• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6267-6272
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• 2015

Background: Extra nodal lymphoma (ENL) constitutes about 33 % of all non-Hodgkin's lymphoma. 18-28% develops in the head and neck region. A multimodality treatment with multi-agent chemotherapy (CT) and radiotherapy (RT) is considered optimum. Materials and Methods: We retrieved the treatment charts of patients of HNENL treated in our institute from 2001-2012. The charts were reviewed and the demographic, treatment details and outcome of HNENL patients were retrieved using predesigned pro-forma. Results: We retrieved data of 75consecutive patients HNENL. Median age was 47years (Range: 8-76 years). Of the 75 patients 51 were male and 24 were female. 55patients were evaluable. The patient and tumor characteristics are summarized in Table 1. All patients were staged comprehensively with contrast enhanced computed tomography of head, neck, thorax, abdomen, pelvis and bone marrow aspiration and biopsy 66 patients received a combination multi-agent CT with CHOP being the commonest regimen. 42 patients received 4 or lesser number of cycles of chemotherapy whereas 24received more than 4 cycles chemotherapy. Post radiotherapy, 41 out of 42 patients had a complete response at 3 months. Only 21patients had a complete response after chemotherapy. All patients received radiation (mostly involved field radiation) as a part of the treatment. The median radiation dose was 45 Gray (Range: 36 Gray-50 Gray). The radiation was planned by 2D fluoro simulation based technique in 37cases and by 3 Dimensional conformal radiation therapy (3DCRT) in 36 cases. Two patients were planned by the intensity modulated radiation therapy (IMRT) technique. IMRT was planned for one thyroid and one nasal cavity primary. 5 patients experienced relapse after a median follow up of 19 months. The median survival was not reached. The estimated two and three year survival were 92.9% (95%CI- 68.6- 95.35) and 88% (95%CI- 60.82 - 92.66) respectively. Univariate analysis revealed higher stage and poorer baseline performance status to be significantly associated with worse progression free survival. 5 patients progressed (relapse or primary disease progression) after treatment. Of the 5 patients, two patients were primary orbital NHL, two patients had NHL nasal cavity and one was NHL thyroid. Conclusions: Combined modality treatment in HNENL confers excellent disease control with acceptable side effects.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권1호
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• pp.43-49
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• 1999

연구 목적：소아를 다루는 임상의들에게 관찰되는 가장 흔한 발달상의 문제 중 하나는 언어 지연이다. 언어 발달은 주변 환경의 자극에 영향을 받게 되는데, 환경과의 상호 작용에는 아동 자신의 기질 또한 중요한 요소로 작용한다. 기질 연구의 가설에 의하면 아동의 고유한 행동 양식은 상당 부분 타고난 것이며, 이것이 향후 발달에 큰 영향을 미친다고 알려져 있는데, 아동의 기질과 언어 지연과의 관계에 대한 연구는 활발치 않아, 본 연구는 한국에서 의사 소통 장애를 가진 아동에서 어떤 기질 특성이 있는지를 밝히고자 했다. 방 법：환자군은 DSM-IV 진단 기준에 의해 의사 소통 장애라고 진단되고, 전반적 발달 장애, 정신 지체, 언어 운동 장애 혹은 감각 장애를 갖지 않은 세 살에서 일곱 살 사이의 아동 20명을 대상으로 하고 정상대조군은 상기 장애를 갖지 않는 50명을 대상으로 하여 어머니에게 한국판 '부모 기질 설문(Parental Temperamental Questionnaire)'을 완성하도록 하여 기질을 측정하였다. 기질의 9가지 범주 및 요인 A점수를 비교하기 위하여 비모수적 통계법을 사용하였으며, 아동들의 기질 진단을 비교하기 위하여 Chi-square통계법을 사용하였다. 결 과：의사 소통 장애를 가진 아동들에서 정상 아동들에 비해 기분의 범주는 통계적으로 유의하게 낮았고, 반응의 강도의 범주는 통계적으로 유의하게 높았다. 기질 진단 면에서는 두 집단은 통계적으로 유의한 차이를 보이지 않았지만 의사 소통 장애를 가진 아동들이 양육 곤란형에 가까운 집단에 더 많이 포함되었다. 결 론：이와 같은 결과는 의사 소통 장애를 가진 아동들에 특징적인 기질 양상이 있음을 시사한다. 기질양상의 조기 발견은 부모들에게 의사 소통 장애 아동들의 발달학적 특성을 이해하고 이들에게 적절한 양육을 제공하는데 도움을 줄 것이다.

