• 대한한방부인과학회지
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• 제35권2호
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• pp.87-105
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• 2022

Objectives: The purpose of this study is to analysis the Clinical Study Trends on Korean Medicine Treatment for Polycystic Ovary Syndrome. Methods: The key words such as 'polycystic ovary syndrome', 'polycystic ovarian syndrome', 'korean medicine', 'herbal medicine', 'acupuncture' are used for the research through 'OASIS', 'KCI', 'KISS', 'RISS'. Results: Ten clinical studies with 73 patients were selected. All studies were the noncomparative studies, and 8 case reports, 1 case series, 1 retrospective chart review. Symptoms accompanied by PCOS were oligomenorrhea, amenorrhea, irregular menstruation, hirsutism, acne, obesity etc. The most used treatment was herbal medicine in all studies with 72 patients (98.6%). The most frequently used acupuncture and moxibustion point was respectively 合谷 (LI4) and 關元 (CV4). The duration of treatment was between 3 months and 10 months, the average 159 days. Outcome measurements were Recovery of menstrual cycle (97.6%), Hormone test (23.8%), Sonogram (61.9%), Indexes of obesity (23.8%). In terms of menstrual recovery, 35 patients (85.4%) have recovered from menstruation in 8 studies with 41 patients. In hormone tests, all 10 patients have decrease of LH/FSH ratio and LH in 3 studies with 10 patients. Through sonogram, Ovulation menstruation was confirmed in all 6 patients. In all 10 patients of 3 studies evaluating weight before and after treatment, weight was reduced. Conclusions: The effect on Korean Medicine treatment for Polycystic Ovary Syndrome had mostly positive results. However, Further large, well-designed clinical trials are needed to establish the foundation of Korean Medicine treatment for Polycystic Ovary Syndrome.

• Nutrition Research and Practice
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• 제17권2호
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• pp.371-385
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• 2023

BACKGROUND/OBJECTIVES: Soy isoflavone (SIF) and soy lecithin (SL) have beneficial effects on many chronic diseases, including neurodegenerative diseases. Regretfully, there is little evidence to show the combined effects of these soy extractives on the impairment of cognition and abnormal cerebral blood flow (CBF). This study examined the optimal combination dose of SIF + SL to provide evidence for improving CBF and protecting cerebrovascular endothelial cells. MATERIALS/METHODS: In vivo study, SIF50 + SL40, SIF50 + SL80 and SIF50 + SL160 groups were obtained. Morris water maze, laser speckle contrast imaging (LSCI), and hematoxylin-eosin staining were used to detect learning and memory impairment, CBF, and damage to the cerebrovascular tissue in rat. The 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the oxidized glutathione (GSSG) were detected. The anti-oxidative damage index of superoxide dismutase (SOD) and glutathione (GSH) in the serum of an animal model was also tested. In vitro study, an immortalized mouse brain endothelial cell line (bEND.3 cells) was used to confirm the cerebrovascular endothelial cell protection of SIF + SL. In this study, 50 µM of Gen were used, while the 25, 50, or 100 µM of SL for different incubation times were selected first. The intracellular levels of 8-OHdG, SOD, GSH, and GSSG were also detected in the cells. RESULTS: In vivo study, SIF + SL could increase the target crossing times significantly and shorten the total swimming distance of rats. The CBF in the rats of the SIF50 + SL40 group and SIF50 + SL160 group was enhanced. Pathological changes, such as attenuation of the endothelium in cerebral vessels were much less in the SIF50 + SL40 group and SIF50 + SL160 group. The 8-OHdG was reduced in the SIF50 + SL40 group. The GSSG showed a significant decrease in all SIF + SL pretreatment groups, but the GSH showed an opposite result. SOD was upregulated by SIF + SL pretreatment. Different combinations of Genistein (Gen)+SL, the secondary proof of health benefits found in vivo study, showed they have effective anti-oxidation and less side reaction on protecting cerebrovascular endothelial cell. SIF50 + SL40 in rats experiment and Gen50 + SL25 in cell test were the optimum joint doses on alleviating cognitive impairment and regulating CBF through protecting cerebrovascular tissue by its antioxidant activity. CONCLUSIONS: SIF+SL could significantly prevent cognitive defect induced by β-Amyloid through regulating CBF. This kind of effect might be attributed to its antioxidant activity on protecting cerebral vessels.

