• Title/Summary/Keyword: local NO

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인과립구 콜로니 자극인자 제제인 HM10411 (rhG-CSF)의 국소자극성 (Local Irritation Test of HM10411 (rhG-CSF) in Rabbits)

  • 차신우;한정희;김충용;서정은;김종춘;권세창
    • Biomolecules & Therapeutics
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    • 제10권3호
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    • pp.170-174
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    • 2002
  • The local irritation study (skin and occular irritation tests) of HM10411, a rhG-CSF (recombinant human granulocyte-colony stimulating factor) was carried out in New Zealand White rabbits. HM10411 was applied to the bare skin at a dose of 2.5 mg/rabbit (5.0 mg/ml, 0.5 ml) and to the conjunctival sac of eye at a dose of 0.5 mg/rabbit (5.0 mg/ml, 0.1 ml) , respectively. In this study, there were no clinical signs which were related to HM10411 compared with those of control group. From above results, HM10411 has not any irritating activity to skin and eye in rabbits.

환기시스템 적용 도로터널의 국소환기 특성 시뮬레이션 및 해석 (Simulation and Analysis of Local Ventilation characteristic of Road Tunnel with Ventilation System)

  • 박기림;오명도;이재헌
    • 설비공학논문집
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    • 제13권5호
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    • pp.321-332
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    • 2001
  • In this study, a design program for ventilation requirements of a longitudinal raod tunnel were developed and investigated. The control volume method was applied to calculate the local air velocity and the local concentration distribution of pollutants, CO, $NO_x$, soot along the tunnel for various tunnel ventilation system. This program was validated by comparing with the practical design data for the road tunnel ventilation system. The calculation results were in good agreement with the practical design data.

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급성 천장골관절 염좌에 스테로이드 및 국소마취제의 관절내 주사 효과 (The Effects of Sacroiliac Injection of Local Anesthetics and Corticosteroids on Patients with Acute Sarcroiliac Sprain)

  • 신근만
    • The Korean Journal of Pain
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    • 제8권2호
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    • pp.293-297
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    • 1995
  • Despite applying recent advances in research and technology and taking into acount proper histories and performing thorough physical examinations, a high percentage of patients with low back pain have no identifiable pathology. Problems especially of the sacroiliac joint are commonly missed. The purpose of this article is to describe the effects of sacroiliac injection of local anesthetics and corticosteroids on patients with acute sacroiliac sprain. The sacroiliac joints are essentially nonweight-bearing joints that allows a small amount of anteroposterior rotatory movement around transverse axis usually about 5 to 10 cm below the promontory of the sacrum vertically. The ligamentous portion of sacroiliac joint is vulnerable to rotatory movement particularly when the individual is in an awkward position. Injections of 3 ml of 2% lidocaine and 10 mg of methylprednisolone were given twice at two day intervals to 26 patients with acute sacroiliac sprain. Most of those patients obtained excellent results without any adverse effects.

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Interaction of the State Authority and Business Structures in the In novative Development of the State Local Governance and Self-Governing in Kazakhstan

  • Karlygash, Mukhtarova;Laura, Ashirbekova
    • 동아시아경상학회지
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    • 제3권3호
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    • pp.27-34
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    • 2015
  • The authors consider, that the effectiveness of the government's activity, the improvement of decisions' quality depends on implementation of modern innovative technologies through activation the direct and feedback connection between public authority system and the business -community, through increasing the level of their collaboration by participating in solving main social problems and discu ssing innovative projects (initiative) according questions about socio-economic development of the country, improving the system of the state and local government in the Republic of Kazakhstan.

지방자치단체 교통사고통합지수 개발방안에 관한 연구 (A Study on Development of Traffic Accident Merging Index for Local Governments)

  • 임철웅;조정권;김수열;김주영
    • 한국안전학회지
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    • 제27권3호
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    • pp.147-152
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    • 2012
  • Traffic Accident Merging Index (TAMI) is developed for TMACS (Traffic Safety Information Management Complex System). TAMI is calculated by combining 'Severity Index' and 'Frequency'. The existing indexes are Traffic deaths per 100,000 population, Traffic deaths per 100,000 inhabitants/per billion veh-km, etc. However, there is no consistency in using them among local governments, so it can create confusion. Moreover, the index level is too complicated to understand. Therefore, this study suggests new traffic safety index, TAMI. It will work to improve the weaknesses and present accurate status of traffic safety in local governments.

대상포진 후 동통에 대한 치료 효과 (Effect on the Management of Postherpetic Neuralgia)

  • 구본업;박대팔
    • Journal of Yeungnam Medical Science
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    • 제8권1호
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    • pp.136-141
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    • 1991
  • 영남의대 부속병원 통증 치료실에 내원한 대상포진후 신경통 환자에 특별한 부위에 국소마취를 하여 좋은 효과를 나타내었기에 그 결과를 분석하였다. 1) 남여비 및 좌우측의 발생빈도는 비슷하였다. 2) 연령은 50~70세였으며 발생부위는 경부, 어깨, 팔이었으며 경부에 제일 많았다. 3) 국소마취의 효과는 연령과 시간에 관계없이 효과가 좋았으며 치료회수는 7~10회였다.

