• Title/Summary/Keyword: international

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Development and characterization of a fully functional small anti-HER2 antibody

  • Gao, Jie;Li, Bohua;Li, Huimei;Zhang, Xunmin;Zhang, Dapeng;Zhao, Lei;Wang, Chong;Fang, Chen;Qian, Weizhu;Hou, Sheng;Kou, Geng;Wei, Huafeng;Shi, Shu;Wang, Hao;Guo, Yajun
    • BMB Reports
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    • v.42 no.10
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    • pp.636-641
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    • 2009
  • The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

A Study on the Suppression and Punishment of International Terrorism (국제(國際)테러리즘의 억제(抑制)와 처벌(處罰)에 관한 연구(硏究) -중국민항기(中國民航機) 공중납치사건(空中拉致事件)을 중심(中心)으로-)

  • Yoh, Yeung-Moo
    • The Korean Journal of Air & Space Law and Policy
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    • v.1
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    • pp.87-123
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    • 1989
  • The purpose of this thesis is to do a research on suppression of peacetime international terrorism and penal system of terrorists by political and economic means. International terrorism means wanton killing, hostage taking, hijacking, extortion or torture committed or threatened to be comitted against the innocent civilian in peacetime for political motives or purposes provided that international element is involved therein. This research is limited to international terrorism of political purposes in peacetime, especially, hijacking of civil aircraft. Hijacking of civil aircraft include most of international terrorism element in its criminal act and is considered to be typical of international terrorism in view of multinationality of its crews, passengers and transnational borders involved in aircraft hijacking. Civil air transportation of today is a indispensable part of international substructure, as it help connect continuously social cultural and economic network of world community by dealing with massive and swift transportation of passengers and all kinds of goods. Current frequent hijacking of civil aircraft downgrade the safety and trust of air travel by mass slaughter of passengers and massdestruction of goods and endanger indispensable substructure of world community. Considering these facts, aircraft hijacking of today poses the most serious threat and impact on world community. Therefore, among other thing, legal, political, diplomatic and economic sanctions should be imposed on aircraft hijacking. To pursue an effective research on this thesis aircraft hijacking by six Chineses on 5th May, 1983, from mainland China to Seoul, Korea, is chosen as main theme and the Republic of Korea's legal, political and diplomatic dealing and settlement of this hijacking incident along with six hijackers is reviewed to find out legal, political diplomatic means of suppression and solution of international terrorism. Research is focused on Chinese aircraft hijacking, Korea-China diplomatic negotiation, Korea's legal diplomatic handling and settlement of Tak Chang In, mastermind of aircraft hijacking and responses and position of three countries, Korea, China and Taiwan to this case is thoroughly analyzed through reviewing such materials as news reportings and comments of local and international mass media, Korea-China Memorandum, statements of governments of Korea, China and Taiwan, verdicts of courts of Korea, prosecution papers and oral argument by the defendants and lawyers and three antiaircraft hijacking conventions of Hague, Tokyo and Montreal and all the other instruments of international treaties necessary for the research. By using above-mentioned first-hand meterials as yardsticks, legal and political character of Chinese aircraft hijacking is analyzed and reviewed and close cooperation among sovereign states based on spirit of solidarity and strict observance of international treaties such as Hague, Tokyo and Montreal Conventions is suggested as a solution and suppressive means of international terrorism. The most important and indispensable factor in combating terrorism is, not to speak, the decisive and constant resolution and all-out effort of every country and close cooperation among sovereign states based on "international law of cooperation."

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The Effects of International Entrepreneurial-orientation on the Export performance of Chinese Export company - The moderating Effects of degree of International and Market dynamism - (중국 수출기업의 국제기업가지향성이 수출성과에 미치는 영향 - 국제화정도와 시장역동성의 조절효과를 중심으로 -)

  • Piao, Zeng-Nan;Yu, Seung-Hun
    • Management & Information Systems Review
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    • v.36 no.5
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    • pp.99-120
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    • 2017
  • Recent studies shows that international entrepreneurship orientation is recognized as a very important tool for improving corporate performance in international business activities. However, these relationships show various research results. Therefore, it can be a very interesting research topic to examine whether these relationships are linear or non-linear when selected as a target in developing country like China. The purpose of this study is to examine whether the effects of international entrepreneurship orientation on the export performance is non-liner type in China's manufacturing firms. And investigated the moderating role of degree of internationalization and market dynamism relative to the relationship between the international entrepreneurial-orientation and the export performance. A total of 478 questionnaires were used for the hypothesis test. The results of this study are summarized as follows: First, there is a J-shaped. relationship between international entrepreneurship orientation and export performance. Second, degree of Internationalization strengthened the reverse J-shaped relationship between international entrepreneurship orientation and export performance. Finally, degree of internationalization and market dynamics show that J-shaped relationship between international entrepreneurial orientation and export performance is strengthened. The results of the study's theoretical contribution and the managerial contribution is as followed. As a theoretical contribution, it is confirmed that international entrepreneurial orientation (J-shaped) and export performance form a non-linear relationship, and it is possible to make an empirical contribution that can newly approach the relationship between international entrepreneurial orientation and export performance. The managerial contribution suggests that China's exporting companies have a higher degree of Internationalization in their international business activities and that the higher the dynamics of the overseas markets, the more advanced the international entrepreneurial behavior should be required to improve the export performance.

