• 보건행정학회지
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• 제34권1호
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• pp.68-77
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• 2024

연구배경: 우울은 저하된 기분이 비교적 경미한 수준인 일상 우울과 병적 상태인 임상적 우울로 구분할 수 있다. 우울 경험은 치료순응도 저하, 신체증상 등을 경험하게 하여 의료이용을 높일 수 있으나 우울 중 임상적 우울 집단은 질환에 대한 사회적 편견을 경험하여 의료이용이 제한될 수 있다. 의료이용은 개인 나아가 사회 문제의 원인이 되어 중요하다는 측면에서 본 연구는 임상적 우울 집단, 일상 우울, 비우울 집단의 의료이용을 비교하여 살펴보고자 한다. 방법: 일반화 성향점수(generalized propensity score) 기반 처치역확률가중기법(inverse probability of treatment weighting)을 이용하여 비우울, 일상 우울, 임상적 우울 집단 간 공변량의 불균형을 최소화하고 우울과 의료이용, 총진료비의 관계를 각각 음이항 회귀분석과 로그변환한 선형회귀분석을 통해 확인하였다. 결과: 우울은 여성, 소득이 낮은 집단, 교육수준이 낮거나 배우자가 없거나 건강보험에 가입되지 않았거나 경제활동을 하지 않은 집단에서 높았으며, 우울중 임상적 우울은 경제활동을 하지 않거나 민간의료보험에 미가입된 집단, 질환의 보유개수가 많은 집단에서 비중이 높았다. 의료이용 횟수는 우울 집단(일상 우울 집단 및 임상적 우울 집단)이 비우울 집단보다 유의하게 높았으며, 임상적 우울 집단이 일상 우울 집단보다 유의하게 높았다. 총진료비는 우울 집단이 비우울 집단보다 높았으나, 임상적 우울 집단과 일상 우울 집단 간에는 유의한 차이가 없었다. 결론: 의료이용은 비우울 집단보다 우울 집단(임상적 우울 집단 과 일상 우울 집단)에서 높았으며, 임상적 우울 집단보다 일상 우울 집단에서 높았다.

• 한국전기전자재료학회논문지
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• 제20권1호
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• pp.8-13
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• 2007

In MIS capacitor structure, we have studied the electrical properties in Ammonium Sulfide solution treatment while AIN thin film as a insulator is being formed by reactive sputtering method. The deposition process conditions of AIN thin film we temperature $250^{\circ}C$, DC Power 150 W, pressure 5 mTorr and 8 sccm(Ar : 4 sccm, $N_{2}$ : 4 sccm). The surface of GaAs was treated with Ammonium Sulfide solution, it was shown the leakage current was less than $10^{-8}\;A/cm^{2}$. The deep depletion phenomena of inverse area with treating Ammonium Sulfide solution in C-V analysis was improved as compared the condition of without Ammonium Sulfide solution and hysteresis property as well.

• 한국의학물리학회지:의학물리
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• 제5권1호
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• pp.67-74
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• 1994

선량분포특성은 거리의 제곱에 반비례하기 때문에 근접조사에서 선원의 조그마한 오차는 선량계산에서 큰 차이를 초래할 수 있어서 선원의 정확한 거리 이동과 그에 따른 critical organ에 조사되는 선량의 정확도는 자궁경부암 환자의 치료성적에 결정적인 역할을 할 수가 있다. 특히 High Dose Rate의 RALS(Remote After Loading System)에서 선원의 정확한 calibration은 자궁경부암 환자의 치료에서 선량분포에 지대한 영향을 미치며 나아가 이 선량분포는 치료후 나타나는 재발 및 합병증이나 휴유증의 발생에도 큰 영향을 미치게 된다. 본 연구에서는 실제 RALS시 선원의 거리 이동을 측정하여 치료계획용 computer에서 계산된 선원간의 거리 이동과 비교 검토하였으며 Rectum 위치에 chamber를 삽입하여 실제 Rectum에 조사되는 선량과 computer에서 계산된 값들을 비교검토하였다. Tandem Source을 1cm 간격으로 거리를 이동하면서 실험을 되풀이 한 결과 처음 monitor로 1cm을 이동할 때 측정치가 0.8cm 이동한 것으로 나타났으며, 2번째부터 5번째까지의 거리 이동에서는 monitor의 값과 측정치의 값이 정확하게 일치하였다. 또한 12명의 환자를 대상으로 실시한 Rectum dose의 측정치는 computer계산치보다 평균 8%로 낮게 나타났다.

