• Genomics & Informatics
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• 제14권4호
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• pp.196-204
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• 2016

Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: three methods in Haploview (confidence interval, four gamete test, and solid spine), MIG++ implemented in PLINK 1.9 and S-MIG++. We used several experimental datasets obtained by sampling subsets of single nucleotide polymorphism (SNP) markers of chromosome 22 region in the 1000 Genomes Project data and also the HapMap phase 3 data to compare the results of haplotype block partitions by five methods. With decreasing sampling ratio down to 20% of the original SNP markers, the total number of haplotype blocks decreases and the length of haplotype blocks increases for all algorithms. When we examined the marker-independence of the haplotype block locations constructed from the datasets of different density, the results using below 50% of the entire SNP markers were very different from the results using the entire SNP markers. We conclude that the haplotype block construction results should be used and interpreted carefully depending on the selection of markers and the purpose of the study.

• 한국경제지리학회지
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• 제3권2호
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• pp.63-80
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• 2000

전통적인 농수산업지역인 광양에 제철소가 입지하여 세계 제1의 제철소로 발전하는 과정에서 광양지역은 급격한 인구유입과 함께 사회적.경제적 변화를 경험했다. 제철소의 입지는 연관단지의 조성과 관련산업을 육성시켜 광양지역을 신흥공업도시로 변모시켰고 고용을 확충시켰다. 2000년 말 현재 광양제철소와 직접 관련된 고용인원은 17,240명이며 광양시에 거주하는 39,593명(28.7%)이 직접 관련된 인구로 조사되었다. 본 연구는 광양제철소의 입지가 광양지역의 공습화와 경제구조변화에 미친 영향을 분석하기 위해 변이할당분석과 지역성장률시차분석을 수행했다. 1981년 594명이던 광양의 고용인구는 1992년에 29,865명으로 증가하였고, 다시 1998년에 23,399명으로 감소하였다. 지역경제구조변화는 제조업과 건설업이 주도적 역할을 하였다.

• 정보과학회지
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• 제4권2호
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• pp.34-44
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• 1986

본 연구에서는 mini computer를 이용하는 relational data base 관리 운영 체제의 실현적인 구현을 위한 시스템 설계를 소개한다.이 시스템은 독자적으로 개발한 간단한 operating system을 이용하며, assembly 언어로 쓰여졌으므로 기 존 assembler를 사용하였다. 시스템 설계방법에 data base가 차지하는 공간 (memory space)의 효율을 주로 고려하였으며, mini computer로는 No.A 840 system을 이용하였다.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2002년도 제38회 학술심포지움
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• pp.13-19
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• 2002

To elucidate the regulatory mechanism for expression of sialyl-glycoconjugates and their biological functions, ninetheen sialyltransferase cDNAs including eleven by our group or co-works have been cloned and characterized so far. The cloned sialyltransferases are classified into four families according to the carbohydrate linkages they synthesize: ${\alpha}2,3-sialyltransferase$ (ST3Gal I-VI), ${\alpha}$ 2,6-sialyltransferase (ST6Gal I), GalNAc ${\alpha}$ 2,6-sialyltransferase (ST6GalNAc I-VI), and ${\alpha}2,8-sialyltransferase$ (ST8Sia I-VI). Each of the sialyltransferase genes is differentially expressed in a tissue-, cell type-, and stage-specific manner. These enzymes differ in their substrate specificity and various biochemical parameters. However, enzymatic analysis conducted in vitro with recombinant enzyme revealed that one linkage can be synthesized by multiple enzymes. We present here an overview of structure and function of sialyltransferases performed by our group and co-works. Genomic structures and transcriptional regulation of two kinds of human sialyltransferase gene are also presented.