• 한국자연치유학회지
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• 제8권2호
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• pp.63-70
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• 2019

목적: 본 연구의 목적은 둔부근육의 협착, 틀어진 체형, 어깨 통증이 있는 기혈순환이 나쁜 대상자들을 상대로 기혈테라피의 효과를 탐색하는 것이었다. 방법: 기혈테라피와 교정 기혈운동을 사용 하였다. 결과: 기혈테라피를 시술하기 전에 둔부 근육이 거의 움직이지 않았지만, 시술한 후에는 근육의 탄력이 회복되었고 회색으로 경화되었든 피부의 색상도 밝아지었고 항문 괄약근에도 힘이 생기었다. 대상자의 체형이 우측으로 -7°가량 틀어지면서 우측 팔이 좌측팔에 비해서 약 6 cm정도 길었었으나, 체형교정 후에는 우측 팔의 길이가 약 5 cm 정도 줄어들었고, 틀어졌던 체형이 거의 평형을 이루었다. 목 및 어깨교정 후에는 쇄골과 목의 간격이 7 cm로 간격이 넓어졌고, 승모근을 풀어준 후에는 10 cm로 넓어졌으며, 어깨통증이 많이 완화 되었다. 골반교정 후 둔부통증이 완화되었고, 고관절의 위치가 바르게 돌아왔다. 좌측으로 45°각도 틀어졌던 우측다리가 바르게 교정이 되었으며, 4 cm 정도 길었던 우측 다리의 길이도 좌우가 같아졌다. 둔부통증 및 무릎통증도 완화되었다. 골반교정 기혈운동 후에 대상자 1의 고관절의 위치가 바로 잡히어 좌측으로 45°각도 틀어졌던 우측다리가 바르게 교정이 되었고, 4 cm 정도 길었던 우측 다리의 길이도 좌우가 거의 같아졌다. 대상자2는 교정 전에는 무릎이 붙지가 않았고, 오른쪽 무릎이 왼쪽에 비해서 위로 5 cm 정도 올라갔었으며, 발목이 좌측에 비해서 30° 각도로 굽어져 있었는데, 교정 후에는 두 다리의 무릎이 안정되게 붙일 수 있게 되었고, 무릎의 높이도 같아 졌으며, 발목꺾임이 각도도 정상으로 교정이 되었다. 결론: 꾸준하게 기혈테라피와 척추교정 및 골반교정 기혈운동을 한다면 틀어졌던 체형도 바르게 회복되고, 아픈 통증도 완화되어 관련 질환들을 예방 및 치유하는데 효과가 있다고 본다.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.479-493
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• 2019

본 연구는 중고령층 문해학습자의 흥미 유발 및 학습 효과를 높이는 문해교육 방법을 제시하는데 목적을 두었다. 이를 위해 충북 중고령층 문해교사, 기관 운영자, 평생교육사, 문해학습자 총11명을 면담 및 참여관찰 하였다. 연구결과 중고령층 학습자들은 배운 것을 쉽게 잊어버리고 받아쓰기를 통해 글씨를 정확하게 익히며, 높은 경쟁 심리 등 공부가 일상생활에서 1순위가 되고 있다. 글씨 형성 의미를 알게 하는 놀이활동, 실생활과 연결된 학습, 받아쓰기가 기억력 및 인지력 향상에 효과적이다. 또한 일상생활에서 익숙한 재료를 활용한 만들기, 교과서에 나오는 극과 시로 역할극, 글씨 큰 그림 동화책 활용, 팀 단위 게임 및 활동, 배우기 쉬운 악기 및 노래 부르기, 공연 및 발표회 등 무대 경험, 실생활 및 교육문화 시설 현장 체험 등이 중고령층의 흥미와 학습 효과를 높일 수 있다. 결과 공유 발표회 및 연합 행사, 자료 및 재료비, 문해교사 역량강화 교육 및 공유, 문해교육 연중 운영, 학력인정과정과 병행 및 보조강사 지원이 중요하다. 시사점으로는 문해교사 교육, 보조강사 활용, 학력인정 문해교육과정 활성화 방안에 대한 연구가 필요하다.

• 한국노년학
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• 제30권3호
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• pp.793-802
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• 2010

