DOI QR코드

DOI QR Code

A Review of the Literature Using the Korean National Environmental Health Survey (cycle 1-3)

국민환경보건기초조사 1~3기의 연구성과 검토

  • Lee, Seungho (Department of Occupational and Environmental Medicine, Ajou University School of Medicine) ;
  • Kim, Jin Hee (Department of Integrative Bioscience & Biotechnology, Sejong University) ;
  • Choi, Yoon-Hyeong (Department of Preventive Medicine, Gachon University) ;
  • Kim, Sungkyoon (Department of Environmental Health Sciences, Seoul National University) ;
  • Lee, Kyung mu (Department of Environmental Health, Korea National Open University) ;
  • Park, Jae Bum (Department of Occupational and Environmental Medicine, Ajou University School of Medicine)
  • 이승호 (아주대학교 의과대학 직업환경의학과) ;
  • 김진희 (세종대학교 바이오융합공학과) ;
  • 최윤형 (가천대학교 의과대학 예방의학교실) ;
  • 김성균 (서울대학교 보건대학원 환경보건학과) ;
  • 이경무 (한국방송통신대학교 보건환경학과) ;
  • 박재범 (아주대학교 의과대학 직업환경의학과)
  • Received : 2021.05.31
  • Accepted : 2021.06.20
  • Published : 2021.06.30

Abstract

Objectives: The Korean National Environmental Health Survey provides representative biomonitoring data for environmental pollutants in South Korea. Over the last decade, there have been various studies published using this data. In this study, we aimed to provide information and implications by reviewing each study. Methods: We searched comprehensive electronic databases from PubMed, Google Scholar, and Naver Academic database using the key words 'Korean National Environmental Health Survey' and 'KoNEHS' through March 2021. A total of 57 studies were selected after reviewing the relevance of the data. Results: The most frequently studied pollutants were heavy metals (10), Cotinine (8), Bisphenol A (7), and Phthalates (6), in that order. In particular, Phthalates, Bisphenol A, and Parabens were often studied together (6). A decline in urinary cotinine and heavy metals in the body was shown over time among studies on exposure association. It was demonstrated that Phthalates and Bisphenol A were significantly related to obesity and diabetes from the studies of health impacts. Cross-section study design, spot urine, and insufficient health status information were mostly reported as limitations of the data. Conclusion: Since research has been focused on adults, further investigations of children and adolescents are required. In this regard, it is necessary to maintain the consistency of the data structure and provide integrated weights for all ages. In addition, it would allow the measurement of several environmental pollutants by considering subsample design. Lastly, integrated studies with multi-cycles and the health effects from co-exposure to multiple chemicals would be expected to provide important knowledge.

Keywords

Acknowledgement

본 논문은 국립환경과학원 "국가 환경보건 바이오뱅크 구축 및 운영 로드맵 마련" 사업에서 연구비를 지원받아 수행된 연구결과를 포함하고 있습니다. 연구지원과 국민환경보건기초조사 자료를 위한 모든 노력에 감사드립니다.

