• Archives of Pharmacal Research
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• v.29 no.10
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• pp.928-933
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• 2006

Percutaneous delivery of NSAIDs has advantages of avoiding hepatic first pass effect and delivering the drug for extended period of time at a sustained, concentrated level at the inflammation site that mainly acts at the joint and the related regions. To develop the new topical formulations of pranoprofen that have suitable bioadhesion, the gel was formulated using hydroxypropyl methylcellulose (HPMC) and poloxamer 407. The effects of temperature on drug release was performed at $32^{\circ}C$, $37^{\circ}C$ and $42^{\circ}C$ according to drug concentration of 0.04%, 0.08%, 0.12%, 0.16%, and 0.2% (w/w) using synthetic cellulose membrane at $37{\pm}0.5^{\circ}C$. The increase of temperature showed the increased drug release. The activation energy (Ea), which were calculated from the slope of lop P versus 1000/T plots was 11.22 kcal/ mol for 0.04%, 10.79 kcal/mol for 0.08%, 10.41 kcal/mol for 0.12% and 8.88 kcal/mol for 0.16% loading dose from the pranoprofen gel. To increase the drug permeation, some kinds of penetration enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants and the fatty acids were incorporated in the gel formulation. Among the various enhancers used, propylene glycol mono laurate showed the highest enhancing effects with the enhancement factor of 2.74. The results of this study suggest that development of topical gel formulation of pranoprofen containing an enhancer is feasible.

• Journal of Yeungnam Medical Science
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• v.17 no.1
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• pp.93-98
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• 2000

Symphysis pubis Reparation is an uncommon but not rare complication of delivery. Characteristic symptoms of symphyseal separation include suprapubic pain and tenderness which radiale to the back or legs, difficult ambulation, and bladder dysfunction. Clinical history, presenting symptoms, and response to therapy are sufficient to make the diagnosis, although radiographic documentation of symphyseal separation by x-ray or ultrasound are frequently used to confirm the diagnosis. The underlying etiology of symptomatic symphyseal separation has not been fully elucidated. Associations with macrosomia, pathological joint loosening. and increased force placed on the pelvic ring have been suggested as possible etiologies. Conservative therapy, including bed rest, pelvic binders, ambulation devices, and mild analgesics usually result in complete recovery within 4-16 weeks. Our experience of three cases of peripartum symphysis pubis separation delivered from 1998 to 1999 were reviewed with related articles.

• Journal of Veterinary Clinics
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• v.33 no.5
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• pp.300-303
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• 2016

An age-unknown, 4.8 kg, male, wild, domestic short-hair cat was presented for left hindlimb lameness. A physical examination revealed a draining tract which was suspected of bite on left calcaneal bone. The left tarsal joint was markedly swollen and exudates were observed around the draining tract. Sequestrum at left calcaneus bone, and osteolysis were identified by radiography. The sequestrum and its surrounding exudative tissue were debrided during surgery and the tissue was submitted for bacterial culture and sensitivity test. The debridement caused a bone defect ($1.5cm{\times}0.5cm{\times}0.5cm$) on the medial left calcaneal bone. Plate and screw fixation was performed to the calcaneus bone as buttress plate. Recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded hydroxyapatite was implanted in the bone defect. Furthermore, Amikacin-impregnated collagen sponges were also placed around bone plate to deliver local antibiotics. A systemic antibiotic treatment regimen based on bacterial culture and sensitivity test results was administered for 4 weeks. The wound properly healed without any signs of infection, and the bone healing was confirmed by radiography. The patient showed normal weight bearing ambulation at 18 weeks after surgery. The use of rhBMP-2 and local antibiotic delivery system is a good surgical option for the one-stage treatment of chronic osteomyelitis.

