• 대한한방내과학회지
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• 제41권6호
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• pp.1141-1161
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• 2020

Objectives: Parkinson's disease (PD) is a neurodegenerative disease of the elderly characterized by impaired behavior from lack of dopamine secretion. However, no accurate quantitative diagnosis method has been established. The purpose of this study was to analyze the patent trends (PTs) of health examination and daily monitoring/healthcare technology for PD. Methods: For analyzing PTs, a search summary for classifying each analysis target technology was set, and a final search formula was constructed by collecting keywords. After constructing a database of related patents through the final search formula, noise was removed to extract valid patents. PTs by major countries were analyzed using the valid patents, and PTs and growth stages were analyzed by the detailed technologies. Results: The survey analysis showed that, despite the existence of unpublished patents between 2018 and 2020, patent activity has increased rapidly in the recent period, and this increasing trend was led by the USA. This technology is considered to be in its early- or mid-stage growth period, which means that the marketability is high and the barriers are low. Korea's market share is only about 25%, but it has a larger number of applications than those of Europe and Japan. Integrated monitoring and diagnosis technologies for PD have a share of 34%. Conclusion: The advances in diagnosis and healthcare technology for PD means that traditional Korean medicine must continue to pay attention to related technologies and to review plans that are applicable to clinical practice.

• 대한물리치료과학회지
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• 제28권1호
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• pp.33-45
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• 2021

Background: Children with cerebral palsy have difficulty acquiring motor skills through motor learning due to lack of motor planning of the central nervous system and musculoskeletal dysfunction. Motor learning is the acquisition or modification of movements with the aim of developing skilled movements and behaviors. Cerebral palsy improve motor function through motor learning, and effective motor learning mainly depends on practice parameters such as learning feedback. Therefore, we investigate the effect of motor learning in children with cerebral palsy and try to present the possibility of clinical application. Design: A systemic review. Methods: Research papers were published from Jan, 2010 to Dec, 2020 and were searched using PubMed and Medline. The search terms are 'task specific training' OR 'motor learning' OR 'feedback(Mesh term)' OR 'goal activity' AND 'cerebral palsy(Mesh term)'. A total of eight papers were analyzed in this study. The paper presented the quality level based on the research evidence, and also presented PEDro (Physiotherapy Evidence Database) scores to evaluate the quality of design studies in randomized clinical trials. Results: The results showed that motor learning coaching in children with cerebral palsy improved motor function in post and follow up tests. Also, self-control feedback of motor learning is more effective than external control feedback. 100% external control feedback of motor learning is effective in the acquisition phase and 50% external feedback of motor learning is effective in the retain phase. Conclusion: These results suggest that it will be an important data for establishing evidence on the effect of motor learning arbitration methods in children with cerebral palsy to develop clinical applicability and protocols.

• 한국운동역학회지
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• 제31권2호
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• pp.140-147
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• 2021

Objective: The purpose of this study is to identify the mechanism of changes in maximum voluntary torque with the magnitude and duration of pre-activation torque during voluntary isometric knee extension. Method: 11 male subjects (age: 25.91±2.43 yrs., height: 173.12±3.51 cm, weight: 76.45±7.74 kg) participated in this study. The subjects were required to produce maximal voluntary isometric torque with a particular pre-activation torque condition. The properties of pre-activation torque consisted of the combinations of 1) three levels of magnitude, e.g., 32 Nm, 64 Nm, 96 Nm, and 2) two levels of duration, e.g., 1 sec, and 3 sec; thus, a total of six conditions were given to the subjects. The force and EMG data were measured using the force transducers and wireless EMG sensor, respectively. Results: The results showed that the maximum voluntary torque increased the most with relatively large and fast (96 Nm, 1 sec) pre-activation condition. Similarly, with relatively large and fast (96 Nm, 1 sec) preactivation, it was found that the integrated EMG (iEMG) of the agonist muscles increased, while no significant changes in the co-contraction of the antagonist muscles for the knee extension. Also, the effect of pre-activation conditions on the rate of torque development was not statistically significant. Conclusion: The current findings suggest that relatively larger in magnitude and shorter in duration as the properties of pre-activation lead to a larger magnitude of maximal voluntary torque, possibly due to the increased activity of the agonist muscles during knee extension.

• 한국콘텐츠학회논문지
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• 제21권3호
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• pp.761-770
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• 2021

본 연구는 초등아동을 위해 학교 정규교육시간 이외의 시간에 마을에서 제공하는 돌봄서비스가 아동이 행복한 일상생활을 보장하는 돌봄, 즉 아동권리가 실현되는 정책으로 실현되고 있는지 현황과 개선점을 살펴보고자 한다. 방과후 돌봄은 생존권과 보호권은 물론 창의적인 교육활동과 주체적인 시민성장을 지원하는 통합적 방법으로서 중요하며, 코로나 상황을 맞아 공공의 역할이 더욱 강조되고 있다. 따라서 온종일돌봄 정책 중학교밖 돌봄의 주축이 되는 다함께돌봄 정책을 아동권리 관점에서 분석하였다. 분석결과, 보호자의 역할을 대신하는 보호권에 초점이 맞추어져 아동의 4대 권리를 충분히 보장하는 포괄적 정책으로서 한계점이 있었다. 안전한 돌봄공간 마련도 중요하지만 마을의 다양한 자원을 돌봄 콘텐츠로 적극 활용하여 놀면서 배우는 아동의 선택권 확대를 위한 정책설계가 부족하다. 이를 위한 공공의 역할은 서비스의 양적확대와 더불어 내용적 공공성인 책임성, 공정성, 민주성, 공익성을 담보하기 위한 보완이 요청된다. 다함께 돌봄 정책은 아직 실행초기인 정책으로, 아동권리 관점을 반영하여 유연한 공적돌봄 체계로 발전할 수 있는 정책 개선방향을 제언하였다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제10권6호
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• pp.201-210
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• 2021