• 전기학회논문지P
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• 제58권1호
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• pp.48-55
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• 2009

In order to keep safe driving conditions under road networks, there are several formations such as road structure, road surface condition, traffic occupancy and supplement of an accurate information of traffic status ahead To support safe-driving on each road formation, each formation is supplied with various information to help the driver. However, in some cases like rapid status change at local-scale geography, traffic information systems often displays insufficient information because of the lack of information correlation. In order to accurately aware the driver, all road formation must be in sync. It is important to supply accurate information to the driver because this information directly impacts the drivers on the road. This paper discusses the amber information to keep the least safety driving over road formations including tunnels and bridges. This paper also will propose the informations for safe-driving conditions, information linkage on the road and rule-base safety information, as ITS technology, being displayed for all drivers under the worst weather conditions.

• 대한수학회보
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• 제49권4호
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• pp.715-736
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• 2012

Brown provided a structure theorem for a class of perfect ideals of grade 3 with type ${\lambda}$ > 0. We introduced a skew-symmetrizable matrix to describe a structure theorem for complete intersections of grade 4 in a Noetherian local ring. We construct a class of perfect ideals I of grade 3 with type 2 defined by a certain skew-symmetrizable matrix. We present the Hilbert function of the standard $k$-algebras R/I, where R is the polynomial ring $R=k[v_0,v_1,{\ldots},v_m]$ over a field $k$ with indeterminates $v_i$ and deg $v_i=1$.

• 한국인쇄학회지
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• 제13권1호
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• pp.1-12
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• 1995

Polymeric mesogens having a regularly alternating rigid-flexible repeating structure in the main-chain polymer exhibit distinct even-odd oscillation in their thermodynamic quantities with respect to the number of methylene units in the spacer. The even-odd oscillation depends on the number of methylene groups in the spacer the entropy change at the NI(nematic-isotropic) phase transition becomes less distinct when the linking group is replaced by the carbonate. In our previous work, we have suggested that the characteristics arise from the geometrical arrangement of the linkage. In this work, we have prepared a series of carbonate-type monomer and dimer liquid crystals. The thermodynamic behaviors at the NI phase transition have been compared with those previous reported for the ether- or ester-type liquid crystals. For the dimer series, the orientational order parameter of the mesogenic core was determined by using H-NMR technique. The origin of the difference observed among linking groups was found to the geometrical characteristics of chemical structure.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.371.3-372
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• 2002

We have reported cytotoxicities based on several types of sugar linkage in saponins in addition to antitumor and antiinflammatory effects. In order to find further structure-activity relationship on the cytotoxicity of saponins. we intended to isolate oleanane disaccharides Irom the saponin-containing extract of Akebia Quinata (Lardizabalaceae). (omitted)

• Asia pacific journal of information systems
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• 제10권1호
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• pp.61-79
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• 2000

ERP system is a very popular tool for pushing management innovation and implementing an integrated information system. The purpose of this research is to investigate the relationship among the structure of production systems, types of implementation strategy, relative importance of competitive goals, information technology and culture level, and the efficiency from using the system. The data for this study were collected from 45 Korean manufacturing firms that have implemented ERP system. Research results confirm that the success factors include the top managements' strategic views and culture level related to new information technology. But the linkage between the structure of production systems and types of implementation strategy is proved to be very weak. Also control effect of types of implementation strategy on the efficiency of the organization is not strongly recognized. A summarized report of other findings is provided as well.

• 한국자기공명학회논문지
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• 제23권3호
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• pp.67-72
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• 2019

Caveolae are small plasma membrane invaginations that play many roles in signal transduction, endocytosis, mechanoprotection, lipid metabolism. The most important protein in caveolae is the integral membrane protein, caveolin, which is divided into three families such as caveolin 1, caveolin 2, and caveolin 3. Caveolin 1 and 3 are known to incorporate palmitate through linkage to three cysteine residues. Regulation of the protein palmitoylation cycle is important for the cellular processes such as intracellular localization of the target protein, membrane association, conformation, protein-protein interaction, and activity. However, the detailed aspect of individual palmitoylation has not been studied. In the present work, the role of each lipid modification at three cysteines was studied by NMR. Our results suggest that each lipid modification at the natively palmitoylation site has its own roles. For example, lipidations to C106 and C129 are play a role in structural stabilization, however, interestingly, lipid modification to C116 interrupts the structural stabilization.