• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.331-340
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• 2022

Early afterdepolarization (EAD), a significant cause of fatal ventricular arrhythmias including Torsade de Pointes (TdP) in long QT syndromes, is a depolarizing afterpotential at the plateau or repolarization phase in action potential (AP) profile early before completing one pace. AP duration prolongation is related to EAD but is not necessarily accounted for EAD. Several computational studies suggested EAD can form from an abnormality in the late plateau and/or repolarization phase of AP shape. In this sense, we hypothesized the slope during repolarization has the characteristics to predict TdP risk, mainly focusing on the maximum slope during repolarization (dVm/dt_{max_repol}). This study aimed to predict the sensitivity of dVm/dt_{max_repol} to ion channel conductances as a TdP risk metric through a population simulation considering multiple effects of simultaneous reduction in six ion channel conductances of g_NaL, g_Kr, g_Ks, g_to, g_K1, and g_CaL. Additionally, we verified the availability of dVm/dt_{max_repol} for TdP risk prediction through the correlation analysis with qNet, the representative TdP metric. We performed the population simulations based on the methodology of Gemmel et al. using the human ventricular myocyte model of Dutta et al. Among the sixion channel conductances, dVm/dt_{max_repol} and qNet responded most sensitively to the change in g_Kr, followed by g_NaL. Furthermore, dVm/dt_{max_repol} showed a statistically significant high negative correlation with qNet. The dVm/dt_{max_repol} values were significantly different according to three TdP risk levels of high, intermediate, and low by qNet (p<0.001). In conclusion, we suggested dVm/dt_{max_repol} as a new biomarker metric for TdP risk assessment.

• Therapeutic Science for Rehabilitation
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• v.10 no.2
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• pp.23-36
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• 2021

Objective : The purpose of this study was to analyze group programs for the elderly living in communities and to provide basic data for applying effective occupational therapy programs for the elderly in the community. Methods : From January 2009 to December 2019, articles on group programs for the elderly in the community were searched for in the NDSL, DBPia, Riss, and PubMed databases. Based on the inclusion and exclusion criteria, a total 16 out of the 147 identified studies were selected and analyzed. This review analyzed the characteristics of the participants, contents of the group program, session and duration of the intervention, outcome measures, and effect of the group program. Results : Single group pre-post test studies with evidence level III were most common (8, 50.0%), and five (31.3%) of the studies were conducted on the community-dwelling elderly. Across all the 16 studies, there were 10 types of group programs, and the most frequently used was an exercise group program (25.0%). According to the analysis of the group program period, sessions and time, the intervention period was most commonly 12 weeks (37.5%), with 8 sessions or 12 sessions (25.0%). The intervention time in the group program was most commonly 60 minutes (43.8%). Conclusion : This study can be used as a basis for the development of effective group programs for the elderly and patients with dementia in community-based long-term care services.

• Korean Association of Arts Management
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• no.53
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• pp.207-247
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• 2020

is a project for the senior generation with humanistic knowledge to become a mentor and communicate with them to present the wisdom and direction of life to the new generations of mentees based on various life experiences. has been expanding since 2015, starting with the pilot operation in 2014. In general, projects such as these are assessed to establish effectiveness indicators to verify effectiveness and to establish project management and development strategies. However, most of the evaluations have been conducted quantitatively and qualitatively based on the short-term duration of the project. Therefore, in the case of continuous projects such as , especially in the field of culture and arts where long-term effectiveness verification is required, the short-term evaluation is difficult to predict and judge the actual meaningful effects. In this regard, tried to examine the qualitative change of key participants in this project through the 2017 and 2018 image tracking survey. For this purpose, we adopted qualitative research methodology through interview video shooting, field shooting, and value coding as a research method suitable for the research subject. To analyze the results, first, the interview images were transcribed, keywords were extracted, value encoding works were matched with human psychological values, and the theoretical method was used to identify changes and to derive the meaning. In fact, despite the fact that the study conducted in this study was a follow-up survey, it remained a limitation that it analyzed the changed pattern in a rather short time of 2 years. However, this study systemized the specific methodology that researchers should conduct for follow-up and provided the flow of research at the present time when there is hardly a model for follow-up in the field of culture and arts education business in Korea as well as abroad. Significance can be derived from this point. In addition, it can be said that it has great significance in preparing the detailed system and case of comparative analysis methodology through value coding.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.32 no.4
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• pp.409-416
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• 1987

