• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.551-557
• /
• 2015

Background: Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. Materials and Methods: We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. Results: A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). Conclusions: Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.

• International Commerce and Information Review
• /
• v.16 no.1
• /
• pp.3-24
• /
• 2014

When the Korean Wave was sweeping over China, Asia, Other Countries, Some people worried that the ambiguity of the copyright act would obstruct export of the entertainment contents. To solve this problem, the copyright authentication was introduced in the copyright act, enforcement for its, etc. There are two authentication systems at copyright. One is right authentication protected by copyright, Other one is licence authentication received from the owner. This study is meant to seeking the problem of insufficient regulation related to copyright authentication. According to analysis of FGI in this study, the existing system does not support a proper and specific way how to suggest a long term perspective in the transaction of Korean Contents between Korea and China. The key to success of copyright authentication system between Korea and China depends upon the implementation of the system of copyright mutual authentication. To do so, In reality, laws, institutions, technologies, policies, and operations, etc. should be Inter-operability. Also we should realize that this system gives mutual benefits at transaction between the two countries. Thus, it is important for two countries to effort trade cooperation continuously.

• Journal of the Economic Geographical Society of Korea
• /
• v.18 no.1
• /
• pp.115-135
• /
• 2015

In the glocalization a common phenomenon of several nations reveals knowledge innovation and growth by the important subject of region and state and is studied at theory and practice. the successful cases of regional development in an advanced country have leading innovation through regional innovation system and cluster. therefore we are necessary to analyse how the knowledge spillovers in innovative cluster as the reduced model of regional innovation system guide firm innovation and region growth. this article reviews theories and empirical studies of the knowledge spillovers in the regional innovation system and innovative cluster of innovative geography and proposes a new research issues for further explorations of the knowledge spillovers. Previous studies assist that knowledge spillovers exist in knowledge-based industries of specific local area and local innovation accomplishes through pure knowledge spillover. but limits of these studies include narrow region and technological area, few analytical variable and exclusion of rent knowledge spillover. therefore new research topics related with that exemplifies geographical dimension(concentration and decentralization), technological dimension(knowledge based industry), category of analytic variables(previous indicators, time, and social capital), conceptualization(appropriation means, markets for technology) etc.

• Journal of the Korean Institute of Telematics and Electronics C
• /
• v.35C no.12
• /
• pp.85-98
• /
• 1998

This paper proposes a new design method of neuro-FLC by the Lamarckian co-adaptation scheme that incorporates the backpropagation learning into the GA evolution in an attempt to find optimal design parameters (fuzzy rule base and membership functions) of application-specific FLC. The design parameters are determined by evolution and learning in a way that the evolution performs the global search and makes inter-FLC parameter adjustments in order to obtain both the optimal rule base having high covering value and small number of useful fuzzy rules and the optimal membership functions having small approximation error and good control performance while the learning performs the local search and makes intra-FLC parameter adjustments by interacting each FLC with its environment. The proposed co-adaptive design method produces better approximation ability because it includes the backpropagation learning in every generation of GA evolution, shows better control performance because the used COG defuzzifier computes the crisp value accurately, and requires small workspace because the optimization procedure of fuzzy rule base and membership functions is performed concurrently by an integrated fitness function on the same fuzzy partition. Simulation results show that the Lamarckian co-adapted FLC produces the most superior one among the differently generated FLCs in all aspects such as the number of fuzzy rules, the approximation ability, and the control performance.

• Asian-Australasian Journal of Animal Sciences
• /
• v.20 no.9
• /
• pp.1334-1341
• /
• 2007

This study identified hepatic differentially expressed genes (DEGs) affecting the marbling of muscle. Most dietary nutrients bypass the liver and produce plasma lipoproteins. These plasma lipoproteins transport free fatty acids to the target tissue, adipose tissue and muscle. We examined hepatic genes differentially expressed in a differential-display reverse transcription-polymerase chain reaction (ddRT-PCR) analysis comparing high- and low-marbled Hanwoo steers. Using 60 arbitrary primers, we found 13 candidate genes that were upregulated and five candidate genes that were downregulated in the livers of high-marbled Hanwoo steers compared to low-marbled individuals. A BLAST search for the 18 DEGs revealed that 14 were well characterized, while four were not annotated. We examined four DEGs: ATP synthase F0, complement component CD, insulin-like growth factor binding protein-3 (IGFBP3) and phosphatidylethanolamine binding protein (PEBP). Of these, only two genes (complement component CD and IGFBP3) were differentially expressed at p<0.05 between the livers of high- and low-marbled individuals. The mean mRNA levels of the PEBP and ATP synthase F0 genes did not differ significantly between the livers of high- and low-marbled individuals. Moreover, these DEGs showed very high inter-individual variation in expression. These informative DEGs were assigned to the bovine chromosome in a BLAST search of MS marker subsets and the bovine genome sequence. Genes related to energy metabolism (ATP synthase F0, ketohexokinase, electron-transfer flavoprotein-ubiquinone oxidoreductase and NADH hydrogenase) were assigned to BTA 1, 11, 17, and 22, respectively. Syntaxin, IGFBP3, decorin, the bax inhibitor gene and the PEBP gene were assigned to BTA 3, 4, 5, 5, and 17, respectively. In this study, the in silico physical maps provided information on the specific location of candidate genes associated with economic traits in cattle.