References

  1. Park C, Hwang M, Kim H, Ryu S, Lee K, Choi K, et al. Early snapshot on exposure to environmental chemicals among Korean adults-results of the first Korean National Environmental Health Survey (2009-2011). Int J Hyg Environ Health. 2016; 219(4-5): 398-404. https://doi.org/10.1016/j.ijheh.2016.04.001
  2. Ministry of Environment. The 10-Year Master Plan for Environmental Health (2021~2030)-2nd [press release]. 2020; p. 37-73.
  3. Park C, Yu SD. Status and Prospects of the Korean National Environmental Health Survey (KoNEHS). J Environ Health Sci. 2014; 40(1): 1-9. https://doi.org/10.5668/JEHS.2014.40.1.1
  4. Choi W, Kim S, Baek YW, Choi K, Lee K, Kim S, et al. Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012-2014). Int J Hyg Environ Health. 2017; 220(2 Pt A): 29-35. https://doi.org/10.1016/j.ijheh.2016.10.002
  5. Jeon HL, Hong S, Joo Y, Kwon YM, Jung SK, Lee C, et al. Urinary Exposure Levels of Cotinine and Influence Factors among Non-smokers in Korean Adults-Korean National Environmental Health Survey (2009-2017). J Environ Health Sci. 2020; 46(2): 214-223.
  6. Jung S, Shin H, Park S. Factors Affecting on Human Exposure to Bisphenol A in Children and Adolescents: Korean National Environmental Health Survey (KoNEHS) Cycle 3, 2015-2017. J Environ Health Sci. 2021; 47(1): 87-100. https://doi.org/10.5668/JEHS.2021.47.1.87
  7. Korea Disease Control Agency. Korea National Health & Nutrition Examination Survey. Available: https://knhanes.kdca.go.kr/knhanes/sub03/sub03_05.do [accessed 25 May 2021].
  8. Park JH, Lee CK, Kim SY, Suh C, Kim KH, Kim JH, et al. Decline in non-smoking workers' urine cotinine levels after increased smoking regulation in Korea. Ann Occup Environ Med. 2015; 27(1): 17. https://doi.org/10.1186/s40557-015-0066-z
  9. Kim J, Lee K. Characterization of urinary cotinine in non-smoking residents in smoke-free homes in the Korean National Environmental Health Survey (KoNEHS). BMC Public Health. 2016; 16: 538. https://doi.org/10.1186/s12889-016-3212-9
  10. Park JH, Lee CK, Kim KH, Son BC, Kim JH, Suh CH, et al. Decrease in the urine cotinine concentrations of Korean non-smokers between 2009 and 2011 following implementation of stricter smoking regulations. Int J Hyg Environ Health. 2016; 219(1): 123-128. https://doi.org/10.1016/j.ijheh.2015.10.001
  11. Kim S, Park JS, Park M, Kim Y, Lim S, Lee HE. Female non-smokers' environmental tobacco smoking exposure by public transportation mode. Ann Occup Environ Med. 2018; 30(1): 24. https://doi.org/10.1186/s40557-018-0239-7
  12. Moon SY, Kim TW, Kim YJ, Kim Y, Kim SY, Kang D. Public Facility Utility and Third-Hand Smoking exposure without first and second-hand smoking according to urinary cotinine level. Int J Environ Res Public Health. 2019; 16(5): 855. https://doi.org/10.3390/ijerph16050855
  13. Kim J, Lee K. Changes in urinary cotinine concentrations in non-smoking adults from the Korean National Environmental Health Survey (KoNEHS) II (2012-2014) after implementation of partial smoke-free regulations. Int J Hyg Environ Health. 2020; 224: 113419. https://doi.org/10.1016/j.ijheh.2019.113419
  14. Kim J, Shim IK, Won SR, Ryu J, Lee J, Chung HM. Characterization of Urinary Cotinine Concentrations Among Non-smoking Adults in Smoking and Smoke-free Homes in the Korean National Environmental Health Survey (KoNEHS) Cycle 3 (2015-2017). BMC Public Health (in review). 2021.
  15. Kim SA, Kwon Y, Kim S, Joung H. Assessment of Dietary Mercury Intake and Blood Mercury Levels in the Korean Population: Results from the Korean National Environmental Health Survey 2012-2014. Int J Environ Res Public Health. 2016; 13(9): 877. https://doi.org/10.3390/ijerph13090877