Research on Trends in International Research Cooperation through Analysis of International Research Cooperation Books (국내외 단행본 분석을 통한 국제연구협력 동향 연구)

  • Noh, Younghee;Kwak, Woojung
    • The Journal of the Korea Contents Association
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    • v.22 no.6
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    • pp.35-44
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    • 2022
  • In this study, we tried to confirm the characteristics of books published on the topic of international cooperation, what kind of international cooperation-related research is being conducted through this book, and what are the main contents of international cooperation. In order to achieve this research purpose, we conducted data construction, statistical analysis, and text mining based on textom in international research cooperation at home and abroad. As a result of the study, it can be seen that there has been a particularly high interest in international research and international cooperation since the 2010s. Through this, it was found that he is interested in development, economy, technology, development, region, and relations and wants to promote development. In addition, topics such as environment, trade, education, and society appeared, and interest in international research cooperation centered on environment, trade, and education was high, was found to have a high influence on society as a whole. Through this study, we find the research significance in that it can serve as a basic research to confirm the characteristics of some national and public research institutes participating in international research cooperation, and that it confirms the trend of participating in international research cooperation in a relatively specific type of institution. can see.

Going beyond Border? Intention to Use International Bank Cards in Vietnam

  • PHAN, Dzung Tran Trung;NGUYEN, Thanh Thi Ha;BUI, Tuan Anh
    • The Journal of Asian Finance, Economics and Business
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    • v.6 no.3
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    • pp.315-325
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    • 2019
  • The paper aims to explore the factors affecting potential users of international bank cards in Vietnam. With milestones treaties being signed CPTPP and EVFTA, Vietnam is now exposing itself to the international open environment. Bank card market is at the core of this wind of change, and that is the reason for us to research the intention to use international bank cards. Given that the decision to choose international bank cards could either be the switch from domestic cards or adopting a brand new card, we develop some specific constructs to reflect that consideration, specifically PE and PD, asides from traditional constructs used in TPB and TAM frameworks. The analysis work is conducted using PLS-SEM approach. Our findings reveals that most of our proposed hypotheses are supported, in which SN plays the most important direct role to INT, while total effect of PU on INT is similar to that of SN. The newly introduced PD negatively and significantly impacts INT, and PE also has a positive impact on INT. The findings suggest that overall, it is important for bank card issuers to have a balance approach to the market, with focus on increasing usefulness and reducing potential disadvantages of international bank cards.

A Comparative Study of Service Quality between Incheon and Kimpo International Airport (인천국제공항과 김포국제공항 서비스품질 비교 연구)

  • 장대성;황인천
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2001.10a
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    • pp.35-38
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    • 2001
  • This study was conducted a comparative study to identify the differences in service quality between Incheon and Kimpo international Airport and critical factors influencing satisfaction of airport customers. According the results of this study, all service quality factors except the service factor of geographical location of Incheon international airport are better than those of Kimpo international airport. However, all of service quality factors of Incheon airport are evaluated as inferior to those of american, western european and japanese international airports by both the airport visitors and the employees of one korean airliner. In addition the service factors such as response, safety, airport facility and geographical location are found as critical factors influencing satisfaction of the airport visitors and the airliner's employees. Among them the service quality factor of geographical location of Incheon airport is much inferior to that of Kimpo airport comparing with other service quality factors. Thus, the results of this study suggest that the managing team implement TQM and six sigma to enhance the service quality level of the Incheon international airport up to that of the american and western european international airport. Especially, it is strongly required that the Korean governmen deliberate in deciding the geographical location in case of planning new international airport because geographical location is related to not only traffic to airport but also safety of landing, taking off and flying.

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A Study on the Use of LD Clause against the Seller's Breach of Delivery of Goods in the Contract for the International Sale of Goods (국제물품매매계약에서 매도인의 물품인도의무 위반에 대비한 손해배상액의 예정조항 (Liquidated Damage Clause: LD조항)의 활용에 관한 연구 - ICC Model International Sale Contract를 중심으로)

  • Oh, Won-Suk;Youn, Young-MI;Li, Jing Hua
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.50
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    • pp.3-25
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    • 2011
  • The purpose of this paper is to examine the use of LD Clause against the seller's breach of contract in connection with delivering the goods in the international sales contract, and international guarantee system using standby L/C or demand guarantee. For this purpose, the author, first, considered the outline of the buyer's remedies in cases that the seller had not performed his obligations in contract and the difficulties in the buyer's remedies. As alternatives for overcoming the difficulties, this author recommended the LD Clauses (Liquidated Damage Clauses) based on ICC Model International Sales Contract, and explained each Model Clause. To enhance the feasibility of LD Clause, this author suggested the guarantee system, like the standby L/C or demand guarantee. But these guarantee systems have several limitations in practical use. Thus, these guarantee systems would greatly contribute to Korean exportation in the future. The reason is that the Korean export structure would be more complex and the period of sales contract would be longer and longer, which result to in long-terms supply contracts. These changes would require the guarantee much urgently.

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