• 대한한방내과학회지
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• 제41권6호
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• pp.1119-1140
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• 2020

Objective: The purpose of this study was to review Chinese clinical studies of the treatment of gastroesophageal reflux disease (GERD) with herbal medicine including Pinellia ternata. Methods: We searched the China National Knowledge Infrastructure (CNKI) database for clinical studies on herbal treatments including Pinellia ternata for GERD, from January 1st, 2015 to September 30th, 2019. We evaluated the risk of bias using Cochrane's risk of bias to confirm the quality of the 37 selected documents. Results: The 37 papers included high-dose and middle-dose Pinellia ternata groups. The outcome measures included treatment effectiveness rate, symptom comparisons, and endoscopy effectiveness rates or scores. In both groups, most studies showed significant improvement in the treatment group compared with the control group. The meta-analysis revealed a higher treatment effectiveness rate and a lower recurrence rate in the treatment group than in the control group. Conclusions: Comparing the treatment effect between the two groups was difficult due to the low quality of most studies. However, the results suggest that herbal remedies including Pinellia ternata showed statistically significant improvement in GERD compared to control groups.

• 정보보호학회논문지
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• 제17권3호
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• pp.69-80
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• 2007

정보를 배포할 때 개인정보를 보호하기 위해 데이터 소유자는 이름이나 주민등록번호와 같은 명시적인 개인 신원정보를 암호화하거나 삭제한다. 그러나, 배포되는 정보들을 서로 연결함으로써 개인 신원을 확인할 수 있고 결국 개인정보가 노출되게 된다. 배포되는 정보로부터 개인정보를 보호하는 방법에 대한 최근의 연구는 k-anonymity 방법과 $\ell$-diversity 방법이다. 그러나, 이들 연구는 데이터의 삽입이나 삭제가 없는 정적 인 환경을 가정하고 있다. 따라서, 동적 인 데이터베이스 환경에 기존 기법들을 그대로 적용할 경우 갱신된 데이터의 내용이 반영됨으로써 개인정보가 유출되는 취약성이 발견된다. 특히, 삽입 환경에서 발생되지 않는 삭제 환경에서의 고려사항은 k-anonymity와 l-diversity 스킴이 붕괴될 수 있다는 것이다. 본 논문에서는 삭제 환경에서 동적 데이터베이스 환경에서 k-anonymity와 $\ell$-diversity를 그대로 따르면서 데이터베이스 익명화를 유지할 수 있는 기법을 제안한다.

• 한국환경보건학회지
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• 제47권3호
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• pp.227-244
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• 2021

Objectives: The Korean National Environmental Health Survey provides representative biomonitoring data for environmental pollutants in South Korea. Over the last decade, there have been various studies published using this data. In this study, we aimed to provide information and implications by reviewing each study. Methods: We searched comprehensive electronic databases from PubMed, Google Scholar, and Naver Academic database using the key words 'Korean National Environmental Health Survey' and 'KoNEHS' through March 2021. A total of 57 studies were selected after reviewing the relevance of the data. Results: The most frequently studied pollutants were heavy metals (10), Cotinine (8), Bisphenol A (7), and Phthalates (6), in that order. In particular, Phthalates, Bisphenol A, and Parabens were often studied together (6). A decline in urinary cotinine and heavy metals in the body was shown over time among studies on exposure association. It was demonstrated that Phthalates and Bisphenol A were significantly related to obesity and diabetes from the studies of health impacts. Cross-section study design, spot urine, and insufficient health status information were mostly reported as limitations of the data. Conclusion: Since research has been focused on adults, further investigations of children and adolescents are required. In this regard, it is necessary to maintain the consistency of the data structure and provide integrated weights for all ages. In addition, it would allow the measurement of several environmental pollutants by considering subsample design. Lastly, integrated studies with multi-cycles and the health effects from co-exposure to multiple chemicals would be expected to provide important knowledge.

