• Journal of the Korea Society of Computer and Information
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• v.14 no.5
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• pp.37-44
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• 2009

Recently, as the quality of multimedia data gets higher, multimedia servers require larger storage capacity and higher I/O bandwidth. In these large scale multimedia servers, the load-unbalance problem among disks due to the difference in access frequencies to multimedia objects according to their popularities significantly affects the system performance. To address this problem, many data replication schemes have been proposed. In this paper, we propose a novel data migration/replication scheme to provide better storage efficiency and performance than the dynamic data replication scheme which is typical data replication scheme employed in multimedia servers. This scheme can reduce the additional storage space required for replication, which is a major defect of replication schemes, by decreasing the number of copies per object. The scheme can also increase the number of concurrent users by increasing the caching effect due to the reduced lengths of the intervals among requests for each object.

• IMMUNE NETWORK
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• v.1 no.1
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• pp.32-35
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• 2001

Background: rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing on the uninfected wounds. Methods: Thirty Sprague-dawley white mice(250-300g) were selected in this study. The number of wound with the diameter of 5 mm, was 3 in left and 3 in right at the symmetric sites, respectively. The site of rhGM-CSF dressing was decided by a randomization. rhGM-CSF($Leucogen^{(R)}$) was diluted in the distilled water($5{\mu}g/mL$). The experimental wound group was dressed by l mL of distilled water mixed with rhGM-CSF and control wound group was dressed by l mL of distilled water. The dressing was done, every 24 hours. The criteria of comparison were the duration of wound healing duration, histologic findings and the bacterial culture of wound sites. Results: The duration of wound healing was $10.3{\pm}1.7days$ in experimental group and $10.2{\pm}2.8days$ in control group, without significant difference. There was no specific difference of histologic findings between both groups. The pathogen was not found, at all. Conclusion: It seems to be that rhGM-CSF has no prominent effect on the uninfected wound healing in the mice without immune suppression.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.10
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• pp.2359-2368
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• 2013

In this paper, an IRD (internal read data) circuit preventing the reentry into the read mode while keeping the read-out DOUT datum at power-up even if noise such as glitches occurs at signal ports such as an input signal port RD (read) when a power IC is on, is proposed. Also, a pulsed WL (word line) driving method is used to prevent a DC current of several tens of micro amperes from flowing into the read transistor of a differential paired eFuse OTP cell. Thus, reliability is secured by preventing non-blown eFuse links from being blown by the EM (electro-migration). Furthermore, a compared output between a programmed datum and a read-out datum is outputted to the PFb (pass fail bar) pin while performing a sensing margin test with a variable pull-up load in consideration of resistance variation of a programmed eFuse in the program-verify-read mode. The layout size of the 8-bit eFuse OTP IP with a $0.18{\mu}m$ process is $189.625{\mu}m{\times}138.850{\mu}m(=0.0263mm^2)$.

• Journal of Gastric Cancer
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• v.9 no.1
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• pp.1-5
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• 2009

In the past, conservative bypass surgery was usually performed for palliation of malignant obstruction of the gastrointestinal tract. However, endoscopic stenting was developed recently, and technical advances and clinical experience have made it possible to establish stent implantation as one of the main treatment options. There are several advantages in stent implantation over bypass surgery, such as high feasibility and technical success rate, non-invasiveness, rapid symptomatic response, short hospitalization, and cost-effect benefits. Complications, such as stent ingrowth, stent injury by bile or acid, and migration, may occur and early re-insertion is frequently needed. Recently, diverse novel stents which are powered to predict stent migration or ingrowth have been developed and are being used in the clinical setting. In general, stent implantation is known to be beneficial in patients who are expected to survive <6 months, and surgical bypass may be more effective in patients who can survive >6 months. In this review, we have compared the technical feasibility, clinical outcomes, complications, and cost-benefit between stent implantation and bypass surgery, and determined the optimal treatment strategy in malignant upper gastrointestinal obstruction.

• Journal of Sensor Science and Technology
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• v.9 no.3
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• pp.203-207
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• 2000

The sensitivity of ISFET glucose sensor is improved by employing amperometric actuation method. However, this method takes long time to recover the primary output voltage after measurement because of slow migration of the hydrogen ion between internal and external sensing membranes. Consequently, such a recovery-time delaying problem is one of obstacles to a practical use. In this paper, a new method is proposed to control the concentration of hydrogen ion in internal membrane, which applies a reduction potential to the working electrode for supplying hydroxide ion. Experimental results show that the recovery-time was reduced within 2 minute against decades minute of conventional method.

