• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.47-47
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• 2001

The neuropeptide vasopressin (VP) is a nine- amino acid hormone synthesized as preprohormone in the cell bodies of hypothalamic magnocellular neurons. The tumor in magnocellular neurons of the hypothalamus is associated with disfunctions of the cell bodies, leading to the diabetes insipidus. In order to study with the diabetes insipidus caused by a defect in VP synthesis and its secretion, we have produced the transgenic mice regulated by vasopressin promoter inserted to SV40 T antigen coding sequence (pVPSV.IGR2.1). One transgenic line expressing high levels of SV40 T antigen was propagated. The founder and all transgene positive adult animals have appeared with shorten mortality or apparent phenotypic abnormalities, including immune complex disease, and eventually die between 4 and 8 months of age. The mRNA and protein of SV40T antigen transgene were detected in brain of fetus as well as in brain, spleen, lung and lymph node in moribund at the age of 20 weeks. Histological analysis of transgenic mice showed that tumor developed in brain similar to primitive neuroectodermal tumors (PNET) in man. We also detected lymphomas in spleen and lymph node, and consequent tumor formation in various tissues of the transgenic mice. In pVPSV.IGR2.1, 21% mice showed brain tumor (PNET) at 5 weeks and 100% mice showed brain tumor after 15 weeks. In addition, Expression of apoptosis related genes (Bcl-28 & Bax) was increased over their age in mice with PNET as compared to control mice. Apoptosis related gene expression might be deregulated in mice with brain tumor. However, transgenic mice were not developed with the diabetes insipidus. These mice represent the first disease model to exhibit primitive neuroectodermal tumor in brain, as well as a unique model system for exploring the cellular pathogenesis of lymphomas.

• 대한한방종양학회지
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• 제5권1호
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• pp.19-32
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• 1999

To evaluate the antitumor activity and antimetastatic effects of Kamigumgusingihwan(KGSH) studies have ken done. The results were obtained as follows: 1. KGSH extracts exhibited a weak cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines. But exhibited potent cytotoxicity against P388 cell line in a dose-dependent manner. 2. The concentration inhibiting adhesion of A549, to complex extracellular matrix up to below 30% of control was recognized at $10^{-3}g/ml$ of KGSH 3. KGSH extracts showed a weak inhibitoty effect on DNA topo-isomerase I from calf thymus. 4. The T/C% was 137% in KGSH treated group in S-180 bearing ICR mice. 5. In pulmonary colonization assay, a number of colonies in the lungs were decreased significantly in KGSH treated group as compared with control group. 6. In hematological changes in B16-BL6 injected C57BL/6, numbers of WBC were decreased insignificantly in KGSH treated groups, and also those of platelet were increased insignificantly in KGSH treated groups as compared with control. 7. In CAM assay, KGSH extracts inhibited angiogenesis at $15{\mu}g/egg $concentration significantly as compared with control. Taken together these results, it is strongly demonstrated that KGSH significantly suppressed tumor metastasis by blocking cell adhesion to extracellular matrix. Therefore, KGSH is expected to be clinically a potent antimetastatic drug for the prevention and treatment of cancer.

• 시스템엔지니어링학술지
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• 제7권2호
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• pp.7-11
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• 2011

A high-speed railway system represents a typical example of large-scale multi-disciplinary system, consisting of subsystems such as rolling-stock, electrical hardware, electronics, control, information, communication, civil technology etc. The system design and acquisition data of the large-scale system must be the subject under strict configuration control and management. Systems engineering technology development project for Korea next generation High-speed Electric Multiple Unit (HEMU) system in progress is a national large system development project that is not only a large-size and complex but also multi-disciplinary in nature. Therefore, all stakeholders must understand and share the functional and performance requirements of HEMU throughout its life-cycle phases. Also in the test and evaluation phase, all systems requirements must be verified. In 2011, the prototype train manufacturing will be completed. It will do test run on the commercial line and all systems requirements are verified until 2012. For the system verification, the test and evaluation process have to be established before the test trial run. Using a systems engineering tool, the system design database(SDD) with requirements traceability and development process management in the course of the development have to be established. This paper represents the test and evaluation process development based on the SEMP(Systems Engineering Management Plan) developed in the design stage. The test and evaluation process is refined and updated in comparison to the design stage one. The test and evaluation process consists of procedure, test and evaluation method and schedule. So through this process, it is defined that each systems requirements is verified on which test and about what time.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 춘계학술대회 논문집 전기설비전문위원
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• pp.74-77
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• 2006

