• Journal of Society of Preventive Korean Medicine
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• v.18 no.1
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• pp.83-92
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• 2014

Objective : This study was performed to investigate the antineoplastic effect of Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes and Trichosanthes kirilowii on SNU-80 anaplastic thyroid carcinoma cell line. Method : We examined whether our herbal medicines decreases cell growth rate of SNU-80 using MTT assay. We performed western blot analysis to verify that our herbal medicines induces apoptosis via caspase-dependent mechanism. We also performed wound healing assay and transwell invasion assay to investigate whether our herbal medicines affects the migration and invasion of anaplastic cancer cells, SNU-80. We also carried out ELISA assay to know our herbal medicines suppresses the expression of proinvasive molecules, such as VEGF and MMP-2 secreted from SNU-80. Results : MTT assay demonstrates that Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed strongly the growth of SNU-80. Western blot analysis demonstrates that Trichosanthes kirilowii induces apoptosis activating the cleavages of caspases (caspase-8, caspase-3) and PARP. Wound healing assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the migration of SNU-80. Transwell invasion assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the invasion of SNU-80. Elisa assay demonstrates that Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed the expression of VEGF and MMP-2. Conclusion : We could conclude that several herbal medicines suppresses the growth and inhibits the migration and invasion of SNU-80 which is anaplastic thyroid cancer cells. Especially, Rhus verniciflua Stokes, Trichosanthes kirilowii had stronger anti-cancer effect suggesting that we can apply them to treat anaplastic thyroid cancer.

• Korea journal of population studies
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• v.21 no.1
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• pp.42-79
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• 1998

There was a rapid population change accompanied with changes in population structure recently in Korea. The changes were nationwide though greater in rural, where the population decreased steeply, through the internal migration from rural to urban. There, in the structure of Gun's population, severely distorted features have been shown in the study. Also, the structure differ greatly by Gun. It indicated that the rural problems were much more serious than anticipated when analyzed generally. It tells us that we should consider the problems related with different population structure in developing the programs for the rural.

• Journal of the Korean Geographical Society
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• v.51 no.2
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• pp.185-200
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• 2016

The discipline of Geography is broadly concerned with the interconnections between people and the environment. Particularly, this unique human-environment relationship often can be typically reflected from, and well illustrated by, the dynamics of microstates' island environment. While Tuvaluans living on vulnerable, low-lying atolls in the Pacific are not primarily responsible for contributing to climate change, yet they are experiencing its dreadful effects. Population pressure, caused by the differences in population size, distribution, and composition, has been constantly affected by resource unavailability and environmental instability on the islands. It also represents one of our challenges in understanding the complex influence of population dynamics on the living environment. What can be learned from Tuvalu in the context of population geography and environmental geography as well as its relationship with other Pacific island microstates? What are Tuvaluans' migration responses to their atolls' environmental crisis as well as the carrying capacity scenarios related to overpopulation? What are the current living experiences and settlement situations of Tuvaluan internal and external migrants both at home and abroad? This research examines the contemporary migration literature in the context of Tuvalu's population geography, while analyzing Tuvaluan migration patterns, discourses and perspectives in relation to environmental change.

• Journal of the Korean Ceramic Society
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• v.35 no.11
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• pp.1121-1129
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• 1998

Reactions between Ag-Pd internal electrode materials and{{{{ { {Bi }_{2 }O }_{3 } }} in multilayer chip varistor were in-vestigated. For more than 1 mol%{{{{ { {Bi }_{2 }O }_{3 } }} in varistor composition internal electrode structure was destroyed due to the reaction between internal electrode and{{{{ { {Bi }_{2 }O }_{3 } }} But for typical varistor compositions (below 1 mol% of{{{{ { {Bi }_{2 }O }_{3 } }} content) microstructural changes around the internal electrode were not observed. However SEM-EDS and TEM-EDS analysis showed the uneven distribution of{{{{ { {Bi }_{2 }O }_{3 } }} in the internal electrode which was due to the migration of{{{{ { {Bi }_{2 }O }_{3 } }} to the electorde during sintering. As a results the nonlinear coefficient of multilayer varistor showed very large distribution as well as the breakdown voltage.

• 한국해양학회지
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• v.10 no.1
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• pp.1-6
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• 1975

A marine geological investigation of the glass sand deposit in the beach along the west coast of Ahnmyeon Island, South Chung Cheong Province, Korea was carried out to solve the problen of sand material migration, textural properties of the sands and the glass sand reserve for future exploitation. Several bos coring analyses by means of the internal sedimentary structure.i.e., cross- stratification show significantly that most sands are moving and accumulation along the mean vector direction of $N20^{\circ}E-N60^{\circ}$ E in the area investigated. The average mean size of the sand sediments in the area studied ranges from 0.212mm to 0.275mm. The mechanism of sand migration in the area is considered to be interplay between longshore drift and flood tidal current. The sorting value of the sands ranges from 0.24 to 0.50. Therefore, these sand sediments are characteristic to be "well sorted". The average chemical composition of the glass sand in the area is the following: $SiO\_2$:-90.8%, $Al_2O_3$: -2.18%, $Fe_2O_3$:-0.73%, CaO:-1.79. The binocular microscope examination of the sands show that most of the sands are characteristically ice- clear quartz in mineral composition and their count percentage is mostly 92% or 96%.

