• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.521-524
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• 2005

In order to measure ECG in daily life, a new ECG measurement method on bed was developed. The provided method does not require any direct conductive contact between the instrument and bare skin, so that it does not cause the uncomfortable feel of touch and the possible skin trouble which are typical shortcomings of the conventional conductive contact ECG measurement. The provided method utilized an array of high-input-impedance active electrodes fixed on the mattress and an indirect-skin-contact ground made of a large conductive textile sheet and laid on lower area of the mattress. A thin cotton bedcover covered the mattress, the electrodes, and the conductive textile and subjects lay on the mattress over the bedcover. ECG was obtained successfully. However its signal quality is lower and the motion artifact is larger than direct-contact measurement. Careful measurement setup was needed to reduce the motion artifact originated from variation in static electricity. From the ECG obtained by the provided method, R-peak could be discriminated easily and the information about the position and the posture of the subject could be obtained.

• East Asian mathematical journal
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• v.34 no.4
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• pp.511-536
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• 2018

There is currently a growing need to nurture creative and convergent talent in the face of the fourth Industrial Revolution. Developing such talent requires interdisciplinary convergent education across the science, engineering, humanities, social studies, and arts disciplines. Such interdisciplinary convergence could cultivate humanities and social knowledge and qualities along with scientific expertise. In Korea, there are currently six science schools for the gifted that aim to discover and nurture science, technology, engineering, and mathematics (STEM) researchers from an early stage, and two science and art schools for the gifted that aim to cultivate new talent combining students' scientific and artistic qualities. These schools establish and follow curriculums that are suited to achieving the education objectives guaranteed by the Gifted Education Promotion Act and its Enforcement Decrees. This study compares the curriculums and curriculum tables of the science schools for the gifted to those of the science and art schools for the gifted to evaluate their methods of operation and performance. Additionally, it determines which curriculums provide an opportunity for students to nurture convergent thinking, and discusses how suitable curriculums could be implemented to develop convergent thinking.

• Genomics & Informatics
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• v.18 no.1
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• pp.11.1-11.3
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• 2020

In genome-wide association studies, pathway-based analysis has been widely performed to enhance interpretation of single-nucleotide polymorphism association results. We proposed a novel method of hierarchical structural component model (HisCoM) for pathway analysis of common variants (HisCoM for pathway analysis of common variants [HisCoM-PCA]) which was used to identify pathways associated with traits. HisCoM-PCA is based on principal component analysis (PCA) for dimensional reduction of single nucleotide polymorphisms in each gene, and the HisCoM for pathway analysis. In this study, we developed a HisCoM-PCA software for the hierarchical pathway analysis of common variants. HisCoM-PCA software has several features. Various principle component scores selection criteria in PCA step can be specified by users who want to summarize common variants at each gene-level by different threshold values. In addition, multiple public pathway databases and customized pathway information can be used to perform pathway analysis. We expect that HisCoM-PCA software will be useful for users to perform powerful pathway analysis.

• Genomics & Informatics
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• v.14 no.4
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• pp.160-165
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• 2016

Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. However, such tests are computationally demanding and methodologically challenging. Recently, a simple but powerful method, named "BOolean Operation-based Screening and Testing" (BOOST), was proposed for genome-wide gene-gene interaction analyses. BOOST was designed with a Boolean representation of genotype data and is approximately equivalent to the log-linear model. It is extremely fast, and genome-wide gene-gene interaction analyses can be completed within a few hours. However, BOOST can not adjust for covariate effects, and its type-1 error control is not correct. Thus, we considered two-step approaches for gene-gene interaction analyses. First, we selected gene-gene interactions with BOOST and applied logistic regression with covariate adjustments to select gene-gene interactions. We applied the two-step approach to type 2 diabetes (T2D) in the Korea Association Resource (KARE) cohort and identified some promising pairs of single-nucleotide polymorphisms associated with T2D.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.5
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• pp.487-493
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• 2017

The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the ACC, show that the ACC can modulate mechanical hyperalgesia. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC in a model of chronic inflammatory pain to assess their motivational effect in the conditioned place preference (CPP) test. Selective inhibition of pyramidal neurons induced preference during the CPP test, while activation of parvalbumin (PV)-specific neurons did not. Moreover, chemogenetic inhibition of the excitatory pyramidal neurons alleviated mechanical hyperalgesia, consistent with our previous result. Our results provide evidence for the analgesic effect of inhibition of ACC excitatory pyramidal neurons and a prospective treatment for chronic pain.

