• BMB Reports
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• 제39권2호
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• pp.113-131
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• 2006

Sphingolipids have emerged as molecules whose metabolism is regulated leading to generation of bioactive products including ceramide, sphingosine, and sphingosine-1-phosphate. The balance between cellular levels of these bioactive products is increasingly recognized to be critical to cell regulation; whereby, ceramide and sphingosine cause apoptosis and growth arrest phenotypes, and sphingosine-1-phosphate mediates proliferative and angiogenic responses. Sphingosine kinase is a key enzyme in modulating the levels of these lipids and is emerging as an important and regulated enzyme. This review is geared at mechanisms of regulation of sphingosine kinase and the coming to light of its role in disease.

• BMB Reports
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• 제39권2호
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• pp.189-196
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• 2006

Alterations in the amino acid structure or sequence can generate neo-epitopes from self-proteins causing autoaggressive immune attack. Reactive nitrogen species are an important factor that induces post-translational modification of proteins by cellular reduction and oxidation mechanism; cysteinyl-nitrosylation or tyrosine nitration leading to potentially pathogenic pathways. It was thought of interest to investigate the immunogenicity of nitrated poly L-tyrosine vis-$\`{a}$-vis its possible role in the induction of antibodies in systemic lupus erythematosus (SLE). Commercially available poly L-tyrosine was exposed to nitrating species and the damage was monitored by UV spectroscopy and alkaline gel electrophoresis. The results indicated the formation of 3-nitrotyrosine. Nitrated poly L-tyrosine induced higher titre antibodies as compared to the native form. Nitrated poly L-tyrosine was recognized by the autoantibodies present in the sera of patients suffering from SLE by enzyme immunoassays and band shift assay. The possible role of nitrated self-proteins has been discussed in the production of circulating anti-DNA antibodies in SLE.

• KIEAE Journal
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• 제5권4호
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• pp.59-64
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• 2005

This work was designed for the Green Fund Aid 2004 of Korea Forest Service. It won the prize and has been constructed. We can have an opportunity to play a leading role in improving partnership with participation of local communities, promoting environmental education, and enhancing the environmental quality by constructing biotops in urban areas where energy flow in the ecosystem is not balanced. This design includes 'citizen participation process' and 'local community partnership' that is expected to promote local community participation in the process of design. This work suggests that biotope construction with citizen involvement and community partnership plays an important role not only in design items but also in the revitalization of local community. This sort of design process could not be fully achieved without cooperation with stakeholders - environmental specialists, local authorities, relevant societies, schools, teachers, parents of students.

• BMB Reports
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• 제51권5호
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• pp.225-229
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• 2018

In humans, hormonal regulation is crucial for the preparation of uterine environment leading to either successful implantation or menstrual cycle. Estrogen is a pivotal female steroid hormone that regulates the uterine dynamics along with progesterone in the estrous and menstrual cycles in humans. Estrogen signals act via nuclear estrogen receptor or membrane-bound receptor. The membrane-bound estrogen receptor plays a crucial role in the rapid response of estrogen in the uterine epithelium. Recently, RASD1 has received attention as a novel signal transducer of estrogen in various systems including female reproductive organs. In this review, we discuss the regulation of estrogen and RASD1 signaling in the uterus and also provide insights into RAS as a novel signaling molecule in repeated implantation failure.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 1999년도 제15회 하계 학술발표회 논문집
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• pp.176-202
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• 1999

Korea has exerted her efforts to assimilate nuclear power technology, and reportedly localized 95 percent of nuclear power technology by 1995. This paper investigates the evolution of nuclear power program in Korea to exploit the development process of the nuclear power industry and key factors for the technological localization of nuclear power plant. In developing countries, an imitative catching-up process can be shown as a course for developing the absorptive capacity of foreign technology, which depends on prior knowledge base and the intensity of effort. The process of technological learning consists of five stages including preparation, implementation of foreign technology, acquisition of peripheral technology, acquisition of core technology, and improvement f foreign technology. Moreover, this paper discusses six essential factors that have influenced the successful achievement of technological localization of nuclear power plants in Korea. They include the role and strategies of the government, the leading role of utility firm, the development and cooperation of the related organizations, the development of human resources and their efforts, market conditions and the assistance of foreign donors, and social conditions. Finally, this paper discusses about implications offered by the Korean experience for other developing countries.

