• Korean Journal of Veterinary Research
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• v.34 no.4
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• pp.679-686
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• 1994

The development of esophagus in fetuses between 60, 90, 120 days of gestation and neonates of Korean native goats was investigated by light, scanning electron microscopy. The results were summarized as follows; 1. The esophageal wall appeared to be differentiated into the epithelium, lamina propria, tunica muscularis and tunica adventitia at 60 days of gestation. The esophageal epithelium was stratified cuboidal at 60 days, being transformed into stratified squamous epithelium at 90 days, and completely transformed into squamous epithelium an 120 days. 2. In scanning electron microscopy, the longitudinal furrows and ridges appeared on the epithelium of the esophagus of the fetuses at 60 days of gestation. The longitudinal furrow became deeper and microplicae appeared in 90-day-old fetuses. The transverse and longitudinal folds appeared on the epithelial surface of esophagus and the esophageal epithelium started to be keratinized in the neonates.

• Korean Journal of Veterinary Pathology
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• v.1 no.2
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• pp.149-152
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• 1997

A 13-years and 8-months old Jindo dog showed vomiting and pale red vulvular discharge. At necropsy, the uterus was swollen and endometrium was diffusely thickened by numerous protruding cysts which measured approximately from 0.5 to 1 cm in diameter. On sectioning the cysts exuded pale red watery fluid. histologically the endometrium was thickened and characterized by mild to moderate edema congestion and hemorrhagic foci. The cystic endometrial glands were lined by a single layer of flattened cuboidal or vacuolated columnar epithelium. Occasional dilated glands had traversed through the submucosa into the myometrial region. Afew mixed inflammatory cells infiltrated in the lamina propria. Bacteriologically Escherichia coli was isolated from the uterine contents. Gross and microscopic finding were consistent with cystic endometrial hyperplasia.

• Korean Journal of Veterinary Research
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• v.13 no.1
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• pp.1-4
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• 1973

This experiment was performed in order to investigate the effect of radioiodine upon the uterus and the ovary of guinea pigs. The animals were injected single dose of 4. 5 mCi of radioiodine per kg of body weight. They were sacrificed on various time intervals; 1, 7, 14, 28, 42 and 56 days after the injection. The results were as follows: 1. In the ovary, the follicle cells and the ova were degenerated with lapse of time after the injection. 2. In the uterus, hyperplasia of the lamina propria of the endometrium and atrophy of the myometrium were observed in accordance with time after the injection.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.23 no.1
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• pp.28-32
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• 2012

Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

• Proceedings of the KSLP Conference
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• 2017.04a
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• pp.87-87
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• 2017

• Korean Journal of Veterinary Pathology
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• v.2 no.2
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• pp.107-116
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• 1998

Twelve colostrum-deprived piglets were inoculated oral1y with porcine epidemic diarrhea virus isolated from Korea. The piglets were euthanatized from at 12 hour postinoculation(PI) at 6-hour intervals. At 24 to 36 hours PI, all infected piglets showed severe yellowish to watery diarrhea, dehydration, depression, and anorexia. At necropsy, the intestinal wall looked thin, mesenteric vessels congested, and mesenteric lymph nodes edematous. The histological findings showed marked villous atrophy and fusion, severe degeneration of enterocytes and monomuclear cell infiltration in the lamina propria. On electron microscopy, villous epithelial cells of infected jejunum contained viral particles at 18 hour PI. The viral particles were pleomorphic spheres with a mean diameter of 95∼180nm including 18nm projections.

• Korean Journal of Veterinary Service
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• v.21 no.4
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• pp.401-405
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• 1998

A male badger which showed depression and bloody diarrhea was submitted to Iksan Branch of Chonbuk Veterinary Service Laboratory for necropsy on May 1998. Grossly, paleness of the mucous membranes was observed and the small intestinal contents were hamorrhagic. The numerous tiny hookworms, sized in 5-10 mm and greyish-white in color, attached to the intestinal mucosa. Male bursa was well developed. Histologically, intestinal lumen was filled with hemorrhagic contents, which contained worms. The epithelial cells of the villi were underwent degeneration and lamina propria was infiltrated by lymphocytes and plasma cells, and goblet cells were hyperplastic. There were rounded cutting plates in the funnel-shaped buccal capsule and transverse striation on sheath in hookworm, ultrastructurally, which were consistent with Uncinaria sp. The shape of eggs were ellipsoidal and morula, and some eggs contained a mobile larva. It was concluded that this badger was infected with Uncinaria.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.21 no.2
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• pp.101-104
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• 2010