열 스트레스는 건강의 위험요인으로 장시간 노출시 열손상과 근기능 감소 등 신체 기능을 감소시키며 특히 생리적 기능이 감소되어 있는 노인에서 영향을 받기 쉽다. 본 연구는 여름철 폭염주의보 수준의 열 스트레스가 여성노인들의 근기능 및 근손상 지표에 미치는 영향을 살펴보고자 시도되었다. 65세 이상의 여성 자원자 총 8명을 대상으로 2주일 간격으로 상온(20℃) 그리고 폭염주의보 수준의 고온(33℃)에서 등속성 슬관절 근기능을 측정하였으며, 폭염주의보 수준의 열 스트레스가 근손상에 미치는 영향을 알아보기 위하여 근기능 측정 전과 후에 채혈을 실시하였다. 각속도 60°/sec 운동시, 고온(33℃) 환경에서 우측 굴곡근과 신전근에서 최대우력, 단위체중당 최대우력, 평균파워 그리고 단위체중당 평균파워에서 근기능이 감소하였다(p<0.05). 또한 각속도 180 °/sec 운동시, 고온(33℃) 환경에서 우측 슬관절 신전근 피로도가 증가하였으며(p<0.05), 굴곡근 총일량은 유의하게 증가하였다(p<0.05). 고온환경(33℃)에서 근손상 지표인 HSP70, CK 그리고 LDH는 상온(20℃)과 비교하여 유의하게 증가하였다(p<0.05). 결론적으로 열 스트레스가 여성노인들의 근기능을 감소시키고 근손상을 유발하는 것으로 나타났다. 따라서 여성노인들의 건강유지를 위하여 여름철 폭염환경에서 열 스트레스의 노출 및 신체활동을 최소화 시키는 방안이 효과적이라 사료된다.

• 무역학회지
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• 제48권1호
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• pp.127-163
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• 2023

본문에서는 실증분석 부분을 두 시기로 나누어 COVID-19 전후에 해운지수 간의 변동성 파급효과 차이를 비교 분석하고자 하였다. 코로나19 전후에 해운지수 간의 평균 파급효과 및 지수 관계를 비교하기 위해 VAR 모델에 구축된 공적분 분석과 Granger 인과관계 테스트를 활용하였다. 또한, 본 연구에서는 해운지수가 단기적으로 자신의 충격에 대한 반응과 한 지수가 다른 지수에 대한 충격을어떻게 반영하는지 밝히기 위해서 충격반응함수 및 예측 오차 분산분해를 활용하였다. COVID-19 전염병 이전에는 BDI 해운지수가 CCFI 해운지수에 미치는 관계가 존재하지만 COVID-19 이후에는 BDI지수와 CCFI지수 사이에 뚜렷한 lead-lag 관계가 없다는 것으로 나타났다. COVID-19 전염병 이전에는 BDI지수는 SCFI지수의 변화를 설명하고 있고, 코로나19 확산 이후에는 SCFI 지수가 BDI 지수를 앞서고 있다는 것을 보여주고 있다. 또한 VAR-BEKK-GARCH 모델을 활용하여 COVID-19 전후 벌크 화물 해운시장 및 컨테이너 해운시장 간의 변동성 파급효과를 분석하였을 때 코로나19 이전의 BDI지수는 CCFI지수와 SCFI 지수에 대한 단발성 변동성 파급효과를 보였고 COVID-19 이후에도 BDI 지수의 변동성이 CCFI 지수에 여전히 영향을 미친다는 것을 보여준다. 하지만 코로나19 확산 이후에는 BDI지수와 SCFI지수 간의 변동성 파급 관계가 존재하지 않는 것으로 나타났다.

• 대한본초학회지
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• 제39권3호
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• pp.57-67
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• 2024

Objectives : The aim of this study is to evaluate the potential biological activity of Veronica incana extracts (VIE) through in vitro, ex vivo, and in vivo experiments. Methods : In vitro, we conducted analyses on the total polyphenol (TP) and total flavonoid (TF) levels, alongside DPPHand ABTS radical scavenging activities. Ex vivo evaluations on adipose tissue measured glycerol release as a marker of lipolysis. In LPS-induced RAW 264.7 cells, we quantified nitric oxide (NO) production. Following H₂O₂ induction in U2OS cells, we performed mitochondrial assays such as MitoSox and MitoTracker. Moreover, Bodipy assays were conducted in 3T3-L1 cells. In vivo, we performed anti-osteoarthritis effect of VIE against monosodium iodoacetate (MIA)-induced osteoarthritis in rats. Results : The results presented encompass a myriad of models, from cell culture to animal experiments as well as ex vivo studies. VIE demonstrated high TP and TF contents, potent DPPH and ABTS scavenging activities, and regulated glycerol release. Moreover, the inhibition of NO production in LPS-induced inflammation was notably confirmed and the reduction of lipid droplets was distinctly shown. Furthermore, in H₂O₂-induced U2OS cells, MitoSox was effectively reduced while MitoTracker noticeably increased. In vivo assays confirmed a significant increase in hindpaw weight distribution (HWD) decreased by MIA after VIE treatment. Additionally, VIE inhibited serum inflammatory cytokines (TNF-𝛼, IL-6, and IL-1𝛽) and MDA levels in joint tissue. Conclusion : In conclusion, Veronica incana exhibited various pharmacological effects including antioxidant, anti-obesity, and anti-inflammatory properties.

