• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1543-1551
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• 2020

Panax ginseng has a wide range of activities including a neuroprotective effect, skin protective effects, enhanced DNA repairing, anti-diabetic activity, and protective effects against vascular inflammation. In the present study, we sought to discover the inhibitory effects of a mixture of natural products containing Panax ginseng, Ziziphus jujube, Rubi fructus, Artemisiae asiaticae and Scutellaria baicalensis (PZRAS) on osteoclastogenesis and bone remodeling, as neither the effects of a mixture containing Panax ginseng extract, nor its molecular mechanism on bone inflammation, have been clarified yet. PZRAS upregulated the levels of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GSH-R) and glutathione peroxidase (GSH-Px) and reduced malondialdehyde (MDA) in LPS-treated RAW264.7 cells. Moreover, treatment with PZRAS decreased the production of IL-1β and TNF-α. PZRAS also inhibited osteoclast differentiation through inhibiting osteoclastspecific genes like MMP-2, 9, cathepsin K, and TRAP in RANKL-treated RAW264.7 cells. Additionally, PZRAS has inhibitory functions on the RANKL-stimulated activation of ERK and JNK, which lead to a decrease in the expression of NFATc1 and c-Fos. In an in vivo study, bone resorption induced by LPS was recovered by treatment with PZRAS in bone volume per tissue volume (BV/TV) compared to control. Furthermore, the ratio of eroded bone surface of femurs was significantly increased in LPS-treated mice compared to vehicle group, but this ratio was significantly reversed in PZRAS-treated mice. These results suggest that PZRAS could prevent or treat disorders with abnormal bone loss.

• Toxicological Research
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• v.24 no.2
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• pp.151-159
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• 2008

Rhus verniciflua Stokes(RVS), one of traditional medicinal plants in Asia, was found to have pharmacological activities such as antioxidative and antiapoptotic effects, raising the possibility for the development of a novel class of anti-cancer drugs. Thus, potential genotoxic effects of RVS in three short-term mutagenicity assays were investigated, which included the Ames assay, in vitro Chromosomal aberration test, and the in vivo Micronucleus assay. In Ames test, the addition of RVS water extracts at doses from 313 up to 5000 mg/plate induced an increase more than 2-fold over vehicle control in the number of revertant colonies in TA98 and TA1537 strains for detecting the frame-shift mutagens. The similar increase in reversion frequency was observed after the addition of RVS ethanol extracts. To assess clastogenic effect, in vitro chromosomal aberration test and in vivo micronucleus assay were performed using Chinese hamster lung cells and male ICR mice, respectively. Both water and ethanol extracts from RVS induced significant increases in the number of metaphases with structural aberrations mostly at concentrations showing the cell survival less than 60% as assessed by in vitro CA test. Also, there was a weak but statistically significant increase in number of micronucleated polychromatic erythrocytes(MNPCEs) in mice treated with water extract at 2000 mg/kg while ethanol extracts of RVS at doses of up to 2000 mg/kg did not induce any statistically significant changes in the incidence of MNPCEs. Therefore, our results lead to conclusion that RVS acts as a genotoxic material based on the available in vitro and in vivo results.

• Journal of Aerospace System Engineering
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• v.11 no.1
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• pp.1-7
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• 2017

While a satellite is carried into orbit by a launch vehicle, it is exposed to the severe launch environment with random vibrations and shock. Accordingly, these vibration sources affect electronic equipment, particularly the printed circuit board (PCB) in the satellite. When the launch load impacts the PCB, it causes negative behavior. This causes perpendicular bending around the boundary of fixation points that finally leads to the failure of solder joints, lead wires, and PCB cracks. To overcome these issues, the electronic equipment design must meet reliability requirements. In this paper, Steinberg's method is used to derive allowable and maximum deflection to verify design from a life perspective concerning the control board of the Antenna Pointing Driver (APD) mounted on KOMPSAT-3.

