• 한국정보과학회논문지:데이타베이스
• /
• 제32권1호
• /
• pp.12-23
• /
• 2005

지난 10년간 CPU의 속도는 메모리의 속도에 비해 급속한 속도로 발전하였다 그 결과 데이터 베이스 시스템을 포함한 다른 컴퓨터 응용분야에서 메모리의 접근이 병목현상을 일으키게 되었다. 메모리의 접근 속도를 줄이기 위해 캐시 메모리가 도입되었다 하지만 캐시 메모리는 원하는 데이타가 캐시에 옮겨져 있어야 메모리 접근 속도를 줄일 수 있다. 때문에 응용프로그램에서 데이타를 어떤 순서로 액세스 하느냐에 따라 캐시의 활용도가 달라지고 응용프로그램의 성능이 달라지게 된다. 이 시점에서 현재 컴퓨터에서 B+-트리가 T-트리보다 더 빠르다는 사실이 알려졌다. B+-트리가 T-트리보다 캐시를 더 효율적으로 사용하기 때문이다. 또한 B+-트리를 개선하여 캐시를 더욱 효율적으로 사용하는 CSB+-트리(Cache Sensitive B+-tree)가 제안되기도 하였다 본 논문의 목표는 T-트리가 캐시를 효율적으로 사용하도록 새로운 T-트리 구조를 개발하는 것이다. CSB+-트리와 같이 시스템의 L2 캐시를 최대한 활용하며 기존 T-트리가 가지는 장점을 가지는 새로운 CST-트리(Cache Sensitive T-트리)를 설계 개발하고, 실험을 통해 기타 다른 인덱스 구조에 비교하여 CST-트리의 우수성을 보인다.

• The Korean Journal of Pain
• /
• 제32권4호
• /
• pp.256-263
• /
• 2019

Background: Antinociceptive anti-inflammatory drugs have many adverse effects. The goal of this investigation is to study the probable anti-inflammatory and analgesic effects of verapamil and N-acetylcysteine (NAC) in experimental rats. Methods: Adult male Wistar rats were randomly divided into 4 groups in the antinociceptive study, each containing 6 rats; the normal control group, which received saline (1 mL/kg); the diclofenac group, which received diclofenac sodium (5 mg/kg); the NAC group, which received NAC (125 mg/kg); and the verapamil group, which received verapamil (8 mg/kg). In the anti-inflammatory study, 5 groups were used, the 4 previous groups with the addition of an edema control group, received saline and were subjected to formalin test. Hot plate latency time was recorded for antinociceptive evaluation. Paw edema thickness and biochemical parameters were recorded for anti-inflammatory evaluation. Results: Administration of NAC showed significant prolongation of hot plate latency time at 1 hour when compared to the control group while verapamil showed a significant prolongation of hot plate latency time at 1 and 2 hours when compared to the control group and NAC group values. Administration of NAC and verapamil significantly decreased paw edema thickness at 2, 4, and 8 hours when compared to edema control values. Regarding biochemical markers, NAC and verapamil significantly decreased serum nitric oxide synthase, C-reactive protein, and cyclooxygenase-2 levels compared to the edema control value. In accordance, a marked improvement of histopathological findings was observed with both drugs. Conclusions: NAC and verapamil have antinociceptive and anti-inflammatory effects comparable to diclofenac sodium.

• Journal of Dental Anesthesia and Pain Medicine
• /
• 제22권2호
• /
• pp.145-153
• /
• 2022

Background: Postoperative analgesia (POA) is an important determinant of successful treatment. Dexmedetomidine (DEX) has recently gained attention as a promising adjuvant to local anesthetics (LA). The present study aimed to evaluate the efficacy and safety of levobupivacaine (LB) as an adjuvant during inferior alveolar nerve block (IANB) in the extraction of lower impacted third molars (LITM). Methods: A prospective, randomized, placebo-controlled, triple-blind, parallel-arm, and clinical study was performed on 50 systemically healthy participants who required removal of an asymptomatic LITM. Using a 1:1 distribution, the participants were randomized into two groups (n = 25). Group L (control group) received 1.8 mL of 0.5% LB and 0.2 mL normal saline (placebo) and Group D (study group) received a blend of 1.8 mL of 0.5% LB and 0.2 mL (20 ㎍) DEX. The primary outcome variable was the duration of POA and hemodynamic stability, and the secondary variable was the total number of analgesics required postoperatively for up to 72 h. The participants were requested to record the time of rescue analgesic use and the total number of rescue analgesics taken. The area under the curve was plotted for the total number of analgesics administered. The pain was evaluated using the visual analog scale. Data analysis was performed using paired students and unpaired t-test, Mann-Whitney U test, Chi-square test, and receiver operating characteristic analysis. Statistical significance was set at P < 0.05. Results: The latency, profoundness of anesthesia, and duration of POA were statistically significant (P < 0.05). The differences between mean pain scores at 6, 12, 24, 48, and 72 h were found to be significant (each P = 0.0001). Fewer analgesics were required by participants in group D (2.12 ± 0.33) than in L (4.04 ± 0.67), with a significant difference (P = 0.0001). Conclusion: Perineurally administered LA with DEX is a safe, effective, and therapeutic approach for improving latency, providing profound POA, and reducing the need for postoperative analgesia.

