• International Neurourology Journal
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• 제22권4호
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• pp.237-245
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• 2018

Purpose: Presenilins are functionally important components of ${\gamma}$-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer because both involve substrates of ${\gamma}$-secretase. However, numerous clinical studies have reported an inverse correlation between AD and cancer. Interestingly, AD is a neurodegenerative disorder, whereas cancer is characterized by the proliferation of malignant cells. However, this inverse correlation in the PSEN double-knockout (PSEN dKO) mouse model of AD has been not elucidated, although doing so would shed light onto the relationship between AD and cancer. Methods: To investigate the inverse relationship of AD and cancer under conditions of PSEN loss, we used the hippocampus of 7-month-old and 18-month-old PSEN dKO mice for a microRNA (miRNA) microarray analysis, and explored the tumorsuppressive or oncogenic role of differentially-expressed miRNAs. Results: The total number of miRNAs that showed changes in expression level was greater at 18 months of age than at 7 months. Most of the putative target genes of the differentially-expressed miRNAs involved Cancer pathways. Conclusions: Based on literature reviews, many of the miRNAs involved in Cancer pathways were found to be known tumorsuppressive miRNAs, and their target genes were known or putative oncogenes. In conclusion, the expression levels of known tumor-suppressive miRNAs increased at 7 and 18 months, in the PSEN dKO mouse model of AD, supporting the negative correlation between AD and cancer.

• 전자공학회논문지B
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• 제29B권8호
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• pp.15-23
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• 1992

Neural network control has many innovative potentials for fast, accurate and intelligent adaptive control. In this paper, two kinds of neurocontrol architectures for the dynamic control of robot manipulators are developed. One is based on a System Identification and Control scheme and the other is based on the Feedback-Error leaming scheme. Both of the proposed architectures use an inverse dynamic neurocontroller in parallel with a linear neurocontroller. The difference is that the first architecture uses the system identifier to get the signals used for training neurocontrollers, while the second architecture uses a properly defined energy function. Compared with the previous types of neurocontrollers which are using an inverse dynamic neurocontroller and a fixed PD gain controller, the proposed architectures not only eliminate the painful process of the fixed gain tuning but also exhibit superior peformances because the linear neurocontroller can adapt its gains according to the applied task. This superior performance is tested and verified through computer simulation of the dynamic control of the PUMA 560 arm.

• 제어로봇시스템학회논문지
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• 제14권10호
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• pp.977-982
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• 2008

In this paper Haar functions are developed to approximate the solutions of continuous time linear system. Properties of Haar functions are first presented, and an explicit expression for the inverse of the Haar operational matrix is presented. Using the inverse of the Haar operational matrix the full order Stein equation should be solved in terms of the solutions of pure algebraic matrix equations, which reduces the computation time remarkably. Finally a numerical example is illustrated to demonstrate the validity of the proposed algorithm.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2002년도 춘계 학술발표회 논문집
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• pp.125-132
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• 2002

In this study, a numerical method is developed for nonlinear analysis for soil-pile-structure interaction system in time domain. Finite elements considering material nonlinearity are used for the near field and boundary elements for the far field. In the near field, frame elements are used for modeling a pile and plane-strain elements for surrounding soil and superstructure. In. the far field, boundary element formulation using the dynamic fundamental solution is adopted and coupled with the near field. Transformation of stiffness matrices of boundary elements into time domain is performed by inverse FFT. Stiffness matrices in the near field and far field are coupled. Newmark direct time integration method is applied. Developed soil-pile-structure interaction analysis method is verified with available literature and commercial code. Also, parametric studies by developed numerical method are performed. And seismic response analysis is performed using actual earthquake records.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.863-869
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• 2007

An improved method based on a normal frequency response function (FRF) is proposed to identify structural parameters such as mass, stiffness and damping matrices directly from the FRFs of a linear mechanical system. The method for estimating structural parameters directly from the measured FRFs of a structure is presented. This paper demonstrates that the characteristic matrices are extracted more accurately by using a weighted equation and eliminating the matrix inverse operation. The method is verified for a four degree-of-freedom lumped parameter system and an eight degree-of-freedom finite element beam. Experimental verification is also performed for a free-free steel beam whose size and physical properties are the same as those of the finite element beam. The results show that the structural parameters, especially the damping matrix, can be estimated more accurately by the proposed method.

• 전기학회논문지
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• 제67권2호
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• pp.277-284
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• 2018

In this paper, a new numerical method of finding the roots of a nonlinear system is proposed, which extends the conventional fixed point iterative method by relaxing the constraints on it. The proposed method determines the real valued roots and expands the convergence region by relaxing the constraints on the conventional fixed point iterative method, which transforms the diverging root searching iterations into the converging iterations by employing the metric induced by the geometrical characteristics of a polynomial. A metric is set to measure the distance between a point of a real-valued function and its corresponding image point of its inverse function. The proposed scheme provides the convenience in finding not only the real roots of polynomials but also the roots of the nonlinear systems in the various application areas of science and engineering.

• 한국생산제조학회지
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• 제26권4호
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• pp.402-409
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• 2017

Selection of optimal cutting conditions is important for improving productivity and implementing efficient process control in metal machining. In this study, improvement of cutting conditions in machining using end-mills is studied by using deep-layered neural networks, which comprise an input layer, output layer, and two hidden layers. System networks are designed with inputs as cutting conditions, and they output the cutting force. A pseudo-inverse network is designed that has the adjustable cutting condition as output and cutting force and other cutting conditions as input. The combination of the system network and pseudo-inverse network enables selection or improvement of cutting conditions that results in the expected cutting force.

• 대한수학회보
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• 제48권5호
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• pp.969-990
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• 2011

Assume that X, partitioned into $2{\times}2$ block form, is a solution of the system of quaternion matrix equations $A_1XB_1$ = $C_1,A_2XB_2=C_2$. We in this paper give the maximal and minimal ranks of the submatrices in X, and establish necessary and sufficient conditions for the submatrices to be zero, unique as well as independent. As applications, we consider the common inner inverse G, partitioned into $2{\times}2$ block form, of two quaternion matrices M and N. We present the formulas of the maximal and minimal ranks of the submatrices of G, and describe the properties of the submatrices of G as well. The findings of this paper generalize some known results in the literature.

• 조명전기설비학회논문지
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• 제24권3호
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• pp.33-38
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• 2010

In this paper, the nature of iron loss in electrical steel during alternating field excitation is investigated more precisely. The exact definition of AC iron loss is cleared by accurately measuring the iron loss for conditions of both the sinusoidal magnetic field and sinusoidal magnetic flux density. The results of this approach to iron loss calculations in electrical steel are compared to experimentally-measured losses. In addition, an inverse hysteresis model considering eddy current loss was developed to analyze the iron loss when the input is the voltage source. With this model, the inrush current in the inductor or transformer as well as the iron loss can be calculated.

• 한국신뢰성학회지:신뢰성응용연구
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• 제14권2호
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• pp.93-96
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• 2014

RFID (Radio Frequency IDentification) system is recognition technology which can maintain various object's information. Reliability of RFID tags is the most important factor in RFID system. In this paper, we proposed ALT (Accelerated Life Test) method for UHF RFID tags. Temperature and humidity were adopted as stress factors and the accelerated life tests were conducted in three different conditions. We performed failure analysis for identifying failure mechanism and statistical analysis of test data. In the statistical analysis, we employed Inverse Power law for relationship between tag's life and stress. Through the statistical analysis, we proposed acceleration factor for several levels of temperature-humidity. The reliability qualification test plans were also designed for the tag's target reliability.