• 혜화의학회지
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• 제10권2호
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• pp.83-89
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• 2002

In the literatual study of anti-tumor effects of chunghwangsan for leukemia, the results were as follows. 1. Chunghwangsan is composed of Indigo naturalis and Realgar. The composing rate is 9 : 1 and it is made into capsule or piece. The basic administration is 0.3g per day and could increase the quantity each day. 2. The effects of Chunghwangsan is expelling toxin and colling, colling blood to detumescence, drying wetness and anticancer are. So it can be used to treat AML, CML and lymphoma. 3. The anticancer component of Indigo naturalis is indirubin which has the effects of suppression the transplanted tumor, activating the phagocyte of macrophage, promoting the maturation of myeloblast to improve cure rate of CML. The anticancer component of Realgar is $As_2O_3$ which has the direct cellular toxicity for leukemia cell. 4. In viewpoints of oriental medicine, leukemia is malignant myeloid neoplasia in which pathogen invade to shaoyin(少陰). So Chunghwangsan which is expelling toxin and colling, colling blood to detumescence, drying wetness and anticancer is effective to leukemia. 5. In clinical reports, Chunghwangsan is often used in CML, and also used in AML, lymphoma and so on. 6. Chunghwangsan is cool-natured, so we must carefully pay attention to pregnant women and hematsdthenic patients. The main side effects are nausea, bone marrow pain, diarrhea, polydefecation, hematokezia and purpora. We sometimes take invigorating stomach medicine to prevent the side effects. 7. If we continuously develop Chunghwangsan and therapy for leukemia with syndrome differentiation. we can improve the response and cure rate for leukemia in the future.

• 혜화의학회지
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• 제9권1호
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• pp.337-352
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• 2000

According to the literatual study on the Infantile Vomiting since the publication of ${\ll}Hwangjenaekung{\gg}$, the results were as follows. 1. The causes of vomiting are classified into the following kind: external cause are the cold and heat, not external and internal are disorder of food and mood, internal are the dysfuntion of spleen, stomach, liver, kidney. 2. The Oriental Medical cause of Infantile Vomiting is disorder of food, intusion of outside evil, heat accumulation in the stomach, deficiency of stomach liquid, reverse flowing of Qi resulted from fear and being frightened. There are so many causes of Infantile Vomiting, but they are all related to the stomach. 3. The Western Medical cause of Infantile Vomiting are classified with the situation of stimulation, age, accompanied symptom. The main cause related with the age is inhalation of amniotic fluid, maternal blood, infectious disease, wrong lactation method, functional and organic abnormality. 4. The Infantile Vomiting is similar with the adults, but the spleen and stomach of infants is so feeble that the vomiting happens very easily. The reverse flowing of Qi resulted from fear and being frightened and disorder of food are the main cause in infants. 5. The cause of Infantile Vomiting between Oriental Medicine and Western's is so similar and both emphasized the function of spleen and stomach. But the comment on the external cause(cold, heat) and not internal & external cause(mood disorder) is a creative view of Oriental Medicine.

• 한방안이비인후피부과학회지
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• 제12권1호
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• pp.268-294
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• 1999

External therapy is a very useful method in today. But a study of theoretical basis of external therapy is very poor in Korea. So I carried out to investigate of 《Li Yue Pian Wen, 理淪騈文》. And I translated and analyzed to , firstly. Wu Shi Ji (吳師機) was one of the physician in qing(淸) dynasty (AD). He wrote the 《Li Yue Pian Wen, 理淪騈文》 which is the first special book on the external therapy(外治法). This is composed of 5 parts. In these parts,

• 혜화의학회지
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• 제10권1호
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• pp.133-148
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• 2001

From this book, $\ll$GeumGueyoryak Hakbyeongmaekjeungbyeongchi$\gg$, I finally got these conclusions of symptoms and pathology of Hakbyeong. 1. Hakbyeong has main symptoms of repetition of chillness and fever and its main pulse is pulse of Hyeon(弦) and position is in the middle of inside and outside. 2. Change in shape of pulse caused by Hakbyeong can have shape of pulse of Sak(數), Jee(遲), Kin(緊), Dae(大) and more kinds depending on patients constitution, the cause of disease, or whether he/she has been poisoned by other kinds. 3. After 15 days of symptoms, As Cheonki(天氣) and Inki(人氣) get stronger and Saki(邪氣) gets weaker, Jeongki(正氣) can be more recovered and the diseases can be disappeared. But if the disease dose not get away after another 15 days of showing symptom, that disease can be treated as cutting the Jingha under side of him/her. 4. The type of Hakbyeong which is diseased by the keeping the Haksa for long time, can be classified as Hagmo which has symptoms of chillness and fever outside, and of Jinggha inside, Danhag which has symptoms of difficulty with breathing, chest discomfort - caused by fever in the lung at ordinary times -, fever of extremities and nausea and that would make people worn out and thin after all, Onhag which has main symptoms of fever and Mohag which has symptoms of less fever and more chillness. 5. In this thesis it has been described, the Byulgabjunhwan(鼈甲煎丸), Baekhogagaejitang(白虎加桂枝湯), and Chokchilsan(蜀漆散) is the respective prescription for treatment of Hagmo, Onhag, and Mohag. From this conclusion, if the more research about the cause of disease, pathology and prescription of the each symptom from GeumGueyoryak hereafter, I could say more effective prophylaxis and treatment of epidemic disease like todays Hakbyeong can be found.