• BMB Reports
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• 제51권11호
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• pp.545-546
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• 2018

With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient's environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as $TGF-{\beta}$ and elevation of regulatory T cells (Tregs) and T helper-2 cells (Th2 cells), would play important roles, in the neuroprotective effect on motor neuronal cell death mechanisms in ALS. Single cycle of repeated intrathecal injections of BM-MSCs demonstrated a clinical benefit lasting at least 6 months, with safety, in ALS patients. Cytokine profiles of CSF provided evidence that BM-MSCs, have a role in switching from pro-inflammatory to anti-inflammatory conditions. Inverse correlation of $TGF-{\beta}1$ and MCP-1 levels, could be a potential biomarker to responsiveness. Thus, additional cycles of BM-MSC treatment are required, to confirm long-term efficacy and safety.

• Communications for Statistical Applications and Methods
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• 제23권1호
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• pp.1-20
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• 2016

Causal inference methodologies have been developed for the past decade to estimate the unconfounded effect of an exposure under several key assumptions. These assumptions include, but are not limited to, the stable unit treatment value assumption, the strong ignorability of treatment assignment assumption, and the assumption that propensity scores be bounded away from zero and one (the positivity assumption). Of these assumptions, the first two have received much attention in the literature. Yet the positivity assumption has been recently discussed in only a few papers. Propensity scores of zero or one are indicative of deterministic exposure so that causal effects cannot be defined for these subjects. Therefore, these subjects need to be removed because no comparable comparison groups can be found for such subjects. In this paper, using currently available causal inference methods, we evaluate the effect of arbitrary cutoffs in the distribution of propensity scores and the impact of those decisions on bias and efficiency. We propose a tree-based method that performs well in terms of bias reduction when the definition of positivity is based on a single confounder. This tree-based method can be easily implemented using the statistical software program, R. R code for the studies is available online.

• 상하수도학회지
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• 제25권4호
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• pp.547-554
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• 2011

In small-scale water systems, the measurement of quality of raw water in running water is generally implemented when the quality of water is stable and frequency of measurement is low. However, units such as water temperature and pH, which are easily monitored, are frequently measured. In establishing an improvement plan for a water treatment system, the range of concentration of the target material present in the raw water of the running water provides relevant information. If the concentration of target material can be specified by the quality of water of data items that are measured daily, inverse estimation of the range of concentration is possible as well. In this paper, we took note of manganese in the raw water from Ogasawara-mura, Tokyo, and estimated the manganese concentration in the raw water of the running water for the past five years. Based on the results obtained, we have proposed a manganese removal system, considering the current situation and geographical conditions of Ogasawara-mura.

• Applied Microscopy
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• 제45권3호
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• pp.170-176
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• 2015

In this work, various electron microscopy and analysis techniques were used to investigate the microstructural evolution of a 9% Cr tempered martensite ferritic (TMF) steel T91 upon ultrasonic nanocrystalline surface modification (UNSM) treatment. The micro-dimpled surface was analyzed by scanning electron microscopy. The characteristics of plastic deformation and gradient microstructure of the UNSM treated specimens were clearly revealed by crystal orientation mapping of electron backscatter diffraction (EBSD), with flexible use of the inverse pole figure, image quality, and grain boundary misorientation images. Transmission electron microscope (TEM) observation of the specimens at different depths showed the formation of dislocations, dense dislocation walls, subgrains, and grains in the lower, middle, upper, and top layers of the treated specimens. Refinement of the $M_{23}C_6$ precipitates was also observed, the size and the number density of which were found to decrease as depth from the top surface decreased. The complex microstructure and microstructural evolution of the TMF steel samples upon the UNSM treatment were well-characterized by combined use of EBSD and TEM techniques.