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.93-100
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• 2018

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In mammals, especially humans, a proper neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia, and neurons is essential for the homeostasis and survival of the central nervous system (CNS). In addition, the regeneration of neurovascular systems from neural stem cells and endothelial precursor cells after CNS diseases is responsible for functional repair. This review focused on the possible role of CO/HO in the neurovascular unit in terms of neurogenesis, angiogenesis, and synaptic plasticity, ultimately leading to behavioral changes in CNS diseases. CO/HO may also enhance cellular networks among endothelial cells, pericytes, astrocytes, and neural stem cells. This review highlights the therapeutic effects of CO/HO on CNS diseases involved in neurogenesis, synaptic plasticity, and angiogenesis. Moreover, the cellular mechanisms and interactions by which CO/HO are exploited for disease prevention and their therapeutic applications in traumatic brain injury, Alzheimer's disease, and stroke are also discussed.

• Asian Journal of Innovation and Policy
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• 제1권1호
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• pp.50-70
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• 2012

This paper analyzes the factors that determine technology innovation in Korean manufacturing firms, focusing on the role of intra-firm knowledge diffusion and market strategy in patent production. For empirical analysis, zero-inflated negative binomial (ZINB) regression is applied to the 2009 Human Capital Corporate Panel data. The empirical findings confirm the critical role of intra-firm knowledge-sharing processes in technology innovation; firms with a market-leading strategy oriented to new product development also tend to be prolific in patent production.

• Perspectives in Nursing Science
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• 제14권1호
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• pp.32-36
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• 2017

Purpose: The purpose of this study is to analyze the factors influencing students' active practice in clinical nursing education and to find ways to improve them. Methods: In this study, the factors affecting students' practice in nursing clinical practice were reviewed and their opinions were discussed. Results: A limited clinical practice environment, lack of a role model of leading and independent nurse interferes with the active practice of nursing students and negatively affects the image of nurses. On the other hand, semantics that links practice to students'life supports active practice. Conclusion: Clinical practicum educators should actively carry out the role of introducing students to rational of their practice, and arrange meetings with nurses and students who carry out nursing care independently with leadership. In addition, the clinical nursing education should include courses that allow students to discuss the various issues they have in the nursing practice.

• 간호행정학회지
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• 제18권1호
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• pp.87-95
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• 2012

Purpose: This study was conducted to explore the perspectives of gender and role in the family for nurses' work-family balance. Method: Data were collected through in-depth interviews with 14 married nurses having children, who were selected through convenience sampling and purposive sampling from November 1, 2011 to January 20, 2012. The data were analyzed using qualitative thematic analysis. Results: The common themes resulted from data analysis included following traditional gender roles, giving up any expectation of spouse's role, coordinating the division of family roles, and refusing to stick to gender roles. The age of nurse, family background of husband, and social-economic contexts were essential to explain the couple dynamics. Conclusions: Nurses who received private family support were stably leading a work-family balance, yet unable to change the gender structure of spouse for the work-family balance. On the other hand, young nurses who were unable to get any support, had a tendency of cooperating with their spouses and adopting more negotiable and pragmatic approach to work-family balance.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 A
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• pp.667-669
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• 2003

Since the restructuring in electricity industry, single utility company, KEPCO, was being unbundled horizontanly and vertically, which resulted in 6 generation companies. Hence, electricity statistics system leaded by KEPCO is no longer efficiently sustainable. By introduction of electricity market, the importance of statistical information is getting higher and higher. From now on, the leading role played in statistical system in electricity field should be switched from KEPCO to government. This paper looks into change in statistical work driven by electricity and provides alternatives applicable to new electricity market. In addition, this paper provides new standard form for the collection of statistical data and construction of statistical system.