• The Korean Journal of Pain
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• v.26 no.2
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• pp.135-141
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• 2013

Background: Although paclitaxel is a widely used chemotherapeutic agent for the treatment of solid cancers, side effects such as neuropathic pain lead to poor compliance and discontinuation of the therapy. Ethyl pyruvate (EP) is known to have analgesic effects in several pain models and may inhibit apoptosis. The present study was designed to investigate the analgesic effects of EP on mechanical allodynia and apoptosis in dorsal root ganglion (DRG) cells after paclitaxel administration. Methods: Rats were randomly divided into 3 groups: 1) a control group, which received only vehicle; 2) a paclitaxel group, which received paclitaxel; and 3) an EP group, which received EP after paclitaxel administration. Mechanical allodynia was tested before and at 7 and 14 days after final paclitaxel administration. Fourteen days after paclitaxel treatment, DRG apoptosis was determined by activated caspase-3 immunoreactivity (IR). Results: Post-treatment with EP did not significantly affect paclitaxel-induced allodynia, although it tended to slightly reduce sensitivities to mechanical stimuli after paclitaxel administration. After paclitaxel administration, an increase in caspase-3 IR in DRG cells was observed, which was co-localized with NF200-positive myelinated neurons. Post-treatment with EP decreased the paclitaxel-induced caspase-3 IR. Paclitaxel administration or post-treatment with EP did not alter the glial fibrillary acidic protein IRs in DRG cells. Conclusions: Inhibition of apoptosis in DRG neurons by EP may not be critical in paclitaxel-induced mechanical allodynia.

• Journal of the Korean Society of Safety
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• v.34 no.6
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• pp.88-95
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• 2019

It has been only a few years since drones have been introduced to Korea, and as the use of drones has increased in industrial sites as well as in hobby activities, accidents such as workers' body parts coming into contact with rotating propellers have been occurring since 2016. Industrial accident cases are being filed. In the case of a remote control vehicle, if you release the remote controller in the event of an abnormal situation, it stops in place and no further danger occurs but in case of drones flying over the sky is different. Sudden motor stops during flight, uncontrolled changes in flight posture, loss of radio waves, loose propeller, etc, numerous factors can lead to accidents due to unintentional movements. Therefore, drone operators need safety knowledge as well as high knowledge about drones. However, drones with a weight of less than 12 kg can fly without a pilot's certification, and therefore, a minimum accident prevention measure is required. 10 accidents approved as industrial accidents since 2016, 23 accidents surveyed by general drone operator, 40 accidents surveyed by the Korean Consumer Resources Unfortunately for the purpose of writing this paper, drones are a new species and do not have many parameters for analysis but my experience has shown that the type of disaster does not deviate significantly. In addition, there is no paper that analyzes drone related industrial accidents not only in Korea but also in other countries. However, even if you watch an overseas drone accident video through YouTube, it is not much different from the case that occurs in Korea. I hope that this study will be of little help to all the drone pilots as well as the work safety of industrial drones used in industrial sites.

• Journal of Advanced Navigation Technology
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• v.26 no.5
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• pp.312-318
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• 2022

Currently, the Republic of Korea is facing the problem of a decrease in military service resources due to the demographic cliff, and is pursuing military restructuring and changes in the military force structure in order to respond to this. In this situation, the Army is pushing forward the deployment of a drone-bot combat system that will lead the future battlefield. The battlefield of the future will be changed into an integrated battlefield concept that combines command and control, surveillance and reconnaissance, and precision strike. According to these changes, unmanned combat system, including dronebots, will be widely applied to combat situations that are high risk and difficult for humans to perform in actual combat. In this paper, as one of the countermeasures to these changes, autonomous behavior software with a BDI architecture-based decision-making system was developed. The autonomous behavior software applied a framework structure to improve applicability to multiple models. Its function was verified in a PC-based environment by assuming that the target UAV is a battalion-level surveillance and reconnaissance UAV.