• Advances in aircraft and spacecraft science
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• v.10 no.6
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• pp.495-519
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• 2023

The drone serves the customers not served by vans. At the same time, considering the safety, policy and terrain as well as the need to replace the battery, the drone needs to be transported by truck to the identified station along with the parcel. From each such station, the drone serves a subset of customers according to a direct assignment pattern, i.e., every time the drone is launched, it serves one demand node and returns to the station to collect another parcel. Similarly, the truck is used to transport the drone and cargo between stations. This is somewhat different from the research of other scholars. In terms of the joint distribution of the drone and road vehicle, most scholars will choose the combination of two transportation tools, while we use three. The drone and vans are responsible for distribution services, and the trucks are responsible for transporting the goods and drone to the station. The goal is to optimize the total delivery cost which includes the transportation costs for the vans and the delivery cost for the drone. A fixed cost is also considered for each drone parking site corresponding to the cost of positioning the drone and using the drone station. A discrete optimization model is presented for the problem in addition to a two-phase heuristic algorithm. The results of a series of computational tests performed to assess the applicability of the model and the efficiency of the heuristic are reported. The results obtained show that nearly 10% of the cost can be saved by combining the traditional delivery mode with the use of a drone and drone stations.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.43
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• pp.337-370
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• 2009

The Joint Cargo Committee of International Underwriting Association of London (IUA) and Lloyd’s Market Association (LMA) have issued the revised version of Institute Cargo Clauses A, B, C, Institute Cargo Clauses (Air) and their accompanying War and Strikes Clauses. The Institute Cargo Clauses ("ICC") were last revised in 1982. Following a two year long consultation process, the latest edition of the ICC clauses became available to the Market on 1st January 2009. The overall result of the amendments to the 1982 ICC has been to create clearer policies that are more favourable to the Assured. Exclusions have also been amended to the advantage of the assured. The Transit Clause has seen a large revision, again more favourable to the Assured. The insurance now attaches within the warehouse or place of storage when the goods are "first moved$\cdots$ for the purpose of the immediate loading into or onto the carrying vehicle or other conveyance for the commencement of transit" whereas previously the insurance would not attach until the goods left the warehouse. Furthermore, the insurance now terminates on completion of unloading from the vessel at (rather than delivery to) the final warehouse or at a warehouse prior to the destination named in the contract of insurance which the Assured or their employees elect to use either for storage or distribution.

• Journal of muscle and joint health
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• v.14 no.1
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• pp.33-41
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• 2007

Purpose: The purpose of the study was to identify the pain patterns and factors affecting low back pain in middle-aged women with backache. Method: A descriptive research design was utilized. The participants were middle-aged women who visited to two back pain clinics in Wonju from October, 2006 through February, 2007. A total of 195 low back pain patients agreed to participate in this study, and data from 177 were analyzed. Data were collected using a questionnaire which included a modified short-form Korean pain rating scale, demographic factors, factors related to low back pain and health behavior. Descriptive statistics and multiple regression analysis was utilized in the analysis. Results: The mean score for low back pain was relatively low(M=21.57, SD=11.44). Among pain patterns, scores for dull pain were the highest of all the dimensions. In the regression analysis, significant factors affecting low back pain were found to be age, level of education, religion, BMI, experience of pregnancy, delivery type and exercise. These variables explained 24.8% of variance in low back pain(F=3.79, p<.001). Conclusion: These results suggest that nurses need for assessment and intervention to take into consideration pain patterns as well as factors affecting middle-age women with backache.

• Journal of muscle and joint health
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• v.3 no.2
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• pp.151-165
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• 1996

The purpose of this study is to describe the acknowledgement of the cause of the illness in the patients with RA. I used naturalistic inquiry as a research methodology. The purposive sampling was conducted. 23 subjects who experienced RA, lived in middle-sized city in Korea, and 19 women and 4 men. I collected data using indepth structured interview, "What is the acknowledgement of the cause of the illness?" I used inductive data analysis-such as unitizing and categorizing. This process is used constant comparative method. Summerising the results of this study, the acknowledgement of the cause of the illness are composed of physical constitution, fatalism, the attribution of physical overload, the attribution of stress, the lack of nutrition. The factors which affect the acknowledgement of the cause of the illness are composed of internal factors, external factors, environmental factors. The internal factors are the weakness of the childhood, the illness experience in the family members, juvenile rheumatoid arthritis, personality, lack of nutrition. The external factors are pregnancy, delivery, role burden and conflict, economic problem. The environmental factors are humid condition, abrupt environmental change. It is needed to explaine the coping pattern according to the acknowledgement of the cause of the illness in the next research.