• Journal of the Korean Society for Precision Engineering
• /
• v.3 no.1
• /
• pp.40-49
• /
• 1986

Crack, craze and void are common defects which may be found in the bulk of polymeric materials such as either themoplastics or thermosets. The healing phenomena, autohesion, of these defects are known to be a intrinsic material property of various polymeric materials. However, only a few experimental and theoretical investigations on crack, void and craze healing phenomena for various polymeric materials have been reported up to date [1, 2, 3]. This may be partly due to the complications of healing processes and lacking of appropriate theoretical developments. Recently, some investigators have been urged to study the healing phenomena of various polymenic materials since the significance of the use of polymer based alloys or composites has been raised in terms of specific strength and energy saving. In the earlier published reports [1, 2, 3, 4], the crack and void healing velocity, healing toughness and some other healing mechanical and physical properties were measured experimentally and compared with predicted values by utilizing a simple model such as the reptation model under some resonable assumptions. It seems, however, that the general acceptance of the proposed modeling analyses is yet open question. The crack healing processes seem to be complicate and highly dependent on the state of virgin material in terms of mechanical and physical properties. Furthermore, it is also strongly dependent on the histories of crack, craze and void development including fracture suface morphology, the shape of void and the degree of disentanglement of fibril in the craze. The rate of crack healing may be a function of environmental factors such as healing temperature, time and pressure which gives different contact configurations between two separated surfaces. It seems to be reasonable to assume that the crack healing processes may be divided in several distinguished steps like stress relaxation with molecular chain arrangement, surface contact (wetting), inter- diffusion process and com;oete healing (to obtain the original strength). In this context, it is likely that we no longer have to accept the limitation of cumulative damage theories and fatigue life if it is probable to remove the defects such as crack, craze and void and to restore the original strength of polymers or polymer based compowites by suitable choice of healing histories and methods. In this paper, we wish to present a very simple and intuitive theoretical model for the prediction of healed fracture toughness of cracked or defective polymeric components. The central idea of this investigation, thus, may be the modeling of behavior of chain molecules under healing conditions including the effects of chain scission on the healing processes. The validity of this proposed model will be studied by making comparisons between theoretically predicted values and experimentally determined results in near future and will be reported elsewhere.

• Journal of The Korean Association For Science Education
• /
• v.32 no.2
• /
• pp.388-401
• /
• 2012

This study attempted to propose a theoretical model for STEAM education, entitled to the Ewha-STEAM education model, which could provide more concrete guidelines for science educators and curriculum developers to execute STEAM ideas. We identified key knowledge and key competencies to nurture future creative/convergent human resources. Key knowledge included an understanding of core ideas cutting across traditional disciplinary boundaries as well as the nature of different disciplines. And additionally, key competencies implied such abilities as to explore the scientific world, to resolve problems, and to communicate and collaborate with others. We also added creativity and character as an essential part of key competencies. In order to provide more specific guidelines when developing, implementing, and evaluating STEAM curriculum, we suggested three elements of convergence to consider: 1) unit of convergence (i.e. concept/skills, problem/phenomenon, activity), 2) degree of convergence (i.e. multi-disciplinary, inter-disciplinary, extra-disciplinary), and 3) context of convergence (i.e. personal, societal, global). It is expected that the Ewha-STEAM education model would contribute towards diverse education communities understanding the direction of STEAM education and its educational potentials.

