• Genomics & Informatics
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• 제14권4호
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• pp.173-180
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• 2016

The meta-analysis has become a widely used tool for many applications in bioinformatics, including genome-wide association studies. A commonly used approach for meta-analysis is the fixed effects model approach, for which there are two popular methods: the inverse variance-weighted average method and weighted sum of z-scores method. Although previous studies have shown that the two methods perform similarly, their characteristics and their relationship have not been thoroughly investigated. In this paper, we investigate the optimal characteristics of the two methods and show the connection between the two methods. We demonstrate that the each method is optimized for a unique goal, which gives us insight into the optimal weights for the weighted sum of z-scores method. We examine the connection between the two methods both analytically and empirically and show that their resulting statistics become equivalent under certain assumptions. Finally, we apply both methods to the Wellcome Trust Case Control Consortium data and demonstrate that the two methods can give distinct results in certain study designs.

• 대한기계학회논문집B
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• 제22권12호
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• pp.1715-1725
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• 1998

A two-dimensional transient inverse heat conduction problem involving the estimation of the unknown location, ($X^*$, $Y^*$), and timewise varying unknown strength, $G({\tau})$, of a line heat source embedded inside a rectangular bar with insulated boundaries has been solved simultaneously. The regular conjugate gradient method, RCGM and the modified conjugate gradient method, MCGM with adjoint equation, are used alternately to estimate the unknown strength $G({\tau})$ of the source term, while the parameter estimation approach is used to estimate the unknown location ($X^*$, $Y^*$) of the line heat source. The alternate use of the regular and the modified conjugate gradient methods alleviates the convergence difficulties encountered at the initial and final times (i.e ${\tau}=0$ and ${\tau}={\tau}_f$), hence stabilizes the computation and fastens the convergence of the solution. In order to examine the effectiveness of this approach under severe test conditions, the unknown strength $G({\tau})$ is chosen in the form of rectangular, triangular and sinusoidal functions.

• 산업경영시스템학회지
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• 제37권1호
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• pp.50-59
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• 2014

In this paper, we develop an efficient approach to solve a multiple-item budget-constraint newsboy problem with a reservation policy. A conventional approach for solving such problem utilizes an approximation for the evaluation of an inverse of a Gaussian cumulative density function when the argument of the function is small, and a heuristic method for finding an optimal Lagrangian multiplier. In contrast to the conventional approach, this paper proposes more accurate method of evaluating the function by using the normalization and an effective numerical integration method. We also propose an efficient way to find an optimal Lagrangian multiplier by proving that the equation for the budget-constraint is in fact a monotonically increasing function in the Lagrangian multiplier. Numerical examples are tested to show the performance of the proposed approach with emphases on the behaviors of the inverse of a Gaussian cumulative density function and the Lagrangian multiplier. By using sensitivity analysis of different budget constraints, we show that the reservation policy indeed provides greater expected profit than the classical model of not having the reservation policy.

• Structural Engineering and Mechanics
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• 제41권3호
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• pp.339-348
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• 2012

The slope stability analysis is usually done using the methods of calculation to rupture. The problem lies in determining the critical failure surface and the corresponding factor of safety (FOS). To evaluate the slope stability by a method of limit equilibrium, there are linear and nonlinear methods. The linear methods are direct methods of calculation of FOS but nonlinear methods require an iterative process. The nonlinear simplified Bishop method's is popular because it can quickly calculate FOS for different slopes. This paper concerns the use of inverse analysis by genetic algorithm (GA) to find out the factor of safety for the slopes using the Bishop simplified method. The analysis is formulated to solve the nonlinear equilibrium equation and find the critical failure surface and the corresponding safety factor. The results obtained by this approach compared with those available in literature illustrate the effectiveness of this inverse method.