This research is focused on the development of GIS Diagnostic SYSTEM to prevent accidents beforehand by inspecting the internal defects of GIS (Gas Insulated Switchgear) which is a main power-facility for substations. GIS Diagnostic SYSTEM is categorized as 'Real time on-line test type' and 'Portable test type' depending on the types of testing, it uses PD(partial discharge) which mostly incurs in GIS internal defects, to inspect. As of now, mostly foreign equipments are imported for use due to the lack of the technology localization, and these are installed and operated on only some parts of highly-graded GIS power-facilities such as in 76skv or 345kv for its being expensive. Furthermore, other than foreign equipments being costly, it also has a weak point of very long unavailability in case of Diagnostic system break-down while using, because it takes a comparatively long period of corrective maintenance precesses. We have localized to develop personal real-time multi -functional GIS Diagnostic system which can test on all GIS power-facility comprehensively and economically therefore overcome all these problems mentioned above, a market expansion is expected from the decrease of price and replacing the import equipments in the future. As the equipment was developed to be Personal for the simple ways of installing and utilizing, it can be operated without any complex cable installation like other existing GIS Diagnostic system requires, therefore also decrease the cost of cable installation.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.1476-1479
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• 1996

발전설비나 자동차 그리고 항공우주분야에 사용되는 각종 bearing, 원형부품들에 사용되는 ring을 생산하는 방법중, 가장 효과적이고 경제적인 방법은 ring rolling (ring 압연)이다. 이 방법은 직경 50cm에서 2m이상의 원형 ring을 연속적으로 짧은 시간내에 (한 ring당 약 1분) 생산 가능하다. 이제까지의 수학적 모델을 사용한 제어시스템은 ring의 단면적이 사각형인 제품에는 최소한의 오차로 생산 가능하였으나, plant의 생산성과 제품의 다양성을 위하여 ring의 단면적이 복잡한 것을 생산시에는 문제점이 노출되었다. 왜냐하면 기존의 수학적모델이 roll gap 또는 metal forming zone에 근거하여 modelling하였기 때문이다. 본 논문에서는, 이러한 문제점을 고전적인 수학적 모델을 기초로한 adaptive control system의 방법대신에, 축적된 control system설계와 운용 경험을 이용하여 설계한 퍼지제어기 및 그것의 실적용 그리고 그 결과를 소개한다. 실적용 결과는, 제조된 단면적이 상대적으로 복잡한 bearing의 형상이 (filling grad)이 제어기의 제어정도 판단기준이었는데, 99.5%의 형상도를 보임으로서 industry에서 요구하는 제품기준을 만족시켰다. 또한 짧은 제어기 설계 및 on-line optimization 기간 또한 이 제어기의 장점이었다.

• 제어로봇시스템학회논문지
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• 제5권5호
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• pp.568-576
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• 1999

Using a laser sheet beam projector combined with a CCD-Camera, an efficient technique to recognize complex surface of curvature and lane has been demonstrated for the purpose of mobile robot navigation. In general, obstacles of indoor environments in the field of SLIT-RAY plane are captured as segments of an elliptical arc and a line in the camera image. The robot has been capable of moving along around the obstacle in front of it, by recognizing the original shape of each segment with the differential coefficient by means of least squares method. In this technique, the imaged pixels of each segment, particularly elliptical arc, have been converted into a corresponding circular arc in the real-world coordinates so as to make more feasible the image processing for the position and radius measurement than conventional way based on direct elliptical are analyses. Advantages over direct elliptical cases include 1) higher measurement accuracy and shorter processing time because the circular arc process can reduce the shape-specifying parameters, 2) no complicated factor such as the tilt of elliptical arc axis in the image plane, which produces the capability to find column position and radiua regardless of the camera location . These are essentially required for a mobile robot application. This technique yields an accuracy less than 2cm for a 28.5cm radius column located in the range of 70-250cm distance from the robot. The accuracy obtained in this study is sufficient enough to navigate a cleaning robot which operates in indoor environments.

