• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.159-169
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• 2005

Anxiety is essentially a normal emotion with great adaptive significance like pain. to ease human suffering, treatment is sought to quell pain and anxiety only when they are excessive or when they interfere with performance or general health. In oriental medicine, anxiety has been also known as a important factor which is cause of body and mind disease. We obtained some points after studying of bibliographic research about anxiety and anxiety disorder like follows: 1. The signification of anxiety is similar to fear affection(恐情) and anxious feelings are fearful, long for solitary life and afraid of captivity. 2. Mechanism of anxiety disorder is related with kidney(腎) as well as heart(心), liver(肝), gall bladder(膽) and stomach(胃). 3. The prescription of fear affection is tonifying of kidney(益腎) and fixing of kidney's pure substance(固精) that is based on deficiency of kidney(賢氣不足) 4. A representative disorder about anxiety and phobia are Keongke(驚悸) and Cheongchung(정충). 5. Keongke(驚悸) and Cheongchung(정충) may be understood as phobias(恐佈症), general anxiety disorder(凡不安障碍) and panic disorder(恐慌障碍).

• YAKHAK HOEJI
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• v.42 no.2
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• pp.181-186
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• 1998

This study was attempted to investigate the pharmacokinetics of cyclosporine (10mg/kg, oral) in rabbits with $CCI_4$ and bile duct ligation-induced hepatic disorder. The area under the curve (AUC) of blood cyclosporine concentration versus time was significantly increased ($CCI_4$-induced hepatic disorder. Elimination rate constant (Kel) was significantly decreased (p<0.05, p<0.01) in rabbits with $CCI_4$ and bile duct ligation-induced hepatic disorder. Volume of distribution (Vdss) and total body clearance (CLtot) were significantly decreased (p<0.01) in rabbits with $CCI_4$-induced hepatic disorder. But Vdss was significantly increased (p4-induced hepatic disorder were 874ng/ml and 2.71 hr, respectively. Cmax and Tmax values in rabbits with bile duct ligation were 105ng/ml and 2.834 hr, respectively. From results of this experiment. It is desirable to do therapeutic drug monitoring of cyclosporine for effective treatment when the cyclosporine is administered to patients with liver disorder m clinical practice.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.4
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• pp.225-232
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• 2013

Children with abnormal liver function can often be seen in outpatient clinics or inpatients wards. Most of them have respiratory disease, or gastroenteritis by virus infection, accompanying fever. Occasionally, hepatitis by the viruses causing systemic infection may occur, and screening tests are required. In patients with jaundice, the tests for differential diagnosis and appropriate treatment are important. In the case of a child with hepatitis B virus infection vertically from a hepatitis B surface antigen positive mother, the importance of the recognition of immune clearance can't be overstressed, for the decision of time to begin treatment. Early diagnosis changes the fate of a child with Wilson disease. So, screening test for the disease should not be omitted. Non-alcoholic fatty liver disease, which is mainly discovered in obese children, is a new strong candidate triggering abnormal liver function. Muscular dystrophy is a representative disease mimicking liver dysfunction. Although muscular dystrophy is a progressive disorder, and early diagnosis can't change the fate of patients, it will be better to avoid parent's blame for delayed diagnosis.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.207-213
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• 2007

1. The pathogenic factors of diarrhea are external sensation, jungjishiljo, weakness of the spleen and stomach, improper diet, sinyanghueson, sueumyujang, liver Gi invades the spleen, uhhyuljeche. 2. The etiological causes of diarrhea are classified into pung, han, seo, seup, yul, sikjuk, ju, chiljung, damsul. Morphology of diarrhea are classified into yu, hwal, son, pok, goe, dongsul. 3. The etiological cause of diarrhea are closely related to the malfunction of the spleen, stomach and the related jang and bu's pathological alternation such as splees & stomach, large intestine, small intestine, liver, spleen, and kidney. 4. Diarrhea was mentioned in literatures not only as chronic Heohansung disorder, but also acute silyulsung disorder, based on hanyulheosil theory.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.247-251
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• 2000

A male German Shepherd dog, $2{\frac{1}{2}}$years of age, was admitted with sudden anemia, weakness, hyperpyrexia, anorexia and lethargy. The patient showed hypoplastic anemia, thrombocytopenia, absolute and relative lymphocytosis, absolute and relative granulocytopenia, hypoalbuminemia, slight hepatic disorder, slight azotemia, hematuria and proteinuria by the screening examination. The bone marrow aspiration smear showed high cellularity, severs infiltration of lymphoblasts and prolymphocytes, and mitotic figures of lymphoid cells. The liver aspiration smear demonstrated infiltration of lymphoblasts. Acute lymphoblastic leukemia was diagnosed as none of the superficial lymph nodes showed enlargement and marked functional disorder of important organs other than the liver was not found. The patient was treated with vincristine, cyclophophamide, predniosolone for chemotherapy and blood transfusion and either ampicillin or cefoperazone for supportive treatment. But the patient did not show marked remission and died 9 days after the start of the chemptherapy. The necropsy was not permitted.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.187-196
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• 2010