• 대한약침학회지
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• 제27권1호
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• pp.14-20
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• 2024

Objectives: Frozen shoulder (FS) is one of the most challenging shoulder disorders for patients and clinicians. Its symptoms mainly include any combination of stiffness, nocturnal pain, and limitation of active and passive glenohumeral joint movement. Conventional treatment options for FS are physical therapy, nonsteroidal anti-inflammatory drugs, injection therapy, and arthroscopic capsular release, but adverse and limited effects continue to present problems. As a result, pharmacoacupuncture (PA) is getting attention as an alternative therapy for patients with FS. PA is a new form of acupuncture treatment in traditional Korean medicine (TKM) that is mainly used for musculoskeletal diseases. It has similarity and specificity compared to corticosteroid injection and hydrodilatation, making it a potential alternative injection therapy for FS. However, no systematic reviews investigating the utilization of PA for FS have been published. Therefore, this review aims to standardize the clinical use of PA for FS and validate its therapeutic effect. Methods: The protocol was registered in Prospero (CRD42023445708) on 18 July 2023. Until Aug. 31, 2023, seven electronic databases will be searched for randomized controlled trials of PA for FS. Authors will be contacted, and manual searches will also be performed. Two reviewers will independently screen and collect data from retrieved articles according to predefined criteria. The primary outcome will be pain intensity, and secondary outcomes will be effective rate, Constant-Murley Score, Shoulder Pain and Disability Index, range of motion, quality of life, and adverse events. Bias and quality of the included trials will be assessed using the Cochrane handbook's risk-of-bias tool for randomized trials. Meta analyses will be conducted using Review Manager V.5.3 software. GRADE will be used to evaluate the level of evidence for each outcome. Results: This systematic review and meta-analysis will be conducted following PRISMA statement. The results will be published in a peer-reviewed journal. Conclusion: This review will provide scientific evidence to support health insurance policy as well as the standardization of PA in clinical practice.

• 사상체질의학회지
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• 제10권2호
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• pp.351-429
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• 1998

The Purpose of Study 1. Inspection of clinical application on TCD to CVA 2. Objective Comparement and analysis about treatment effect of Western-Medicine, Korean Medicine, Cooperative consultation of Korean and Western medicice for CVA The Subject of Study We intended for the eighty six patient of CVA who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center from 1997. 8. I to 1998. 7. 31 1. View of CT, MRI : the patient of Cb infarction 2. Attack Time : The patient who coming hospital falling ill within the early one week The method of study 1. Treat four group of Korean medicine, Constitution medicine, Western medicine, cooperative consultation of Korean medicine and Western medicine. 2. Application of TCD Check the result for three times, immediatly after the attack, two months later, four months later 3. Comparative analysis of each treatment effect by clinical symptoms and pathologic examination 4. The Judgement of the patient The Result From 8/1/1997 to 7/31/1998, We have the following result by clinical analysis intended for CVA 86 patients who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center from 1997. 8. 1 to 1998. 7. 31 in 1. Analysis according to Age The first stage of thirties, forties, seventies is heavier than forties, fifties in improvement and Index of improvement of symptom 2. Analysis according to sex We have no special relation in an average of symptom and improvement, Index improvement 3. Analysis according to Family History We have the better result in first stage and improvement, index improvement when no family history. 4. Analysis according to Past History We have no special relation in past history like hypertension, DM, heart problem 5. Analysis devided two group, above group and under group on the basis of the average in first stage of all patient. We have the better result when the first stage is light, that the first score of barthel index and CNS is high. 6. Analysis of the effect of treatment about Korean medical treatment, Western medical treatment, cooperative treatment. In this study, the highest group of rate of treatment at four contrast groups (Korean medicine, Constitution medicine, Western medicine, cooperative treatment according to dyagnosis and range of treatment was the patient group of doing dyagnosis and method of treatment based on constitution medicine theory. This is that of doing demostation, A-Tx, po-herb-medication according to dyagnosis and treat method of constitution of Lee Je-ma In case of left, the case of dyagnosis any disease according to doctor view but, normal in TCDwas 22-beginning of attack, 20- two weeks later, 11 case-four weeks later in case of right, 15-beginning of attack, 12-two weeks later, 9 case four weeks later. So left vessel compares to right vessel is more interference, in fact more than a 1/2 of the patients of MCA disease can't do dyagnosis. In rate of imparement, the state of pacient improved but there isn't the improved case of result in TCD. 7. In TCD dyagnosis, between the case of inconsus the doctor view specially MCA in brain blood vessel is in large numbers and in total 86's patient, impossible case of dyagnosis according to interferiance of temporal is 21 case. 7. Result study about application of Kreaan medical treatment 1) The impossible patient of observation MCA blood vescular for interference temporal bone happened in large numbers. 2) There is the case having difference result to CT,MRI, MRA result. 3) Because individual difference is large, excluding to ananalogy of symptom. This is normal numerical value that has possibility of being checked as abnormal numerical value 4) there are a lot of cases that the speed of normal part is as similarly measured as that of abnormal part. It means that we cannot judge the disease by this measure 5) It is rare that this measure represent degree of improvement in patient's condition of disease. When we observe patient's condition become better, but we have no case that the result of TCD test better. 6) The result could be appear differently by the technique of the tester or by the experience of the tester 7) In the TCD test, abnormal symptoms is checked at 0 week, but at 2th week, normal symptoms is checked, again at 4th week abnormal is checked. According to the above result, CVA diagnosis is difficult only with TCD, as it appear in diagnosis error check which is suggested in the problem connected to project, for the aged persons who have the worst hardening of part of the cranium (1998. 5. 26 77 of 83 patients is 50s) there is a lot of cases that the measurement is impossible by TCD and the correction of measurement numerical value is decreased, as the age of cerebral infarction is high, TCD is inappropriate to diagnosis equipment through this study.