• 한방안이비인후피부과학회지
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• 제13권2호
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• pp.20-50
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• 2000

This paper was written into condsideration records about the definition of "Ong-Jeo", the difference between "Ong" and "Jeo", the Western medical approach to "Ong-Jeo", and the etiology and pathologic mechanism of "Ong-Jeo". After this study, I report the following results from it. 1. "Ong" is an acute diapyesis disease which is found is in our skin and muscle and flesh. The chrateristics of this disease is that the affacted site is shine, no head, and the size is 3-4 chon. The prossess of the diesease shows that it is very quick, and very easily swell, and becomes pus easily, easily become to ulcer, easily converge. But this don't damage to the muscle and bone. 2. "Jeo" is the disease which damages bone-skeleton, muscle and flesh, and even destroy the stationary tissue. Jeo can be divided into two. One is called "Yudujeo" and it is acute diapydesis disease. The characteriscs of this disease is the miliary abscess, swell, has fever, and has an ache which is feeled spaned. And this is diffused into periphrey tissue and is diffused into deep site. After the ulcer, this becomes to shape the cellula. The size is more than 3-4 chon and this disease goes into chuk if this is serious. The other one is called "Mudujeo" and this disease is the ulcerative one in our joint and skeleton. The characteristic of this disease shows that the color of skin be not changed, and swell diffusely, and is not easily vanished, not easily becomes ulcerative, and not easily becomes converged. 3. "Ong-Jeo" is caused by the bacteriunm named by the "Golden and Yeollw Staphylococcus" in the Western medicine. "Ong" can be applicable to the carbuncle, acute diapyesis lymphadenitis, and some of cellulitis. "Jeo" can belong to cellulitis, and Mudujeo can belong to suppurative arthritis, suppurative osteomyelitis, tuberculous arthritis and osteomyelitis, and tuberculous lymphadenitis. 4. The etiologies of "Ong-Jeo" can be divided three, which are internal, external and other etiology which can not be clasiffied by two etiologies above. The internal etiology is seven emotion, and the external etiology is the six eumsa, unki, chunhang and so on. Other etiology is inadequate absorption of food, and excessive bang-sa. 5. The etiology of "Ong" is suppurative one which is choked between our skin and muscle and flesh, and is congested, become to hot, and finally erodes the muscle and flesh because of the inbalance of cirrculation in the enegy and blood. "Jeo" is the same as the Ong, but this is the suppurative disease which damages the muscle, flesh, and skeleton, and even damages into five Zang, the internal intestine.

• 동의생리병리학회지
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• 제16권4호
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• pp.630-636
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• 2002

After The Yellow Emperor's Canon of Internal Medicine, The text researches of pathologic change to the liver disease concluded the next, 1, The category of liver-disease(肝病) include the Symptoms of abnormality due to vital energy and blood motion, emotion and intention, muscular and reproductive function, and legions around descending liver channel. 2. In the theory that Liver-Yang energy(肝陽氣) is always overproducing, Liver-Yin blood(肝陰血) is always lacking, pathologic characteristics for liver disease is functional change of malfunction of the use of body(體用失調), So nourishing the liver and kidney is used for the principal aspects of a disease. regulating and calm the liver is used for the secondary aspects of a disease as the treatment plan, 3. If malfunctioning of the functions of dispersion and discharge(疏泄), Iiver-energy(肝氣) is becoming degected, So overproduct and overflow of ascent and exhalation of liver-yang(肝陽) is becoming blood are ascending following energy. complete usage of Yin-blood(陰血) is responsible for some kinds of mass formed by blood stasis in the early stage of pathogenesis of liver disease syndrome of the energy system as the progession of disease extravasated blood is forming. the pathologic characteristics is appeared loss of control of the vital energy and blood(體用失調) at the liver disease. 4. Sthenia-syndrome of liver(肝實證) and liver-heat syndrome(肝熱證) is appered that overproducing and overflow of dispersion(疏泄太過) and discharge is responsible for overfunctioning of liver disease or some kinds of heat syndrome such as liver fire(肝火), Sthenia of liver-yang(肝陽上亢), the syndromes of sthenic liver heat(肝實熱) are appered. deficiency of the liver(肝虛證) and cold syndrome of liver(肝寒證) is classified pathologic characteristics of cold and heat, deficiency and excess that regression of sensory, motor, mental due to lack of dispersion and discharge(疏泄不及), or intruding of the cold miasma, are degected. 5. The liver is close relation of physiologic function and internal organ such as spleen, stomach, lung, heart, kidney, gall bladder by the meridian channels, because of property of wind Zang, rapid progession is classified by phthologic charateristics.

