• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.331-338
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• 2006

A rapid, selective and sensitive reverse-phase HPLC methods for the determination of atenolol and chlorthalidone in human serum and whole blood were validated, and applied to the pharmacokinetic study of atenolol and chlorthalidone combination therapy. Atenolol and an internal standard, pindolol, were extracted from human serum by liquid-liquid extraction, and analyzed on a $\mu$-Bondapak C18 $10-{\mu}$ column in a mobile phase of methanol-0.01 M potassium dihydrogenphosphate(30:70, v/v, adjusted to pH 3.5) and fluorescence detection(emission: 300 nm, excitation: 224 nm). Chlorthalidone and an internal standard, probenecid, were extracted form human whole blood by liquid-liquid extraction, and analyzed on a Luna C18 $5-{\mu}$ column in a mobile phase of acetonitrile containing 77% 0.01 M sodium acetate and UV detection at 214 nm. These analysis were performed at three different laboratories using the same quality control(QC) samples. The chromatograms showed good resolution, sensitivity, and no interference by human serum and whole blood, respectively. The methods showed linear responses over a concentration range of 10-1,000 ng/mL for atenolol and 0.05-20 ${\mu}g/mL$ for chlorthalidone, with correlation coefficients of greater than 0.999 at all the three laboratories. Intra- and inter-day assay precision and accuracy fulfilled international requirements. Stability studies(freeze-thaw, short-, long-term, extracted sample and stock solution) showed that atenolol and chlorthalidone were stable. The lower limit of quantitation of atenolol and chlorthalidone were 10 ng/mL and 0.05 ${\mu}g/mL$, respectively, which was sensitive enough for pharmacokinetic studies. These methods were applied to the pharmacokinetic study of atenolol and chlorthalidone in human volunteers following a single oral administration of Hyundai $Tenoretic^{\circledR}$ tablet(atenolol 50 mg and chlorthalidone 12.5 mg) at three different laboratories.

• Journal of the Korean Association of Geographic Information Studies
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• v.19 no.2
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• pp.27-46
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• 2016

In this study, the parameter-elevation regressions on independent slopes model-Kongju National University(PRISM-KNU) system was developed to interpolate monthly precipitation data. One of the features of PRISM-KNU is that it can adjust the allowable range of slope according to the elevation range in the equation representing a linear relationship between the precipitation and elevation. The parameter value of the model was determined by using the optimization technique, and the result was applied to produce monthly precipitation data with a spatial resolution of $1{\times}1km$ from 2000 to 2014 in South Korea. In the result, the Kling-Gupta Efficiency for model evaluation was over 0.7 in 86% of the total cases simulated. In addition, a dramatic change in the spatial pattern of precipitation data was observed in the output of the Modified Korean PRISM, but such a phenomenon did not occur in the output of the PRISM-KNU. This study confirmed the appropriateness of the PRISM-KNU, and the result showed that the spatial consistency of the data produced by the model improved compared with that produced by the Modified Korean PRISM. It is expected that the PRISM-KNU and its output will be utilized in various studies in the future.

• Journal of the Korean Geophysical Society
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• v.2 no.3
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• pp.191-200
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• 1999

Analysis of chirp high-resolution seismic profiles from the central Yellow Sea reveals that depositional environments in this area can be divided into three distinctive zones from west to east: (1) subaqueous delta system near the Shandong Peninsula, (2) erosional zone in the central Yellow Sea, and (3) tidal sand ridges and sand waves near the Korean Peninsula. The Shandong subaqueous delta, extending southward from the Shandong Peninsula, changes gradually into prodelta southeastward. The sediments originated from the Yellow River are transported southward along the Chinese coastal area. The erosional zone in the central Yellow Sea contains numerous paleochannels and shows linear erosional features trending northwest-southeast. The erosional zone would be dominated by non-depositional or erosional processes during the Holocene. Tidal sand ridges and sand waves are well developed along the western coast of Korea. The residual sands, which were originally fluvial sediments at the sea-level lowstand, are interpreted as the result of winnowing process during the sea-level rise. Modern sand ridges generally migrates in a northeast-southwestern direction, which coincide with dominant tidal current direction.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.41 no.1
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• pp.9-18
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• 2004