• 동의신경정신과학회지
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• 제32권2호
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• pp.111-127
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• 2021

Objectives: To review and analyze clinical and preclinical evidence of effectiveness, safety, and underlying mechanisms of yokukansan (YKS), a herbal medicine, in alleviating aggression. Methods: Classical records on YKS were searched in the Korean Traditional Medicine Knowledge Database (KTMKD). By searching five electronic databases, prospective clinical studies and preclinical studies of YKS for alleviating aggression/agitation published up to March 30, 2021 were included. Results: Only two classical records on YKS were found from the KTMKD. A total of 11 clinical studies and 15 preclinical studies were found from the five electronic databases. Among 11 clinical studies, seven enrolled patients with dementia and four enrolled patients with other neuropsychiatric disorders. Most clinical studies reported significant improvement in one or more outcomes related to aggression in the YKS group after treatment. Among 15 preclinical studies, all studies except two reported a significant decrease in aggression/agitation-related behavior of YKS or yokukansankachimpihange. Suggested underlying mechanisms of YKS or yokukansankachimpihange for aggression/agitation in these studies included regulation of serotonin receptor, amelioration of abnormal glucocorticoid level related to the hypothalamic-pituitary-adrenal axis, regulation of orexin secretion, amelioration of degeneration in brain cells including glia cells, and suppression of excessive glutamatergic or dopaminergic activity. Conclusions: There were some clinical and preclinical evidence supporting the effectiveness and safety of YKS for alleviating aggression. Given that aggression is the most frequent and destructive symptoms of behavioral and psychological symptoms of dementia, applicability of YKS as a herbal medicine should be further investigated in future high-quality research.

• 문화기술의 융합
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• 제8권1호
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• pp.131-138
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• 2022

본 연구는 국내 간호대학생의 안전에 관한 연구 동향을 분석하고자 실시하였다. 7개의 데이터 베이스를 통해 'safety', 'safety*', 'patient safety', 'patient safety*' 'nursing students', and 'nursing * students' 검색한 결과 총 29개의 논문이 추출되었다. 연구결과, '2015-2019년' 69.0%, '기타 저널' 79.3%, 대상자는 평균 242.4 명으로 '200명 이하' 51.7%, 대상지역은 '1개 지역' 48.2%, 참여 학교는 '3개 학교이상' 42.3%, 학년은 '4학년' 56.2%, 대상자 산출근거는 'G*power' 86.2%, IRB '미승인' 58.6%, 분석방법은 '회귀분석' 75.9%, 저자는 '2명' 58.6%로 대다수를 차지하였다. 키워드 분석에서도 지식중심에서 환자중심으로 변화하였다. 간호대학생의 안전역량을 파악하기 위한 전국적인 실태조사와 간호학적인 안전역량 함양을 위한 실무중심의 교육이 요구된다.

• 방사성폐기물학회지
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• 제19권4호
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• pp.459-467
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• 2021

In the majority of countries, the upper limit of buffer temperature in a repository is set to below 100℃ due to the possible illitization. This smectite-to-illite transformation is expected to be detrimental to the swelling functions of the buffer. However, if the upper limit is increased while preventing illitization, the disposal density and cost-effectiveness for the repository will dramatically increase. Thus, understanding the characteristics and creating a database related to the buffer under the elevated temperature conditions is crucial. In this study, a strategy to investigate the bentonite found in Korea under the elevated temperatures from a mineral transformation and radionuclides retardation perspective was proposed. Certain long-term hydrothermal reactions generated the bentonite samples that were utilized for the investigation of their mineral transformation and radionuclide retardation characteristics. The bentonite samples are expected to be studied using in-situ synchrotron-based X-Ray Diffraction (XRD) technique to determine the smectite-to-illite transformation. Simultaneously, the 'high-temperature and high-pressure mineral alteration measurement system' based on the Diamond Anvil Cell (DAC) will control and provide the elevated temperature and pressure conditions during the measurements. The kinetic models, including the Huang and Cuadros model, are expected to predict the time and manner in which the illitization will become detrimental to the performance and safety of the repository. The sorption reactions planned for the bentonite samples to evaluate the effects on retardation will provide the information required to expand the current knowledge of repository optimization.

• 한방재활의학과학회지
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• 제32권2호
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• pp.95-103
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• 2022

Objectives This study was conducted to assess the effect of chuna manual therapy after hip arthroplasty. Methods We searched across 9 electronic databases (PubMed, Cochrane Library, Wangfang data, China National Knowledge Infrastructure [CNKI], Oriental Medicine Advanced Searching Integrated System [OASIS], National Digital Science Library [NDSL], Korean Medical Database [KMBASE], Koreanstudies Information Service System [KISS], Research Information Sharing Service [RISS]) to find randomized controlled clinical trials for chuna manual therapy after hip arthroplasty. Results On inclusion criteria, 11 appropriate studies were included and analyzed. The deep vein thrombosis incidence of the chuna manual therapy group was statistically lower than the conventional treatment group (p=0.0002). Chuna manual therapy significantly improved the Harris hip score compared with conventional treatment (p<0.00001). Also, chuna manual therapy combined with herbal fumigation therapy significantly elevated the hip joint function score of Harris hip score compared with the conventional therapy group (p<0.00001). Conclusions The systematic review showed that chuna manual therapy had significant effects on hip arthroplasty. Nonetheless, considering the high risk of bias and geographic bias, further research with well-designed studies is required to support the effectiveness of chuna manual therapy.

