• The Journal of Internal Korean Medicine
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• v.21 no.3
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• pp.355-362
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• 2000

This study was performed to evaluate the effect of Kami-bun-sim-ki-eum on irritable bowel syndrome and to find the factors valuable to diagnosis of symptom-complex of them. Four major sympoms were classified in all 31 paients(female 17, male 14), which was index of abdominal, fecal, autonomic dysfunction, and gastric dysfucton and pain severity score method was used in monitoring with the effect of Kamibun-sim-ki-eum on irritable bowel syndrome before and after adminstration of 2 packs I day for 10 days. We have found that Kami-bun-sim-ki-eum was effective only in female group ,but not in male and only sex factor was recognized significantly among factors to have influenced the effect of Kami-bun-sim-ki-eum. Rate of improvement was mean 61% in female, accompanied with improvement of each symptom after administration. Therefore, we have concluded that Kami-bun-sim-ki-eum can be applyed as one of an choice medicines in treating female irritable bowel syndrone.

• Clinical Endoscopy
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• v.51 no.6
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• pp.570-575
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• 2018

Background/Aims: Capsule endoscopy is a diagnostic method for evaluating the small bowel lumen and can detect undiagnosed lesions. The aim of this study was to evaluate the diagnostic yield and clinical impact of capsule endoscopy in patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain. Methods: This study involved a retrospective analysis of prospectively collected data, maintained in a database. Patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain within the period of March 2012 to March 2014 were included. Capsule endoscopy was used to detect small bowel pathologies in both groups. Results: Sixty-five patients (53.8% female) fulfilled the inclusion criteria and had a mean (${\pm}$standard deviation) age of $50.9{\pm}15.9$ years. Clinically significant lesions were detected via capsule endoscopy in 32.5% of the patients in the abdominal pain group and 54.5% of the patients in the diarrhea group. Overall, 48% of patients had small bowel pathologies detected during the capsule endoscopy study. Inflammatory lesions and villous atrophy were the most frequent lesions identified in 16.9% and 15.3% of patients in the abdominal pain and the diarrhea groups, respectively. Conclusions: Routine use of capsule endoscopy in patients with irritable bowel syndrome should not be recommended. However, in patients with refractory conditions, capsule endoscopy may identify abnormalities.

• The Korean Journal of Gastroenterology
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• v.72 no.5
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• pp.252-257
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• 2018

This guidance is an updated version of the irritable bowel syndrome (IBS) guidelines based on evidence-based medicine. IBS is a common chronic gastrointestinal syndrome that occurs in approximately 10% of the population and causes chronic abdominal pain as well as bowel habit changes, such as stool frequency or consistency. The final diagnosis of IBS is based on the exclusion of organic diseases that would explain the symptoms and the absence of endoscopic abnormalities. IBS can reduce the quality of life and cause a major disease burden, such as repeated examinations and continuous drug use, by mistaking organic diseases including malignancy. The major changes are as follows: 1) when to perform a colonoscopy under the impression of IBS; 2) effect of a low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyol diet; 3) impact of probiotics in IBS; and 4) role of antibiotics in IBS. The Korean Society of Neurogastroenterology and Motility recently updated these guidelines to support physicians for qualified medical services and reduce the socioeconomic burden of IBS.

• The Journal of Internal Korean Medicine
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• v.41 no.5
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• pp.877-884
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• 2020

The purpose of this study was to report the clinical effects of Korean medicine on a patient who suffered from Irritable Bowel Syndrome with diarrhea, abdominal pain, and anorexia for few months. The patient was treated with herbal medicine, acupuncture, and moxibustion in combination with Western medicine for 7 weeks. The clinical symptoms (diarrhea, abdominal pain, and anorexia) were improved after Korean medicine treatment. Therefore, this case is useful for describing Korean medicine treatment for Irritable Bowel Syndrome, and further case reports and studies will be needed in the future.

• Journal of Acupuncture Research
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• v.37 no.1
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• pp.59-63
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• 2020

The effects of complex Korean medicine treatment including acupotomy, on irritable bowel syndrome (IBS) are reported in this case study. A 54-year-old woman with diarrheal symptoms that alternatively improved and worsened for many years and worsening abdominal pain visited the emergency room and was diagnosed with IBS; she was admitted for approximately 2 weeks at the Acupuncture and Moxibustion Department of National Medical Center (NMC). Numerical rating scale (NRS), irritable bowel syndrome-quality of life (IBS-QOL), and gastrointestinal symptom rating scale (GSRS) scores were evaluated on the day of hospitalization, midway through the hospitalization period, and on the day of discharge. Abdominal pain was measured daily using NRS, and the score decreased from 8 at admission to 0 at discharge. The IBS-QOL percentile score improved from 42 points to 100 points. The total GSRS score also improved, from 30 points to 2 points. These results suggest that complex Korean medicine treatment with acupotomy, is useful for treating internal diseases, such as IBS, as well as musculoskeletal disorders.

