• Journal of The Korean Society of Integrative Medicine
• /
• v.12 no.2
• /
• pp.197-210
• /
• 2024

Purpose : This study aimed to analyze research trends in the field of integrative medicine through a bibliometric analysis of articles published in Integrative Medicine Research (IMR) journal from 2017 to 2022. Methods : Articles published in IMR journal between 2017 and 2022 were searched using the Web of Science database on August 22, 2023. The analysis was performed using the Bibliometrix and Biblioshiny tools in R (version 4.3.1) and VOSviewer (version 1.6.19). Results : The key findings were as follows: average citations per article (9.41), total authors (1,142), single-authored articles (12), average articles per author (0.27), average co-authors per article (5.27), and rate of international co-authorships (15.69 %). The most-cited article was on the cryopreservation of cells or tissues and their clinical applications. The top keyword analysis by author keywords showed that "acupuncture" was the most frequently used keyword (33 times). Co-occurrence network analysis showed 85 high-frequency keywords that appeared five or more times, and the top five keywords by total link strength were "acupuncture," "herbal medicine," "prevalence," "alternative medicine," and "complementary." The study found that, contrary to the trend in complementary and alternative medicine research in Korea, the IMR journal actively conducts intervention studies to provide clinical evidence. Conclusion : In the IMR journal, "acupuncture" was the most frequent of author keywords. The analysis of keyword trend topics over time showed that the keyword "systematic review" continued to appear from 2020 to 2022, and the keyword "clinical practice guideline" appeared for the first time in 2021. In particular, the co-occurrence network analysis highlighted keywords related to intervention research, in contrast to domestic research trends. While this study analyzed only one journal, future studies expanding the category of integrative medicine and increasing the number of journals analyzed may provide further insights.

• Journal of Korean Traditional Oncology
• /
• v.12 no.1
• /
• pp.1-13
• /
• 2007

• Korean Journal of Oriental Medicine
• /
• v.17 no.3
• /
• pp.35-42
• /
• 2011

Objectives : The terms, CAM and Integrative Medicine, have been often used to conceptualize relation between TKM and western medicine in Korea. But both terms often lead to confusion since the backgrounds of those were not being properly discussed. Methods : We researched the concepts of CAM and Integrative Medicine through the changes in definitions and research methods. Results : Although modern medical verification of CAM showed some results through scientific researches, there existed certain limitations. The term Integrative Medicine newly emerged for this reason. The rise of the new term came to criticize existing research methodologies such as RCTs or SRs. However in Korea, Integrative Medicine has often been misunderstood as a unification of two different medical systems. Conclusions : Thus, in future research of relationship between TKM and western medicine, debates on plausibility & philosophical background of TKM, and research methodology are indispensable.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2020.06a
• /
• pp.157-157
• /
• 2020

• Journal of Korean Medicine Rehabilitation
• /
• v.28 no.1
• /
• pp.53-60
• /
• 2018

Objectives The purpose of this study is to analyze research trends on Eastern-Western integrative medicine in Korea. Methods We searched the studies on Eastern-Western integrative medicine in 5 Korean web database (NDSL, KoreanTK, KISS, OASIS, DBPIA). 66 research papers we founded. Results 13 papers were published at 2010. The studies on Eastern-Western integrative medicine were mainly published in the Journal of Society of Preventive Korean Medicine. 24 papers were case report, include 7 studies on neurology, 4 studies on each oncology and dermatology, 2 studies on each gastroenterology and ophthalmology and otorhinolaryngology, 1 study on each obstetrics and gynecology and endocrinology and nephrology. In 24 case reports, 7 kinds of Eastern medicine treatment method and 4 kinds of Western medicine treatment method were existed. In case reports, medication (100%), herbal medicine, acupuncture (95.8%), moxibustion (58.3%), cupping, infusion solution (25%), pharmacopuncture (20.8%), physical therapy (12.5%), laser, injection, rehabilitation (8.3%) were used. Conclusions In this study, we analyzed the trends of Eastern-Western integrative medicine in korea from 2010 to 2017. There were various studies about Eastern-Western integrative medicine. In case reports, Eastern-Western integrative medicine tend to concentrated on treatment not diagnosis. Not only treatment but also diagnosis is needed in Eastern-Western integrative medicine studies.