• 대한중풍순환신경학회지
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• 제7권1호
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• pp.34-39
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• 2006

Objectives and methods : The Euibujipsung is the one of the huge-scale encyclopedias about Oriental Medicine. To investigate the most frequently used acupoints for hemiparesis after stroke, we used Euibujipsung CR-ROM database with several key words concerned with motor weakness (半身不遂 不遂不隨 癱瘓 中臟 中腑 風痱, etc.). Results : In the result, we found five popular acupoints (GV20, LI11, LI15, ST36 and GB39), and four meridians (Stomach, Gall bladder, Large intestine and Small intestine). We also found that the Yang meridians were cited more frequently than the Yin. Conclusion : Therefore we think that these findings can give further ideas to clinical practice and research fields for stroke rehabilitation in Oriental medicine.

• 대한중풍순환신경학회지
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• 제8권1호
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• pp.28-33
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• 2007

Objectives and methods : The Euibujipsung is one of the huge-scale encyclopedias about Oriental Medicine. To search the most frequently used aupoints for dysarthria after stroke, we used Euibujipsung CD-ROM database with several chinese character keyword concerned with vernal function(語, 言, 音, 啞, 瘖, etc). Results : We found four popular acupoints(PC5, GV20, GV16, TE6), and five meridians (Governor vessel, Gall Bladder, Heart, Large Intestine and Triple Energizer). We also found that the extra meridians were used more frequently than other type of meridians. Conclusion : We think that these findings can give further ideas to clinical practice and research fields for stroke rehabilitation in Oriental medicine.

• Journal of Acupuncture Research
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• 제22권3호
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• pp.253-270
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• 2005

수종(水腫)의 분류(分類), 병인(丙因), 병기(病機), 치법(治法), 변증시치(辨證施治)에 따른 치료혈(治療穴)의 관계(關係)에 대해 황제내경이후(黃帝內經以後) 34종의(種) 문헌(文獻)을 고찰한 결과(結果) 다음과 같은 결론(結論)를 얻었다. 1. 수종(水腫)은 육음외야(六淫外耶), 노권내상(勞倦內傷), 혹(或) 음식실조(飮食失調) 등으로 폐(肺) 비(脾) 비신(脾腎)과 방광(膀胱) 삼초(三焦)의 기능이 장애(障碍)되어 진액수포(津液輸布)를 실상(失常)함으로써 수액(水液)이 저유(貯留)하여 기부(肌膚)로 범일(泛溢)한 것으로 얼굴 팔다리 가슴 배, 심하면 온 몸에 머물러 붓는 병증(病症)이다. 2. 수종(水腫)의 분류(分類)는 병인(病因)과 맥증(脈證)에 따라서 오장수(五臟水) (간수(肝水) 심수(心水) 비수(脾水) 폐유(肺兪) 신수(腎水)), 오종수(五種水) 풍수(風水) 피수(皮水) 정수(正水) 석수(石水) 황한(黃汗)), 십수(十水)(청수(淸水) 적수(赤水) 황수(黃水) 백수(白水) 흑수(黑水) 원수(元水) 풍수(風水) 석수(石水) 이수(里水) 기수(氣水))로 구분(區分)되며, 이밖에 십이수(十二水)와 이십사수후(二十四水候), 양수(陽水)와 음수(陰水)로 대별(大別)되기도 한다. 3. 수종(水腫)의 병인(病因)은 풍사외습(風邪外襲) 폐기부선(肺氣不宣), 수습내침(水濕內侵) 비부건운(脾不健運), 노권태과(勞倦太過) 기포(飢飽) 생육부절(生育不節) 등(等)에서 벗어나지 않으며, 양수(陽水)의 병인(病因)으로 풍수범람(風水泛濫) 습열옹성(濕熱壅盛), 음수(陰水)의 병인(病因)으로 전양쇠허 신기쇠미(腎氣衰微) 등이 있다. 4. 수종(水腫)의 병기(病機)는 폐(肺) 비(脾) 신(腎) 삼경장기(三經臟氣)의 기능실조(機能失調)에 지나지 않으며, 그 병의(病) 근본(根本)은 모두 신에(腎) 있다. 5. 수종(水腫)의 침구치료(針灸治療)에 있어서, 침구치료(鍼灸治療)를 병용(竝用) 하거나 혹은 구법(灸法)만 사용하기도 한다. 문헌상(文獻上) 침자혈위(針刺穴位)는 '수구(水溝)' 혈이(穴) 최요혈(最要穴)이며 '수분(水分) 수구(水構)' 혈이(穴) 구법(灸法)의 최요혈(最要穴)로 기재(記載)되어 있다. 6. 수종(水腫)의 병인병기(病因病耭)에 따른 침구치료(針灸治療)에 있어서 주로 풍(風) 습(濕) 열에(熱) 해당하는 양수(陽水)나 실증(實證)엔 산풍(散風) 청열리습(淸熱利濕) 선폐리전하기 위해 '수구(水構) 족삼리(足三里) 비유(脾兪) 제릉천(除陵泉)(사)(瀉)' 등의 혈을(穴) 침랄사법(針剌瀉法) 하거나 혹구(或灸)하며, 비양허(脾陽虛) 신기허(腎氣虛)에 해당하는 음수(陰水)나 허증(虛證)엔 온운비양(溫運脾陽) 온신조양(溫腎助陽) 화기행수(化氣行水) 하기 위해 '수분(水分) 족삼리(足三里) 기해(氣海)(구)(灸) 비유(脾兪) 신유(腎兪) 삼초유(三焦兪) 태계(太溪)' 혈을(穴) 보(補) 평보평사(平補平瀉) (침자(針刺))하거나 구법(灸法)을 활용한다.