• Journal of Korean Society of Transportation
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• v.34 no.1
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• pp.68-80
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• 2016

Interest in freeway truck traffic has increased largely due to greater safety concerns regarding truck-related crashes. The negative interactions between slow-moving trucks and other vehicles are a primary cause of hazardous conditions, which lead to crashes with larger speed variations. To improve operational efficiency and safety, providing a climbing lane that separates slow-moving trucks from higher performance vehicles is frequently considered when upgrading geometrics. This study developed an operations strategy for freeway climbing lanes based on traffic conditions in real time. To consider traffic safety when designing a dynamic strategy to determine whether a climbing lane is closed or open, various factors, including the level of service (LOS) and the percentage of trucks, are investigated through microscopic simulations. A microscopic traffic simulator, VISSIM, was used to simulate freeway traffic streams and collect vehicle-maneuvering data. Additionally, an external application program interface, VISSIM's COM-interface, was used to implement the proposed climbing lane operations strategies. Surrogate safety measures (SSM), including the frequency of rear-end conflicts and, were used to quantitatively evaluate the traffic safety using an analysis of individual vehicle trajectories obtained from VISSIM simulations with various operations scenarios. It is expected that the proposed algorithm can be the backbone for operating the climbing lane in real time for safer traffic management.

• Journal of Korean Society of Transportation
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• v.36 no.1
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• pp.38-50
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• 2018

Emerging automated driving environments will lead to a mixed traffic flow depending on the interaction between automated vehicles (AVs) and manually driven vehicles (MVs) because the market penetration rate (MPR) of AVs will gradually increase over time. Understanding the characteristics of mixed traffic conditions, and developing a method to control both AV and MV maneuverings smoothly is a backbone of the traffic management in the era of automated driving. To facilitate smooth vehicle interactions, the maneuvering of AVs should be properly determined by various traffic and road conditions, which motivates this study. This study investigated whether the aggressiveness of AV maneuvering, defined as automated driving aggressiveness (ADA), affect the performance of mixed traffic flow. VISSIM microscopic simulation experiments were conducted to derive proper ADAs for satisfying both the traffic safety and the operational efficiency. Traffic conflict rates and average travel speeds were used as indicators for the performance of safety and operations. While conducting simulations, level of service(LOS) and market penetration rate(MPR) of AVs were also taken into considerations. Results implies that an effective guideline to manage the ADA under various traffic and road conditions needs to be developed from the perspective of traffic operations to optimize traffic performances.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.374-380
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• 2017

The Internet of Things (IoT) refers to intelligent technologies and services that connect all things to the internet so they can interactively communicate with people, other things, and other systems. The development of the IoT environment accompanies advances in network protocols applicable to more lightweight and intelligent sensors, and lightweight and diverse environments. The development of those elemental technologies is promoting the rapid progress in smart car environments that provide safety features and user convenience. These developments in smart car services will bring a positive effect, but can also lead to a catastrophe for a person's life if security issues with the services are not resolved. Although smart cars have various features with different types of communications functions to control the vehicles under the existing platforms, insecure features and functions may bring various security threats, such as bypassing authentication, malfunctions through illegitimate control of the vehicle via data forgery, and leaking of private information. In this paper, we look at types of smart car services in the IoT, deriving the security threats from smart car services based on various scenarios, suggesting countermeasures against them, and we finally propose a safe smart car application plan.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.762-767
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• 2017

This paper presents an analysis for improving the power transfer capability in transmission lines caused by the movable load charging of electric vehicles (EVs). EVs are expected to be used more widely and replace gas fuel vehicles in the near future due to the shortage of fossil fuels and for environmental preservation. Movable load charging of EVs could lead to the convergence of transferred power flow and overloading conditions in transmission lines in a specific area of a power system, which is conventionally based on estimated fixed load capability. To analyze these conditions, the New England Test System was divided into four regions based on the load characteristics, and different charging scenarios were considered. In these scenarios, the regional power load was highly increased to 31% based on the standard charging capacity of an EV. As a solution to the overloading problem of transmission lines, a TCSC was installed serially on the overloaded line to directly control the transferred power under limited line capability (100% load capability). The simulation showed that the application of a few TCSCs could efficiently and economically control the line capability problem caused by movable load charging of EVs.