• 한국융합학회논문지
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• 제9권9호
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• pp.9-14
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• 2018

본 연구는 학술논문의 출현순서에 따른 저자키워드의 중요도를 측정해보고자 하는 연구이다. 이를 위해 학술논문 저자키워드의 출현순서를 측정한 후 네트워크 분석 방법의 연결정도중심성, 근접중심성, 매개중심성, 위세중심성 지수를 사용하여 저자키워드의 중요도를 측정해보았으며 다음으로 각각의 네트워크지수 값과 저자키워드의 출현순서와의 상관관계 분석을 수행하여 출현순서의 특징을 살펴보고자 하였다. 연구결과 연결정도중심성, 근접중심성, 매개중심성, 위세중심성 모두 4번 째 출현순서가 높은 군집의 논문수가 많은 것으로 나타났다. 다음으로 상관관계 분석결과 근접중심성을 제외한 연결정도중심성, 매개중심성, 위세중심성의 경우 출현순서의 뒷부분으로 갈수록 지수 값이 모두 높아지는 것을 볼 때 네트워크 상에서 상대적으로 중요한 용어가 뒷부분에 위치한다는 것을 알 수 있다. 본 연구는 대략적으로 연구자들의 저자키워드 부여 행태를 살펴볼 수 있었다는 점에서 의의를 지닌다. 향후 저자키워드의 전개양상을 심층적으로 살펴 보기 위해서는 상황적 요인, 행동, 심리 등을 파악하여 보완하는 후속 연구가 반드시 필요하다.

• Clinical and Experimental Pediatrics
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• 제63권2호
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• pp.34-43
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• 2020

Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I²=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.

• Korean Journal of Acupuncture
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• 제34권4호
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• pp.191-208
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• 2017

Objectives : The purpose of this study was to analyze the trend of pharmacopuncture in Korean patent in order to establish database for patent technology. Methods : Electronic literature searches for Korean patents related to pharmacopuncture were performed in two electronic databases (Korea Intellectual Property Right Information Service and National Digital Science Library) to June 2017. Patents that were not Korean ones, did not use medicinal herb, only described method of manufacture, or had nothing to do with pharmacopuncture were excluded in this study. The status and application date of patents, Medicinal herb, target diseases, International Patent Classification (IPC), model of experiment and extracting methods were analyzed. Results : A total of 379 patents were retrieved. Based on our inclusion/exclusion criteria, 297 patents were excluded. Of 82 included patents, 27 patents did not include experiments using pharmacopuncture, and 9 patents were invented for treating animals such as pig or calf. In IPC analysis, Bee Venom, Panax (ginseng), Angelica, and Paeoniaceae were used frequently. Musculoskeletal diseases were the most targeted diseases followed by nervous diseases. For extracting, hot water extraction, distillation extraction, and solvent extraction using alcohol, ethanol, or methanol for solvent were commonly used. Conclusions : These data are useful for inventing new patent and extending range of pharmacopuncture in clinical use, however, more systematically analyzed patent studies and pharmacopuncture-related studies for new application on various diseases are needed in further studies.

• Journal of Gastric Cancer
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• 제15권4호
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• pp.256-261
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• 2015

Purpose: Gastric cancer is the third leading cause of cancer-related mortality, with the incidence and mortality being higher in men than in women. Various studies have shown that eating carrots may play a major role in the prevention of gastric cancer. We conducted a meta-analysis to determine the relationship between carrot consumption and gastric cancer. Materials and Methods: We searched multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx. The following search terms were used: stomach or gastric, neoplasm or cancer, carcinoma or tumor, and carrot. Statistical analyses were performed using Comprehensive Meta Analysis/2.0 software. Results: We retrieved 81 articles by searching the databases. After considering the inclusion and exclusion criteria, 5 articles were included in this study. The odds ratio (OR) obtained by fixed effects model showed that a 26% reduction in the risk of gastric cancer has been associated with the consumption of carrots) OR=0.74; 95% confidence interval=0.68~0.81; P<0.0001). According to funnel graph, the results showed that the possibility of a publication bias does not exist in this study. Conclusions: The findings of this study showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.

• 대한한의학회지
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• 제20권1호
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• pp.30-43
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• 1999

This is a fundamental study for bibliometric analysis investigating the general, research, copyright activities and cited literature related to the field of Oriental Medicine, The data used for this study included theses published by the Journal of Korean Oriental Medicine Society over a period of nine years, from 1990 to 1998, We investigated the productivity of national authors, distribution of cited literature and subject analysis about Oriental Medicine and its authors quantitatively, So we were able to reach several conclusions: 1. The rule of Lotka is applied considerably to analyze the productivity of authors in the field of Oriental Medicine, When it comes to the analysis of national authors it was found that most authors in this field of study published 2 to 10 volumes, likewise other studies. And the rate of co-authorships was high, because most surveys are clinical. 2. When it comes to distribution of cited literatures, independent volumes were cited more than journals. This represents that the citing style of Oriental Medicine has a tendency to follow the methodology of historical research. 3. Scholars in the field of Oriental Medicine mainly tend to cite self-subjects among cited literatures. After analysing self-subjects in this field, the result is that the order of frequency used as cited literatures is as follows: Internal Medicine, Herbology and Oriental Prescription, Acupuncture & Moxibustion. Acupuncture point, and subjects with the circulatory system diseases were mainly cited as far as subordinary subjects of Internal Medicine.

