• 대한전자공학회논문지SD
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• 제41권4호
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• pp.101-112
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• 2004

본 논문에서는 3차원 인터커넥트(3D interconnect) 구조를 해석하기 위하여 ADI-유한차분시간영역(ADI-FDTD: Alternating Direction Implicit Finite Difference Time Domain)법으로 맥스웰 회전 방정식(Maxwell's curl equation)을 계산하는 수치 해석 모델을 개발하였고, 개발한 ADI-유한차분시간영역법을 이용하여 3.3 V CMOS 기술로 설계된 샘플러 회로의 일부의 영역에 대해 컴퓨터 모의 실험 결과하여 입력된 구형 전압 신호가 금속 배선을 거치면서 5∼10 ps의 신호 지연과 0.1∼0.2 V의 신호 왜곡이 발생되는 것을 확인하였다. 결론적으로 ADI-유한차분시간영역법을 이용한 풀-웨이브 해석을 통하여 고속의 VLSI 인터커넥트에서의 전자기 현상을 정확하게 분석할 수 있음을 제시하였다.

• Bulletin of the Korean Chemical Society
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• 제35권12호
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• pp.3571-3575
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• 2014

Proteasome, a multicatalytic protease complex, has been validated as a promising therapeutic target in oncology. Carfilzomib (Kyprolis$^{(R)}$), a tetrapeptide epoxyketone, irreversibly inhibits the chymotrypsin-like (CT-L) activity of the proteasome and has been recently approved for multiple myeloma treatment by FDA. A chemistry effort was initiated to discover the compounds that are reversibly inhibit the proteasome by replacing the epoxyketone moiety of carfilzomib with a variety of ketones as reversible and covalent warheads at the C-terminus. The newly synthesized compounds exhibited significant inhibitory activity against CT-L activity of the human 20S proteasome. When the compounds were tested for cancer cell viability, 14-8 was found to be most potent in inhibiting Molt-4 acute lymphoblastic leukemia cell line with a $GI_{50}$ of $4.4{\mu}M$. Cytotoxic effects of 14-8 were further evaluated by cell cycle analysis and Western blotting, demonstrating activation of apoptotic pathways.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2465-2470
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• 2014

The rate constants of solvolysis of phenyl N-phenyl phosphoramidochloridate (PhNHPO(Cl)OPh, Target Compound-TC1) have been determined by a conductivity method. The solvolysis rate constants of TC1 are well correlated with the extended Grunwald-Winstein equation, using the $N_T$ solvent nucleophilicity scale and YCl solvent ionizing scale, and sensitivity values of $0.85{\pm}0.14$ and $0.53{\pm}0.04$ for l and m, respectively. These l and m values were similar to those obtained previously for the complex chemical substances dimethyl thiophosphorochloridate; N,N,N',N'-tetramethyldiamidophosphorochloridate; 2-phenyl-2-ketoethyl tosylate; diphenyl thiophosphinyl chloride; and 9-fluorenyl chloroformate. As with the five previously studied solvolyses, an $S_N2$ pathway is proposed for the solvolyses of TC1. For four representative solvents, the rate constants were measured at several temperatures, and activation parameters (${\Delta}H^{\neq}$ and ${\Delta}S^{\neq}$) were estimated. These activation parameters are also in line with the values expected for an $S_N2$ reaction.

• 한국철도학회논문집
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• 제9권6호
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• pp.746-752
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• 2006

The major objective of this study is to investigate the dynamic behavior evaluation of split PC sleepers for railway turnout by the field test. In railway engineering, a turnout is necessary to allow a vehicle to move from one track to another. So, turnout is required very complex railway technologies such as lolling stock, track. In reference to conventional line speed-up and improvement railway, accurate assembly of turnout affects travel ins qualify of turnout area and running safety. Because of heavy weight and a large volume of the long sleeper used to turnout and car limit, transport and the prerequisite for trouble-free transport of the factory pre-assembled major turnout components is achieved through division of long sleepers. The one of the advantages for using a split sleeper is to reduce the dynamic vibration according to the information of developed nations. Therefore, we investigate the characteristic of dynamic behaviors of split sleepers which are adopted for the first time to improve performance of turnout From the field test results of the split sleeper, it is evaluated that the modification of weight, material and stiffness compared with wood sleeper is very effective for the ballast safety. However, the decrease in vibration of split sleeper was not found out.

• 한국광학회지
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• 제12권1호
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• pp.55-60
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• 2001

광학적 Hough 변환 필터 배열을 이용하여 입력영상의 특징을 추출할 수 있는 방법을 제안한다. 여기서는 입력 영상의 부분들이 대용되는 필터 배열의 요소들에 의해 독립적으로 동시에 Hough 변환된다. 하나의 광학적 Hough 변환 필터를 사용하여 입력영상 전체에 대한 변환 결과를 얻는 기존의 방식에 비해, 제안한 방법은 입력 영상에 존재하는 선소 특징의 대략적 위치 정보를 함께 얻을 수 있고 복잡한 입력영상에 대해서도 광학적 정확성을 높일수 있다. 이 방식을 실험적으로 입증하기 위해 $5\times5$ Hough 변환 필터 배열을 제작하고 기초적인 실험을 수행하였다.

