• The Journal of the Acoustical Society of Korea
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• 제22권1E호
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• pp.43-48
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• 2003

The effects of linear acoustic channels have been analyzed and compensated at mel-frequency feature domain. Unlike popular RASTA filtering our approach incorporates separate filters for each mel-frequency band, which results in better recognition performance for heavy-reverberated speeches.

• 한국안전학회지
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• 제33권4호
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• pp.98-104
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• 2018

Macroscopic accident analyses have been conducted to incorporate transportation safety into long-term transportation planning. In macro-level accident prediction model, exposure variable(e.g. a settled population) have been used as fundamental explanatory variable under the concept that each trip will be subjected to a probable risk of accident. However, a settled population may be embedded error by exclusion of active population concept. The objective of this research study is to develop macro-level accident prediction model using floating population variable(concept of including a settled population and active population) collected from mobile phone data. The concept of accident prediction models is introduced utilizing exposure variable as explanatory variable in a generalized linear regression with assumption of a negative binomial error structure. The goodness of fit of model using floating population variable is compared with that of the each models using population and the number of household variables. Also, log transformation models are additionally developed to improve the goodness of fit. The results show that the log transformation model using floating population variable is useful for capturing the relationships between accident and exposure variable and generally perform better than the models using other existing exposure variables. The developed model using floating population variable can be used to guide transportation safety policy decision makers to allocate resources more efficiently for the regions(or zones) with higher risk and improve urban transportation safety in transportation planning step.

• 한국소프트웨어감정평가학회 논문지
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• 제16권2호
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• pp.143-151
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• 2020

인터넷을 기반으로 하는 디지털 컨텐츠 응용 분야에서 디지털 콘텐츠의 보안 및 인증은 매우 중요하다. 특히, 콘텐츠의 인증을 수행하는 방법에는 여러 가지가 있다. 디지털 워터 마킹은 이와같은 방법 중 하나이다. 특히, 논문은 디지털 이미지의 응용에서 동작하는 디지털 워터마크 기반 인증 방법을 제시한다. 제안 된 워터마크는 3 상태 정보를 가지고 있으며 참조 콘텐츠 없이 임베딩 및 검출을 수행하는 블라인드 워터마킹 방법이다. 디지털 콘텐츠의 소유자 정보를 인증 할 때 자기 상관 함수를 사용한다. 또한, 주파수 영역(DWT Domain)에서 원본 콘텐츠의 신호에 적응적이도록 대역 확산(Spread Spectrum) 방식을 사용한다. 따라서 은닉정보의 검출에서 일어나는 오류의 가능성을 줄였다. DWT에서의 워터마킹은 다른 변환 방법 (DFT, DCT 등)보다 빠른 은닉/검출의 장점을 가진다. 크기가 N=m X m인 이미지를 사용할 때의 계산량은 2상태 워터마크는 O (N·logN)인 반면 O (N)으로 줄어들 수 있다. 가장 우수한 장점은 비트 당 더 많은 정보를 숨길 수 있다는 것이다.

• Childhood Kidney Diseases
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• 제4권2호
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• pp.144-153
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• 2000

목 적 : 만성신부전 완자에서 1/scr, log Scr을 연속적으로 측정하여 신부전의 진행을 예측하고 있으나 연령에 따라 creatinine 생성율의 차이가 있는 소아에서는 정확한 진행예측에 어려움이 있다. 신장(height, Ht) 은 creatinine 생성율에 관여하는 중요한 인자이므로 따라서 저자들은 1/scr에 신장 (height, ht)을 도입한 Ht/Scr과 1/scr, log Scr을 연속적으로 측정하여 만성 신부전의 진행 예측도의 정확성을 비교하고저 하였다. 방 법 : 말기신부전으로 진행된 환아 63 명을 대상으로 혈청 크레아티닌 (Scr) 이 2 mg/dl에서 5 mg/dl 될 때까지 매 환자에서 1/Scr, log Scr, Ht/Scr을 연속적으로 측정하여 이들로부터 회기방정식을 구하여 Scr 이 10 mg/dl 이상인 시기를 예견하였다. 예측오차는 Scr 이 10 mg/dl 이상인 예측시기에서 실제시기를 뺀 것으로 하고 세군 간의 예측오차를 비교함으로써 만성신부전증 진행 예측의 정확도를 관찰하였다. 결 과 : 1) Ht/Scr 의 예측오차는 0.01 개월로 1/Scr, log Scr 의 예측오차인 2 개월, 10.6 개월보다 적었다(P<0.0001). 2) 선천성 신질환 환아의 Ht/Scr의 예측오차는 1.2 개월로 1/Scr, log Scr 의 예측오차인 3.2 개월, 8.2 개월보다 적었다 (p<0.000l). 사구체신염 환아의 경우 Ht/Scr, l/Scr, Ht/Scr의 예측오차는 각각 0.9 개월, 0.5 개월, 9.9 개월이었고 통계적인 차이는 없었다. 3) 13 세이전의 경우는 Ht/Scr 의 예측오차가 가장 적었고 그 이후 연령의 경우는 1/Scr의 예측오차가 적었으나 Ht/Scr과 통계적인 차이는 없었다. 4) Log Scr의 예측시기는 실재시기보다 늦었다. 결 론 : 소아 만성신부전 환아에서 시간에 따른 혈청 크레아티닌의 역수와 신장의 변화를 연속적으로 관찰함으로서 신부전의 진행 및 투석시기를 정확히 예측할 수 있었다.

