In diagnosis of lung cancer, rapid distinction between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) tumors is very important. Serum markers, including lactate dehydrogenase (LDH), C-reactive protein (CRP), carcino-embryonic antigen (CEA), neurone specific enolase (NSE) and Cyfra21-1, are reported to reflect lung cancer characteristics. In this study classification of lung tumors was made based on biomarkers (measured in 120 NSCLC and 60 SCLC patients) by setting up optimal biomarker joint models with a powerful computerized tool - gene expression programming (GEP). GEP is a learning algorithm that combines the advantages of genetic programming (GP) and genetic algorithms (GA). It specifically focuses on relationships between variables in sets of data and then builds models to explain these relationships, and has been successfully used in formula finding and function mining. As a basis for defining a GEP environment for SCLC and NSCLC prediction, three explicit predictive models were constructed. CEA and NSE are requentlyused lung cancer markers in clinical trials, CRP, LDH and Cyfra21-1 have significant meaning in lung cancer, basis on CEA and NSE we set up three GEP models-GEP 1(CEA, NSE, Cyfra21-1), GEP2 (CEA, NSE, LDH), GEP3 (CEA, NSE, CRP). The best classification result of GEP gained when CEA, NSE and Cyfra21-1 were combined: 128 of 135 subjects in the training set and 40 of 45 subjects in the test set were classified correctly, the accuracy rate is 94.8% in training set; on collection of samples for testing, the accuracy rate is 88.9%. With GEP2, the accuracy was significantly decreased by 1.5% and 6.6% in training set and test set, in GEP3 was 0.82% and 4.45% respectively. Serum Cyfra21-1 is a useful and sensitive serum biomarker in discriminating between NSCLC and SCLC. GEP modeling is a promising and excellent tool in diagnosis of lung cancer.
Journal of the Korean Crystal Growth and Crystal Technology
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v.21
no.4
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pp.158-163
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2011
$CuInS_2$ thin films were prepared using a sol-gel spin-coating method. That makes large scale substrate coating, simple equipment, easy composition control available. The structural and optical properties of $CuInS_2$ thin films that include less toxic materials (S) instead of Se, tetragonal chalcopyrite structure. Copper acetate monohydrate ($Cu(CH_3COO)_2{\cdot}H2O$) and indium acetate ($In(CH_3COO)_3$) were dissolved into 2-propanol and l-propanol, respectively. The two solutions were mixed into a starting solution. The solution was dropped onto glass substrate, rotated at 3000 rpm, and dried at $300^{\circ}C$ for Cu-In as-grown films. The as-grown films were sulfurized inside a graphite container box and chalcopyrite phase of $CuInS_2$ was observed. To determine the optical properties measured optical transmittance of visible light region (380~770 nm) were less than 30 % in the overall. The XRD pattern shows that main peak was observed at Cu/In ratio 1.0 and its orientation was (112). As annealing temperature increases, the intensity of (112) plane increases. The unit cell constant are a = 5.5032 and c = 11.1064 $\AA$, and this was well matched with JCPDS card. The optical transmittance of visible region was below than 30 %.
Purpose: This study was conducted to identify factors affecting nurses' organizational commitment of the JCI. Methods: This cross-sectional study was performed using questionnaire. Data were collected from 198 nurses who worked at one hospital from 5 to 14 May 2013. Tools were used general characteristics, perception(Yang & Choi, 2014), job stress(Park, 2005), organizational commitment(Mowday, Porter, & Steers, 1979). Results: The scores of perception, job stress, and organizational commitment of the JCI were 3.21/5, 4.08/5, and 2.65/5 respectively. Organizational commitment was significantly different according to degree. A positive correlation was observed between perception and organizational commitment. Organizational commitment was negatively correlated with job stress. The explained variances for organizational commitment was 26.3% and factors affecting nurses' organizational commitment were degree, perception, and job stress. Conclusion: These results showed the significant factors for nurses' organizational commitment of JCI. These findings can be utilized to development of strategies for reducing job stress, and enhancing perception of JCI.
The study was carried out to suggest the development scheme of Forestry Association by the method of member's consciousness inclination analysis. The results are as follows ; 1. Most of Association members perceived the necessity for re-education about cooperative association, especially the research suitable to the characteristics of Korea Forestry. 2. 59.9% of members had negative response against revision of Forestry Association Law, and 39.5% of members had negative opinion about taking exclusive charge of forest working by Forestry Association, noting the need of immediate publicity activities for those charges. 3. Large number of members pointed out that the most serious problems for the management of private forest were the budgetary deficit and the lack of joint marketing system of forest products. 25.9% of members had complaints about the management of their own forests after joining the association. 4. 34.0% of members opposed Proxy Management and 48.8% of members wanted Portion Consignment System. 5. The analysis noted that due to increase of the aged in rural communities, it is necessary to establish Forestry Working Corps, which is under the control of the Government and Forestry Association to supply forestry labor in a appropriate time. 6. Most of Association members liked establishment of Special Association for each forest products.