• 한국임상약학회지
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• 제29권2호
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• pp.109-114
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• 2019

Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests as joint damage or athletic disability via sustained inflammation of the synovial membrane. The risk of cardiovascular disease (CVD) is higher in RA patients. This study aimed at evaluating the association between CVD comorbidities and RA by comparing a pharmacotherapy group with a non-pharmacotherapy group. Methods: Patient sample data from the Health Insurance Review and Assessment Service (HIRA-NPS-2016) were used. Inverse probability of treatment weighting (IPTW) using the propensity score was used to minimize the differences in patient characteristics. Logistic regression analysis was used to evaluate the risk of CVD comorbidities. Results: The analyses included 1,207,213 patients, of which 33,122 (2.8%) had RA. The odds ratios (OR) of CVD comorbidities were increased in RA patients; ischemic heart disease (IHD: OR 1.75; 95% CI 1.73, 1.77), cerebral infarction (CERI: OR 1.28; 95% CI 1.26, 1.30), hypertension (HTN: OR 1.44; 95% CI 1.43, 1.45), diabetes mellitus (DM: OR 2.04; 95% CI 2.03, 2.06), and dyslipidemia (DL: OR 3.49; 95% CI 3.47, 3.51). The ORs of IHD, CERI, HTN, and DM in the traditional DMARD and biologic treatment groups were decreased, compared with those in the non-pharmacotherapy group. Conclusions: Thus, CVD risk was higher in RA patients, considering age, sex, and socioeconomic status. Appropriate pharmacotherapy could decrease the risk of CVD comorbidities in RA patients.

• Environmental Engineering Research
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• 제24권3호
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• pp.501-512
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• 2019

The seasonal effects on the biostability of drinking water were investigated by comparing the seasonal variation of assimilable organic carbon (AOC) in full-scale water treatment process and adsorption of AOC by three filling materials in lab-scale column test. In full-scale, pre-chlorination and ozonation significantly increase $AOC_{P17\;(Pseudomonas\;fluorescens\;P17)}$ and $AOC_{NOX\;(Aquaspirillum\;sp.\;NOX)}$, respectively. AOC formation by oxidation could increase with temperature, but the increased AOC could affect the biostability of the following processes more significantly in winter than in warm seasons due to the low biodegradation in the pipes and the processes at low temperature. $AOC_{P17}$ was mainly removed by coagulation-sedimentation process, especially in cold season. Rapid filtration could effectively remove AOC only during warm seasons by primarily biodegradation, but biological activated carbon filtration could remove AOC in all seasons by biodegradation during warm season and by adsorption and bio-regeneration during cold season. The adsorption by granular activated carbon and anthracite showed inverse relationship with water temperature. The advanced treatment can contribute to enhance the biostability in the distribution system by reducing AOC formation potential and helping to maintain stable residual chlorine after post-chlorination.

• Membrane and Water Treatment
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• 제6권2호
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• pp.127-139
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• 2015

Rejection of ionic solutes by reverse osmosis (RO) and nanofiltration (NF) membranes is controlled mainly by electrochemical interaction as well as pore size, but it is very difficult to directly evaluate such electrochemical interaction. In this work, we used an inverse HPLC method to investigate the interaction between ionic solutes and poly (m- phenylenediaminetrimesoyl) (PPT), a polymer similar to the skin layer of polyamide RO and NF membranes. Silica gel particles coated with PPT were used as the stationary phase, and aqueous solutions of the ionic solutes were used as the mobile phase. Chromatographs obtained for the ionic solutes showed features typical of exclusion chromatographs: the ionic solutes were eluted faster than water (mobile phase), and the exclusion intensity of the ionic solute decreased with increasing solute concentration, asymptotically approaching a minimum value. The charge density of PPT was estimated to be ca. 0.007 mol/L. On the basis of minimum exclusion intensity, the exclusion distances between a salt and neutralized PPT was examined, and the following average values were obtained: 0.49 nm for 1:1 salts, 0.57 nm for 2:1 salts, 0.60 nm for 1:2 salts, and 0.66 nm for 2:2 salts. However, $NaAsO_2$ and $H_3BO_3$, which are dissolved at neutral pH in their undissociated forms, were not excluded.