• 한국지구과학회지
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• 제35권1호
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• pp.69-87
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• 2014

이 논문에서는 구성 자료의 지구통계학적 시뮬레이션을 위해 다중 자료 변환 기반 조건부 시뮬레이션 틀을 제안하였다. 우선 일반적인 통계 기법의 적용이 가능하도록 구성 자료에 로그비 변환을 적용하였다. 다음 변환들로는 최소/최대 자기상관 인자 변환과 지시자 변환을 순차적으로 적용하였다. 독립적인 새로운 변수의 생성을 위해 최소/최대 자기상관 인자 변환을 적용하였으며, 적용 결과 개별 변수들의 독립적인 시뮬레이션이 가능해진다. 그리고 다중 가우시안 확률 모델을 따르지 않는 변수들의 비모수적 조건부 누적 확률 분포 모델링을 위해 지시자 변환을 적용하였다. 최종적으로는 적용한 변환 방법들의 역순으로 역 변환을 적용하였다. 간석지 표층 퇴적물 성분 자료를 대상으로 제안 시뮬레이션 기법의 적용 가능성을 예시하였다. 모든 시뮬레이션 결과들은 구성 자료의 제한 조건을 만족하면서 샘플 자료의 통계 특성을 잘 반영하였다. 구성 자료의 다수의 시뮬레이션 결과들을 이용한 표층 퇴적물 분류를 통해 기존 크리깅에서는 얻을 수 없는 분류 결과의 확률론적 평가가 가능하였다. 따라서 제안 시뮬레이션 틀은 다양한 구성 자료의 지구통계학적 시뮬레이션에 효과적으로 이용될 수 있을 것으로 기대된다.

• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.223-229
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• 2002

Metformin is an oral antihyperglycemic agent used in the therapy of noninsulin-dependent diabetes mellitus and does not cause hypoglycemia at the therapeutic dose. Its mechanism of action may involve an increased binding of insulin to its receptors and glucose uptake at the post-receptor level. The purpose of the present study was to evaluate the bioequivalence of two metformin tablets, Glucophage (Daewoong Pharmaceutical Co., Ltd.) and Glycomin (Ilsung Pharmaceuticals Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The metformin release from the two metformin tablets in vitro was tested using KP VII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $23.75{\pm}1.96$ years in age and $68.77{\pm}10.41\;kg$ in body weight, were divided into two groups with a randomized $2{\times}2$ cross-over study. After one tablet containing 500 mg as metformin was orally administered, blood was taken at predetermined time intervals and the concentrations of metformin in serum were determined using HPLC with UV detector. Besides, the dissolution profiles of two metformin tablets were very similar at 떠1 dissolution media. The pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated. The ANOVA test was performed for the statistical analysis of the logarithmically transformed $AVC_t\;and\;C_{max}$, untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Glucophage were 0.09%, 6.09% and -8.22%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.94){\sim}log(1.09)\;and \;log(1.01){\sim}log(1.15)$\;for\;AVC_t\;and\;C_{max},\;respectively)$, indicating that Glycomin tablet is bioequivalent to Glucophage tablet.