The Journal of the Korean bone and joint tumor society
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v.18
no.2
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pp.59-65
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2012
Purpose: Multidisciplinary approaches of surgical resection and chemotherapy have been widely used for the treatment of non-metastatic osteosarcomas. We aimed to assess the effect of neoadjuvant chemotherapy for metastasis and disease-specific survival. Materials and Methods: Authors retrospectively reviewed 225 young (<30 years old) and non-metastatic osteosarcoma patients who underwent surgical resection and postoperative chemotherapy between February 1984 and July 2010. Mean age was 14.4 years old (ranged: 4-29 years old) and average follow-up period was 9.1 years (2-28 years). The patients were divided into two groups according to the application of preoperative chemotherapy. Both groups were compared with clinical characteristics, metastasis-free survival and disease-specific survival. Results: All of 225 patients, 32 patients were treated with postoperative chemotherapy and 193 patients were performed preoperative and postoperative chemotherapy. Postoperative chemotherapy group showed significantly high rate of amputation (p<0.001). Metastasis was occurred in 101 patients. Postoperative chemotherapy group indicated significant higher rate of metastasis (69% vs 41%, p=0.004) and early development of metastasis (mean: 11.5 vs 20.3 months, p=0.045) than pre-and postoperative chemotherapy group. Fifty-seven patients were died of osteosarcoma. Postoperative chemotherapy group revealed significant lower rate of 5-year disease-specific survival than pre-and postoperative chemotherapy group (51% vs 84%, p=0.001). Adult (>15 years) and large sized tumor (>8 cm) were meaningful risk factors of metastasis and disease-specific survival. Although, local recurrences were occurred in 13 patients, there was no significant difference. Conclusion: Neoadjuvant chemotherapy offers better disease-specific survival and metastasis-free survival.
We can usually found the children who do overactive and aggressive behaviors. They disrupt classroom order and cause other children immense damage. Their teachers exert themselves to control or manage them in class. This may lead to a reduction of precious time for teaching-learning classroom activities. This study has counseled those children doing overactive and aggressive behaviors with solution-focused brief counseling. This study also explores the following problems. First, how does solution-focused brief counseling affect their overactive and aggressive behaviors? Second, what changes do they experience through solution-focused brief counseling? Third, is solution-focused brief counseling useful in elementary schools? To do this study task, four students have been chosen with the help of teachers in the fifth year at B Elementary School in Ansan. The four children scored high in Mi-hyun Han's 'The ratings of the child's behavior problems' and Se-Yong Jeong's 'Life of school and behavior test'. They are all eleven years old and had two interviews before the experiment and five interviews during the experiment. The analysis of the counseling has been interpreted according to the different analytical methods based on the tasks. Solution-focused brief counseling's effect on children doing overactive and aggressive behaviors has been studied by quantity-analysis method, their changes in behaviors by quality analysis method; phenomenal and psychological method and the usefulness of this counseling in school surroundings by the joint of above two methods. The analysis has provided the following results. First, solution-focused brief counseling has been effective in the reduction of behavioral problems for those children doing overactive and aggressive behaviors and the continuation of the counseling has had a positive effect but it has depended on the individual characteristics and the degree of severity in their behaviors. Second, solution-focused brief counseling has lent itself to encouraging children to have egostrength, confidence, and volition in their behavioral changes with a favorable attitude to the counseling. Third, The egostrength formed through counseling has led children to a progressive direction of their behaviors in their school life. The increasing frequency in counseling has caused a decreasing time-period expected for counseling, and a feasibility of counseling with less resistance. In conclusion, solution -focused brief counseling may be a useful means to help children have positive self-esteem and lead a proper school life, leading to be a helpful facilitation for school site facing a deficiency of counseling.
This investigation was designed to compare the craniofacial and dental morphology of class III malocclusion with that of normal occlusin in children, and to determine the incidence of various class III craniofacial skeletal patterns. The material selected for this study consisted in standard lateral cephalograms of eighty two Korean children, forty one boys and forty one girls, aged 10 through 12 years, having class III malocclusion, and forty two Korean children, twenty boys and twenty two girls, with normal occlusion in the same age. Using the tracings of the standard lateral cephalograms, various angular and linear measurements were recorded, tabulated and statistically analyzed, and then the class III craniofacial skeletal morphology was divided into various patterns by the degree of SNA and SNB, which respectively were below, within or beyond the normal range of those of normal occlusion. The following characteristics of the craniofacial and dental morphology of class III malocclusion were observed. 1. The cranial base length of class III malocclusion was smaller than that of normal occlusion, and the small saddle angle was a characteristic figure of class III malocclucion. 2. Maxillary length of class III malocclusion was smaller than that of normal occlusion, and point A was retropositioned relative to cranial base but not PNS in class III malocclusion. Maxillary base inclination was not significantly different between the two, but occlusal plane to palatal plane was small in class III malocciusion. 3. The mandibular body length shown no difference between the two, but the mandibular body positioned anteriorly relative to cranial base in class III malocclusion. Ramus height, gonial angle, and mandibular effective length were large in class III malocclusion. Mandibular plane angle and joint angle had no difference between the two, and occlusal plane to mandibular plane angle was large in class III malocclusion. 4. Maxillary incisor inclination was not significantly different between class III malocclusion and normal occlusion, but mandibular incisors positioned and inclined lingually and consequently interincisal angle was large in class III malocclusion. 5. Class III malocclusion was divided into six categories of craniofacial skeletal pattern. The most common class III pattern was found to be one in which the maxilla was within the normal range of prognathism while the mandible extended beyond this range. The pattern in which the maxilla was below the normal range of prognathism while the mandible was within this range was approximately one fifth of the class III sample.