We have come to a conclusion below after studying about the cause of limb hyperhidrosis through references, putting the result into practice clinically from Hyungsang remedy point of view, examining the effect of treatment. The cause of limb, palm and sole hyperhidrosis. The cause of limb hyperhidrosis is stomach heat(Yangmyung heat), weakness and coldness of stomach, moisture and heat of spleen and stomach, energy insufficiency of spleen and stomach, weakness of Yin of spleen and stomach, heat by weakness Yin meridian, unspread energy of liver, severe heat of heart, weakness of heart, shortage of blood, the functional disorder of kidney meridian and heart meridian(disposition of water ascension and fire descent), heat of blood(the functional disorder of heart) etc. The cause of palm hyperhidrosis is blood insufficiency of heart and liver or the functional disease of heart and stomach. The cause of sole hyperhidrosis is the functional disease of heart and kidney or the functional disease of kidney. Types classified by the cause of limb hyperhidrosis. The case of stomach heat, moisture and heat of spleen and stomach is found a lot in Yangmyeong and Fish Type. The case of weakness and coldness of stomach or insufficiency energy of spleen and stomach is found in Bangkwang and Ki Type, the shape of disorder of transfer and transformation of spleen and stomach. The case of severe heat of heart, the functional disorder of kidney meridian and heart meridian(disposition of water ascension and fire descent), heat of blood(the functional disorder of heart), heat by weakness of meridian of Yin is found a lot in Dam, Bird and Shin Type. Limb sweat caused by unspread energy of liver is found a lot in Horse Type. Palm sweat is found a lot in Bird or Yangmyeong Type. Sole sweat is found a lot in Fish or Taeum Type. Jeokbokryung-tang was good especially for type limb hyperhidrosis falling under the shape of the small intestines heat which conforms to the person having a short perpendicular furrow of the upper lip or lifted upper lip. Palmul-tang was good for type limb hyperhidrosis tending to having leaking liquid and humor because of the disorder of transfer of Jung, Ki, Shin, Hyul. Dossipyungwi-san and Hyangsapyungwi-san were good for type limb hyperhidrosis caused by stomach heat by food accumulation and Ki depression.

• Journal of Haehwa Medicine
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• v.22 no.1
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• pp.91-104
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• 2013

Objective : This study was designed to analyze the clinical studies on Tic disorder in traditional Korean medicine and traditional Chinese medicine. Methods : To figure out the Tic disorder, Korean medical studies from Oriental Medicine Advanced Searching Integrated System (OASIS) and Chinese Medical Journals from Wangfang data and China National Knowledge Infrastructure (CNKI) which published in 2008 to 2012 were analyzed. Results & Conclusions : 1. DSM-IV(7 studies), CCMD(3 studies) were frequently used in the diagnosis of tic disorder. 2. The herbs used for the treatment of tic disorder are Uncariae ramulus et Uncus(釣鉤藤), Paeoniae Radix Alba(白芍藥), Poria(白茯苓), Buthus martensi Karsch(全蝎) etc. 3. Acupuncture points frequently used were Paek'oe(GV20), Pungji(GB20), Naegwan(PC6), Sasinchong(EX-HN1), T'aech'ung(LR3), Joksamni(ST36), Hapgok(LI4) and so on. 4. The cause of Tic disorder is connected with liver, heart, spleen, kidney, gall bladder among the internal organs and Fire(火), Wind(風), Dampness(濕) of external causes.

• Journal of Oriental Neuropsychiatry
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• v.27 no.1
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• pp.11-21
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• 2016

Objectives: This study was performed to review the research trends in the treatment of eating disorder in traditional Chinese medicine (TCM). Methods: The CNKI database (China National Knowledge Infrastructure) was searched under the key words ‘Eating Disorder’, ‘Anorexia Nervosa’, and ‘Bulimia Nervosa’. Results: Thirteen articles were selected. These included 2 studies on bulimia nervosa, and 11 studies on anorexia nervosa. According to study design, studies were classified into 1 randomized controlled trial, 2 single group before-and-after studies, and 8 case reports. According to therapy method, they included 11 herbal medicine studies, and 2 complex treatment studies. The most common pattern identification was ‘liver qi depression’ (肝氣鬱結), and the most used herb was ‘Root of Bupleurum falcatum’ (柴胡). Most of the studies showed effective results. Conclusions: The results of our study indicated that TCM clinical studies on eating disorder were being conducted more actively than in Korean medicine. Korean medical treatment might be effective to relieve eating disorder symptoms. In the future, more scientifically designed clinical studies should be performed to prove the effectiveness of traditional Korean medicine treatment on eating disorder.

• Korean Journal of Plant Resources
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• v.33 no.3
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• pp.163-169
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• 2020

Alcoholic fatty liver disorder has become a frequent health concern worldwide. To investigate the effects of Brassica oleracea (B. oleracea) sprout extract (BOE), the present study was designed with alcoholic fatty liver in the rat. Initially, the effects of BOE on liver parameters were examined. Male rats were divided into five groups. The normal control group was fed the normal diet, and the BOE group was fed the high fat diet and ethanol with/without BOE for 4 weeks. After 4 weeks feeding period, rats were sacrificed and their livers and blood were used for fatty liver-related biomarkers analyses. As a result, BOE ameliorated fatty liver-related enzymes profiles in liver tissues and also reduced blood alcohol concentration in rat model. We demonstrated that BOE protected the high fat diet and alcohol-induced fatty liver in rat model. Furthermore, BOE increased detoxificative abilities against alcohol.

• Advances in Traditional Medicine
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• v.4 no.2
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• pp.100-103
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• 2004

The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.