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Fluorine-Induced Local Magnetic Moment in Graphene: A hybrid DFT study

  • 김현중;조준형
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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    • pp.127.1-127.1
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    • 2013
  • Recent experimental evidence that fluorinated graphene creates local magnetic moments around F adatoms has not been supported by semilocal density-functional theory (DFT) calculations where the adsorption of an F adatom induces no magnetic moment in graphene. Here, we show that such an incorrect prediction of the nonmagnetic ground state is due to the self-interaction error inherent in semilocal exchange-correlation functionals. The present hybrid DFT calculation for an F adatom on graphene predicts not only a spin-polarized ground state with a spin moment of ${\sim}1{\mu}_B$, but also a long-range spin polarization caused by the bipartite nature of the graphene lattice as well as the induced spin polarization of the graphene states. The results provide support for the experimental observations of local magnetic moments in fluorinated graphene.

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The effect of vibratory stimulus on pain perception during intraoral local anesthesia administration in children: a systematic review and meta-analysis

  • Tirupathi, Sunny Priyatham;Rajasekhar, Srinitya
    • Journal of Dental Anesthesia and Pain Medicine
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    • 제20권6호
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    • pp.357-365
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    • 2020
  • Background: To evaluate the effectiveness of vibration as a counter-stimulatory measure in reducing subjective pain due to local anesthesia administration in children. Methods: Electronic databases (PubMed, Ovid SP, Cochrane Central Register of Controlled Trials) were searched until April 2020. Studies were screened by titles and abstracts, followed by full text evaluation of the included studies. Results: A total of seven studies involving 376 children aged 5-17 years were included in the systematic review and meta-analysis. The meta-analysis compared vibration as a counter-stimulatory measure with no vibration as a comparator. The primary outcome evaluated was pain perception or subjective pain reported by the child. The secondary outcome evaluated was objective pain evaluated in each study. The pooled mean difference favored vibration to be effective for the first outcome. Conclusion: Within the limits of this systematic review, low quality evidence suggests that vibration as a counter-stimulatory measure is effective in reducing the subjective pain reported by children during local anesthesia administration.

갑상선 질환의 외과적 절제술에 대한 국소적 합병증 (Local Complication after Surgical Resection for Thyroid Disease)

  • 조현진;조태형
    • 대한두경부종양학회지
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    • 제11권1호
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    • pp.9-17
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    • 1995
  • This study was retrospectively reviewed and analysis of postoperative local complication on all patient undergoing thyroid operation of 242 cases of thyroid disease, at Department of General Surgery, Chosun University Hospital from January 1988 to December 1992. The result were follow: Postoperative local complication are as follow; 52 cases of transient hypocalcemia, 7 cases of thansient hoarseness, 3 cases of permanent hypocalcemia, 2 cases of permanent hoarseness, and other local complication were postoperative bleeding with airway obstraction, hematoma, infection. In pathologic classification according to complicative patients; The most common frequency of complication in benign disease was Graves' disease with 13 cases(54.2%), and the most frequency of complication in malignance disease was follicalar adenocarcinoma with 7 cases(53.9%). The frequency of complication according to operation procedure were unilateral lobectomy in 31 cases(19.9%), subtotal thyroidectomy in 15 cases(39.5%), near total thyroidectomy in 12 cases (44.4%), and total thyroidectomy in 10 cases(55.6%). There was a significant relationship between extent of operative procedure and frequency of complication. The incidence of local complication after thyroid resection was 57 of 196(29.1%) in the benign disease that was 15 of 26(57.7 %) in the intrathyroidal carcinoma and 13 of 20(65.0%) in the extrathyroidal carcinoma. There was significant different in frequency of local complication according to invasion and malignance of pathologic lesion. The most frequent complication after thyroid resection is transient hypocalcemia ; 39 of 196(19.9%) in the benign disease, 7 of 26(26.9%) in the intrathyroida1 carcinoma, and 6 of 10(30.0%) in the extrathyroidal carcinoma. Their complication rate increased in direct relationship to the invasion and malignance of pathologic lesion, but there was no statistically significant. Transient hypocalcemia was encountered in 52 cases of the total 242 patient(21.9%) ; 29 of 156(18.6%) after unilateral lobectomy, 9 of 38(23.7%) after subtotal thyroidectomy, and 5 of 18(27.8 %) after total thyroidectomy. The relation ship between temporal hypocalcemia and the extent of surgery was not statistically significant.

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마이크로파 여기 프라즈마법으로 제조한 강자성 터널링 접합의 국소전도특성 (Local Current Distribution in a Ferromagnetic Tunnel Junction Fabricated Using Microwave Excited Plasma Method)

  • 윤대식;김철기;김종오
    • 한국자기학회지
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    • 제13권2호
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    • pp.47-52
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    • 2003
  • DC 마그네트론 스파터법과 RLSA(Radial Line Slot Antenna)을 이용한 마이크로파 여기 프라즈마를 이용하여 Ta/Cu/Ta/NiFe/Cu/Mn$_{75}$Ir$_{25}$/ $Co_{70}$Fe$_{30}$/Al-oxide 구조의 접합을 제조한 후, contact-mode AM(Atomic Force Microscope)을 이용하여 Al 산화막의 국소전도 특성의 평가를 수행하였다. AFM 동시전류측정으로부터, 얻어지는 표면상과 전류상은 대응하지 않는다. 국소 전류-전압(I-V)의 측정 결과, 전류상은 절연층의 barrier height의 분포를 나타내고 있다는 것을 알았다.다.다.