• 한국축산식품학회지
• /
• 제37권5호
• /
• pp.646-653
• /
• 2017

Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HTP) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP ($13.50{\mu}g/mL$), while neutrase hydrolysis showed the lowest 5-HTP content ($5.23{\mu}g/mL$). The liquid egg white to water ratio (1:1) was optimal for the production of 5-HTP with high amino-nitrogen (A-N) content and degree of hydrolysis. The 5-HTP, amino-nitrogen, and degree of hydrolysis increased until 24 h of hydrolysis and slightly increased thereafter during hydrolysis with 2% and 5% enzyme addition. 5-HTP administration at doses of 6 and 9 mg/kg significantly increased sleep duration and decreased sleep latency time compared to that in the control (p<0.05). LEH (150 mg/mouse), which was equivalent to 5-HTP at 6 mg/kg, significantly decreased sleep latency time and increased sleep duration time compared to that in the control (p<0.05). Oral administration of LEH showed sleep-potentiating effects because of 5-HTP. The sleep-potentiating activity of LEH may have occurred through 5-HTP in our pentobarbital-induced sleep model. LEH may be a valuable alternative to sleep enhancement and may be used as a sleep-potentiating agent.

• 한국정보과학회논문지:시스템및이론
• /
• 제32권2호
• /
• pp.85-94
• /
• 2005

DRAM에 의해 지원되는 페이지(page) 접근 모드나 버스트(burst) 접근 모드를 신중하게 이용하면 DRAM의 접근 시간(access latency) 및 접근 시에 소모되는 에너지를 줄일 수 있음이 많은 설계들에서 입증되었다. 최근에는 변수들을 메모리에 적절하게 배열함으로써 페이지 접근 횟수와 버스트 접근 회수론 각각 극대화시킬 수 있음이 밝혀졌다. 그러나 이러한 최적화문제는 쉽게 최적의 해를 구할 수 없다고 알려졌기 때문에. 주로 간단한 greedy 휴리스틱을 이용해서 풀려졌다. 본 논문은 기존의 방법보다 더 좋은 결과를 얻기 위해서 0-1 선형 프로그래밍(ILP)을 근간으로 한 기법을 제안한다. 벤치마크 프로그램들을 이용한 실험 결과를 보면, 제안된 알고리즘은 각각 OFU(order of first use) 방식과, [2]의 방식, [3]의 방식에 비해 평균적으로 각각 32.3%, 15.1%, 3.5%만큼 페이지 접근 회수론 증가시켰으며, 또한 각각84.4%, 113.5%, 10.1%만큼의 버스트 접근 회수를 증가시켰다.

• Journal of Audiology & Otology
• /
• 제24권1호
• /
• pp.10-16
• /
• 2020

Background and Objectives:The blockage of adenosine receptors by caffeine changes the levels of neurotransmitters. These receptors are present in all parts of the body, including the auditory and vestibular systems. This study aimed to evaluate the effect of caffeine on evoked potentials using auditory brainstem responses (ABRs) and cervical vestibular-evoked myogenic potentials (cVEMPs) in a double-blind placebo-controlled study. Subjects and Methods: Forty individuals (20 females and 20 males; aged 18-25 years) were randomly assigned to two groups: the test group (consuming 3 mg/kg pure caffeine powder with little sugar and dry milk in 100 mL of water), and the placebo group (consuming only sugar and dry milk in 100 mL water as placebo). The cVEMPs and ABRs were recorded before and after caffeine or placebo intake. Results: A significant difference was observed in the absolute latencies of I and III (p<0.010), and V (p<0.001) and in the inter-peak latencies of III-V and I-V (p<0.001) of ABRs wave. In contrast, no significant difference was found in cVEMP parameters (P13 and N23 latency, threshold, P13-N23 amplitude, and amplitude ratio). The mean amplitudes of P13-N23 showed an increase after caffeine ingestion. However, this was not significant compared with the placebo group (p>0.050). Conclusions: It seems that the extent of caffeine's effects varies for differently evoked potentials. Latency reduction in ABRs indicates that caffeine improves transmission in the central brain auditory pathways. However, different effects of caffeine on auditory- and vestibular-evoked potentials could be attributed to the differences in sensitivities of the ABR and cVEMP tests.