• Korean Journal of Materials Research
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• v.4 no.5
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• pp.502-509
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• 1994

New damping measurement equipment was designed using the dynamic strain gage and high speed analog to digital signal 12 bit converter and compared it with existing equipment. The damping properties of general material and high damping material were also studied by this machine. The SDC (specific damping capacity) was measured with various heat treatment condition, initial vibration amplitude and internal stress. The vibration amplitude of high damping material is decreased within nearly less than 0.4 second after applying the initial forced vibration. But that of general material is still vibrating at the same time. After furnace-cooling heat treatment, SDCmax of Fe-lGwt.%Cr system was more than 40% and that of Fe-5.5wt.%Al alloy was more than 30% after air-cooling heat treatment. Upon increasing of initial vibration amplitude, it is detected the migration of SDCmax into the region of small vibraton amplitude. Damping capacity is decreased rapidly as the internal stress Increases. Damping measurement equipment in the present study was ahln to give the more accurate results of damping properties in the small vibration amplitude region.

• Transactions of Materials Processing
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• v.17 no.4
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• pp.240-248
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• 2008

The effect of alloying elements(Mn, S, Mo, B) on the high temperature deformation behavior of Fe-29%Ni-17%Co (Kovar) alloy were investigated. And the effect of high temperature oxidation on the hot ductility was also studied. The hot ductility of Kovar alloy was drastically increased with the addition of Mn and lowering of S content. It has been found that the brittle intergranular fracture at high temperature cracking is closely associated with the FeS sulfide along the grain boundary. When Mn was added, the type of sulfide was changed to MnS from FeS and ductile intergranular fracture and transgranular fracture were promoted. The formation of oxide layer was found to have minimized the hot ductility of the Kovar alloy significantly. Grain boundary micro-cracks in the internal oxide region were noted following deformation due to high temperature, one of which acting as a notch that caused the poor hot workability of the oxidized specimen. The addition of Mo to the Kovar alloy could also retard the decrease in the hot ductility of the oxidized specimen through the prevention of notching due to internal oxidation. Hot ductility was remarkably improved by the addition of Boron. The improvement of hot ductility results from the grain boundary migration mainly due to the dynamic recrystallization at lower temperature range ($900{\sim}1000^{\circ}C$).

• Natural Product Sciences
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• v.26 no.1
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• pp.71-78
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• 2020

The plant Dendropanax morbifera Léveille is effective folk medicines for the treatment of several conditions, such as infectious diseases, skin diseases, and other illnesses. Although the inhibitory effects of D. morbifera on the proliferation and migration of vascular smooth muscle cells (VSMCs) have been shown in our previous study, its effects in vivo remain to be elucidated. In this study, we aimed to investigate the protective effects of the extracts from D. morbifera (EDM) on neointimal hyperplasia of rat carotid artery and explore the underlying mechanisms. We observed that the ratio of intima to media thickness (I/M) was significantly decreased in the EDM-treated groups by ~80% compared to that of the control. The expression of Ki-67 and proliferating cell nuclear antigen was decreased by ~70% in the EDM-treated groups compared to that of the control. In addition, matrix metalloproteinase (MMP)2 and MMP9 significantly reduced in the neointimal layer of the EDM-treated groups. Moreover, the decreased levels of contractile phenotypic markers of VSMCs, such as α-smooth muscle actin, myocardin, and smooth muscle-myosin heavy chain, were successfully restored by EDM treatment. Furthermore, the levels of synthetic phenotypic markers, cellular retinal binding protein 1 and connexin 43 were also restored to normal levels. These results suggest that EDM inhibits vascular neointimal hyperplasia induced by balloon injury in rats via phenotypic modulation of VSMCs. Therefore, EDM may be a potential drug candidate for the prevention of restenosis.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• Journal of People, Plants, and Environment
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• v.24 no.3
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• pp.285-300
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• 2021

Background and objective: Rural migrants are an important human resource in urban and rural exchange (URE) business, therefore it is necessary to enhance their awareness and intent-to-participate. This study was to analyze the rural migrants' recognition and intent-to-participate of URE business and to propose the enhancement of them both. Methods: The questionnaire was designed to analyze the socio-demographic background, motivations, satisfaction with settlement, intent-to-persist, and intent-to-participate of URE business including tourism. The data of 144 respondents was subject to the statistical analysis. Results: The motives of migration were to enjoy leisure life after retirement, increased tiredness of city life, health problems, etc. The satisfaction with settlement was 3.67 at 5-point Likert scale. The intent-to-recommend and intent-to-publicize were 3.40 and 3.46, respectively. The intent-to-participate was 3.45, which was affected by the necessity of URE business and the support of central/local governments, and also showed a significant correlation with the satisfaction with settlement, intent-to-recommend, intent-to-publicize, tourism resources for green tourism or rural tourism, driving a car in Namhae county, and the service and price of meals. They thought the missions that the Namhae county office must focus on were to establish an internal/external public relations systems, establish a support system of central/local governments, and foster/support local leaders. Conclusion: It is necessary to improve the satisfaction with settlement and intent-to-persist, expand exchanges with local people, improve internal/external public relations systems, foster/support leaders, improve transportation in the county, enhance the service and price of meals, and develop/operate URE programs including tourism.