• Biomedical Science Letters
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• v.17 no.1
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• pp.89-93
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• 2011

Asthma is an inflammatory airway disease and is characterized by the releases of inflammatory mediators including chemokines. They are mainly associated with the recruitment, activation and dysregulation of specific inflammatory cells, especially neutrophils in neutrophilic asthma. CC chemokines bind to CC chemokine receptors (CCRs) in the surface of their target cells. The aims of this study are to examine the CCR expression in neutrophils of bronchoalveolar lavage fluid (BALF) of asthmatic patients and to determine the alternation of migration and apoptosis of neutrophils by the BALF. We demonstrate that CCR3 strongly expresses in BALF neutrophils of asthmatic patients as compared to other CCRs and increases during apoptosis of the BALF neutrophils. The migration of asthmatic blood neutrophils increases in response to asthmatic BALF as compared to BALF of normal volunteer. In addition, asthmatic BALF includes the higher levels of IL-8 protein than normal BALF and it has no effect on apoptosis of asthmatic blood neutrophils. Taken together, our results indicate that CCR3 expression may be associated with unknown function of asthmatic BALF neutrophils and BALF may be involved in the recruitment of neutrophils into the airway, but not in the neutrophils apoptosis.

• Korea journal of population studies
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• v.11 no.1
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• pp.117-130
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• 1988

Though most of East European coutries seem to hold a pronatalist policy, they approve of family planning and provide contraceptive services. One of the most popular contraceptive method has traditionally been the coitus interruptus in these countries. One of the major reasons for adopting family planning is to decrease the incidence of induced abortion has been closely related to the popular use of coitus interruptus in these countries. Most of the East European countries liberalized induce abortion legally mainly to neutralize the wide practice of illegal abortion. However, the practice of induced abortion is under the strict control of the public health authorities in these countries. Migration and redistribution of population of population are mostly under the control of the state in these socialist countries. Policies on migration and redistribution are usually carried out to achieve the general goal of socio-economic development plan of the states. Both incentive measures and control measures are mobilized to affect the internal migration and redistribution of population. With respect to public health East European countries are characterized by the socialized medicine following the Soviet model. Public health measures and medical practice are controlled by the state and highly centralized in many countries except Yugoslavia. They place much emphasis on preventive medicine, primary health care, occupatinal and industrial medicine, and health education. Private sectors in medical practice do not exist in these countries of Eastern Europe.

• Journal of the Korean Society of Visualization
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• v.19 no.1
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• pp.74-80
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• 2021

Cells regulate their shapes and motility by sensing the cues from the internal and external microenvironment. Under different circumstances, microglia, the brain resident immune cells, undergo dynamic phenotypic changes, one of which is a remarkable periodic oscillatory migration in vitro. However, very little is known about the kinematic and dynamic perspectives of this oscillatory behavior. In this study, we tracked the changes in cell morphology and nuclear displacement, and visualized the forces using traction force microscopy (TFM). By correlation analyses, we confirmed that the lamellipodia formation preceded the nuclear translocation. Moreover, traction, developed following lamellipodia formation, was found to be localized and fluctuated at two ends of the oscillating cells. Taken together, our results imply that oscillatory microglial cells feature a viscoelastic migration, which will contribute to the field of cell mechanics.

• Journal of the Korean Society of Radiology
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• v.84 no.4
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• pp.934-940
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• 2023

Ventriculoperitoneal shunting is the most common neurosurgical procedure for treatment of hydrocephalus. Shunt-related complications are relatively common and associated with a high rate of shunt revision. However, migration of the distal ventriculoperitoneal shunt, especially into the cardiac and intravascular regions, has rarely been reported. Awareness of this rare but potentially hazardous complication is important owing to its significant morbidity, which can be prevented by prompt management. Here, we introduce a case of a 23-year-old male with migration of the distal shunt catheter through the left internal jugular vein into the cardiac chamber and both pulmonary arteries, which occurred 2 months after receiving ventriculoperitoneal shunting. Furthermore, we discuss the possible mechanisms and management of this condition.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.518-526
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• 2008

Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response of airway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseases including asthma. Production of chemokines by bronchial epithelial cells may contribute to the allergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect of Gamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion of chemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. These findings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression of chemokines secretion associated with local accumulation of eosinophils.