• 산업융합연구
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• 제18권1호
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• pp.65-71
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• 2020

최근 프로 스포츠에서는 데이터를 활용하는 분야가 주목을 받기 시작하였다. 데이터 활용 분야는 경기 내적으로 파생되는 클래식 기록 뿐만 아니라, 효율성을 강조한 2차 기록도 적극적으로 활용되고 있다. 이에 본 연구에서는 경기 외적인 데이터인 일일 평균 습도를 통하여 투수들의 탈삼진 능력과의 상관관계를 연구하고자 한다. 이를 위하여 KBO리그에 소속된 10개 팀의 홈구장과 보조구장에 소재한 지역의 일일 평균 기록을 참고로 하였고, 선발 투수와 구원 투수들의 특성을 파악하기 위하여 다승, 홀드, 세이브 부문의 상위 5명 씩의 K/9기록을 대상으로 분석하였다. 본 연구결과를 통하여 선발 투수와 구원 투수와의 K/9 기록에 유의미한 차이를 발견하였으며, 프로 스포츠의 데이터 활용에 대하여 학문 및 산업 전반의 발전을 기대할 수 있다.

• 한국수산과학회지
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• 제30권6호
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• pp.984-991
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• 1997

New tumor suppressor gene, snm23, homologous to human nm23/NDP kinase (human nucleoside diphosphate kinase) gene whose product has a tumor metastasis inhibitory activity, was first cloned from Korean tiger shark (Scyliorhinus forazame) skin cDNA library constructed by using a $\lambda$ ZAP-II cDNA synthesis kit. About $1\times10^5$ plaques were screened and several positive plaques were isolated and confirmed by second screening. The phagemid containing a positive clone from the Uni-Zap XR vector was excised in vivo and the gene containing the tumor metastasis suppressor protein was named as snm23. Cloned gene, snm23, was sequenced with ABI-PRISM 310 Genetic Analyzer. The nucleotide and deduced amino acid sequences of snm23 have shown an open reading frame consisting of 450 base pairs that correspond to a protein of 150 amino acid residues, with a calculated molecular mass of 16.8 kDa. Sequence comparison of snm23 with human nm23/NDP kinase was performed by using Blast protein data base of National Center for Biotechnology Information. In order to determine tissue specificity, reverse transcription-polymerase chain reaction (RT-PCR) was used. Good expression level of snm23/NDP kinase was detected at the tissues from skin, cartilage, and liver of Korean tiger shark.

• Archives of Plastic Surgery
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• 제37권4호
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• pp.317-322
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• 2010

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

• Parasites, Hosts and Diseases
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• 제49권3호
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• pp.221-228
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• 2011

Rodent malaria parasites, such as Plasmodium berghei, are practical and useful model organisms for human malaria research because of their analogies to the human malaria in terms of structure, physiology, and life cycle. Exploiting the available genetic sequence information, we constructed a cDNA library from the erythrocytic stages of P. berghei and analyzed the expressed sequence tag (EST). A total of 10,040 ESTs were generated and assembled into 2,462 clusters. These EST clusters were compared against public protein databases and 48 putative new transcripts, most of which were hypothetical proteins with unknown function, were identified. Genes encoding ribosomal or membrane proteins and purine nucleotide phosphorylases were highly abundant clusters in P. berghei. Protein domain analyses and the Gene Ontology functional categorization revealed translation/protein folding, metabolism, protein degradation, and multiple family of variant antigens to be mainly prevalent. The presently-collected ESTs and its bioinformatic analysis will be useful resources to identify for drug target and vaccine candidates and validate gene predictions of P. berghei.

• Plant Breeding and Biotechnology
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• 제5권3호
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• pp.183-191
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• 2017

Finger millet (Eleusine coracana L. Gaertn.) is an important cereal crop in eastern Africa and southern India with excellent grain storage capacity and the unique ability to thrive in extreme environmental conditions. In this study, we analyzed the genetic diversity and population structure of finger millet using 12 developed microsatellites. By sequencing 815 clones from an SSR-enriched genomic DNA library, we obtained 12 polymorphic SSR markers, which also revealed successful amplicons in finger millet accessions. Using the developed SSR markers, we estimated genetic diversity and population structure among 76 finger millet accessions in Asia, Africa, and unknown origins. The number of alleles ranged from 2 to 9, with an average of 3.3 alleles. The mean values of observed heterozygosity and expected heterozygosity were 0.27 and 0.35, respectively. The average polymorphism information content was 0.301 in all 76 finger millet accessions. AMOVA analysis showed that the percentage of molecular variance among the populations was 1%, that among individuals was 5%, and that within individuals was 94%. In STRUCTURE analysis, the 76 finger millet accessions were divided into two subpopulations which had an admixture of alleles. There was a correspondence among PCoA, AMOVA, and population structure. This study may form the basis for a finger millet breeding and improvement program.