Archives of Plastic Surgery

  • 제37권4호
  • /
  • Pages.317-322
  • /
  • 2010
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
권호 표지

비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석

Difference of Gene Expression between Hypertrophic Scar Keratinocytes and Normal Keratinocytes

  • 최성원 (대구파티마병원 성형외과) ;
  • 정호윤 (경북대학교 의학전문대학원 성형외과학교실) ;
  • 임영국 (대구파티마병원 성형외과) ;
  • 김훈남 (대구파티마병원 성형외과) ;
  • 오지원 (경북대학교 의학전문대학원 면역학교실) ;
  • 김문규 (경북대학교 의학전문대학원 면역학교실) ;
  • 전세화 (테고 사이언스(주)) ;
  • 홍용택 (대구파티마병원 성형외과)
  • Choi, Sung-Won (Department of Plastic and Reconstructive Surgery, Fatima Hospital) ;
  • Chung, Ho-Yun (Department of Plastic and Reconstructive Surgery, School of Medicine, Kyngpook National University) ;
  • Lim, Young-Kook (Department of Plastic and Reconstructive Surgery, Fatima Hospital) ;
  • Kim, Hoon-Nam (Department of Plastic and Reconstructive Surgery, Fatima Hospital) ;
  • Oh, Ji-Won (Department of Immunology, School of Medicine, Kyngpook National University) ;
  • Kim, Moon-Kyu (Department of Immunology, School of Medicine, Kyngpook National University) ;
  • Jeon, Sae-Hwa (Tego Science Inc.) ;
  • Hong, Yong-Taek (Department of Plastic and Reconstructive Surgery, Fatima Hospital)
  • 투고 : 2010.04.08
  • 심사 : 2010.06.09
  • 발행 : 2010.07.10
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초록

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

키워드

참고문헌

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