• The Journal of Internal Korean Medicine
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• v.40 no.4
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• pp.629-636
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• 2019

Objective: This study was designed to assess the correlation between gastrointestinal symptoms, depression, and anxiety in patients with irritable bowel syndrome (IBS). Method: New patients who visited the ${\bigcirc}{\bigcirc}$ Oriental Hospital completed standardized questionnaires. These consisted of questionnaires for IBS based on Rome III criteria, the Gastrointestinal Symptom Rating Scale (GSRS), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI). Results: A total of 103 patients participated. Among them, IBS was observed in 42 patients. There was a weak correlation between GSRS and BDI, but it was not statistically significant. There was a statistically significant weak correlation between GSRS and BAI. The main symptom factors affecting BAI were borborygmus, increased flatus, sucking sensations in the epigastrium, and abdominal distension. Conclusion: There was a statistically significant correlation between gastrointestinal symptoms and anxiety in patients with irritable bowel syndrome.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.3
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• pp.1-13
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• 2017

Objectives The purpose of this study is to investigate how irritable bowel syndrome (IBS) affects fatigue scales and eating habits in children and adolescents using Rome IV criteria. Methods Questionnaires and The $PedsQL^{TM}$ Multidimensional Fatigue Scale (MFS) have been given to 211 children and adolescents aged 8 to 18 years old who were admitted to ${\bigcirc}{\bigcirc}$ university Korean medicine hospital pediatric departments, from 29th, July, 2016 to 12th, August, 2016 to evaluate their eating habits and fatigue. Additionally, PASW statistics 18.0 were used to analyze influence of irritable bowel syndrome on eating habits and fatigue in children and adolescents by using chi-square test, independent t-test and linear regression. Results In total of 211 subjects, 29 (13.7%) were diagnosed with IBS according to the Rome IV criteria. 1. There was a statistically significant difference (p<0.05) between IBS group and non-IBS group on a specific question in the eating habit questionnaire: the amount of sugar intake and the prevalence of IBS. 2. There was a statistically significant difference in general fatigue and cognitive fatigue categories when comparing the MFS subscores according to the prevalence of IBS. Conclusions Considering patients eating habits and fatigue is a necessary process for the successful treatment of irritable bowel syndrome. Korean medicine that maximizes quality of life while minimizing the potential risks to the patients of gastrointestinal disease should also include administrative interventions that may be helpful in the daily life of IBS patients.

• Journal of Sasang Constitutional Medicine
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• v.24 no.3
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• pp.93-103
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• 2012

Objectives Rate of gastroesophageal reflux disease accompanied by irritable bowel syndrome is on the increase. This case study reports significant improvement of patients with gastroesophageal reflux disease and irritable bowel syndrome who had suffered from chest pain, globus pharyngis and diarrhea after taking Sasang constitutional treatment. Methods This patient was diagnosed as Large Yin type Esophagus Cold pattern(Taeeumin Wiwanhanjeung). Herb medicine(Jowiseungcheong-tang) was taken by the patient, three or two times per day during treatment periods. We assessed the changes of the main symptoms such as chest pain, globus pharyngis, defecation discomfort, insomnia et al. using visual analogue scale(VAS). Results The symptoms of chest pain, globus pharyngis, defecation discomfort, insomnia decreased from VAS 7~8 to VAS 0~1 for about three months. Conclusions This case shows that Sasang constitutional medicine treatment can be effective treatment method for gastroesophageal reflux disease accompanied by irritable bowel syndrome.

• The Journal of the Society of Stroke on Korean Medicine
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• v.20 no.1
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• pp.53-64
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• 2019

■ Objectives The purpose of this case is to report the effectiveness of Korean medicine in the treatment of irritable bowel syndrome with diarrhea. ■ Methods The patient was diagnosed as a Soeumin, one of the 4 constitution types in Korean medicine, and treated with herbal medicine, Osuyubujaijung-tang and acupuncture treatment. The severity of symptom was assessed using daily defecation frequency, Numerical Rating Scale (NRS) of abdominal pain, Gastrointestinal Symptom Rating Scale (GSRS) score and Irritable Bowel Syndrome - Quality of Life (IBS-QOL) score. ■ Results After treatment, the defecation frequency was reduced from 6 to 2 times a day, and the severity of abdominal pain was reduced from NRS 6 to NRS 2. Also, GSRS score was decreased from 18 to 4 and IBS-QOL score was improved from 70.59 to 81.18. ■ Conclusion This study suggested that Korean medical treatment could be an effective option for treating irritable bowel syndrome with diarrhea.

• Journal of Neurogastroenterology and Motility
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• v.24 no.4
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• pp.544-558
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• 2018

Because of the sex-gender differences that are shown in a diversity of physiological and psychological factors, it can be speculated that the clinical presentation of symptoms as well as treatment strategies in women and men with irritable bowel syndrome (IBS) may differ. Studies have revealed that IBS is more common in women than men. As for the IBS subtype, IBS with constipation is significantly more prevalent among women than men. Sex hormones and gender differences may play important roles in the pathophysiology of IBS. However, its pathophysiologic mechanisms still remain largely unknown, and therapeutic implications are limited. Moreover, women IBS patients have been reported to feel more fatigue, depression, anxiety, and lower quality of life than men IBS patients. Furthermore, there has been evidence of differences in the appropriate treatment efficacy to IBS in men and women, although relatively few men are enrolled in most relevant clinical trials. A more sex-gender-oriented approach in the medical care setting could improve understanding of heterogeneous patients suffering from IBS. An individualized and multicomponent approach including sex and gender issues might help improve the treatment of IBS.