  16. Lee S, Shin M, Hong YC, Kim JH. Temporal variability of blood lead, mercury, and cadmium levels in elderly panel study (2008-2014). Int J Hyg Environ Health. 2017; 220(2 Pt B): 407-414. https://doi.org/10.1016/j.ijheh.2016.11.014
  17. Cho CM. Levels of Heavy Metal Exposure Depending on the Lifestyles and Dietary Habits in Youth. J Korean Soc Living Environ Sys. 2017; 24(4): 508-516. https://doi.org/10.21086/ksles.2017.8.24.4.508
  18. Son BC, Lee CK, Suh CH, Kim KH, Kim JH, Jeong SU, et al. Blood lead concentration and exposure related factors in Korea from the National Environmental Health Survey (KoNEHS) II (2012-2014). J Occup Environ Hyg. 2019;16(12): 763-774. https://doi.org/10.1080/15459624.2019.1668000
  19. Joo Y, Kwon YM, Kim SY, Choi K, Lee C, Yu SD, et al. A Study on Heavy Metals Exposure and Major Sociodemographic Influence Factors among Korean Adults-Korean National Environmental Health Survey (2009-2017). J Environ Health Sci. 2019; 45(5): 541-55. https://doi.org/10.5668/JEHS.2019.45.5.541
  20. Choi W, Ahn R, Kim JH. Influential Factors on Blood Pb and Hg Concentrations in Koreans over 50 Years Old: Data Analysis of the 1 st (2009-2011) and 2 nd (2012-2014) KoNEHS. Toxicol Environ Health Sci. 2019; 11(4): 295-304. https://doi.org/10.1007/s13530-019-0416-2
  21. LaKind JS, Pollock T, Naiman DQ, Kim S, Nagasawa A, Clarke J. Factors affecting interpretation of national biomonitoring data from multiple countries: BPA as a case study. Environ Res. 2019; 173: 318-329. https://doi.org/10.1016/j.envres.2019.03.047
  22. Park JS, Kim S, Park M, Kim Y, Lee H, Choi H, et al. Relationship between dietary factors and bisphenol a exposure: the second Korean National Environmental Health Survey (KoNEHS 2012-2014). Ann Occup Environ Med. 2017; 29: 42. https://doi.org/10.1186/s40557-017-0200-1
  23. Kim Y, Park M, Do Jin Nam EHY, Ryoo JH. Relationship between seafood consumption and bisphenol A exposure: the Second Korean National Environmental Health Survey (KoNEHS 2012-2014). Ann Occup Environ Med. 2020; 32: e10. https://doi.org/10.35371/aoem.2020.32.e10
  24. Hwang MY, Ryu JM, Kown YM, Hong SY, Park CH. Seasonal Variations of Exposure to Environmental Chemicals: Implication from the Korean National Environmental Health Survey (2012-2014). J Environ Health Sci. 2018; 44(6): 572-580.
  25. Hwang MY, Hong SY, Kwon YM, Jo HJ, Park CH. Differences of Chemical Exposure Levels according to Residential and Personal Life-style Characteristics of Korean adult population-from Korean National Environmental Health Survey. J Environ Health Sci. 2019; 45(2): 142-153.
  26. Kim SW, Jung SW, Lee JG, Joo JH, Lee JH, Lee KJ. The exposure level of environmental harmful substances related to the secondhand smoke in Korean non-smoker adults: data from the second Korean National Environmental Health Survey (KoNEHS 2012-2014): a cross-sectional study. Ann Occup Environ Med. 2019; 31(6): e30. https://doi.org/10.35371/aoem.2019.31.e30
  27. Park C, Hwang M, Baek Y, Jung S, Lee Y, Paek D, et al. Urinary phthalate metabolite and bisphenol A levels in the Korean adult population in association with sociodemographic and behavioral characteristics: Korean National Environmental Health Survey (KoNEHS) 2012-2014. Int J Hyg Environ Health. 2019; 222(5): 903-910. https://doi.org/10.1016/j.ijheh.2019.02.003
  28. Kwon YM, Joo Y, Park CH, Kim SY, Choi K, Lee C, et al. Exposure Levels and Influence Factors of PAHs and Benzene Metabolites in the Urine of the General Korean Adult Population-Korean National Environmental Health Survey (2009-2017). J Environ Health Sci. 2019; 45(5): 529-540. https://doi.org/10.5668/JEHS.2019.45.5.529
