• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.84-84
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• 2003

Lead has long been considered as a toxic environmental pollutant, which severely damages central nervous system. Lead can cause hypo- and de-myelination, and glial cells are closely related with myelination or demyelination. Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in the remodelling of the extracellular matrix in a variety of physiological and pathological processes. MMPs also seem to be important in the pathogenesis of inflammatory demyelinating diseases of the central and peripheral nervous system. In this study, we investigated whether lead affects MMP-9 expression in rat primary glial cells. Treatment of 0.1-5 ${\mu}$M lead dose- and time-dependently increased MMP-9 expression in rat primary glial cells. The activity of MMPs was determined using zymography. Lead activated Erk(1/2) but neither of the other endogenous MAP kinases, p38 or JNK. Inhibition of Erk(1/2) activation by PD98059, a MEK inihibitor, prevented lead-induced expression of MMP-9. The results of the present study suggest that lead intoxication may adversely affect brain function at least in part by inducing MMP-9 expression through Erk(1/2) activation in primary glial cells.

• 한국환경과학회지
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• 제32권11호
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• pp.757-765
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• 2023

Lead, a heavy metal widely employed in various industries, continues to pose a threat to both human health and the environment. Therefore, the development of a sensor capable of rapidly and accurately detecting lead(II) ions in real-time at contaminated sites is crucial. In this study, we have engineered a fluorescent sensor with the ability to efficiently detect lead(II) ions under actual environmental conditions, including tap water and freshwater. The compound, tetraphenylethylene carboxylic acid derivative (TPE-COOH), exhibits high selectivity and sensitivity toward lead(II) ions in aqueous solution, where the interaction between TPE-COOH and lead(II) ions leads to its aggregation, thus triggering a fluorescence "turn-on" based on the aggregation-induced emission (AIE) mechanism. Impressively, compound TPE-COOH proficiently detects lead(II) ions within a range of 30 to 100 𝜇M in tap water and freshwater, even in the presence of various interfering substances.

• 농업과학연구
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• 제47권3호
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• pp.471-483
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• 2020

Flood prediction is an important issue to prevent damages by flood inundation caused by increasing high-intensity rainfall with climate change. In recent years, machine learning algorithms have been receiving attention in many scientific fields including hydrology, water resources, natural hazards, etc. The performance of a machine learning algorithm was investigated to predict the water elevation of a river in this study. The aim of this study was to develop a new method for securing a large enough lead time for flood defenses by predicting river water elevation using the a long- short-term memory (LSTM) technique. The water elevation data at the Oisong gauging station were selected to evaluate its applicability. The test data were the water elevation data measured by K-water from 15 February 2013 to 26 August 2018, approximately 5 years 6 months, at 1 hour intervals. To investigate the predictability of the data in terms of the data characteristics and the lead time of the prediction data, the data were divided into the same interval data (group-A) and time average data (group-B) set. Next, the predictability was evaluated by constructing a total of 36 cases. Based on the results, group-A had a more stable water elevation prediction skill compared to group-B with a lead time from 1 to 6 h. Thus, the LSTM technique using only measured water elevation data can be used for securing the appropriate lead time for flood defense in a river.

• 경영과학
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• 제17권1호
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• pp.17-30
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• 2000

This paper addresses the effect of protective capacity on the lead time and throughput of a re-entrant line where statistical fluctuations exist in the form of variation in processing times and machine breakdowns. The specific framework employed in the paper is a five station re-entrant line structured as a closed network mode. This paper argues that protective capacity can be used in conjunction with WIP inventory in order to reduce the lead time and to increase the increase the throughput of a line. Simulation analyses are included to give insight into the effectiveness of protective capacity.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 추계학술대회 논문집
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• pp.217-218
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• 2009

• 산업경영시스템학회지
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• 제14권23호
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• pp.1-6
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• 1991

The physical distribution service(PDS) is essential to evaluate the business logistics system. The PDS combines the inventory service with the lead time to deliver. This paper is presented to model Mixed Zero-One integer programming which is to determine distribution center location and to allocation products, considering delivery lead time, from given candidate locations to given customer markets. A numerical example is given to demonstrate the applicability of Mixed Zero-One integer programming for Distribution-Location problem.