This paper presents an efficient image compression method for memory reduction in multimedia processor which can be simply implemented in hardware and provides high performance. The multimedia processor, which includes processing of high-resolution images and videos, requires large memories: they are external frame memories to store frames and internal line memories for implementing some linear filters. If we can reduce those memories by adopting a simple compression method in multimedia processor, it will strengthen its cost competitiveness. There exist many standards for efficiently compressing images and videos. However, those standards are too complex for our purpose and most of them are 2-D block-based methods, which do not support raster scanned input and output. In this paper, we propose a low-complexity compression method which has good performance, can be implemented with simple hardware logic, and supports raster scan. We have adopted 1${\times}$8 Hadamard transform for simple implementation in hardware and compression efficiency. After analyzing the coefficients, we applied an adaptive thresholding and quantization. We provide some simulation results to analyze its performance and compare with the existing methods. We also provide its hardware implementation results and discuss about cost reduction effects when applied in implementing a multimedia processor.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.32 no.2
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• pp.117-132
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• 2014

This paper had a purpose on analyzing result data from pan-sharpening, which have applied on the KOMPSAT-2 and -3 image. Particularly, the study focused on comparing each relative spectral response functions, which considers to cause color distortions of fused image. Two images from same time and location have been collected by KOMPSAT-2 and -3 to apply in the experiment. State-of-the-art algorithms of GIHS, GS1, GSA and GSA-CA were employed for analyzing the results in quantitatively and qualitatively. Following analysis of previous studies, GSA and GSA-CA methods resulted excellent quality in both of KOMPSAT-2/3 results, since they minimize spectral discordances between intensity and PAN image by the linear regression algorithm. It is notable that performances from KOMPSAT-2 and- 3 are not equal under same circumstances because of different spectral characteristics. In fact, KOMPSAT-2 is known as over-injection of low spatial resolution components of blue and green band, are greater than that of the PAN band. KOMPSAT-3, however, has been advanced in most of misperformances and weaknesses comparing from the KOMPSAT-2.

• Economic and Environmental Geology
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• v.29 no.6
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• pp.699-712
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• 1996

Field scale experiments using an automated 144-channel TDR system were conducted which monitored the movement of solute through unsaturated loamy soils. The experiments were carried out on two different field plots of 0.54 ha to study the vertical movement of solute plume created by applying a square pulse of $CaCl_2$ as a tracer. The residence concentration was monitored at 24 locations on a transect and 5 depths per location by horizontally-positioning 50 cm long triple wire TDR probes to study the heterogeneity of solute travel times and the governing transport concept at field scale. This paper describes details of experimental methodology and calibration aspects of the TDR system. Three different calibration methods for estimation of solute concentration from TDR-measured bulk soil electrical conductivity were used for each field site. Data analysis of mean breakthrough curves (BTCs) and parameters estimated using the convection-dispersion model (CDE) and the convective-lognormal transfer function model (CLT) reveals that the automated TDR system is a viable technique to study the field scale solute transport providing a normal distribution of resident concentration in a high resolution of time series, and that calibration method does not significantly affect both the shape of BTC and the parameters related to the peak travel time. Among the calibration methods, the simple linear model (SLM), a modified version of Rhoades' model, appears to be promising in the calibration of horizontally-positioned TDR probes at field condition.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.3
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• pp.275-282
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• 2009

Generally, the sinusoidal cavity dither is adopted to ring laser gyroscope for eliminating the lock-in which is non-linear effect at the small rotation input. Despite this method, there are some remained errors which are generated at the dither turnaround, and those errors produce random walk which is a general character of a ring laser gyroscope. As one of the numerous research results for compensating these errors, there is a special lock-in compensation method which is the method of error estimation and compensation by comparing the beat signal periods of before and after the dither turnarounds. In this paper, by ring laser gyroscope modeling and numerical analysis, we verified the theoretical validity and confirmed the effectiveness of this method in expectation of the possible beat signal measurement time resolution. As a result, we confirmed the random walk decreases from a-half to a-third by this lock-in compensation method. So, it is expected to be a remarkable method for reducing the INS alignment time.