• Journal of Korean Medicine Rehabilitation
• /
• v.21 no.4
• /
• pp.87-96
• /
• 2011

Objectives: This study aims to systematically evaluate the effectiveness of Eastern-Western integrative medicine for musculoskeletal disorders compared with Eastern or Western Medicine. Methods: Systematic sea-mes of 9 major Korean databases were conducted for articles published up to July 2011. Searching keyword was "Integrative Medicine". Prospective studies dealt with musculoskeletal disorders by Eastern-Western integrative medicine were included. Quality assessment of included studies was evaluated by Cochrane risk of bias tool. Results: 470 studies in total were seamed, Amalg them 7 studies met our inclusion criteria(3 randomized controlled clinical trials, 2 non-randomized controlled trials and 2 uncontrolled clinical trials). Included studies dealt with lumbar pan(3), shoulder pain(2), pain after traffic injury(1), spinal compression fracture(1). Eastern-Western integrative medicine showed better or equal effect for the treatment of various muscloskeletal disorders compared with Eastern or Western medicine alone. Conclusions: There is very weak evidence for the effectiveness of Eastern-Western integrative medicine for musculoskeletal disorders compared with Eastern or Western medicine alone. Well designed randomized controlled trials with rigorous methodology are needed to evaluate the effectiveness of Eastern-Western integrative medicine objectively in the future.

• Journal of The Korean Society of Integrative Medicine
• /
• v.9 no.1
• /
• pp.69-90
• /
• 2021

Purpose : This study explores unmet medical services within a region for patients admitted to a single medical institution in one region and was to analyze the importance and satisfaction of hospital selection attributes. Through this, we tried to solve the unmet medical needs of patients and provide useful basic data in terms of hospital management in the region. Methods : It were collected to a total of 250 questionnaires for patients admitted to the regional integrative medical hospital. However, 232 samples were used for the final analysis, excluding 18 copies not reported in good faith. For the analysis, first, demographic frequency analysis of inpatients and inpatients was performed, and second, characteristics of patients, including frequent disease receiving treatment, were analyzed. Next, descriptive statistics analysis was conducted on unmet medical service intentions. In terms of hospital selection attribute, the items of continuity maintenance (I quadrant), priority visibility (II quadrant), low priority (III quadrant), and excessive effort (IV quadrant) were derived using the IPA (importance-performance analysis) matrix technique. Results : The derived results were classified by item and area. In the priority administration area, it was the reputation and recognition of medical institutions and the service area of medical institutions. In the case of items, there were 6 items including the importance of surgery and medical expenses, and diet at hospitalization. 1) Conclusion : Thus a result of this study, resources are efficiently allocated to priority correction areas with high importance but low satisfaction and circulatory medical treatment is performed in the departments required by patients who use medical care and, various methods, such as preparing a policy to support medical expenses, should be sought.

• Korean Journal of Agricultural Science
• /
• v.38 no.2
• /
• pp.295-299
• /
• 2011

The content of hesperidin in the mixed tea, which was composed of dried orange peel, laurel leaf, mulberry leaf, silver magnolia leaf, oriental melon tap, cassia seed, and licorice root, was determined by high performance liquid chromatography (HPLC). Hesperidin was quantified by a reverse phase column with gradient solvent system (watcr:acetonitrile = 80:20 to 35:65 for 30 min) and UV/VIS detection (280 nm). The How rate was kept constant at 1.0 ml/min. The content of hesperidin in the mixed tea was measured in depending on extraction time 1, 2, 3, and 4 min (29.07, 52.39, 52.45, and 88.35 mg/g, respectively).

• Journal of the Korean institute of surface engineering
• /
• v.57 no.2
• /
• pp.71-85
• /
• 2024

This article provides an overview of Raman spectroscopy and its practical applications for surface analysis of semiconductor processes including real-time monitoring. Raman spectroscopy is a technique that uses the inelastic scattering of light to provide information on molecular structure and vibrations. Since its inception in 1928, Raman spectroscopy has undergone continuous development, and with the advent of SERS(Surface Enhanced Raman Spectroscopy), TERS(Tip Enhanced Raman Spectroscopy), and confocal Raman spectroscopy, it has proven to be highly advantageous in nano-scale analysis due to its high resolution, high sensitivity, and non-destructive nature. In the field of semiconductor processing, Raman spectroscopy is particularly useful for substrate stress and interface characterization, quality analysis of thin films, elucidation of etching process mechanisms, and detection of residues.

• BMB Reports
• /
• v.57 no.6
• /
• pp.299-304
• /
• 2024

Upregulation of PRAME (preferentially expressed antigen of melanoma) has been implicated in the progression of a variety of cancers, including melanoma. The tumor suppressor p53 is a transcriptional regulator that mediates cell cycle arrest and apoptosis in response to stress signals. Here, we report that PRAME is a novel repressive target of p53. This was supported by analysis of melanoma cell lines carrying wild-type p53 and human melanoma databases. mRNA expression of PRAME was downregulated by p53 overexpression and activation using DNA-damaging agents, but upregulated by p53 depletion. We identified a p53-responsive element (p53RE) in the promoter region of PRAME. Luciferase and ChIP assays showed that p53 represses the transcriptional activity of the PRAME promoter and is recruited to the p53RE together with HDAC1 upon etoposide treatment. The functional significance of p53 activation-mediated PRAME downregulation was demonstrated by measuring colony formation and p27 expression in melanoma cells. These data suggest that p53 activation, which leads to PRAME downregulation, could be a therapeutic strategy in melanoma cells.