  29. Lim S. The associations between personal care products use and urinary concentrations of phthalates, parabens, and triclosan in various age groups: The Korean National Environmental Health Survey Cycle 3 2015-2017. Sci Total Environ. 2020; 742: 140640. https://doi.org/10.1016/j.scitotenv.2020.140640
  30. Jung K, Oh H, Ryu JY, Kim DH, Lee S, Son B-C, et al. Relationship between housing characteristics, lifestyle factors and phthalates exposure: the first Korean National Environmental Health Survey (2009-2011). Ann Occup Environ Med. 2015; 27(1): 33. https://doi.org/10.1186/s40557-015-0078-8
  31. Lee G, Kim S, Park H, Lee J, Lee JP, Kho Y, et al. Variability of urinary creatinine, specific gravity, and osmolality over the course of pregnancy: Implications in exposure assessment among pregnant women. Environ Res. 2020:110473.
  32. Park HG, Ha NY, Kim DH, Kim JH, Lee CK, Kim K, et al. Relationship between residence characteristics and polycyclic aromatic hydrocarbon exposure in housewives: second Korean National Environmental Health Survey (2012-2014). Ann Occup Environ Med. 2018; 30(1): 23. https://doi.org/10.1186/s40557-018-0236-x
  33. Koh DH, Park JH, Lee SG, Kim HC, Choi S, Jung H, et al. Comparison of polycyclic aromatic hydrocarbons exposure across occupations using urinary metabolite 1-hydroxypyrene. Ann Work Expo Health. 2020; 64(4): 445-454. https://doi.org/10.1093/annweh/wxaa014
  34. Oh HH, Park H, Kim DH, Son BC, Lee CK, Kim K, et al. The relationship between urinary BTEX metabolites and residence setting among Korean homemakers: the first Korea National Environmental Health Survey (2009-2011). Ann Occup Environ Med. 2017; 29(1): 38. https://doi.org/10.1186/s40557-017-0189-5
  35. Park M, Kim S, Kim Y, Nam DJ, Ryoo JH, Lim S. Relationship between personal care products usage and triclosan exposure: the second Korean National Environmental Health Survey (KoNEHS 2012-2014). Ann Occup Environ Med. 2019; 31(1): 2. https://doi.org/10.1186/s40557-019-0283-y
  36. Kang Y, Park J, Youn K. Association between urinary phthalate metabolites and obesity in adult Korean population: Korean National Environmental Health Survey (KoNEHS), 2012-2014. Ann Occup Environ Med. 2019; 31(5): 78-89.
  37. Nam DJ, Kim Y, Yang EH, Lee HC, Ryoo JH. Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017). Ann Occup Environ Med. 2020; 32: e24. https://doi.org/10.35371/aoem.2020.32.e24
  38. Kim SW, Lee J, Kwon SC, Lee JH. Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015-2017. Int J Environ Res Public Health. 2021; 18(5): 2261. https://doi.org/10.3390/ijerph18052261
  39. Park O, Park JT, Chi Y, Kwak K. Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015-2017. Ann Occup Environ Med. 2021; 33: e4 https://doi.org/10.35371/aoem.2021.33.e4
  40. Lee I, Park YJ, Kim MJ, Kim S, Choi S, Park J, et al. Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey (KoNEHS) 2015-2017. Environ Int. 2021; 146: 106227. https://doi.org/10.1016/j.envint.2020.106227
  41. Park C, Choi W, Hwang M, Lee Y, Kim S, Yu S, et al. Associations between urinary phthalate metabolites and bisphenol A levels, and serum thyroid hormones among the Korean adult population - Korean National Environmental Health Survey (KoNEHS) 2012-2014. Sci Total Environ. 2017; 584-585: 950-957. https://doi.org/10.1016/j.scitotenv.2017.01.144
  42. Shim YH, Ock JW, Kim YJ, Kim Y, Kim SY, Kang D. Association between heavy metals, bisphenol a, volatile organic compounds and phthalates and metabolic syndrome. Int J Environ Res Public Health. 2019; 16(4): 671. https://doi.org/10.3390/ijerph16040671