• Journal of Preventive Medicine and Public Health
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• 제10권1호
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• pp.134-137
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• 1977

The most efficient method for reducing the organic content of dilute liquid waste is by aerobic-biological treatment. Basically, the organisms responsible for treatment possess the ability to decompose complex organic compounds and to use the energy so liberated for their bodily functions: reproduction, growth, locomotion and so on. That part of organic matter used to produce energy is converted to the essentially stable end products of carbon dioxide, water and ammonia, while the remainder is converted to new cells which can be settled and thus removed from the liquid before the waste is discharged to the receiving body water. Oxygen must be supplied continuously during the aerobic process. In the field of sewage treatment the Warburg respirometer is used mainly for the measurement of the oxygen uptake of samples. In this experiment the Warburg constant volume respirometer was used to determine the oxygen uptake by bacteria in the presence of various glucose concentrations. The rate of oxygen uptake by the bacteria was expressed as the respiratory quotient. The result indicated that the oxygen uptake was proportional to the glucose concentration. The expecting equation of the regression line was Y=7.7+0.12X where Y: respiratory quotient, ${\mu}l.\;O_2$ taken up/mg. dry wt. bacterium/hr. X: concentration of glucose, mg/l

• 천문학회보
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• 제42권1호
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• pp.32.3-33
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• 2017

Utilizing both the existing observational data for Orion A and the TRAO $^{13}CO$, $^{12}CO$ data for $1^{\circ}{\times}1^{\circ}$ region centered on M42 collected in 2012, we found a clear piece of evidence for a collision of a cloud with the OMC-1. This cloud has a shape like a long cylinder of ${\sim}0.1pc{\times}2pc$ in size, and has a well developed train of clumps of about a few solar masses, and is situated in the dark dust complex between M42 and M43. The cloud's motion is analysed to be moving at about $2.6km\;s^{-1}$, and is calculated to transverse the Orion Nebula ~2 pc above from the nebula center, toward the direction of about $60^{\circ}$ to the line of sight. This cloud had undergone a tidal splitting about a million years ago and had formed a very thin and long cylindrical core well before being engaged in the collision. General implications of this phenomenon are discussed in relation to star formation mechanisms in the GMC.

• 한국해양공학회지
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• 제24권2호
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• pp.67-73
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• 2010

A simplified finite element analysis has been used to predict the weld-induced deformation to bead-on-plate welding of steel plates having curvatures in the welding direction. In this study, the equivalent loading method based on inherent strain was used to investigate the effect of longitudinal curvature on the weld-induced deformation of curved plates. Equivalent loads were derived from the inherent strain distribution around the weld line, and the loads were used for linear finite element analyses. These kinds of numerical simulations can, of course, be performed by using the rigorous thermalelastic-plastic analysis method. This approach is not, however, practical for use in weld-induced deformation analysis of large and complex structures, such as ship structures, in view of computing time and cost. The present equivalent load approach has been applied to several plate models having curvatures in the welding direction, and the results are compared with those obtained by thermal-elastic-plastic analysis and also with those obtained by the other simplified method found in reference. As far as the present results are concerned, the weld-induced deformation of curved plates can be accurately predicted by the method presented in this paper.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.663-668
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• 1990

This paper deals with the application of a Generalized Predictive Control (CPC) to a Pressurized Water Reactor (P.W.R) Nuclear Power Plant. Generalized Predictive Control is a sort of Explicit Self-Tuning Control. Current self-tuning algorithms lack robustness to prior choices of either dead-time (input time delay of a plant) or model order. GPC is shown by simulation studies to be superior to accepted self-tuning techniques such as minimum variance and pole-placement from the viewpoint that it is robust to prior choices of dead-time or model order. In this paper a GPC controller is designed to control the P.W.R. nuclear power rlant with varying dead-time and through the designing procedure the designer is free from the constraint of knowing the exact dead-time. The controller is constructed based on the 2nd order linear model approximated in the vicinity of operating point. To ensure that this low-order model describes the complex real dynamics well enough for control purposes, model parameters are updated on-line with a Recursive Least Squares algorithm. Simulation results are successful and show the possibilities of the GPC control application to actual plants with varying or unknown dead-time.

• 산업공학
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• 제18권3호
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• pp.247-252
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• 2005

In the automated production environment in the present days, the minimization of manual operation becomes a very important factor in increasing the efficiency of the production system. The exit burr produced through the milling operation on the edge of workpiece usually requires manual deburring process to enhance the level of precision of the resulting product. So far, researchers have developed various methods to understand the formation of exit burr in cutting process. One method to analytically identify the formation of exit burr was to use the geometrical information of CAD and CAM data used in automated machining. This method, in turn, generated the information resulting from the analysis such as burr type, cutting region, and exit angle. Up to now, the geometrical data were restricted to the single feature and single path. In this paper, a method to deal with the complicated geometric features such as line segment, arc, hole, and spline will be presented and validated using the field data. This method also deals with the complex workpiece shape which is a combination of multiple features. As for the cutting path, multiple tool path is analyzed in order to simulate the real cutting process. All this analysis is combined into a Windows based software and real data are used to validate the program in the conclusion.