• 대한인간공학회지
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• 제26권2호
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• pp.149-155
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• 2007

Recently, various devices requiring text input such as mobile phone IPTV, PDA and UMPC are emerging. The frequency of text entry for them is also increasing. This study was focused on the evaluation of Korean text entry interface. Various models to evaluate text entry interfaces have been proposed. Most of models were based on human cognitive process for text input. The cognitive process was divided into two components; visual scanning process and finger movement process. The time spent for visual scanning process was modeled as Hick-Hyman law, while the time for finger movement was determined as Fitts' law. There are three questions on the model-based evaluation of text entry interface. Firstly, are human cognitive processes (visual scanning and finger movement) during the entry of text sequentially occurring as the models. Secondly, is it possible to predict real text input time by previous models. Thirdly, does the human cognitive process for text input vary according to users' text entry speed. There was time gap between the real measured text input time and predicted time. The time gap was larger in the case of participants with high speed to enter text. The reason was found out investigating Eye-Hand Coordination during text input process. Differently from an assumption that visual scan on the keyboard is followed by a finger movement, the experienced group performed both visual scanning and finger movement simultaneously. Arrival Lead Time was investigated to measure the extent of time overlapping between two processes. 'Arrival Lead Time' is the interval between the eye fixation on the target button and the button click. In addition to the arrival lead time, it was revealed that the experienced group uses the less number of fixations during text entry than the novice group. This result will contribute to the improvement of evaluation model for text entry interface.

• 한국건축시공학회지
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• 제4권1호
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• pp.105-110
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• 2004

Resource procurement is an important management area because cost of resource covers 40％ of total construction project cost and resource delivery has direct relationship with project performance. Integration of cost provides various potentials for effective and efficient project control. This study investigates the usefulness of time in resource procurement management focused on materials. These days, construction projects have characterized manufacture because of industrialization and component. Therefore, application of systematic resource planning has been requested in the construction. There are many companies conducting procurement of resource on the web by applying MRP, ERP etc. in the construction. However, in applying them in the construction yet, there is obstruction. MRP has the character doing its function under accurate cost prediction of resource. But prediction of resource is difficult in industry mechanism of the construction. If accurate cost prediction of resource is possible in the construction, it will be expected to reduce cost of procurement of resource substantially by applying successful resource planning model in the manufacture. On the basis of recent current, the purpose of study is to present procurement of resource system that period observance of construction and minimization of stock is possible by reflecting accurate lead-time to apply proactive thought to be able to cope with alteration of construction schedule efficiently in analyzing resource planning of the construction site.

• 한국산학기술학회논문지
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• 제7권2호
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• pp.224-230
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• 2006

제조업체의 성공은 고객의 요구를 파악하는 능력과 이들 요구를 만족시키면서, 얼마나 최소비용을 투자하여 제품화를 신속히 개발하는가에 달려있다. 기업의 목표를 달성하기 위해서 제조 판매 및 마케팅 그리고 제품 디자인 및 개발기간과 같은 여러 요소들이 복합적으로 적절히 조화를 이루어야만 한다. 이 논문에서는 여러 요소 중 신제품 개발기간에 초점을 맞추어 현재 각 기업에서 많이 사용되고 있는 6 시그마 기법을 적용하여 새로운 제품의 개발기간을 단축시키기 위한 방법론을 제시한다.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2002년도 추계학술발표회
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• pp.351-354
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• 2002

In this study, variation of electrochemical parameters and characteristics of lead immobilization due to phosphoric acid injection in soil were studied during electrokinetic remediation of lead contaminated soil. TCLP result showed about 100% of soil was satisfied TCLP regulation criteria. And injected ion from cathode reservoir by ionmigration was proportionate to concentration of phosphoric acid and elapsed time. Therefore, when removal is infeasible or not cost-effective, in situ immobilization method would be more effective.