• 한국의류산업학회지
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• 제23권4호
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• pp.423-438
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• 2021

This study compared and analyzed the direction of Louis Vuitton creative directors Kim Jones and Virgil Abloh. Accordingly, 485 photos(251 Kim Jones, 234 Virgil Abloh) were collected. For data analysis, statistical and content analyses were combined. First, as for the overall design characteristics of creative director Kim Jones, complex colors, colorful barrels, tone-in-tone color schemes, H-line, plain fabrics, soft materials, heterogeneous material combinations, casual style. Second, as for the overall design characteristics of creative director Virgil Abloh, achromatic color, colorful tone, tone-on-tone color scheme, I-line, plain fabric, soft material, similar material combination, casual style. There were significant differences in color, tone, color scheme, silhouette, pattern, material type, material combination, fashion image, detail, trimming, top and bottom that differed in the creative directors' design direction. Therefore, it appears that Kim Jones has been directing the luxurious and unique men's wear through H-line, coat and slim pants, colorful color combination, soft material, heterogeneous material combination, plain fabric, and chic active sensibility. Meanwhile, Virgil Abloh is directing men's wear in a loose and trendy street mood through the I-line, jacket and wide pants, achromatic color, soft material, plain fabric, similar material combinations, and soft and sophisticated modern sensibility.

• Journal of Gastric Cancer
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• 제23권1호
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• pp.224-249
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• 2023

Gastric cancer is heterogeneous in morphology, biology, genomics, and treatment response. Alterations in human epidermal growth factor receptor 2 (HER2) overexpression, microsatellite instability (MSI) status, programmed death-ligand 1 (PD-L1) levels, and fibroblast growth factor receptor 2 (FGFR2) can be used as biomarkers. Since the combination of fluoropyrimidine/platinum plus trastuzumab that was investigated in the ToGA trial was approved as a standard of care in HER2-positive patients in 2010, no other agents showed efficacy in the first- (HELOISE, LOGiC, JACOB trials) and second- (TyTAN, GATSBY, T-ACT trials) line treatments. Despite the success in treating breast cancer, various anti-HER2 agents, including a monoclonal antibody (pertuzumab), an antibody-drug conjugate (ADC; trastuzumab emtansine [T-DM1]), and a small molecule (lapatinib) failed to translate into clinical benefits until the KEYNOTE-811 (first-line) and DESTINY-Gastri01 (≥second-line) trials were conducted. The incorporation of HER2-directed treatment with immune checkpoint inhibitors in the form of a monoclonal antibody or ADC is now approved as a standard treatment. Despite the promising results of new agents (engineered monoclonal antibodies, bi-specific antibodies, fusion proteins, and small molecules) in the early phase of development, the management of HER2-positive gastric cancer requires further optimization to achieve precision medicine with a chemotherapeutic backbone. Treatment resistance is a complex process that can be overcome using a combination of chemotherapy, targeted agents, and immune checkpoint inhibitors, including novel agents. HER2 status must be reassessed in patients undergoing anti-HER2 treatment with disease progression after the first-line treatment. As a general guideline, patients who need systemic treatment should receive chemotherapy plus targeted agents, anti-angiogenic agents, immune checkpoint inhibitors, or their combinations.

• 한국축산시설환경학회지
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• 제14권1호
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• pp.15-22
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• 2008

본 연구는 효소복합체 처리가 양돈분뇨의 액비화 과정의 악취제어 가능성을 조사하기 위하여 액비저장 탱크에 4주간 저장하면서 효소복합체 처리, 폭기 처리, 효소와 폭기 동시 처리 및 대조구로 나누어 비교하였다. 또한 효소복합체를 돈사에 살포하여 돈사내 공기의 질과 양돈장 부지경계선에서의 복합악취농도를 조사하였는데, 그 결과를 요약하면 다음과 같다. 효소복합체와 폭기 처리는 양돈분뇨의 액비화 과정의 암모니아와 황화수소 농도에 영향을 미치는 것으로 조사되었으며, 암모니아와 황화수소 농도는 4주간의 액비화 과정 동안 지속적으로 감소되었다. 효소복합체의 일정 수준 처리는 양돈분뇨 액비화 과정의 악취저감을 위한 효율적인 수단이 될 수 있을 것으로 판단된다. 효소복합체와 폭기 처리는 양돈분뇨의 액비화 과정의 총질소, 총인 및 암모니아성 질소 농도에 영향을 미치는 것으로 조사되었으며, 효소복합체 처리는 양돈분뇨 액비의 품질 유지와 악취저감을 위한 하나의 기술적 대안으로 충분한 것으로 보인다. 효소복합체 살포는 돈사내 공기의 질을 개선하고 양돈장의 부지경계선에서의 복합악취 저감에도 효과적으로 작용하는 것으로 나타났다. 이상의 결과를 요약하면, 효소복합체 처리는 양돈분뇨 액비화 과정의 악취제어와 고품질 액비제조 가능성이 인정되며, 돈사 내부 및 양돈장 환경개선과 악취저감 효과가 있는 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.796-805
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• 1997