• Journal of Biomedical Engineering Research
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• v.27 no.5
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• pp.203-209
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• 2006

The aim of this study is to investigate the feasibility of ex vivo MR diffusion tensor imaging technique in order to observe the diffusion-contrast characteristics of human gastric tissues. On normal and pathologic gastric tissues, which have been fixed in a polycarbonate plastic tube filled with 10% formalin solution, laboratory made 3D diffusion tensor Turbo FLASH pulse sequence was used to obtain high resolution MR images with voxel size of $0.5{\times}0.5{\times}0.5mm^3\;using\;64{\times}32{\times}32mm^3$ field of view in conjunction with an acquisition matrix of $128{\times}64{\times}64$. Diffusion weighted- gradient pulses were employed with b values of 0 and $600s/mm^2$ in 6 orientations. The sequence was implemented on a clinical 3.0-T MRI scanner(Siemens, Erlangen, Germany) with a home-made quadrature-typed birdcage Tx/Rx rf coil for small specimen. Diffusion tensor values in each pixel were calculated using linear algebra and singular value decomposition(SVD) algorithm. Apparent diffusion coefficient(ADC) and fractional anisotropy(FA) map were also obtained from diffusion tensor data to compare pixel intensities between normal and abnormal gastric tissues. The processing software was developed by authors using Visual C++(Microsoft, WA, U.S.A.) and mathematical/statistical library of GNUwin32(Free Software Foundation). This study shows that 3D diffusion tensor Turbo FLASH sequence is useful to resolve fine micro-structures of gastric tissue and both ADC and FA values in normal gastric tissue are higher than those in abnormal tissue. Authors expect that this study also represents another possibility of gastric carcinoma detection by visualizing diffusion characteristics of proton spins in the gastric tissues.

• Korean Journal of Remote Sensing
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• v.19 no.4
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• pp.277-284
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• 2003

We present a GPS-derived regional ionosphere model, which estimates Total Electron Content (TEC) in a rectangular grid on the spherical shell over Korea. After dividing longitude and latitude over Korea with 1$^{\circ}$$\times$1$^{\circ}$ spatial resolution, the TEC at the vertex of the grid was estimated by the Kalman filter. The GPS data received from nine nationwide GPS stations, operated by Korea Astronomy Observatory (KAO), were used for this study. To reduce inherent noises, the pseudorange data were phase-leveled by a linear combination of pseudoranges and carrier phases. The solar-geomagnetic reference frame, which is less variable to the ionosphere movement due to the Sun and the geomagnetic field than an Earth-fixed frame, was used. During a quiet time of solar activity, the KAO's regional ionosphere map indicated 30-45 Total Electron Content Unit at the peak of the diurnal variation. In comparison with the Global ionosphere Map of the Center for Orbit Determination in Europe, RMS differences were at the level of 4-5 TECU for five days.

• Korean Journal of Remote Sensing
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• v.24 no.4
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• pp.369-379
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• 2008

The aerosol retrieval algorithm for the Moderate Resolution Imaging Spectroradiometer (MODIS) measurements was updated recently. This paper reports on the comparison and validation of two latest versions (Collection 4 and 5, shortly C004 and C005) of the MODIS aerosol product over northeast Asian region. The differences between the aerosol optical thickness (AOT) from the C004 and C005 retrieval algorithms and the correlation with ground based AERONET sunphotometer observations are investigated. Over the study region, spatially averaged annual mean AOT retrieved from C005 algorithm $(AOT_{C005})$ is about 0.035 AOT (5%) less than the C004 counterparts. The linear correlations between MODIS and AERONET AOT also are R=0.89 (slope=0.86) for the C004 and R=0.95 (slope=1.00) for the C005. Moreover, the magnitude of the mean error in $AOT_{C005}$, difference between MODIS AOT and AERONET AOT, is 40% less than that in $AOT_{C004}$.