Local Irritation Test of HM10411 (rhG-CSF) in Rabbits

인과립구 콜로니 자극인자 제제인 HM10411 (rhG-CSF)의 국소자극성

  • 차신우 (한국화학연구원 부설 안전성평가연구소) ;
  • 한정희 (한국화학연구원 부설 안전성평가연구소) ;
  • 김충용 (한국화학연구원 부설 안전성평가연구소) ;
  • 서정은 (한국화학연구원 부설 안전성평가연구소) ;
  • 김종춘 (전남대학교 수의과대학) ;
  • 권세창 (한미약품공업주식회사)
  • Published : 2002.09.01

Abstract

The local irritation study (skin and occular irritation tests) of HM10411, a rhG-CSF (recombinant human granulocyte-colony stimulating factor) was carried out in New Zealand White rabbits. HM10411 was applied to the bare skin at a dose of 2.5 mg/rabbit (5.0 mg/ml, 0.5 ml) and to the conjunctival sac of eye at a dose of 0.5 mg/rabbit (5.0 mg/ml, 0.1 ml) , respectively. In this study, there were no clinical signs which were related to HM10411 compared with those of control group. From above results, HM10411 has not any irritating activity to skin and eye in rabbits.

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