• 동의생리병리학회지
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• 제30권4호
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• pp.289-299
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• 2016

This study is aimed to report two cases of chronic kidney disease treated with Korean traditional medicine. We treated the patients with traditional herbal medicine and other treatments including acupuncture. We measured serum creatinine, estimated glomerular filtration rate(eGFR), blood urea nitrogen(BUN), albumin, red blood cell count(RBC), hemoglobin for several times during admission. Case 1 patient was diagnosed with right medulla infarction, bladder stone, chronic kidney disease. The symptoms were quadriplegia, right side dysesthesia, drowsiness and edema. Case 2 patient was diagnosed with acute cerebral infarction, hypertension, chronic kidney disease. The symptoms were right side weakness, delusion, anorexia, low back pain. Case 1 patient was hospitalized for 80 days, and case 2 patient was for 31 days. Korean traditional medicine decreased serum creatinine and BUN level, improved eGFR, increased RBC and hemoglobin. The symptoms of chronic kidney disease such as edema, general body weakness and anorexia were also improved. These cases suggest that Korean traditional medicine can be effective and safe for patients with chronic kidney disease.

• The Journal of the Acoustical Society of Korea
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• 제29권3E호
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• pp.119-130
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• 2010

Extracorporeal shock wave therapy (ESWT) is simply evolved from extracorporeal shock wave lithotripsy known as a revolutionary non-invasive technique for treating kidney stone diseases. Since ESWT was approved for treating plantar fasciitis by FDA in 2000, it has been rapidly accepted into various clinical practices. Its indication includes chronic tendinitis and pseudoarthrosis, and has been widened to various applications other than orthopeadics. Little has been reported on their acoustic properties, yet, even if a number of clinical ESWT systems are readily available. This article reviews the acoustical aspects of ESWT and discusses critical issues towards acoustic exposure optimization and shock wave dosimetry.

• Advances in pediatric surgery
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• 제6권1호
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• pp.68-69
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• 2000

A case of primary hyperparathyroidism due to parathyroid adenoma is presented. A 14 year-old male was admitted to the hospital comptaining of voiding difficulty. The intravenous pyelogram demonstrated a stone in the proximal one third of the left ureter and marked hydronephrosis of the left kidney. The Tc-99m sestamibi nuclear scan demonstrated a hot spot below the lower pole of the left lobe of the thyroid. Laboratory study demonstrated hypercalcemia (12.4 mg/dL) and elevated parathyroid hormone (143.67 pg/mL). A parathyroid gland located below the lower pole of the left lobe of the thyroid was excised. A parathyroid adenoma, consisting of mainly chief cells was found on pathologic examination. Postoperatively the patient had transient hypocalcemic symptoms, which resolved with administration of calcium preparation and vitamin D.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.287.2-287.2
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• 2003

Rubia akane (Rubiaceae) is a perennial vine plant and generally grows at the mountain, field and fence of Korea, Japan, China and Taiwan. This plant grows about two meters and has empty stem and red roots. The roots of this plant have been used as a Korean traditional medicine for the treatment of cough, the stone in the bladder and kidney, inflammation of the joints, uterine hemorrhage and uteritis. (omitted)

• Childhood Kidney Diseases
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• 제17권2호
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• pp.122-126
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• 2013

8개월 여아가 지속적인 발열 및 다발성 요로 결석으로 입원하여 시행한 신장 초음파에서 오른쪽 신우 및 요관, 왼쪽 수질 부위의 다발성 요로 결석이 보였고, 자연 배출된 1 cm 크기의 결석이 100% 시스틴석으로 확인되었다. 소변 검사에서 시스틴을 비롯한 이염기 아미노산의 상승과 유전자 검사에서 SLC3A1의 c.1820del (p.L607fs)의 동형접합자로 확인되어 시스틴뇨증으로 진단되었다. 충분한 수분 섭취와 소변 알칼리화, 동물성 단백질 제한에도 불구하고 결석의 수와 크기가 증가하여 현재는 tiopronin으로 치료 중이다.

• 한국콘텐츠학회논문지
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• 제17권1호
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• pp.120-128
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• 2017

요로결석증으로 인한 급성 옆구리 통증은 환자들이 응급실로 방문하는 가장 흔한 질병이다. 연구의 목적은 수신증이 동반되지 않은 환자에서 컬러 도플러를 이용하여 요관결석 검출의 유용성에 대하여 알아보고자 한다. 신장, 요관, 방광의 단순 x-ray 검사에서 요로결석 의심 소견자 또는 소변검사에서 혈뇨 양성반응을 보인 161명의 환자를 대상으로 초음파 검사를 시행하고 후향적으로 분석하였다. 초음파검사에서 진단된 요관결석은 161명 환자 중 154례 (95.6%) 이었다. 수신증이 없고 컬러 도플러 초음파검사에서 섬광인공물(TA)을 동반한 요관결석은 21명 중 18례 (85.7%)이었다(p<0.001). 초음파는 비교적 저렴하고, 보편적으로 사용하므로 옆구리 통증을 갖는 환자의 요로결석 진단에 우선적으로 이용할 수 있다. 컬러 도플러를 이용하여 구분되지 않은 결석, 비확장성 요관결석, 중간요관 결석 검출에 높은 진단 효과를 갖는다.

