFA results for the frequency response functions has been performed.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.517-520
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• 2004

The power flow analysis(PFA) can be effectively used to predict structural vibration in medium-to-high frequency ranges. In this paper, vibration experiment has been performed to observe the analytical characteristics of the power flow analysis of the vibration of a plate. In the experiment, the loss factor of the plate and the input mobility at a source point have been measured. The data for the loss factor has been used as the input data to predict the vibration of the plate with PFA. The frequency response functions have been measured over the surface of the plate. The comparison between the experimental results and the predicted results for the frequency response functions showed that PFA can be an effective tool to predict structural vibration in medium-to-high frequency ranges.

• 한국정보과학회논문지:시스템및이론
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• 제34권5_6호
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• pp.187-194
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• 2007

Local alignment 알고리즘은 두 문자열을 비교하여 크기가 l, 유사도 점수가 s인 부분 문자열쌍을 찾는다. 크기가 충분히 크고 유사도 점수도 높은 부분 문자열 쌍을 찾기 위해 단위 길이당 유사도 점수 s/l을 최대화하는 정규화 방법이 제안되어있다. 본 논문에서는 증가함수 f, g를 도입하여 f(s)/g(l)을 최대화하는, 함수에 의한 정규화 방법을 제시한다. 여기서 함수 f, g는 DNA 서열을 비교하는 실험을 통해 정한다. 이러한 실험에서 함수에 의한 정규화 방법이 좋은 local alignment를 찾는다. 또한 유사도 점수의 기준으로 longest common subsequence를 채택한 경우, 기존의 정규화 알고리즘을 이용하면 별다른 시간 손실 없이 함수에 의해 정규화된 점수 f(s)/g(l)을 최대화 할 수 있음을 보인다.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2002년도 종합학술발표회 논문집 Vol.12 No.1
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• pp.423-433
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• 2002

A very fast method of moments(MoM) for the analysis of microstrip structure is considered based upon the use of rooftop basis and razor test functions in conjunction with a new closed-form Green's functions. The present method presents a robust approach to obtain the Green's functions which can be derived by use of only one set of approximation parameters independently of operating frequency range. Moreover, using the present MoM scheme, the MoM matrix elements can be analytically evaluated with few number of terms in comparison with the previous method. So, the computational efficiency can be improved significantly without loss of the precision. In order to check the validity of the present method, performance is demonstrated for the example of a coaxially-fed microstrip transmission line and the present results are compared with the previous results.