연구배경 : 세포주기의 활성화, 그 중에서도 특히 $G_1$/S 이행에 관여하는 세포주기관련 단백질들은 암발생에 있어서 매우 중요한 역할을 하는 것으로 알려져 있다. $G_1$ 세포주기 관련 단백질 중의 하나인 cdk4 (cyclin dependent kinase 4)의 억제제로 알려져 있는 p16 유전자는 최근에 밝혀진 종양억제유전자중의 하나로서 MTS1 (multiple tumor suppressor 1)이라고도 불린다. p16 유전자는 지금까지 알려진 어느 종양관련 유전자보다도 유전자변이의 빈도가 높은 암억제유전자인데, 특히 비소세포폐암인 경우는 70% 이상의 세포주에서 p16 단백질의 발현이 없는 것으로 밝혀져 있어 p16 유전자는 비소세포폐암 발생에 매우 중요한 역할을 할 것이라고 알려져 있다. 본 연구에서는 비소세포폐암에서 p16을 이용한 유전자치료의 타당성을 입증하기 위하여 다음과 같은 연구를 시행하였다. 방 법 : p16이 결여된 비소세포폐암 세포주 (NCI-H441)에, 정상섬유아세포에서 총 RNA를 추출하여 역전사효소 및 DNA 중합효소반응으로 증폭된 p16 cDNA를 유핵세포 발현 vector인 pRC-CMV plasmid에 subcloning하여 구축된 pRC-CMV-p16 plasmid vector를 lipofectin을 이용하여 유전자 이입한 후, 단백질을 추출하여 Western blot 분석과 면역침전법으로 $G_1$ 세포주기관련 단백질의 변동을 관찰하고, colony 형성능을 비교함으로써 암억제효과를 확인하였다. 결 과 : p16이 유전자주입된 NCI-H441 세포주에서 p16과 cdk4가 복합체를 형성하고 있고 인산화 Rb가 대조 세포주에 비해 감소되어 있음을 확인할 수 있어, p16이 cdk4와 결합함으로써 cdk4에 의한 Rb의 인산화를 방해하고 이에 따른 $G_1$ 세포주기 정체에 의해 종양억제효과가 나타난다는 설명을 뒷받침할 수 있었다. Clonogenic assay 결과는 p16 유전자주입된 NCI-H441 세포주의 colony 형성능이 대조 세포주에 비하여 현격히 감소함을 관찰하였다. 결 론 : 이상의 결과로 p16(MTS1) 유전자를 p16 단백질을 발현하지 못하는 비소세포폐암 세포주에 주입할 경우, 주입한 유전자에서 생성되는 p16 단백질이 cdk와 결합하여 Rb 단백질의 인산화를 저하시켜 궁극적으로 암억제 효과를 일으킬 수 있음이 확인되었고, 이는 향후 비소세포폐암의 유전자치료에 있어서 p16 유전자의 이용 가능성을 확인한 기초자료가 된다고 생각된다.

• Journal of Advanced Marine Engineering and Technology
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• 제40권9호
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• pp.799-804
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• 2016

광대역 전력선 통신은 전류의 흐름과 함께 효과적인 양방향 통신을 얻기 위하여 전력선 분배망을 통신 매체로 이용한다. 그러나 전력선은 통신에 최적화된 채널이 아니므로 인터넷, 음성 및 데이터 서비스에 대한 통신 시스템의 개발은 시뮬레이션에 의한 성능 분석에 적합한 측정 기반의 전송 모델을 필요로 한다. 본 논문에서는 복잡한 전달 함수를 기술하는 분석 모델을 다중 전력선 모델의 감쇠 및 경로 파라미터를 획득하는데 이용하였으며 이를 바탕으로 주파수 응답특성을 계산하였다. 계산된 결과는 다중경로에 의한 주파수 선택성 페이딩과 주파수에 대한 신호의 감쇄를 보여주었으며 이는 실험 결과와 잘 일치하였다. 이론모델에 적용한 배전선을 실험적으로 구성한 후 배전선에 전기적인 신호를 인가하는 방법으로 비접촉식 결합을 위한 페라이트 코어로 구성된 유도 결합 장치를 사용하였다. 신호 결합 손실은 커플러에 감긴 권선수에 의해 최소화 될 수 있다. 3회 권선 결합 효율은 일회 권선 결과보다 6dB 이상 개선됨을 보였다.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2007년도 춘계학술발표회 논문집
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• pp.153-156
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• 2007