• 한국환경생태학회지
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• 제30권4호
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• pp.793-799
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• 2016

본 연구는 도심지 공원 내 식재된 버즘나무와 느릅나무를 대상으로 수관 내부의 온도, 풍량, 풍속 등 미기후 인자간의 상호관계를 규명하는데 그 목적이 있다. 현장조사는 여름철, 8월 한 달간 오전 09시부터 오후 06시까지 1시간 간격으로 측정하였다. 미기후 인자 측정 항목은 광량자센서(PAR Quantum Sensor SKP215), 정밀온도계측기(Pt1000-Sensor), 풍량풍속계(1467 G4 & HG4)를 이용하여 온도, 광량, 풍량 및 풍속 데이터를 수집하였다. 분석 결과, 버즘나무와 느릅나무는 두 종 모두 외부 온도에 비해 수관 내부에서 냉각효과가 있음이 입증되었다. 수관 내부의 냉각효과는 대기 중의 풍량과 풍속이 있을 때 더 효과적이었다. 바람이 있을 때, 버즘나무는 풍량에 의해 수관 내부의 온도가 더 낮아지며, 느릅나무는 풍속에 의해 수관 내부의 온도가 더 낮아지는 것으로 확인되었다. 바람이 없을 때, 두 종간 수관 내 평균온도 변화는 평균적으로 느릅나무가 $-0.9^{\circ}C$, 버즘나무가 $-0.958^{\circ}C$로 버즘나무가 느릅나무보다 식재 공간 내 온도를 낮추는데 비교적 더 효과적이었다. 본 연구는 도심 내 수목이 종별로 미기후에 미치는 영향에 차이가 있으며 또한, 수목의 미기후 형성에 영향을 미치는 인자들이 수종별로 다를 수 있음을 밝혔다는데서 의의가 있다. 향후 활엽교목 이외에 상록수, 관목류 등 다양한 수종 등에 대한 후속 연구가 필요하며, 이를 통해 도시 녹지 공간 내 미기후 조절에 효과적인 조경수를 보급하는데 기여할 것으로 사료된다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.127-127
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• 2017

Aluminum is the most abundant metallic element in the Earth's crust and considered as the most limiting factor for plant productivity in acidic soils. The inhibition of root growth is recognized as the primary effect of Al toxicity. Seeds of wheat cv. Keumkang (Korean cultivar) were germinated on petridish for 5 days and then transferred hydroponic apparatus which was treated with $0{\mu}M$ $AlCl_3$ (control), $100{\mu}M$ $AlCl_3$ and $150{\mu}M$ $AlCl_3$ for 5 days. The length of roots, shoots and fresh weight of wheat seedlings were decreased under aluminum stress. The concentrations of $K^+$, $Mg^{2+}$ and $Ac^{2+}$ were decreased whereas $Al^{3+}$ and $P_2O_5{^-}$ concentration was increased under aluminum stress. Using confocal microscopy, the fluorescence intensity of aluminum was increased with morin staining. In this study, a proteome analysis was performed to identify proteins, which is responsible to aluminum stress in wheat roots. In 10-day-old seedlings, proteins were extracted from roots and separated by 2-DE, stained by CBB. Using image analysis, a total of 47 differentially expressed protein spots were selected, whereas 19 protein spots were significantly up-regulated such as s-adenosylmethionine, oxalate oxidase, malate dehydrogenase, cysteine synthase, ascorbate peroxidase and 28 protein spots were significantly down-regulated such as heat shock protein 70, o-methytransferase 4, enolase, amylogenin by aluminum stress following protein spots analyzed by LTQ-FTICR mass spectrometry. The results provide the global picture of Al toxicity-induced alterations of protein profiles in wheat roots, and identify the Al toxicity-responsive proteins related to various biological processes that may provide some novel clues about plant Al tolerance.