• Investigative and Clinical Urology
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• 제59권6호
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• pp.383-391
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• 2018

Purpose: We aimed to analyze the incidence and prevalence of urolithiasis in Korea over the last decade using the National Health Insurance (NHI) sample cohort data. Materials and Methods: From January 2002 to December 2013, we enrolled sample cohort data from the NHI. Patients diagnosed with international classification of diseases code N20 or N13.2 were included. The incidence and prevalence rate was counted from the same period and patients previously diagnosed with urolithiasis were excluded. We compared the incidence and prevalence of urolithiasis by region, age, and sex, and identified the changes. Results: Total 1,111,828 subjects were included. Of these subjects, 36,857 had urolithiasis. The male-to-female ratio was 1.57:1, and total incidence rate was 3.27 per 1,000 person-years (1,000p-yrs). The annual incidence was lowest in 2013 (3,138 patients) and highest in 2005 (3,751 patients). Incidence rate by diagnostic code was highest in ureter stone only (2.49 per 1,000p-yrs) and was lowest in kidney and ureter stone both (0.17 per 1,000p-yrs). Prevalence gradually increased from 3,172 in 2002 and 5,758 in 2013. Jeollanam-do had the highest incidence rate of 3.70 persons per 1,000p-yrs, and Jeju had the lowest rate of 2.84 persons per 1,000p-yrs. In gender analysis, Daegu had the highest incidence (4.56) in males, Jeollanam-do had the highest incidence (3.20) in females. Conclusions: Annual incidence remained stable, whereas prevalence gradually increased. The incidence in male was 1.57 times higher than female, and the peak incidence age was 45-49 years, with the highest incidence occurring in Jeollanam-do and the lowest in Jeju.

• 한국자원식물학회지
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• 제25권5호
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• pp.507-516
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• 2012

참가시나무 열수 추출물은 강한 항산화제로 xanthine oxidase반응을 억제하며 uric acid생성에 영향을 주어 alfacalcidol과 ethylene glycol로 결석이 유도된 흰쥐에 따르는 혈중 및 뇨의 위험요소 감소시킨 것으로 추측된다. 또한 강력한 이뇨제인 furosemide군과 비슷한 유의성을 나타내었다. 따라서 참가시나무 잎 열수 추출물은 신장결석 예방과 치료를 위해 적합하다고 생각된다.

• Childhood Kidney Diseases
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• 제1권1호
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• pp.60-66
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• 1997

목적 : 요로 결석은 소아에서는 비교적 드물다고 하나, 점점 증가하고 있으며, 유발요인이 있는 경우에는 보다 빨리 진단할 수 있다. 본 연구를 통하여 요로 결석 환아들의 주증상, 진단, 감염및 동반 질환 여부, 치료 등에 대하여 알아보고자 하였다. 방법 : 1986년 1월부터 1996년 6월까지 10년 5개월간 세브란스 병원에 내원한 15세 미만의 요로 결석환아 45명을 대상으로 후향적 고찰을 하였다. 결과 : 요로 결석 환아의 평균 연령은 6.5세, 남녀비는 5.4:1이었고, 가족력은 13.3%에서 나타났다. 주증상은 육안적 혈뇨가 가장 많았고, 요로 감염을 동반한 환아 46.1%,요로 기형 및 질환을 동반한 환아가 35.6%에서 나타났다. 진단 방법으로는 단순 요로 촬영, 경정맥 신우 조영술, 복부 초음파 등이 사용되었는데, 초음파만으로 진단받은 경우도 다수 있어 의의가 크다고 하겠다. 치료로는 체외 충격파 쇄석술, 경피적 신결석 적출술, 수액 요법, 이뇨제등이 사용되었다. 결론 : 소아 요로결석에 대해 관찰한 결과, 유의할 만한 질환으로 생각되며, 요로 폐색이 있는 환아에서는 시급한 치료가 요구된다. 특히 단순 방사선 촬영및 경정맥 신우 조영술에서 발견되지 않은 환아에서는 반드시 초음파를 하여 진단해야 할 것이다. 한편, 결석의 성분 분석이 이루어지지 않아 다소 아쉬운 점이 남는다.

• 한국연소학회지
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• 제11권4호
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• pp.9-13
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• 2006

Recent advances in energetic materials modeling and high-resolution hydrocode simulation enable enhanced computational analysis of bio-medical treatments that utilize high-pressure shock waves. Of particular interest is in designing devices that use such technology in medical treatments. For example, the generated micro shock waves with peak pressure on orders of 10 GPa can be used for treatments such as kidney stone removal, transdermal micro-particle delivery, and cancer cell removal. In this work, we present a new computational methodology for applying the high explosive dynamics to bio-medical treatments by making use of high pressure shock physics and multi-material wave interactions. The preliminary calculations conducted by the in-house code, GIBBS2D, captures various features that are observed from the actual experiments under the similar test conditions. We expect to gain novel insights in applying explosive shock wave physics to the bio-medical science involving drug injection. Our forthcoming papers will illustrate the quantitative comparison of the modeled results against the experimental data.