There have been many studies on extracting building boundaries from LiDAR(Light Detection And Ranging) data. In such studies, points are first segmented, then are further processed to get straight boundary lines that better approximate the real boundaries. In most research in this area, processes like generalization or regularization assume that buildings have only right angles, i.e. all the line segments of the building boundaries are either parallel or perpendicular. However, this assumption is not valid for many buildings. We present a new approach consisting of three steps that is applicable to more complex building boundaries. The three steps consist of boundary tracing, generalization, and regularization. Each step contains algorithms that range from slight modifications of conventional algorithms to entirely new concepts. Four typical building shapes were selected to test the performance of out new approach and the results were compared with digital maps. The results show that the proposed approach has good potential for extracting building boundaries of various shapes.

• 한국주거학회논문집
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• 제16권4호
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• pp.37-44
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• 2005

The purpose of this study is to analyze the typological characteristics of super high-rise housings in Hong Kong. The results are as follows; 1) Most of the plan types of the residential building in Hong Kong are tower types and they show lots of curves on the external resident blocks so that each resident families can face maximum open air. 2) Each residential unit is arranged symmetrically and systematically around the central core. 3) The most of core types are central core types which are usually planned to place void light well to improve lighting and ventilation. 4) Rooms are arranged in line from entrance to kitchen, to living & dinning room, and finally bedroom and bathroom. Dinning area is arranged together with living area. 5) At least, more than two sides of the each unit were facing the open air; one side is for the view from a bedroom or a livingroom, the other side is for the ventilation of a kitchen or a bathroom.

• 산업기술연구
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• 제36권
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• pp.65-69
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• 2016

Deflection of the vertical is used in geodetic surveying associated with geoid network construction for geoid modeling and ellipsoid decision and obtained by gravity survey, astronomic survey etc. Technique of astronomic survey and gravity survey is very complex and requires a significant amount of time until gathering data. So this study is to determined a various method which evaluates deflection of the vertical and components about deflection of the vertical using GPS results and orthometric height value decided by leveling. Results of components about deflection of the vertical using GPS/leveling is that ${\xi}$ conponent is distributed $-2.11^{{\prime}{\prime}}{\pm}0.62$, ${\eta}$ component is distributed $1.75^{{\prime}{\prime}}{\pm}0.71$. Decision of component about deflection of the vertical using GPS is less complex than existing astronomic survey. Decision of component about deflection of vertical line using GPS is not complicated than astronomic surveying and can determine in a very short time. So it will be important means to determine the exact orthometric height, topographic study and diastrophism if can periodically calculate.

• 한국CDE학회논문집
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• 제9권2호
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• pp.93-101
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• 2004

In mechanical design, optimization procedures have mostly been implemented solely by CAE codes combined by optimization routine, in which the model is built, analyzed and optimized. In the complex geometries, however, CAD is indispensable tool for the efficient and accurate modeling. This paper presents a method to carry out optimization, in which CAD and CAE are used for modeling and analysis respectively and integrated in an optimization routine. Application Programming Interface (API) function is exploited to automate CAD modeling, which enables direct access to CAD. The advantage of this method is that the user can create very complex object in Parametric and automated way, which is impossible in CAE codes. Unigraphics and ANSYS are adopted as CAD and CAE tools. In ANSYS, automated analysis is done using codes made by a script language, APDL(ANSYS Parametric Design Language). Optimization is conducted by VisualDOC and IDESIGN respectively. As an illustrative example, a mold design problem is studied, which is to minimize temperature deviation over a diagonal line of the surface of the mold in contact with hot glass.

• 한국CDE학회논문집
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• 제6권1호
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• pp.31-39
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• 2001

Presented in this paper are algorithms to compute the positions of vertices and equations of edges of the Voronoi diagram of a circle set. The circles are located in a Euclidean plane, the radii of the circles are not necessarily equal and the circles are not necessarily disjoint. The algorithms correctly and efficiently work when the correct topology of the Voronoi diagram was given. Given three circle generators, the position of the Voronoi vertex is computed by treating the plane as a complex plane, the Z-plane, and transforming it into another complex plane, the W-plane, via the Mobius transformation. Then, the problem is formulated as a simple point location problem in regions defined by two lines and two circles in the W-plane. And the center of the inverse-transformed circle in Z-plane from the line in the W-plane becomes the position of the Voronoi vertex. After the correct topology is constructed with the geometry of the vertices, the equations of edge are computed in a rational quadratic Bezier curve farm.