• 혜화의학회지
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• 제8권2호
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• pp.211-243
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• 2000

This study was performed to investigate the cause, symptom, treatment, medicine of Wei symptom through the literature of oriental and western medicine. The results obtained were as follows: 1. Wei symptom is the symptom that reveals muscle relaxation without contraction and muscle relaxation occures in the lower limb or upper limb, in severe case, leads to death. 2. Since the pathology and etiology of Wei symptom was first described as "pe-yeol-yeop-cho"(肺熱葉焦) in Hung Ti Nei Ching(黃帝內經), for generations most doctors had have accepted it. but after Dan Ge(丹溪), it had been classified into seven causes, damp-heat(濕熱), phlegm-damp(濕痰), deficiency of qi(氣虛), deficiency of blood(血虛), deficiency of yin(陰處), stagnant blood(死血), stagnant food(食積). Chang Gyeng Ag(張景岳) added the cause of deficiency of source qi(元氣). 3. The concept of "To treat Yangming, most of all"(獨治陽明) was emphasized in the treatment of Wei symptom and contains nourishment of middle warmer energy(補益中氣), clearance of yangming-damp-heat(淸化陽明濕熱). 4. Since Nei-ching era(內經時代), Wei and Bi symptom(痺症) is differenciated according to the existence of pain. After Ming era(明代) appeared theory of co-existence of Wei symptom and pain or numbness but they were accepted as a sign of Wei symptom caused by the pathological factor phelgm(痰), damp(濕), stagnancy(瘀). 5. In the western medical point of view, Wei symptom is like paraplegia, or tetraplegia. and according to the causative disease, it is accompanied by dysesthesia, paresthsia, pain. thus it is more recommended to use hwal-hyel-hwa-ae(活血化瘀) method considering damp-heat(濕熱), qi deficiency of spleen and stornach(脾胃氣虛) as pathological basis than to simply differenciate Wei and Bi symptom according to the existence of pain. 6. The cause of Gullian-Barre syndrome(GBS) is consist of two factors, internal and external. Internal factors include asthenia of spleen and stomach, and of liver and kidney. External factors include summur-damp(暑濕), damp-heat(濕熱), cold-damp(寒濕) and on the basis of "classification and treatment according to the symptom of Zang-Fu"(臟腑辨證論治), the cause of GBS is classified into injury of body fluid by lung heat(肺熱傷津), infiltration of damp-heat(濕熱浸淫), asthenia of spleen and kidney(脾腎兩虛), asthenia of spleen and stomach(脾胃虛弱), asthenia of liver and kidney (肝腎兩虛). 7. The cause of GBS is divided by according to the disease developing stage: Early stage include dryness-heat(燥熱), damp(濕邪), phlegm(痰濁), stagnant blood(瘀血), and major treatment is reducing of excess(瀉實). Late stage include deficiency of essence(精虛), deficiency with excess(虛中挾實), and essencial deficiency of liver and kidney(肝腎精不足) is major point of treatment. 