• 제목/요약/키워드: leukemia cell

검색결과 856건 처리시간 0.053초

Steroid compounds from the marine sponge Raspilia hirsute

  • Rho Jung-Rae
    • 한국자기공명학회논문지
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    • 제10권1호
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    • pp.89-95
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    • 2006
  • The methanolic extract of the marine sponge Raspilia hirsute collected from Keomun Island resulted in three types of sterols: a mixture of (24S)-Poriferasta-5, 25-diene-$3\beta$, 24-diol and (24R)-Stigmasta-5, 25-diene-$3\beta$, 24 -diol (1), 25,26,27-Trinorcholest-5-en-$3\beta$,24-diol (2), and Pregn-5-en-20-on-$3\beta$-ol (3). The isolation and structural determination of these sterols are reported here. Compound 1 showed moderate cytotoxicity against human Leukemia cell line K562.

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Thioredoxin System and Redox Signaling; Defence against Stress and Toxicity

  • Yodoi, Junji;Masutani, Hiroshi;Nakamura, Hajime
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.84-88
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    • 2001
  • Human Thioredoxin (TRX) with with redox-active dithiol (C-C-Y-C-) in the active site has been cloned as adult T cell leukemia derived factor produced by HTLV-I transformed cells. Thioredoxin (TRX) is one of the major components of the thiol-reducing system and plays multiple roles in cellular processes such as proliferation, apoptosis and gene expression.(omitted)

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한국산 생약의 독성 및 항암 작용 (제1보) (Toxicity and Antitumor Activities of Korean Medicinal Plants (I))

  • 장일무;지형준
    • 생약학회지
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    • 제12권3호
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    • pp.125-130
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    • 1981
  • Thirty species of Korean medicinal plants which have been frequently used in Oriental herb prescriptions were evaluated on their acute toxicity and potential antitumor activities against P-388 lymphocytic leukemia. The criteria for toxicity evaluation of measuring weight loss, toxicity day survivors and computing log cell kill indicated that 11 species possessed acute toxicity according to the doses administered. No significant antitumor activities were observed while the root of Angelica gigas Nakai (Umbelliferae) exhibited only 24% increased life span.

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Eupatilin, A Pharmacologically Active Flavone Derived From Artemisia Plants, Inhibits Growth of H-Ras Transformed Human Breast Epithelial Cells Through Cell Cycle Arrest

  • Kim, Do-Hee;Na, Hye-Kyung;Surh, Young-Joon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 춘계학술대회 논문집
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    • pp.89-90
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    • 2003
  • Extracts of Artemisia asiatica Nakai (Asteraceae) have been shown to have anti-inflammatory and anti-oxidative activities. Eupatilin (5,7-dihydroxy-3,4,6-tri-methoxy-flavone), one of the pharmacologically active ingredients derived from Artemisia asiatica, has been shown to induce apoptosis in promyelocytic leukemia (HL-60) cells. (omitted)

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방사선 조사와 병행 처리한 녹차 Polyphenol의 혈구암세포 사멸 촉진 효과 (Synergistic effect of green tea polyphenol co-treated along with gamma radiation in leukemia cell necrosis)

  • 이홍수
    • 대한방사선협회지
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    • 제28권1호
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    • pp.39-48
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    • 2002
  • The Green tea, one of the most popular and favorite drinks in eastern societies, has been reported to have various therapeutic properties. These includes anti-cancer, anti-oxident, anti-endocrine disrupter effects. Its anti-cancer effect was said to be ac

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