• The Journal of Korean Physical Therapy
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• 제15권2호
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• pp.19-51
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• 2003

To demonstrate the effect of massages on the skeletal muscles of immobilization ddY mice models induced by right side sciatic nerve neurectomy, the cross sectional histological profiles of the muscularis (M) gastrocnemius, M. tibialis cranialis and M. tibialis caudalis were observed after 28 days of treatment of massages with the changes of body weight, thickness of hind limb and individual muscle weights. In addition, changes of serum aspartate amino- transferase (AST) and creatine phosphokinase (CK) levels were also demonstrated with diameter of individual muscle fiber and muscle fasciculata, and number of muscle fiber in each of three types of muscles located in the calf. The experimental groups were divided into five groups, 1) Sham-operated group (Sham), 2) Neurectomized but not massage control group (Control), 3) Neurectomized and massage at knee joint regions (T1), 4) Neurectomized and massage at calf regions (T2), and 5) Neurectomized and massages at achilles tendon regions (T3). The experimental animals were used 5 per groups. The results are as follow: 1. No significant changes of body weight were demonstrated in this groups during whole experimental periods compared to that of Sham group. In addition, no significant changes of body weight gains during experimental periods (Day 0 - Day 27: 28 days of treatment) were also observed. 2. The thickness of intact left side hind limb was not changes in all tested groups compared to that of Sham group. However, the thickness of right side hind limb were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of thickness of hind limb between right and left sides were also significantly increased in Control and massage groups (T1, T2 and T3) compared to that of Sham group. However, the thickness of right side of hind limb were significantly increased and the differences of thickness between both sides of hind limb were dramatically decreased in massage groups compared to that of Control group in followed order: T1 > T3 > T2. 3. Absolute and relative weight of M. gastrocnemius in the intact left side of hind limb was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. gastrocnemius were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. gastrocnemius between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. gastrocnemius were significantly increased and the differences of weight between both sides of M. gastrocnemius were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 >. 4. Absolute and relative weight of M. tibialis cranialis in the intact left side was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. tibialis cranialis were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. tibialis cranialis between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. tibialis cranialis were significantly increased and . the differences of weight between both sides of M. tibialis cranialis were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 > T2. 5. Absolute and relative weight of M. tibialis caudalis in the intact left side was not changes in all tested groups compared to that of Sham group. However, the weight of right side M. tibialis caudalis were remarkedly decreased in Control, T1, T2 and T3 groups compared to that of Sham group. In addition, the differences of weight of M. tibialis caudalis between right and left sides were also significantly increased in Control and massage groups compared to that of Sham group. However, the weight of right side M. tibialis caudalis were significantly increased and the differences of weight between both sides of M. tibialis caudalis were dramatically decreased in massage groups compared to that of Control group in followed order: T3 > T1 > T2. 6. A significant increase of serum AST levels were demonstrated in Control group. However, serum AST levels of massage groups were significantly decreased compared to that of Control group in followed order: T3 > T1 > T2. In case of 73 group, the values decreased into similar levels compared to that of Sham group. 7. A significant increase of serum CK levels were demonstrated in Control group. However, serum CK levels of massage groups were significantly decreased compared to that of Control group in followed order: T3 > T1 > T2.