The object of this study was to investigate the differences in dry matter production, physiological characteristic and grain yield of soybean (Glycine max (L.) Merr.) as affected by planting dates in southern region of Korea. This experiment was conducted using four planting dates and four varieties over 3 years (1982-1984). The different responses of soybean varieties to different temperature and daylength, days from planting to flowering were ranged from 43 to 55 days when planted on May 10 long daylength and low temperature condition. Flowering duration was ranged from 12 to 27 days and 9 to 13 days for the plantings made on May 10 and July 9, respectively. Therefore, it was the shortest under the short daylength and high tempera-ture condition. It also appeared that the later planting caused the lower dry matter weight and leaf area index which resulted in lower grain yield. But grain yield was not directly correlated with the unbalance of Xink/Source Ratio and the lodging from excessive vegatative growth. The grain yield was the highest in May 30 and the lowest in July 9 planting: it was ranged from 2.26 to 2.55 t/ha in the former and 0.85 to 1.20 t/ha in the latter, respectively. The increase in yield was depended on the increase in the number of pods per plant, the number of seeds per pod and the seed weight. The distribution ratio of dry matter to leaves was the hightest at the sixth trifoliolate leaf stage and gradually declined thereafter in all planting dates, and it also appeared that the later planting, the lower the ratio of dry matter to leaves.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.4
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• pp.342-351
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• 1990

Experiments were conducted to find out the possibilities of producing good quality seed of summer type soybean at Chuncheon, 74m above sea level and Jinboo, 600m above sea level in 1987. Local variety, Cheonan Jaelae was used. Seeds were sown June 25 harvested five times from 35 days after flowering with five days interval to 55 days. Vegetative period was longer in the early planting and high cool area, Jinboo, which resulted longer stem length than the late planting and in the plain area, Chuncheon. Pod number and 100 grain weight were shown more and heavier in Jinboo. Earlier planting and later harvesting resulted more pod number and heaveier 100grain weight. Grain yield was heigher in Jinboo, and earlier plainting shown more grain yield and its difference was greater in Jinboo. Long grain filling duration resulted more grain yield. Unripened seeds were produced more by earlier planting with earlier harvesting and earlier planting with late harvesting showed the high rates of pod and stem blight (Diaporthe Phaseolorum). Seed With high moisture content by early harvesting showed more rotten seeds in all planting dates production was more advantageous in the high cool area, Jinboo. Optimum planting date was between May 15 and June 5. Harvesting was desirable about 45-50 days after flowering with heigher germination rate seed yield.

• Journal of Chest Surgery
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• v.56 no.1
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• pp.25-32
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• 2023

Background: We reviewed the clinical outcomes of patients with oligometastatic (OM) non-small cell lung cancer (NSCLC) who received multimodal therapy including lung surgery. Methods: We retrospectively analyzed 117 patients with OM NSCLC who underwent complete resection of the primary tumor from 2014 to 2017. Results: The median follow-up duration was 2.91 years (95% confidence interval, 1.48-5.84 years). The patients included 73 men (62.4%), and 76 patients (64.9%) were under the age of 65 years. Based on histology, 97 adenocarcinomas and 14 squamous cell carcinomas were included. Biomarker analysis revealed that 53 patients tested positive for epidermal growth factor receptor, anaplastic lymphoma kinase, or ROS1 mutations, while 36 patients tested negative. Metastases were detected in the brain in 74 patients, the adrenal glands in 12 patients, bone in 5 patients, vertebrae in 4 patients, and other locations in 12 patients. Radiation therapy for organ metastasis was performed in 81 patients and surgical resection in 27 patients. The 1-year overall survival (OS) rate in these patients was 82.8%, and the 3- and 5-year OS rates were 52.6% and 37.2%, respectively. Patients with positive biomarker test results had 1-, 3-, and 5-year OS rates of 98%, 64%, and 42.7%, respectively. These patients had better OS than those with negative biomarker test results (p=0.031). Patients aged ≤65 years and those with pT1-2 cancers also showed better survival (both p=0.008). Conclusion: Surgical resection of primary lung cancer is a viable treatment option for selected patients with OM NSCLC in the context of multimodal therapy.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.30 no.4
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• pp.427-430
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• 1985