• 한국암반공학회:학술대회논문집
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• 한국암반공학회 2000년도 암반공학문제의 수치해석(Numerical Analysis in Rock Engineering Problems)
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• pp.67-75
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• 2000

암석의 파괴인성 측정법으로서 최근에 연구되고 있는 Brazilian 파괴인성 시험을 PFC code를 이용하여 수치해석적으로 시뮬레이션하였다. 이로부터 가압면 형태, 시험편과 모델링 입자의 크기 관계, 가압면 각도 범위, 하중속도 등의 영향 변수에 대한 분석 및 적정 기준에 대해 검 토하였다. 균등한 하중 전달을 위해 가압면이 평면인 Brazilian 시험편을 도입하였는데, 시험편 중앙에서 초기 인장균열을 생성하고 파괴인성 산정에 필요한 안정한 인장균열 진전 시점의 임계하중이 나타나는 하중-변위 곡선을 얻을 수 있는 가압면 각도는 $20^{\circ}C$ -$40^{\circ}C$ 범위로 나타났다. 가압면 각도가 $20^{\circ}C$ 인 경우에, 디스크 시험편의 구성입자 반경이 1 mm 이하이고 하중속도가 0.01 mm/s 이하인 조건에서는 거의 일정한 파괴인성값을 얻을 수가 있었다. 가압면 각도가 $20^{\circ}C$이상이고 하중속도가 0.01 mm/s 이하는 파괴인성 측정에서 중요한 기본 조건인 시험편 중 에서의 인장균열 생성 및 이 인장균열의 안정적인 진전 제어를 위한 조건인 것으로 볼 수가 있다.

• 터널과지하공간
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• 제10권3호
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• pp.320-328
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• 2000

암석의 파괴인성 측정법으로서 최근에 연구되고 있는 Brazilian 파괴인성 시험을 PFC code를 이용하여 수치 해석적으로 시뮬레이션하였다. 이로부터 가압면 형태, 시험편과 모델링 입자의 크기 관계, 가압면 각도 범위, 하중속도 등의 영향 변수에 대한 분석 및 적정 기준에 대해 검토하였다. 균등한 하중 전달을 위해 가압면이 평면인 Brazilian 시험편을 도입하였는데, 시험편 중앙에서 초기 인장균열을 생성하고 파괴인성 산정에 필요한 안정한 인장균열 진전 시점의 임계하중이 나타나는 하중-변위 곡선을 얻을 수 있는 가압면 각도는 20$^{\circ}$~40$^{\circ}$범위로 나타났다. 가압면 각도가 20$^{\circ}$인 경우에, 디스크 시험편의 구성입자 반경이 1mm 이하이고 하중속도가 0.01mm/s 이하인 조건에서는 거의 일정한 파괴인성값을 얻을 수가 있었다. 가압면 각도가 20$^{\circ}$이상이고 하중속도가 0.01mm/s 이하는 파괴인성 측정에서 중요한 기본 조건인 시험편 중앙에서의 인장균열 생성 및 이 인장균열의 안정적인 진전 제어를 위한 조건인 것으로 볼 수가 있다.

• 대한방사선기술학회지:방사선기술과학
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• 제32권4호
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• pp.371-380
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• 2009