  43. Lee I, Park JY, Kim S, An JN, Lee J, Park H, et al. Association of exposure to phthalates and environmental phenolics with markers of kidney function: Korean National Environmental Health Survey (KoNEHS) 2015-2017. Environ Int. 2020; 143: 105877. https://doi.org/10.1016/j.envint.2020.105877
  44. Choi S, Kim MJ, Park YJ, Kim S, Choi K, Cheon GJ, et al. Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population. Environ Int. 2020; 140: 105783. https://doi.org/10.1016/j.envint.2020.105783
  45. Moon S, Seo MY, Choi K, Chang YS, Kim SH, Park MJ. Urinary bisphenol A concentrations and the risk of obesity in Korean adults. Sci Rep. 2021; 11(1): 1603. https://doi.org/10.1038/s41598-021-80980-8
  46. Hwang MY, Lee YM, Jung SW, Hong SY, You JY, Park CH. Relationship between Bisphenol A Exposure and Obesity in Korean Adults from the Second Stage of KoNEHS (2012-2014). J Environ Health Sci. 2018; 44(4): 370-379.
  47. Kwon JA, Shin B, Kim B. Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012- 2014. Chemosphere. 2020; 240: 124918. https://doi.org/10.1016/j.chemosphere.2019.124918
  48. Lee S, Tan YM, Phillips MB, Sobus JR, Kim S. Estimating Methylmercury Intake for the General Population of South Korea Using Physiologically Based Pharmacokinetic Modeling. Toxicol Sci. 2017; 159(1): 6-15. https://doi.org/10.1093/toxsci/kfx111
  49. Lee TW, Kim DH, Ryu JY. The effects of exposure to lead, cadmium and mercury on follicle-stimulating hormone levels in men and postmenopausal women: data from the Second Korean National Environmental Health Survey (2012-2014). Ann Occup Environ Med. 2019; 31: e21. https://doi.org/10.35371/aoem.2019.31.e21
  50. Lee S, Cho SR, Jeong I, Park JB, Shin MY, Kim S, et al. Mercury Exposure and Associations with Hyperlipidemia and Elevated Liver Enzymes: A Nationwide Cross-Sectional Survey. Toxics. 2020; 8(3): 47. https://doi.org/10.3390/toxics8030047
  51. Sohn SH, Heo HC, Jo S, Park C, Sakong J. The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3. Ann Occup Environ Med. 2020; 32: e19. https://doi.org/10.35371/aoem.2020.32.e19
  52. Kim MJ, Kim S, Choi S, Lee I, Moon MK, Choi K, et al. Association of exposure to polycyclic aromatic hydrocarbons and heavy metals with thyroid hormones in general adult population and potential mechanisms. Sci Total Environ. 2021; 762: 144227. https://doi.org/10.1016/j.scitotenv.2020.144227
  53. Lee TW, Kim DH, Ryu JY. Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012-2014). Sci Rep. 2020; 10(1): 17142. https://doi.org/10.1038/s41598-020-74353-w
  54. Sa H, Rim H, Choi J, Kim K, Shin J, Oh E, Kweon H. Association between Environmental Polycyclic Aromatic Hydrocarbons Exposure and Insulin Resistance: Using The Second Korean National Environmental Health Survey. Korean J Fam Pract. 2020; 10(6): 418-423. https://doi.org/10.21215/kjfp.2020.10.6.418
  55. Nam YJ, Kim SH. Association of Urinary Polycyclic Aromatic Hydrocarbons and Diabetes in Korean Adults: Data from the Korean National Environmental Health Survey Cycle 2 (2012-2014). Diabetes Metab Syndr Obes. 2020; 13: 3993-4003. https://doi.org/10.2147/DMSO.S276658
  56. Yoo M, Lim YH, Kim T, Lee D, Hong YC. Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1st Korean National Environmental Health Survey. Ann Occup Environ Med. 2016; 28(1): 2. https://doi.org/10.1186/s40557-015-0079-7
  57. Hwang M, Lee Y, Choi K, Park C. Urinary 3-phenoxybenzoic acid levels and the association with thyroid hormones in adults: Korean National Environmental Health Survey 2012-2014. Sci Total Environ. 2019; 696: 133920. https://doi.org/10.1016/j.scitotenv.2019.133920
  58. Ha NY, Kim DH, Ryu JY. Relationship between triclosan exposure and thyroid hormones: the Second Korean National Environmental Health Survey (2012-2014). Ann Occup Environ Med. 2019; 31.