The origin and growth of laryngology is inseparably linked to the development of endoscopic surgery of the larynx. Phonomicrosurgery is a means of maximally preserving the layered microstructure of the vocal fold, that is, the epithelium and lamina propria. Phonomicrosurgery has developed from convergence of micro laryngoscopic surgical technique theory and the mucosal wave theory of laryngeal sound production. Improvements in technology (i.e., laryngoscopes, handled instruments, and lasers), which in part arise from developments in more frequently performed minimally invasive surgical procedures, will probably facilitate the next generation of procedural innovations. The best methods of optimizing phonosurgical outcomes include making an accurate diagnosis, completing a comprehensive voice evaluation, providing sufficient preoperative therapy, carefully selecting patients to undergo phonomicrosurgical procedures, and requiring sufficient postoperative rest and therapy. Phonomicrosurgery will continue to evolve as a result of the interdependent collaboration of surgeons with voice scientists, speech pathologist, and other voice professionals.

• Korean Journal of Veterinary Research
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• v.37 no.4
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• pp.693-706
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• 1997

The present study was designed to investigate the morphological developments of the stomach in the prenatal and postnatal rats. The gastric fundus of 16- to 22-day-old fetuses, neonates, 7-day-old, 14-day-old, 21-day-old, and adult rats were observed by light and scanning electron microscopy. Light microscopic studies. 1. In the 16-day-old fetuses, the walls of the gastric fundus were differentiated into epithelium, lamina propria, muscle layer, and serosa. The lamina propria was composed of mesenchymal connective tissue cells with sparse nucleus and their fibers. 2. In the 17-day-old fetuses, the muscular layer were differentiated into the circular and longitudinal muscle layers. 3. The epithelium on the fundus of stomach was stratified columnar cells at 16-, 17- and 18-day-old fetuses, but partly converted into simple columnar epithelium at 19-day-old fetuses. 4. The mucous cells were positive by PAS reaction at the 19-day-old fetuses and then these developed rapidly within 1 or 2 days before birth. 5. In the 20-day -old fetuses, the parietal cells were distinguished from other type cells and these cells were chiefly crowded in the middle parts of the gastric glands after 7-day-old. Scanning electron microscopic studies. 6. The surface of gastric mucosa was covered with forms of the various protrusions by forming villi at the last few days before birth and these protrusion forms were fused and folded each other. 7. The mucosal surface was closely packed by polygonal mucous cells. The openings of gastric glands were seen as slit-like round invagination and were more numerous and increased gradually in depth after the postnatal life. The above findings indicate that prominent changes occurred in the pattern of cellular proliferation in the stomach fundus at the end of gestation. The gastric epithelium had well-defined glands composed of parietal, chief and mucous cells just before the birth. The stomach fundus, therefore, were developed morphologically as those of normal adult at fourteen days after birth.

• Advances in pediatric surgery
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• v.1 no.1
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• pp.1-7
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• 1995

The acetylcholinesterase(ACHE) activity in 37 biopsies from the patients with Hirschsprung's disease was analyzed for histochemical patterns according to age, and its evolutional behavior was also assessed. The histochemical criterion used for the diagnosis of Hirschsprung's disease was that of Chow, i.e., "the presence of many coarse discrete cholinergic fibers in the muscularis mucosae and in the immediately subjacent submucosa regard less of an infiltration of cholinergic fibers in the lamina propria." The acetylcholinesterase activity in Hirschsprung's disease was further classified into 3 patterns, advocated by de Brito and Maksoud : Pattern I-many thick fibers exclusively in the muscularis mucosae and submucosa(newborn pattern). Pattern II-many thin fibers in the muscularis mucosae and submucosa with a clear infiltration of cholinergic fibers in the lamina propria(classical pattern). Pattern III-an intermediate pattern showing morphological characteristics of the two patterns with predominance of one or the other. Of 37 biopsies, Pattern 1 was seen exclusively in 16 biopsies taken from the neonates. Pattern III was 11 of 37 biopsies and it was mainly seen in children between 2 to 12 months of age. Pattern II was seen in all 3 biopsies of older than 1 year of age and in 6 ones of 3 to 12 months of age. In summary, this study reinforces the impression that there is an evolutional character of the distribution and morphology of the cholinergic ACHE positive fiber with age. In other words, ACHE activity in Hirschsprung's disease appears to evolve with age from the newborn pattern to the intermediate pattern finally to the classical pattern.