병원규모에 따라 조직문화와 인사체계가 다르기 때문에 이들 병원에서 근무하는 방사선사의 이직요인에 차이가 있을 가능성이 충분히 있으므로, 본 연구는 대전광역시 지역 종합병원과 개인병원에 근무하는 방사선사를 대상으로 이들의 이직의사 수준을 알아보고 이직의사와 인구사회학적 특성, 직업관련 특성, 직무스트레스요인, 직무만족도, 직무성과, 조직몰입 등의 제 요인과의 관련성을 알아보고자 하였다. 2008년 6월 1일부터 6월 30일까지 대전소재 5개 종합병원에서 근무하는 방사선사 158명, 의원에 종사하는 방사선사 117명 총 275명을 대상으로 자기기입식 설문조사(self-administered questionnaire)를 실시하였다. 위계적 다중회귀분석을 실시한 결과 개인병원은 교육수준, 직무스트레스 중 업무요구도, 직무만족도가 이직의사에 영향을 미쳤으며, 종합병원은 연령, 근무기간, 직무만족도, 조직몰입이 이직의사에 영향을 미쳤다. 이는 병원의 인사관리 및 조직관리 시 자료로 고려되어야 할 것으로 생각된다.

• 한국학교보건학회지
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• 제12권2호
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• pp.321-337
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• 1999

The purpose of this study was to obtain basic data for the prevention and control of adolescent back pain through analyzing connections between study environments and physical posture. The subjects were 960 male general high school students in the Chonju area and the data were collected by a self-reported questionnaire from Mar. 17 to Mar. 22, 1999. The collected data were analyzed by a frequency, chi-square and t-test using an SPSS program. The results are as follows; 1) The experience rate of back pain perceived by subjects was 67.5% and by each grade: 1st-27.5%, 2nd-35.4%, 3rd-37.1%. The relationship between grades and the experience of back pain didn't show any significant difference. 2) The causes of back pain perceived by subjects such as 'postures are not good' was 56.7%, 'sitting too much time in a chair' was 39.1%, and 'too severe exercise' was 32.4%. 27.8% had back pain first during the 3rd grade of middle school, and 23.9% had it first during the 1st grade of high school. 3) Intensity of subjects' back pain spread from 'moderate' at 49.6%, to 'severe' at 16.4%. Concerning the frequency of back pain, 58.6% said it was 'irregalar'. 4) Among interventions to deal with back pain: 'move by exercising my back or ask friends to beat my back' was 41.0%, 'just bear it' was 23.1%, and at home 'don't have 'any treatment' was ranked first, at 54.9%. 5) The relationship between subjects' general characteristics and back pain experiences: height (t=-1.99, P=.046), sitting/height (t=-2.61, P=.009), self-perceived condition of health (${\chi}^2=23.530$, P=.000), family history (${\chi}^2=43.903$, P=.000) showed significant difference, but the kinds of transportation, sleeping postures, sleeping method and smoking didn't show significant differences. 6) The relationship between subjects' learning environment and back pain experiences, the height of students' desk and chair showed significant difference (${\chi}^2=23.054$, P=.000), but the sitting time didn't show significant difference. 7) The relationship between the characteristics of subjects' physical postures and back pain experiences: standing postures (${\chi}^2=15.105$, P=.001), and sitting postures (${\chi}^2=20.264$X2, P=.001) showed significant difference, but lifting postures didn't show significant difference.

• 대한치과기공학회지
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• 제32권3호
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• pp.195-207
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• 2010