• 한국빅데이터학회지
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• 제2권2호
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• pp.1-7
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• 2017

ITS(Intelligent Transport Systems)는 시민들의 교통이용 안전과 편의를 도모하고 교통 시스템의 효율적인 운영 및 관리를 위해 대도시를 중심으로 도입되었다. 우리나라의 경우 ITS가 전국적으로 확대되면서 도로소통상황, 교통량, 대중교통운영현황 및 관리상황, 대중교통이용현황 등 다양한 교통정보가 생성되고 있다. 본 논문에서는 ITS에서 수집되는 데이터 중 하나인 DSRC(Dedicated Short Range Communications) 빅데이터를 활용하여 도시 교통구조를 네트워크 분석 기법을 통해 규명한다. 이를 통해 도심에서의 복잡한 교통현상을 단순화시키고, 차량 흐름에 따른 도시 교통의 구조적 특징을 도출한다. 분석 결과는 도시의 교통을 좀 더 쉽게 이해할 수 있도록 도와주고, 향후에 도시교통의 혼잡 해소방안, 도로 확장 계획 등의 교통정책 수립시 기초연구 자료로 활용할 수 있다.

• 한국해양공학회지
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• 제28권2호
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• pp.160-166
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• 2014

Because of industrial development, industrial facilities are becoming more complex and diversified. Plant industries are focused on productivity improvement, cost reduction, and product uniformity by simplifying production processes using automated control. Furthermore, plant industries require higher pressures and temperatures to improve energy efficiency. For this reason, the valves used in plants are operated under harsh conditions. Globe valves and gate valves are mainly used for high pressure these days. However, these valves have various problems, including low maintainability and high cost, due to structural problems. Therefore, butterfly and ball valve applications are increasing in industrial plants. This paper suggests a quadruple-offset butterfly valve that is applicable to bi-direction use, and the principle design parameters are suggested. The selected design parameters are an eccentric flange center line and shaft centerline(Offset 1), an eccentric seat centerline and disc shaft centerline(Offset 2), the angle between the flange centerline and seat wedge angle(Offset 3), the angle between the vertical direction of the disc shaft centerline and seat centerline(Offset 4), and the seat engagement angle. To analyze the interaction effect of the design parameters, ANOM and ANOVA were performed with an orthogonal array. The parameters were found to have effects in the following order: Offset 2, Offset 1, engagement angle, Offset 3, and Offset 4. The interaction between the parameters was insignificant.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2000년도 춘계종합학술대회
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• pp.93-97
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• 2000

최근 주요 선진국 및 표준화 기구들은 급변하는 시장의 요구 및 기술변화를 수용하기 위해 더 많은 새롭고 복잡한 표준들을 보다 짧은 시간 내에 개발하여, 표준화를 통한 동 분야의 경쟁력강화는 물론 이를 시장선점용 전략수단으로 활용하고 있으며, 이를 효과적으로 실현하기 위해 전자적 (표준) 문서 처리시스템(EDH: Electronic Document Handling) 혹은 표준정보유통시스템 개발에 박차를 가하고 있다. 본 논문에서는 이러한 정보통신분야의 환경변화에 효율적으로 대처하기 위해 국내 환경을 고려한 전자적 표준개발환경의 기본 시스템 구성과 이를 지원하기 위한 XML기반 표준 정보 공유 및 교환을 가능하게 하는 차세대 표준 정보 유통망의 구조, 그리고 표준화관련 종합정보의 One-stop Service 통한 표준화 로드맵 역할을 포함하는 차세대 표준정보유통망기능 중 정보서버역할을 하는 표준화전용 보털 사이트(Standardization Vortal Site) 구축 프레임워크를 제시한다.

• 한국주거학회논문집
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• 제21권1호
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• pp.79-88
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• 2010

The purpose of this study is to examine the design characteristic about the public space of privately-built apartment housing after the enforcement of price deregulation in Daegu. The public space of the multi-family housing is monotonous and closed according to the position of an elevator and a stair hall by the 1990's. However, the housing has been gentrified since 2000 because of demands of residents and purpose for selling in lots. Thus, the recognition of the apartments has changed and this change has led to extend the living territory and magnify the role of the public space where help interact with neighbors. This study is based on the survey of thirty nine apartment complex. Also, by using an analysis derived from a precedent study, design elements in approach and interior space of apartment residents are comprehended. The characteristic of the porch is researched and divided according to a roof of porch, form as the door, material of roof, wall, the ceiling and floor. Interior space is analyzed by several elements; forms of core, forms, materials and lights of ceiling, materials of walls and floors, existence and nonexistence of windows, and extra interior components etc. As a result of the study, After the enforcement of price deregulation, the public space of apartments has had improved quality in materials and design and the community center for residents such as waiting rooms and spots facilities has appeared. However, the traffic line of interior space has been very intricate. Also, sports facilities and waiting areas are limited to some apartments.