• 한국전산구조공학회논문집
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• 제26권5호
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• pp.393-399
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• 2013

본 논문은 그래핀의 모드 I 균열 진전에 대한 분자동역학 해석과 수치보조장을 사용하는 영역 투영 방법의 역문제 해석 방법을 결합하여 균열 선단 응집 법칙을 평가하는 효율적인 방법을 제시하고 있다. 그래핀의 균열 선단 응집 법칙을 결정하는 것은 균열 선단에서 멀리 떨어진 영역의 변위를 사용하여 균열 면에서 미지의 응집 트랙션과 열림 변위를 구하는 역문제를 해석해야 하는데 상호 J-적분과 M-적분의 경로 보존성과 효율적인 수치보조장을 사용하는 방법을 적용하였다. 분자동역학 해석에서 원자 변위를 유한요소 절점 변위로 이동최소자승법을 사용하여 근사하였으며 안정적인 역문제 해석을 통하여 원자 단위의 거동을 연속체 해석으로 연결시킬 수 있는 새로운 방법을 보여주었다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.16-19
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• 1996

The objective of this paper is to present a new adaptive nonlinear compensation method, which is based upon the Pth-order inverse theory and can be implemented in a systematic way, for weakly nonlinear systems that can be modeled by a Volterra series. In particular, employment of the proposed approach for the linearization of a given nonlinear system leads to the effective elimination of (up to a required order) nonlinearities in the overall system output. To demonstrate the feasibility of the proposed method, simulation results using a satellite communication system model are also provided.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.33.1-33
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• 2001

We address a novel approach to identify a nonlinear dynamic system for Wiener models, which are composed of a linear dynamic system part followed by a nonlinear static part. The aim of system identification here is to provide the optimal mathematical model of both the linear dynamic and the nonlinear static parts in some appropriate sense. Assuming the nonlinear static part is invertible, we approximate the inverse function by a piecewise linear function. We estimate the piecewise linear inverse function by using the evolutionary computation approach such as genetic algorithm (GA) and evolution strategies (ES), while we estimate the linear dynamic system part by the least squares method. The results of numerical simulation studies indicate the usefulness of proposed approach to the Wiener model identification.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년 학술대회 논문집 정보 및 제어부문
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• pp.220-222
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• 2006

This paper presents intelligent digital redesign method of global approach for hybrid state space fuzzy-model-based controllers. For effectiveness and stabilization of continuous-time uncertain nonlinear systems under discrete-time controller, Takagi-Sugeno(TS) fuzzy model is used to represent the complex system. And global approach design problems viewed as a convex optimization problem that we minimize the error of the norm bounds between nonlinearly interpolated lineal operators to be matched. Also, by using the bilinear and inverse bilinear approximation method, we analyzed nonlinear system's uncertain parts more precisely. When a sampling period is sufficiently small, the conversion of a continuous-time structured uncertain nonlinear system to an equivalent discrete-time system have proper reason. Sufficiently conditions for the global state-matching of the digitally controlled system are formulated in terms of linear matrix inequalities (LMIs). Finally, a T-S fuzzy model for the chaotic Lorentz system is used as an example to guarantee the stability and effectiveness of the proposed method.

• International Journal of Precision Engineering and Manufacturing
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• 제7권3호
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• pp.66-71
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• 2006

Some wheelchair users with neuromuscular disorders experience involuntary extensor thrusts, which may cause injuries via impact with the wheelchair, cause the user to slide out of the wheelchair seat, and damage the wheelchair. Knowledge of the human-generated forces during an extensor thrust is of great importance in devising safer, more comfortable wheelchairs. This paper presents an efficient method for identifying human-generated forces during an extensor thrust. We used an inverse dynamic approach with a three-link human body model and a system for measuring human body motion. We developed an experimental system that determines the angular motion of each human body segment and the force at the footrest, which was used to overcome the mathematical indeterminacy of the problem. The proposed method was validated experimentally, illustrating the force-identification process during an extensor thrust.

• 한국항공우주학회지
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• 제30권7호
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• pp.98-104
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• 2002

본 연구에서는 역섭동법을 이용한 손상탐지의 효율을 개선하는 목적으로 시스템 축소기법을 사용하였다. 이 방법은 손상탐지의 미측정 자유도를 측정된 자유도로 변환하여 역섭동법의 계산효율이 향상되는 장점이 있으나, 부정확한 자유도의 변환으로 수치적인 안정성이 저하될 수 있다. 따라서 자유도 변환식을 수치해법 과정에서 반복적으로 개선하는 방법과, 매우 정확한 accelerated improved reduced system (AIRS) 축소법의 사용으로 역섭동법의 수치적 불안정성을 해결하였다.