Purpose: The purpose of this study was to observe the microstructural changes of surface in the specimens, performing the shear bond strength testing. The currently most used non-precious alloys are nickel-chromium based alloys with or without beryllium. However, their biocompatibility has been questioned concerning possible damages to the health of the patient and professionals involved in the fabrication of prosthesis caused by long exposure to Ni and Be. An option to nickel-chromium alloys is the cobalt-chromium alloy, an alternative that does not sacrifice the physical properties of the metal porcelain systems. Studies in the animals substantially show that the cobalt-chromium alloys are relatively well tolerated, being therefore more biocompatible than the nickel-chromium alloys. Methods: Non-addition Be to nickel-chromium based alloy(Bellabond plus) and cobalt-chromium alloy which has been widely used(Wirobond C) fused with ZEO light porcelain classified control group and cobalt-chromium alloy which is developing alloy of Alphadent company in Korea(Alphadent alloy) fused with ZEO light porcelain classified experimental group. The specimens of $4mm{\times}4mm{\times}0.5mm$ were prepared as-cast and as-opaque to cast body to analyze the mechanical characteristic change, the microstructure of alloy surface. The phase change was used to observe through XRD analysis and OM/SEM was used to observe the surface of specimens as-cast and as-opaque to cast body. Chemical formation of their elements was measured with EDS. Then hardness was measured with Micro Vicker's hardness tester. Shear bond strength test thirty specimens of $10mm{\times}10mm{\times}2mm$ was prepared, veneered, 3mm high and 3mm in diameter, over the alloy specimens. The shear bond strength test was performed in a universal testing machine(UTM) with a cross head speed of 0.5mm/min. Ultimate shear bond strength data were analyzed with one-way ANOVA and the Scheffe's test (P<0.05). Within the limits of this study, the following conclusions were drawn: The X-ray diffraction analysis results for the as-cast and as-opaque specimens showed that the major relative intensity of Bellabond plus alloy were changed smaller than Wirobond C and Alphadent Co-Cr based alloys. Results: Microstructural analysis results for the opaque specimens showed all the alloys increased carbides and precipitation(PPT). Alphadent Co-Cr based alloy showed the carbides of lamellar type. The Vickers hardness results for the opaque specimens showed Wirobond C and Alphadent Co-Cr based alloys were increaser than before ascast, but Bellabond plus alloy relatively decreased. The mean shear bond strengths (MPa) were: 33.11 for Wirobond C/ZEO light; 25.00 for Alphadent Co-Cr alloy/ZEO light; 18.02 for Bellabond plus/ZEO light. Conclusion: The mean shear bond strengths for Co-Cr and Ni-Cr based alloy were significantly different. But the all groups showed metal-metal oxide modes in shear bond strengths test at the interface.

• 한국환경보건학회지
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• 제14권2호
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• pp.73-87
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• 1988

This study was performed to investigate the effect of lactose in 4 different concentrations against the protective effect of calcium on the acute lead poisoning in rats after 4 weeks treatment. In this animal experiment, 70 albino male weanling rats (50-70g of body weight) of Sprague-Dawley strain were used. Lead was dissolved in the distilled water and intubated at the dose of 400mg lead (as acetate)/ kg of body weight/day. Calcium and lactose were administered in drinking water ad libiturn dissolved with the solution of 0.7% calcium gluconate mixed with 40, 80, 160 and 320mM lacotse respectively. The results obtained were summarized as follows: 1. The rate of body weight gain in all treated groups turned out to be lower than that in the control group during 4 weeks treatment. The slow-down of body weight gain was the most significantly observed in the group treated with lead only ( p < 0.05). 2. The relative spleen weight in lead only treated group was significantly lower than that of lead + calcium, lead + calcium + 80mM lactose treated group ( p < 0.05). 3. The value of RBC, WBC, Hb and Hct showed a decreasing tendency in the group treated with lead only ( p < 0.05), however, a significant decrease was not observed in the group treated with lead + calcium. On the other hand, the protective effect of calcium was deteriorated in the group treated with lead + calcium + lactose. 4. The activity of $\delta$-aminolevulinic acid dehydratase ($\delta$-ALAD activity) showed the same tendency as No. 2. 5. The lead concentration in the blood (PbB) showed an increasing tendency and the interrelation among the different groups was also identical with No. 2. 6. With a statistical approach, it was found out that the activity of $\delta$-ALAD and the lead concentration in the blood show a relation of inverse proportion(r=-0.7301). The diagram was interpreted with the logarithmic equation InY = 5.5357-0.0251X (X:PbB, Y:$\delta$-ALAD activity). 7. In the histopathological findings of the kidney, the protective effect of calcium was observed. However, the protective effect of calcium was restricted in the group treated with lead + calcium + lactose. As a conclusion, the intensity of the acute ingested lead poisoning was obviously reduced by calcium, however, the protective effect of calcium was deteriorated in proportion with the concentration of the lactose to be administered. On the other hand, it was also noted that the deterioration was lightly restrained in the group treated with the physiological concentration of 80mM lactose than the results shown in the groups treated with lactose of other concentrations.