8. Following is the herbal medicine of GBS according to the stage. In case of summur-damp(暑濕), chung-seu-iki-tang(淸暑益氣湯) is used which helps cooling and drainage of summer-damp(淸利暑濕), reinforcement of qi and passage of collateral channels(補氣通絡). In case of damp-heat, used kun-bo-hwan(健步丸), In case of cool-damp(寒濕), used 'Mahwang-buja-sesin-tang with sam-chul-tang'(麻黃附子細辛湯合蓼朮湯). In case of asthenia of spleen and kidney, used 'Sam-lyeng-baik-chul san'(蔘笭白朮散), In case of asthenia of liver and kidney, used 'Hojam-hwan'(虎潛丸). 9. Following is the herbal medicine of GBS according to the "classification and treatment according to the symptom of Zang-Fu"(臟腑辨證論治). In the case of injury of body fluid by lung heat(肺熱傷津), 'Chung-jo-gu-pae-tang'(淸燥救肺湯) is used. In case of 'infiltration of damp-heat'(濕熱浸淫), us-ed 'Yi-myo-hwan'(二妙丸), In case of 'infiltration of cool-damp'(寒濕浸淫), us-ed 'Yui-lyung-tang', In case of asthenia of spleen, used 'Sam-lyung-bak-chul-san'. In case of yin-deficiency of liver and kidney(肝腎陰虛), used 'Ji-bak-ji-hwang-hwan'(知柏地黃丸), or 'Ho-jam-hwan'(虎潛丸). 10. Cervical spondylosis with myelopathy is occuered by compression or ischemia of spinal cord. 11. The cause of cervical spondylosis with myelopathy consist of 'flow disturbance of the channel points of tai-yang'(太陽經兪不利), 'stagnancy of cool-damp'(寒濕凝聚), 'congestion of phlegm-damp stagnant substances'(痰濕膠阻), 'impairment of liver and kidney'(肝腎虛損). 12. In treatment of cervical spondylosis with myelopathy, are used 'Ge-ji-ga-gal-geun-tang-gagam'(桂枝加葛根湯加減), 'So-hwal-lack-dan-hap-do-hong-eum-gagam(小活絡丹合桃紅飮加減), 'Sin-tong-chuck-ue-tang-gagam(身痛逐瘀湯加減), 'Do-dam-tang-hap-sa-mul-tang-gagam'(導痰湯合四物湯加減), 'Ik-sin-yang-hyel-guen-bo-tang'(益腎養血健步湯加減), 'Nok-gakyo-hwan-gagam'(鹿角膠丸加減). 13. The cause of muscle dystropy is related with 'the impairement of vital qi'(元氣損傷), and 'impairement of five Zang organ'(五臟敗傷). Symptoms and signs are classified into asthenia of spleen and stomach, deficiency with excess, 'deficiency of liver and kidney'(肝腎不足) infiltration of damp-heat, 'deficiency of qi and blood'(氣血兩虛), 'yang deficiency of spleen and kidney'(脾腎陽虛). 14. 'Bo-jung-ik-gi-tang'(補中益氣湯), 'Gum-gang-hwan'(金剛丸), 'Yi-gong-san-hap-sam-myo-hwan'(異功散合三妙丸), 'Ja-hyel-yang-gun-tang'(滋血養筋湯), 'Ho-jam-hwan'(虎潛丸) are used for muscle dystropy. 15. The causes of myasthenia gravis are classified into 'insufficiency of middle warmer energy'(中氣不足), 'deficiency of qi and yin of spleen and kidney'(脾腎兩處), 'asthenia of qi of spleen'(脾氣虛弱), 'deficiency of qi and blood'(氣血兩虛), 'yang deficiency of spleen and kidney'(脾腎陽虛). 16. 'Bo-jung-ik-gi-tang-gagam'(補中益氣湯加減), 'Sa-gun-ja-tang-hap-gi-guk-yang-hyel-tang'(四君子湯合杞菊地黃湯), 'Sa-gun-ja-tang-hap-u-gyi-eum-gagam'(四君子湯合右歸飮加減), 'Pal-jin-tang'(八珍湯), 'U-gyi-eum'(右歸飮) are used for myasthenia gravis.