This study is to survey the materials purchasing and inventory management status and the characteristics and opinions of the staff in charge of purchasing and inventory of the general hospitals in Busan area in order to contribute to the rationalization of its management through the grasp of actual situation and the presentation of desirable improvement plan for the materials purchasing and inventory management. The status of medical institute had been surveyed by the purchasing/ administration managers of total 26 general hospitals, and the purchasing/ management questionnaires had been commenced with 86 staff of the 26 hospitals. Its major survey results, after the analysis of 24 medical institute statuses (return rate of 92.30%) and 60 staff questionnaires (return rate of 69.76%), are as follows. First, post-purchasing evaluation system is not used actively, orders are being placed by phone or fax, and general merchandise is being purchased through free contracts in most of the hospitals participated in the survey. Second, as per the materials supplying methods, the requisition and delivery system is currently the most popular in the hospitals surveyed, however, both the requisition and delivery system and the par level transfer system are the most desired in the hospitals of more than 500 beds, and the par level transfer system is the most desired in the hospitals under 500 beds for the materials supplying system in the future. Third, as per the inventory management system that is desired the most in the future, the SPD and JIT types are preferred in the hospitals of more than 500 beds, the stockless strategy is preferred in the hospitals under 500 beds, the senior staff above section chief grade prefer the stockless strategy, and the junior staff prefer the ABC classification and SPD types. Fourth, The necessity of purchasing staff's training for the materials management is highly recognized but the effectiveness is not so much acknowledged, which is because such a training is thought to be so superficial and formal that it is not helpful much in the actual field. When summarizing the survey results as above, the materials purchasing and management system is differed for each group of hospitals according to the size of beds, and the more scientific management system is largely required by the general hospitals in Busan city. They also hope the introduction of joint purchasing system, materials management by the bar-code system, and positive execution of the market survey and training of the relevant staff for the management of purchasing affairs. So the more systematic purchasing and inventory management is regarded to be necessary through the introduction of scientific and specialized education of materials management, market survey, and post-purchasing evaluation system also through the computerization of materials purchasing and inventory management as soon as possible.
Ultra-High-Performance Steel Fiber-Reinforced Concrete (SUPER Concrete) exhibits improved compressive and tensile strengths far superior to those of conventional concrete. These characteristics can significantly reduce the cross sectional area of the member and the anchorage strength of a headed bar is expected to be improved. In this study, the anchorage strengths of headed bars with $4d_b$ or $6d_b$ embedment length were evaluated by simulated exterior beam-column joint tests where the headed bars were used as beam bars and the joints were cast of 120 or 180 MPa SUPER Concrete. In all specimens, the actual yield strengths of the headed bars over 600 MPa were developed. Some headed bars were fractured due to the high anchorage capacity in SUPER Concrete. Therefore, the headed bar with only $4d_b$ embedment length in 120 MPa SUPER Concrete can develop a yield strength of 600 MPa which is the highest design yield strength permitted by the KCI design code. The previous model derived from tests with normal concrete and the current design code underestimate the anchorage capacity of the headed bar anchored in SUPER Concrete. Because the previous model and the current design code do not consider the effects of the high tensile strength of SUPER Concrete. From a regression analysis assuming that the anchorage strength is proportional to $(f_{ck})^{\alpha}$, the model for predicting anchorage strength of headed bars in SUPER Concrete is developed. The average and coefficient of variation of the test-to-prediction values are 1.01 and 5%, respectively.
Journal of the Institute of Electronics and Information Engineers
/
v.53
no.12
/
pp.141-146
/
2016
HEVC/H.265 is the latest joint video coding standard proposed by ITU-T SG 16 WP and ISO/IEC JTC 1/SC29/WG 11. In H.265, pictures are divided into a sequence of coding tree units(CTUs), and the CTU further is partitioned into multiple CUs to adapt to various local characteristics. Its coding efficiency is approximately two times high compared to previous standard H.264/AVC. However according to the size of extended CU(coding unit) and transform block, the hardware size of PMR(prediction/mode decision/reconstruction) block within video encoder is about 4 times larger than previous standard. In this study, we propose a new less complex hardware architecture of PMR block which has the most high complexity within encoder without any noticeable PSNR loss. Using this simplified block, we can shrink the overall size the H.265 encoder. For FHD image, it operates at clocking frequency of 300 MHz and frame rate of 60 fps. And also for the test image, the Bjøntegaard Delta (BD) bit rate increase about average 30 % in PMR prediction block, and the total estimated gate count of PMR block is around 1.8 M.
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