• 한국컴퓨터정보학회논문지
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• 제27권9호
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• pp.139-147
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• 2022

본 연구에서는 증강현실 기술을 이용하여, 화학에 입문하는 사람이 화학 학습에 필요한 지식을 쉽게 습득할 수 있도록 모바일 애플리케이션을 개발하는 것을 목표로 한다. 본 연구에서는 2차원 형태의 그림을 인식해 화학 구조를 3차원의 개체로 증강 시켜 사용자의 화면에 보여주고, 이와 관련된 다분야의 정보를 동시에 제공하는 서비스를 활용해 새로운 화학 학습 경험을 제공하는 점이 특징이다. 이를 위해 별도의 시스템과 콘텐츠를 구성하였고, 안전하고 실시간적인 데이터 관리를 위해 로그인 API와 실시간 데이터베이스 기술을 사용하였으며, 이미지 인식 및 3차원 개체 증강 서비스를 위해 이미지 트래킹 기술을 사용하였다. 본 연구를 통한 결과는 실험을 통해 유의미한 결과를 도출하였다. 향후 연구에서는 화학 구조 데이터 라이브러리를 사용하여 효율적으로 데이터를 불러오고 출력할 수 있도록 한다.

• 한방재활의학과학회지
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• 제33권2호
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• pp.19-32
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• 2023

Objectives The purpose of this study is to systematically review the degree of pain and function improvement in acupuncture treatment for patellofemoral pain syndrome (PFPS). Methods Randomized controlled trials (RCTs) were searched from Medline/PubMed, Cochrane Library, Embase, WanFang Data, China National Knowledge Infrastructure (CNKI), Citation Information by NII (CiNII), Koreanstudies Information Service System (KISS), ScienceON, KoreaMed, and Korean Medical Database (KMbase). The methodological quality of selected RCTs' were evaluated according to Cochrane RoB2 tool. Results Total of 158 studies were identified and 7 RCTs were selected for systematic review. Frequently used evaluation method were visual analogue scale and Kujala scores. All studies showed significant effect on pain reduction and knee function between before and after treatment, but showed partial significance between the intervention and control group. Conclusions Research showed that acupuncture treatment is an effective treatment for improving the pain and function of PFPS, but it is difficult to conclude that it has a significant effect compared to other treatments. Selected studies included subjective evaluation indicators and the total of selected studies were small, so the interpretation of the results is limited. Also most of the included studies are evaluated to have some concerns of bias. Therefore, subsequent research should continously be done in more objective and systematic method.

• Journal of Acupuncture Research
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• 제40권3호
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• pp.238-244
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• 2023

Background: Occipital neuralgia (ON) is an established risk factor for headaches in the posterior cervical region. Several conservative treatments by nerve decompression and pain relief are available for ON, but these treatments have limitations. Acupuncture treatment, which is known to demonstrate analgesic effects, involves various stimulation methods, and several studies have reported their clinical benefit. No recent systematic review (SR) has compared each acupuncture type for ON treatment. Thus, this SR aims to investigate the clinical effectiveness of each acupuncture type for treating ON. Methods: We will identify relevant studies using electronic databases, including EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure (CNKI), Korean Studies Information Service System (KISS), Korean Medical Database, KoreaMed, and National Digital Science Library (NDSL) from the inception until August 2023. The primary outcome will include the numerical change of pain symptoms (visual analog scale and numerical rating scale) and effective rate. Safety and secondary outcomes will include adverse events and quality of life. We will compare the conservative treatment with the acupuncture treatment using network meta-analysis. The Cochrane Collaboration "risk of bias" tools will be used to assess the quality of included trials. The Grades of Recommendation, Assessment, Development, and Evaluation will be used to examine the evidence level. Conclusion: This study will provide clinical evidence of several acupuncture types for ON and help clinicians decide on the best.