• Journal of Pharmaceutical Investigation
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• 제33권2호
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• pp.135-140
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• 2003

Fluconazole is an orally active bis-triazole antifungal agent, which is used in the treatment of superficial and systemic candidiasis and in the treatment of cryptococcal infections in patients with the acquired immuno deficiency syndrome (AIDS). The purpose of the present study was to evaluate the bioequivalence of two fluconazole capsules, Diflucan (Pfizer Pharmaceuticals Korea Inc.) and Flucona (Korean Drug Pharmaceuticals Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The fluconazole release from the two fluconazole capsules in vitro was tested using KP VII Apparatus II method at 0.1 M hydrochloride dissolution media. Twenty normal male volunteers, $23.60{\pm}1.88$ years in age and $63.57{\pm}6.17\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After three capsules containing 50 mg as fluconazole was orally administered, blood was taken at predetermined time intervals and the concentrations of fluconazole in serum were determined using HPLC method with UV detector. The dissolution profiles of two fluconazole capsules were very similar at 0.1 M hydrochloride dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Diflucan were 4.96%, 5.65% and -13.76%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(1.01){\sim}log(1.08)\;and\;log(1.00){\sim}log(1.12)\;for\;AUC_t\;and\;C_{max},\;respectively)$, indicating that Flucona capsule is bioequivalent to Diflucan capsule.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.127-133
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• 2002

Levosulpiride is the 1evo-enantiomer form of racemic sulpiride, a benzamide derivative selectively inhibiting dopaminergic $D_2$ receptors at the trigger zone both in the central nervous system and in the gastrointestinal tract. The purpose of the present study was to evaluate the bioequiva1ence of two levosulpiride tablets, Levopride (SK Pharmaceutical Co., Ltd.) and Levopid (Dae Won Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The levosulpiride release from the two levosulpiride tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty eight normal male volunteers, $23.82{\pm}3.26$ years in age and $69.13{\pm}8.58$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 25 mg of levosulpiride was orally administered, blood was taken at predetermined time intervals and the concentrations of levosulpiride in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two levosulpiride tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Levopride were -1.17%, 1.20% and -1.09%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.07)\;and\;log(0.90){\sim}log(1.14)\;for\;AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g.,\;-19.47{\sim}16.20\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Levopid tablet is bioequivalent to Levopride tablet.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.135-140
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• 2002

Cefadroxil is a semi-synthetic cephalosporin active against many Gram-positive and Gram-negative bacteria. The drug has been used for the treatment of the urinary and respiratory tract infections when caused by susceptible strains of the designated microorganism. The purpose of the present study was to evaluate the bioequivalence of two cefadroxil capsules, Duricef (Bo Ryung Pharmaceutical Co. Ltd.) and Hanacef (Korean Pharmaceutical Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cefadroxil release from the two cefadroxil capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $21.58{\pm}2.43$ years in age and $70.74{\pm}10.29$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cefadroxil was orally administered, blood was taken at predetermined time intervals and the concentrations of cefadroxil in serum were determined using HPLC with UV detector. The dissolution profiles of two cefadroxil capsules were very similar at all dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Duricef were 0.05%, -5.29% and 4.53%. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.95){\sim}log(1.05)\;and\;log(0.87){\sim}log(1.02)$ for $AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${pm}20%$ $(e.g.,\;-6.75{\sim}15.74\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Hanacef capsule is bioequivalent to Duricef capsule.

• Biomolecules & Therapeutics
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• 제11권2호
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• pp.145-150
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• 2003

The bioequivalence of two tablet formulations of 12.72mg domperidone maleate (Sinil "$Perinal^{\circledR}$" tablets vs. Janssen Korea "Motilium-$M^{\circledR}$" tablets) was assessed in healthy Korean volunteers after oral administration in a randomized crossover study. Blood samples were collected at spccified time intervals, and plasma concentration was measured as the amount of domperidone base using a validated HPLC method. The pharmacokinetic parameters of $AUC_{0{\rightarrow}48},\; C_{max},\;T_{max}$ and $t_{1/2}$ were determined from plasma concentration-time profile of two formulations. Any significant statistical differences were not observed between these two formulations. On the evaluation of bioequivalence according to Korea Food and Drug Administration Guideline, 90％ confidence limits after logmithmic transformation fell within the acceptable range (log 0.8∼log 1.25). Based on these data, it can be concluded that two domperidone maleate tablets showed comparable pharmacokinetic profiles, which means that the Sinil "$Perinal^{\circledR}$" tablet is bioequivalent to the Janssen Korea ""Motilium-M$^{\circledR}$".