• 제목/요약/키워드: iridoid

검색결과 72건 처리시간 0.017초

Iridoid Compounds가 RNA 및 Protein 생합성에 미치는 영향 (Effects of Iridoid Compounds on RNA and Protein Biosyntheses in Sarcoma 180 cells)

  • 허순옥;김제훈;장일무
    • 생약학회지
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    • 제16권2호
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    • pp.99-104
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    • 1985
  • To investigate a possible biological activity of iridoid glucosides, six compounds, aucubin, catalpol, gardenoside, geniposide, rehmannioside and swertiamarin, were studied in relation with their potential influences in RNA and protein biosyntheses in murine tumor cell, sarcoma 180, in vitro. Protein biosynthesis was slightly inhibited by aucubin, gardenoside and swertiamarin. Degree of inhibition of RNA biosynthesis by those iridoid appeared to be more sensitive than that of protein biosynthesis. When aucubin was pretreated with ${\beta}-glucosidase$ to produce its genin form and the sarcoma 180 cells were exposed to this aucubigenin, the protein and RNA biosyntheses in the cells were profoundly inhibited. The results indicate that a biologically active from of iridoid compounds is the hydrolytic products of glycoside, i.e. genin form. It is also suggested that sarcoma 180 cells used in the experiments appear to lack of ${\beta}-glucosidase$, since the inhibitory actions of iridoid glucosides were so slight that those glucosides were not hydrolysed by the enzyme to their genin forms.

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Iridoid Compounds from the Whole Plant of Galium verum var. asiaticum

  • Lee, Tae Gwan;Kim, Dae Keun
    • Natural Product Sciences
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    • 제19권3호
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    • pp.227-230
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    • 2013
  • One new iridoid glycoside, 10-p-dihydrocoumaroyl-6-${\alpha}$-hydroxygeniposide (1), and six known iridoid glycoside derivatives, 10-p-dihydrocoumaroyl deacetylasperuloside (2), asperulosidic acid methylester (3), asperuloside (4), asperulosidic acid (5), deacetylasperuloside (6), and scandoside (7) were isolated from the methanolic extract of the whole plant of Galium verum var. asiaticum Nakai (Rubiaceae) through repeated column chromatography. Their chemical structures were characterized by spectroscopic analysis. This is the first report of the characterization of compounds 1 - 7 from this plant.

이리도이드 배당체(配糖體)(VI) -조개나물의 이리도이드 배당체- (Iridoid Glycoside(VI) -Studies on the Iridoid Glycoside of Ajuga multiflora Bunge-)

  • 정보섭;유완근
    • 생약학회지
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    • 제16권3호
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    • pp.160-164
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    • 1985
  • Ajuga multiflora Bunge is a perennial herb in the family of Labiatae. The iridoid glycoside was isolated from the ethylacetate fraction and the n-butanol fraction of the plant. The structure of the substance was identified as 8-O-acetylharpagide by UV, IR, NMR spectra and several chemical reactions.

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Iridoid Compounds from Boschniakia rossica

  • Yin, Zong-Zhu;Kim, Hang-Sub;Kim, Young-Ho;Lee, Jung-Joon
    • Archives of Pharmacal Research
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    • 제22권1호
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    • pp.78-80
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    • 1999
  • Four iridoid compounds were isolated from methanol extract of Boschniakia rossica by repeated column chromatography. Their structures were determined as boschnaloside (1), boschnarol (2), bosnarol methylether (3), and 7-deoxy 8-epiloganic acid (4), respectively. Compound 2, 3, and 4 were isolated for the first time form this plant.

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Iridoid Glycosides from the Aerial Parts of Galium spurium L.

  • Ahn, Dal-Rae;Kim, Dae-Keun
    • Natural Product Sciences
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    • 제18권3호
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    • pp.195-199
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    • 2012
  • Nine iridoid glycoside derivatives were elucidated from the methanolic extract of the aerial parts of Galium spurium (Rubiaceae) through repeated column chromatography. Their chemical structures were characterized as 10-O-trans-p-coumaroylscandoside (1a), 10-O-cis-p-coumaroylscandoside (1b), 10-O-trans-p-coumaroyl-10-O-deacetyldaphylloside (2), 10-O-cis-p-coumaroyl-10-O-deacetyldaphylloside (3), asperulic acid methylester (4), asperuloside (5), asperulosidic acid (6), scandoside (7), and deacetyl asperulosidic acid (8) by spectroscopic analysis. This is the first report of the characterization of compounds 1a, 1b, 2, 3 and 7 from this plant.

Iridoid 배당체(配糖體) (IV) -꽃며느리밥풀의 Iridoid 배당체(配糖體)에 관(關)한 연구(硏究)- (Iridoid Glycoside (IV) -Studies on the Iridoid Glucoside of Melampyrum roseum Max-)

  • 정보섭;김영호
    • 생약학회지
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    • 제13권3호
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    • pp.106-111
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    • 1982
  • Melampyrum roseum Max. is an annual herb in Scrophulariaceae plants. The materials were collected in Kyeongi-Do in 1980. The BuOH extract was evaporated under reduced pressure. The residue was column chromatographed over silica gel with benzene-MeOH (8 : 1) as an eluent and it gave the amorphus powder. Compound I has a molecular formula $C_{17}H_{26}O_{10}$ and it was identified as mussaenoside by chemical data, UV, IR, NMR spectra and compared with the authentic sample of mussaenoside tetraacetate.

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Pharmacology of Iridoid: Antimicrobial Activities of Aucubin

  • Lee, Eun-Sook;Ahn, Jung-Wook;Mar, Woong-Chon;Chang, Il-Moo
    • 생약학회지
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    • 제17권2호
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    • pp.129-133
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    • 1986
  • Antimicrobial activities of aucubin, an iridoid glycoside, were investigated. Gram-positive bacterium, S. aureus appeared to be more sensitive to aucubin's aglucone, aucubigenin than Gram-negative, E. coli did. Antimicrobial activities produced by aucubigenin may result in part from the inhibition of RNA and protein biosyntheses in bacterial cells. The conversion of aucubin iridoid glycoside into aucubigenin, an aglucone, appears to be a prerequisite step to exhibit the antimicrobial activities.

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