• 대한청각학회지
• /
• 제24권1호
• /
• pp.10-16
• /
• 2020

Background and Objectives:The blockage of adenosine receptors by caffeine changes the levels of neurotransmitters. These receptors are present in all parts of the body, including the auditory and vestibular systems. This study aimed to evaluate the effect of caffeine on evoked potentials using auditory brainstem responses (ABRs) and cervical vestibular-evoked myogenic potentials (cVEMPs) in a double-blind placebo-controlled study. Subjects and Methods: Forty individuals (20 females and 20 males; aged 18-25 years) were randomly assigned to two groups: the test group (consuming 3 mg/kg pure caffeine powder with little sugar and dry milk in 100 mL of water), and the placebo group (consuming only sugar and dry milk in 100 mL water as placebo). The cVEMPs and ABRs were recorded before and after caffeine or placebo intake. Results: A significant difference was observed in the absolute latencies of I and III (p<0.010), and V (p<0.001) and in the inter-peak latencies of III-V and I-V (p<0.001) of ABRs wave. In contrast, no significant difference was found in cVEMP parameters (P13 and N23 latency, threshold, P13-N23 amplitude, and amplitude ratio). The mean amplitudes of P13-N23 showed an increase after caffeine ingestion. However, this was not significant compared with the placebo group (p>0.050). Conclusions: It seems that the extent of caffeine's effects varies for differently evoked potentials. Latency reduction in ABRs indicates that caffeine improves transmission in the central brain auditory pathways. However, different effects of caffeine on auditory- and vestibular-evoked potentials could be attributed to the differences in sensitivities of the ABR and cVEMP tests.

• 한국컴퓨터정보학회논문지
• /
• 제14권5호
• /
• pp.119-131
• /
• 2009

기존 경로 최적화 방안들은 최적화된 경로가 형성되기까지 경로 최적화 소요시간 이외에 3계층 핸드오프 소요시간도 포함되어 이동 라우터(Mobile Router:MR)의 이동이 빈번한 환경에서는 빠른 경로 최적화가 어렵다는 단점을 가진다. 본 논문에서는 MR이 중첩된 이동 네트워크 환경으로 이동하더라도 별도의 경로 최적화 과정이 없어도 즉시 경로 최적화를 지원하는 3계층 핸드오프 방안을 제안하고자 한다. 이를 위해 제안한 방안에서는 MR과 액세스라우터(Access Router:AR)간의 위치등록과정을 통해 AR로 하여금 MR들의 주소정보를 획득하는 과정을 갖도록 하였다. 이 후 AR은 MR이 수행해야할 홈 에이전트(Home Router:HA)와의 위치등록과정을 대신 수행해줌으로써 AR과 MR의 HA들 사이에 양방향 터널이 형성되고, 패킷들은 해당 목적지 MR의 HA만 경유한 후 AR로 전송된다. 성능평가 결과, 본 논문에서 제안한 3계층 핸드오프 방식은 Reverse Routing Header(RRH), Optimization NEMO(ONEMO) 방안보다 약 $0.6{\sim}1.5[s]$ 감소된 소요시간으로 경로 최적화를 지원할 수 있음을 확인할 수 있었다.

• 정보처리학회논문지C
• /
• 제13C권7호
• /
• pp.873-880
• /
• 2006

최근 이동통신 기술의 발달과 다양한 네트워크의 중복, 사용자의 요구에 따라 기존의 cdma2000 네트워크와 WLAN의 연동과 같은 연구가 활발히 진행되고 있다. 또한, 이동환경에서 높은 전송률을 가진 WiBro 네트워크가 차세대 무선 접속망으로 부각되고 있으며, 이러한 WiBro-cdma2000 네트워크와의 연동은 기존의 WLAN-cdma2000 연동에 비해 높은 시너지 효과를 나타낼 것으로 예상된다. 이를 위해 본 논문에서는 WiBro-cdma2000 연동이 이루어질 경우 단말의 이동성 제공을 위해 패킷손실을 최소화한 L2 핸드오프 방안을 제시한다. 본 논문에서 제안한 L2 핸드오프 방안은 기존의 이동성 제공 방안이 L3 기반의 등록절차를 통한 방안이었음에 착안하여, L3 시그널링이 이루어지기 전, L2 연결설정과정에서 L2 메시지에 핸드오프 정보를 사용하여 패킷손실을 최소화하는 방안을 제시한다. 제안한 방안의 성능을 검증하기 위해 컴퓨터 시뮬레이션을 수행하였으며, 이를 통해 제안한 방안의 우수성을 검증하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제2권4호
• /
• pp.171-183
• /
• 2008

Nowadays, wireless packet data services are provided over Wireless MAN (WMAN) at a high data service rate, while 3G cellular networks provide wide-area coverage at a low data service rate. The integration of mobile WiMAX and 3G networks is essential, to serve users requiring both high-speed wireless access as well as wide-area connectivity. In this paper, we propose a cross-layer optimization scheme for a vertical handover between mobile WiMAX and 3G cellular networks. More specifically, L2 (layer 2) and L3 (layer 3) signaling messages for a vertical handover are analyzed and reordered/combined, to optimize the handover procedure. Extensive simulations using ns-2 demonstrate that the proposed scheme enhances the performance of a vertical handover between mobile WiMAX and 3G networks: low handover latency, high TCP throughput, and low UDP packet loss ratio.