• Journal of muscle and joint health
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• v.29 no.2
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• pp.91-99
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• 2022

Purpose: The purpose of this study was to examine the level of agreement between smartphone apps and self-reported physical activity questionnaires. Methods: Quantitative methods were used to assess the correlation and agreement between the number of steps counted by a smartphone app and the amount of walking reported in a survey. A total of 29 adults who used smartphones were recruited from a university, and their step counts from their smartphone pedometers and responses to the international physical activity questionnaire (IPAQ) were collected over a 10-week period. Results: An analysis of 170 data pairs with Spearman's rho correlation and a Bland-Altman plot revealed a positive correlation between step counts from the smartphone app and walking activity from the IPAQ. The Bland-Altman plot also demonstrated the agreement to be improved among female participants. Conclusion: In assessing walking activity, smartphone pedometer apps showed good correlation with the IPAQ and improved agreement with the IPAQ among women. Therefore, it is suggested that the participants' gender and activity intensity, as well as the accuracy of measurement tools, should be considered in an evaluation of the delivery of physical activity promotion programs through smartphone apps.

• The Journal of Korean Academy of Prosthodontics
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• v.43 no.4
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• pp.528-543
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• 2005

Statement of problem: Repeated delivery and removal of abutment cause some changes such as wear, scratch or defect of hexagonal structure. It may increase the value of rotational freedom(RF) between hexagonal structures. Purpose: The purpose of this study was to evaluate surface changes and rotational freedom between the external hexagon of the implant fixture and internal hexagon of abutment after repeated delivery and removal under SEM and toolmaker's microscope. Materials and methods: Implant systems used for this study were 3i and Avana. Seven pail's of implant fixture, abutment and abutment screws for each system were selected and all fixtures were perpendicularly mounted in liquid unsaturated polyesther with dental surveyor. Each one was embedded beneath the platform of fixture. Surfaces of hexagonal structure before repeated closing and opening of abutment were observed using SEM and rotational freedom was measured by using toolmaker's microscope. Each abutment was secured to the implant future by each abutment screw with recommended torque value using a digital torque controller and was repeatedly delivered and removed by 20 times respectively. After experiment, evaluation for the change of hexagonal structures and measurement of rotational freedom were performed. Result : The results were as follows; 1. Wear of contact area between implant fixture and abutment was considerable in both 3i and Avana system. Scratches and defects were frequently observed at the line-angle of hexagonal structures of implant fixture and abutment. 2. In the SEM view of the external hexagon of implant fixture, the point-angle areas at the corner edge of hexagon were severely worn out in both systems. It was more notable in the case of 3i systems than in that of Avana systems. 3. In the SEM view of the internal hexagon of abutment, Gingi-Hue abutment of 3i systems showed severe wear in micro-stop contacts that were machined into the corners to prevent rotation and cemented abutment of Avana systems showed wear in both surface area adjacent to the corner mating with external hexagon of implant fixture. 4 The mean values of rotational freedom between the external hexagon of the implant fixture and internal hexagon of abutment were 0.48$\pm$0.04$^{\circ}$ in pre-tested 3i systems and 1.18$\pm$0.25$^{\circ}$ after test, and 1.80$\pm$0.04$^{\circ}$ in pre-tested Avana systems and 2.61$\pm$0.16$^{\circ}$ after test. 5. Changes of rotational freedom after test shouted statistical)y a significant increase in both 3i and Avana systems(P<0.05, paired t-test). 6. Statistically, there was no significant difference between amount of increase in the rotational freedom of 3i systems and amount of increase in that of Avana ones(P>0.05, unpaired t-test). Conclusion: Conclusively, it was considered that repeated delivery and remove of abutment by 20 times would not have influence on screw joint stability. However, it caused statistically the significant change of rotational freedom in tested systems. Therefore, it is suggested that repeated delivery and remove of abutment should be minimal as possible as it could be and be done carefully Additionally, it is suggested that the means or treatment to prevent the wear of mating components should be devised.

• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.4
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• pp.196-209
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• 2010

Purpose: To investigate effect of Sweet Bee Venom on postpartum's De Quervain's Disease. Methods: We investigated 3 patients diagnosed as De Quervain's Disease. Sweet Bee Venom Herbal-acupuncture was used for treatment of De Quervain's Disease, once every two days, 5 times. Pain, satisfaction at treatment and function of wrist were measured with VNS, Baumgaertner's nine point scale and dynamometer. Results: Pain reduction, functional improvement, increased grip power were found out in cases treated with Sweet Bee Venom Herbal-acupuncture. In every cases, they represent high subjective satisfaction with treatment. Conclusion: Clinical results show that Sweet Bee Venom Herbal-acupuncture has a good analgesic effect in De Quervain's Disease.