• Title/Summary/Keyword: junctional

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Junctional rhythm with severe hypotension following infiltration of lidocaine containing epinephrine during dental surgery

  • Jeon, Younghoon;Shim, Jihye;Kim, Hyunjee
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.20 no.2
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    • pp.89-93
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    • 2020

  • We experienced an unusual case of accelerated junctional rhythm with severe hypotension after infiltration of lidocaine containing epinephrine during dental surgery under general anesthesia. The patient's electrocardiogram exhibited retrograde P-waves following the QRS complex, which could be misinterpreted as ST-segment depression. As a temporary measure, administration of ephedrine restored the patient's blood pressure to normal levels. The importance of this case lies in its demonstration of an unexpected and serious side effect of commonly used epinephrine infiltration. This case also highlights the need for accurate interpretation of the electrocardiogram and comprehensive understanding of best practices for patient management.

  • https://doi.org/10.17245/jdapm.2020.20.2.89 인용 PDF KSCI

Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling

  • Choi, Hyun-Jung;Kwon, Young-Guen
    • BMB Reports
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    • v.48 no.8
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    • pp.429-430
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    • 2015

  • Angiogenesis is a complex process involving dynamic interaction of various cell to cell interactions. Endothelial cell interactions regulated by growth factors, inflammatory cytokines, or hemodynamic stress are critical for balancing vascular quiescence and activation. Yes-associated protein (YAP), an effector of Hippo signaling, is known to play significant roles in maintaining cellular homeostasis. However, its role in endothelial cells for angiogenic regulation remains relatively unexplored. We demonstrated the critical role of YAP in vascular endothelial cells and elucidated the underlying molecular mechanisms involved in angiogenic regulation of YAP. YAP was expressed in active angiogenic regions where endothelial cell junctions were relatively loosened. Consistently, YAP subcellular localization and activity were regulated by VE-cadherin-mediated PI3K/Akt pathway. YAP thereby regulated endothelial sprouting via angiopoietin-2 expression. These results provide an insight into a model of coordinating endothelial junctional stability and angiogenic activation through YAP. [BMB Reports 2015; 48(8): 429-430]

  • https://doi.org/10.5483/BMBRep.2015.48.8.146 인용 PDF KSCI KPUBS

Congenital Pyloric Atresia with Junctional Epidermolysis Bullosa-a case report (수포성 표피박리증을 동반한 선천성 유문부폐쇄증 1예)

  • Cho, Ma-Hae;Han, Seok-Joo
    • Advances in pediatric surgery
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    • v.3 no.1
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    • pp.77-82
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    • 1997

  • The association of pyloric atresia and epidermolysis bullosa(EB) in newborn is rare and inheritant as an autosomal recessive trait. We report a newborn girl with pyloric atresia and epidermolysis bullosa. Blisters were noted on her skin at birth, especially in pressure-exposed area, and later on the oral mucosa. Junctional epidermolysis bullosa was confirmed by light microscopy and electron microscopy. Radiography revealed pyloric atresia. Segmental resection of 1.5 cm and gastroduodenostomy were carried out at 4 days of age. Protein loosing enteropathy developed after oral feeding. The frequency of episodes of nonscarred blisters and the severity and duration improved significantly with time. The protein loosing enteropathy was persistent, and at 1 year of age, her growth is markedly retarded.

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Both $^{45}Ca^{2+}$ Uptake and $^{45}Ca^{2+}$ Release were Decreased in the Junctional Sarcoplasmic Reticulum Vesicles of Diabetic Heart

  • Kim, Won-Tae;Cho, Kwang-Hyun;Kim, Hae-Won;Kim, Young-Kee
    • Proceedings of the Korean Biophysical Society Conference
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    • 1996.07a
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    • pp.40-40
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    • 1996

  • Abnormally high $Ca^{2+}$ concentrations have been reported in the cardiac myocytes of diabetic mellitus (DM). In order to elucidate the molecular mechanisms of the intracellular $Ca^{2+}$ overload, the activities of $^{45}$ Ca$^{2+}$ uptake and $^{45}$ Ca$^{2+}$ release were measured from the vesicles of junctional SR (Heavy SR, HSR). (omitted)omitted)

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