Extrusion degree of stigma, numbers of opened florets at different time during anthesis, angle of opening florets and outcrossed seed set percent were investigated in four male sterile rices having background of Korean cultivars; Suwon 296A, Suwon 304A, Suwon 310A and Suwon 296GMS, and the Chinese cytoplasmic genetic male sterile rice Zhenshan 97A as control in order to get basic informations for hybrid rice breeding. The results obtained were summarized as follows; Extrusion degree of stigma in the four Korean male sterile lines tested was lower than in the Chinese one Zhenshan 97A. The better extrusion of stigma showed the higher outcross rate in male sterile rices. There were almost no relationships between peak of anthesis and outcrossed seed set in the male sterile rices tested. Large anthesis angle with long anthesis duration appeared to be essential for high outcrossed seed set of the male sterile rices. The genetic male sterile line showed the larger anthesis angle than the cytoplasmic and genetic male sterile one in the lines having the same background to the Korean rice cultivar Suwon 296.

• Tuberculosis and Respiratory Diseases
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• v.86 no.2
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• pp.82-93
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• 2023

Tuberculosis (TB) is a significant public health concern. Globally, TB is among the top 10 and the leading cause of death due to a single infectious agent. Providing standard anti-TB therapy for at least 6 months is recommended as one of the crucial strategies to control the TB epidemic. However, the long duration of TB treatment raised the issue of non-adherence. Non-adherence to TB therapy could negatively affect clinical and public health outcomes. Thus, directly observed therapy (DOT) has been introduced as a standard strategy to improve anti-TB medication adherence. Nonetheless, the DOT approach has been criticized due to inconvenience, stigma, reduced economic productivity, and reduced quality of life, which ultimately could complicate adherence issues. Apart from that, its effectiveness in improving anti-TB adherence is debatable. Therefore, digital technology could be an essential tool to enhance the implementation of DOT. Incorporating the health belief model (HBM) into digital technology can further increase its effectiveness in changing behavior and improving medication adherence. This article aimed to review the latest evidence regarding TB medication non-adherence, its associated factors, DOT's efficacy and its alternatives, and the use of digital technology and HBM in improving medication adherence. This paper used the narrative review methodology to analyze related articles to address the study objectives. Conventional DOT has several disadvantages in TB management. Integrating HBM in digital technology development is potentially effective in improving medication adherence. Digital technology provides an opportunity to improve medication adherence to overcome various issues related to DOT implementation.

• Korean Journal of Social Welfare Studies
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• v.41 no.4
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• pp.277-311
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• 2010

The powerful association between poverty and mental health has been recognized for many decades in the Western Countries. Despite growing poverty studies, there has been little attention to the association between poverty and mental health in Korea. In this article we examine the effects of the mental health on the poverty status transition. In this study we draw on nationally representative data from the The Korean Welfare Panel Study, to estimate the effects of depression and self-respects on the poverty status transition. Major findings are as follows. First, we find that there are mental health disparities between poor and non-poor classes. The mental health conditions of the poor are worse than the non-poor. Second, we find the strong correlations between the mental health and poverty status transition. Whether poor family exits poverty or not depends on the household head's mental health. Third, poverty experiences are different depending on the mental health conditions. To the mental ill-health family, the probabilities of poverty-exit are much lower and poverty duration is more long. Fourth, we find that family poverty status transitions are very significantly related with household head's mental health from the logistic model analysis. These findings suggest that there is a strong relationship between poor mental health and the experience of poverty in Korea. They also suggest that intervention programs to enhance the mental health of the poor are needed in order to reduce the poverty problem in Korea.

• Journal of Industrial Convergence
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• v.21 no.8
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• pp.97-110
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• 2023

This study presents a systematic literature review aimed at integrating and analyzing the research findings regarding the components of various self-care intervention programs conducted for individuals with chronic obstructive pulmonary disease (COPD) both domestically and internationally. The paper selection criteria were established based on materials from PubMed, CINAHL, EMBASE, /MEDLINE, RISS, DBpia, KISS, and KMbase databases, covering the period from January 1, 2000, to September 30, 2022. The inclusion criteria included controlled pre-post experimental study designs. A total of 23 studies were included in this systematic review. The intervention-related factors examined included the sample size, type of intervention mediator, intervention frequency, and duration. Additionally, factors associated with intervention effects, such as measurement tools and variables, were analyzed. The findings of the analysis support the notion that self-care intervention programs for COPD can contribute to the prevention of symptom exacerbation and hospital readmissions among patients. Consequently, the development of a tailored self-care intervention program specifically designed for COPD patients in South Korea is warranted, considering aspects such as patient accessibility, convenience, and motivation for long-term sustainability.