• Journal of the Korean Society of Clothing and Textiles
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• v.44 no.2
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• pp.273-294
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• 2020

Considering the complex relationship between fashion curating and the critical approach of fashion exhibition reviews, this study explores the current state of fashion criticism in museology, focusing on fashion designer exhibition reviews of Fashion Theory. The author selected eighteen exhibition reviews of individual fashion designers' works from 1997 on to the current 2020 issues of Fashion Theory, which provides an interdisciplinary forum to analyze fashion as a cultural construction. The author performed a systematic review that qualitatively summarizes and/or synthesizes the findings of the studies on the topic with the process of a systematic review, such as key question formulation, analytic framework building, evidence mapping, critical appraisal, and evidence synthesis. The results of this study are as follows. First, the exhibition reviews included almost all stages of the inclusive fashion criticism model, based on an artifact study. Second, they reflected various critical discourses that offered current interpretations of historical and contemporary fashion. Third, they showed that fashion criticism in the museum context is the result of an interdisciplinary collaboration of various fashion agents. Finally, they offered a bridge for crossing the boundaries of various scholarly fields, as they combine multidisciplinary scholarship with object-based methods.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.5
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• pp.420-424
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• 2006

A simple method for depleting E. coliS30 extracts of endogenous tRNA has been developed. An $ethanolamine-Sepharose^{(R)}$ column equilibrated with water selectively captured the tRNA molecules in E. coli S30 extracts. As a result, S30 extracts filtered through this column became completely dependent upon the addition of exogenous tRNA to mediate cell-free protein synthesis reactions. We anticipate that the procedures developed and described will be particularly useful for in vitro suppression reaction studies designed to introduce unnatural amino acids into protein molecules.

• Journal of Interdisciplinary Genomics
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• v.4 no.1
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• pp.7-10
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• 2022

Purpose:Maturity onset diabetes of the young (MODY) is the most common hereditary form of diabetes mellitus (DM), with similar clinical manifestations to type 1 or type 2 DM, leading to diagnostic ambiguity. Despite increased genetic research on monogenic DM, studies with Asian populations are limited. Therefore, we investigated mutation in possible monogenic DM and MODY in Korean children and aldolescents. Methods: Targeted panel exome sequencing including 32 targets genes was performed for 41 patients with suspected monogenic DM at Kyungpook National University Children's Hospital. Results: Variants were detected in 19 patients, including those in known MODY-associated genes (HNF4A, GCK, HNF1A, CEL, PAX4, INS, and BLK) and monogenic DM-associated genes (WFS1, FRX6, and GLIS3). Conclusion: MODY variants were detected more than expected. Targeted exon sequencing is helpful in diagnosing MODY or possible monogenic DM patients.

• Genomics & Informatics
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• v.20 no.1
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• pp.9.1-9.6
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• 2022

Mendelian randomization (MR) uses genetic variation as a natural experiment to investigate the causal effects of modifiable risk factors (exposures) on outcomes. Two-sample Mendelian randomization (2SMR) is widely used to measure causal effects between exposures and outcomes via genome-wide association studies. 2SMR can increase statistical power by utilizing summary statistics from large consortia such as the UK Biobank. However, the first-order term approximation of standard error is commonly used when applying 2SMR. This approximation can underestimate the variance of causal effects in MR, which can lead to an increased false-positive rate. An alternative is to use the second-order approximation of the standard error, which can considerably correct for the deviation of the first-order approximation. In this study, we simulated MR to show the degree to which the first-order approximation underestimates the variance. We show that depending on the specific situation, the first-order approximation can underestimate the variance almost by half when compared to the true variance, whereas the second-order approximation is robust and accurate.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.07a
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• pp.189-190
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• 2023

IT 산업의 발전으로 인하여, 이동식 저장장치의 빠른 발전에도 불구하고, 대중적으로 사용되는 USB 저장 장치의 분실 및 탈취로 인한 민감 데이터의 노출 문제가 발생하였다. 이러한 문제점을 해결하기 위하여, 다양한 인증 방식을 적용한 보안 USB 저장장치가 등장하였지만, 소프트웨어의 구조적인 문제점으로 인하여, 사용자 인증정보를 검증하는 함수가 노출되는 것과 같은 인증 과정에서 발생하는 취약점을 악용함으로써, 보안 USB 저장장치에 안전하게 저장된 민감한 데이터를 보호하지 못하는 보안 위협이 발생하는 실정이다. 따라서 본 논문에서는 보안 USB 저장장치 중, F 제품을 대상으로, 지문 인증과정에서 발생하는 취약점을 분석하고 실증한다. 본 논문의 결과는 보안 USB 저장장치의 데이터 보호 및 인증기술을 더욱 안전하게 향상시키기 위한 참고 자료로 활용될 것으로 사료된다.