• Journal of Advanced Navigation Technology
• /
• v.2 no.1
• /
• pp.61-67
• /
• 1998

In this paper, we have described the Ramp Activity Coordination Expert System (RACES) which can solve aircraft parking problems. RACES includes a knowledge-based scheduling problem which assigns every daily arriving and departing flight to the gates and remote spots with the domain specific knowledge and heuristics acquired from human experts. RACES processes complex scheduling problem such as dynamic inter-relations among the characteristics of remote spots/gates and aircraft with various other constraints, for example, custome and ground handling factors at an airport. By user-driven modeling for end users and knowledge-driven near optimal scheduling acquired from human experts, RACES can produce parking schedules of aircraft in about 20 seconds for about 400 daily flights, whereas it normally takes about 4 to 5 hours by human experts. Scheduling results in the form of Gantt charts produced by the RACES are also accepted by the domain experts. RACES is also designed to deal with the partial adjustment of the schedule when unexpected events occur. After daily scheduling is completed, the messages for aircraft changes and delay messages are reflected and updated into the schedule according to the knowledge of the domain experts. By analyzing the knowledge model of the domain expert, the reactive scheduling steps are effectively represented as rules and the scenarios of the Graphic User Interfaces (GUI) are designed. Since the modification of the aircraft dispositions such as aircraft changes and cancellations of flights are reflected to the current schedule, the modification should be notified to RACES from the mainframe for the reactive scheduling. The adjustments of the schedule are made semi-automatically by RACES since there are many irregularities in dealing with the partial rescheduling.

• Journal of the Korean Regional Science Association
• /
• v.13 no.2
• /
• pp.55-74
• /
• 1997

This paper investigates the spatial characteristics of networks, which arise as a firm's strategy to enhance its competitiveness to cope with the changing economic environments characterized by technological changes and increasing competitiveness. The theoretical framework in this study proposes that networks emerge as a firm's strategies to promote its competitiveness through the vertical/horizontal disintegration of the production system. Futhermore, regional industries of networks. The study examines the types of cooperation and the spatial boundary of the computer industry networks in Korea. Questionnaire survey was conducted on 1, 128 computer companies which had more than 10 employees, with 126 questionnaires being used for analysis. In addition, newpaper articles were used to supplement the foregoing work on network characteristics. The review of these articles covers the period from Jan. 1994 to June 1996. Major findings of this study are as follows: The spatial range of cooperative networks varies according to the specific characters of cooperation(R & D, production, and seles). Intralocal networks are being developed in Kangnam and Youido area, the computer industry agglomeration clusres of Seoul. There are the regional differnces in the agents and contents of cooperation. In intra-national R & D and production networks, regional differnces in agglomeratins and non-agglomerations are not detercted. Most networks of this type are found between large firms and small firms. In contrast, foregn R & D and production networks, which are operated mostly by large firms, are found in Kangnam, Youido, and CBD. Intra-national and foreign productino networks are also focused in Kangnam, Youido, and CBD. Small firms are playing an active role in making this type of cooperation possible. In the perspective of localization-globalization, Korean computer industry can be analyzed in two respects: industrial and regional. The localization of small firms and the localization-globalization of large firms' networks are being developed in industrial contexts, while the localization-globalization of agglomerations and the localization of non-agglomerations networks are being developed in regional contexts. As networks for the localization-globalization of industry are growing in agglomerations, interfirm networks could be related to trends in the formation or intensification of industrial agglomerations. industrial agglomeration areas function as a facilitator of localization through subcontracts, intraregional network and interregional network. They also facilitate globalization via foregn networks. In non-agglomeratin areas, localization networks, which are connected with agglomeration areas via subcontracting, interregional R & D. or production cooperation.

• The Korean Journal of Pesticide Science
• /
• v.2 no.1
• /
• pp.79-84
• /
• 1998

This study was conducted to obtain information on occurrance ecology of Aneilema keisak Hassk. and establish its effective control system in direct-seeded rice. Optimum germination temperature and storage temperature to break dormancy were $22^{\circ}C$ and $4^{\circ}C$, respectively. Optimum content of soil moisture for germination was 35%(w/w) in clay loam soil, where recorded 85% of germination rate. In the inter-specific competition between density of Aneilema keisak Hassk. and constant rice-mixed stands, the plant height and the tiller of rice were decreased with increase of density of Aneilema keisak Hassk. Among the herbicides tested, piperophos+dimethametryn(8.2+2.2 g ai/10a) GR and. pyrazosulfuron-ethyl+mefenacet(2.1 + 105 g ai/10g) GR were found to be effective for control of Aneilema keisak Hassk., having more herbicidal effect with an earlier application.