무기체계에 탑재되는 항법소프트웨어의 기능요소들은 다양한 무기체계에 공통적으로 활용될 수 있는 가능성이 높은 것으로 식별되었다. 무기체계 항법소프트웨어 SPL 프레임워크는 다양한 무기체계에 적용되는 항법소프트웨어가 갖는 공통의 기능들을 표준화된 플랫폼으로 개발 및 관리하고, 이를 이용하여 유도무기, 무인기, 잠수함 등의 체계별 항법소프트웨어를 개발하는 방법론을 말한다. 본 논문에서는 SPL 기반 항법소프트웨어 개발 프로세스와 통합개발환경을 제시하고, SPL 프레임워크의 운영개념에 대해 설명한다. 프로세스에 관여하게 되는 참여자의 역할을 정의하고 각 역할자별 활동 시나리오를 도출함으로써 SPL 프레임워크의 운영개념을 정의한다. 제시한 운영개념은 여타 도메인에 SPL을 실현하기 위한 구체적인 지침 마련에 활용될 수 있을 것이다.

• 멤브레인
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• 제31권6호
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• pp.393-403
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• 2021

생체 내 변화에서 효소는 중요한 촉매이다. 효소의 안정성과 재사용성은 촉매 과정에서 중요한 요소이다. 적합한 기질에 효소 고정화는 특정 미세환경의 조성을 통해 효소 활동성을 높인다. 다양한 종류의 분리막이 각각의 생체적합성과 막 표면의 친수성/소수성 조절 용이도에 따라 기질로 사용되었다. 본 논문에서는 셀룰로스, 폴리아크릴로니트릴(PAN), 폴리디메틸실록산(PDMS), 폴리비닐리덴플루오라이드(PVDF), 폴리에테르설폰(PES) 고분자 분리막이 소개되고 토의되었다. 고정화 효소를 이용한 유기오염물의 생물적 분해는 제약 회사 및 섬유 회사 등에서 발생하는 오염물질을 친환경적으로 감소할 수 있는 방법이다. 효소 고정화 생물반응기(EMBR)로 기름의 가수분해를 제어할 수 있고 이를 통해 탄소 배출량 감소 및 환경오염을 줄일 수 있다. EMBR로 만들 수 있는 바이오에탄올과 바이오디젤은 화석 연료의 대체제이다.

• 수면정신생리
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• 제28권2호
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• pp.53-69
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• 2021

Sleep disorders, increasingly prevalent in the general population, induce impairment in daytime functioning and other clinical problems. As changes in cortical excitability have been reported as potential pathophysiological mechanisms underlying sleep disorders, multiple studies have explored clinical effects of modulating cortical excitability through non-invasive brain stimulation in treating sleep disorders. In this study, we critically reviewed clinical studies using non-invasive brain stimulation, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), for treatment of sleep disorders. Previous studies have reported inconsistent therapeutic effects of TMS and tDCS for various kinds of sleep disorders. Specifically, low-frequency repetitive TMS (rTMS) and cathodal tDCS, both of which exert an inhibitory effect on cortical excitability, have shown inconsistent therapeutic effects for insomnia. On the other hand, high-frequency rTMS and anodal tDCS, both of which facilitate cortical excitability, have improved the symptoms of hypersomnia. In studies of restless legs syndrome, high-frequency rTMS and anodal tDCS induced inconsistent therapeutic effects. Single TMS and rTMS have shown differential therapeutic effects for obstructive sleep apnea. These inconsistent findings indicate that the distinctive characteristics of each non-invasive brain stimulation method and specific pathophysiological mechanisms underlying particular sleep disorders should be considered in an integrated manner for treatment of various sleep disorders. Future studies are needed to provide optimized TMS and tDCS protocols for each sleep disorder, considering distinctive effects of non-invasive brain stimulation and pathophysiology of each sleep disorder.

• 기록학연구
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• 제73호
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• pp.125-159
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• 2022

이 연구는 부마항쟁 결락기록에 관한 수집 등의 기록화 방안을 마련하기 위하여 기록학적 수집방법론을 검토하고 Larry Hackman과 Joan Warnow-Blewett이 제시한 '도큐멘테이션 전략'의 실행모델을 적용하여 예비분석을 진행하였다. 먼저 부마항쟁을 개괄적으로 살펴보고, 효과적인 기록화 방안을 도출하기 위해서 범위를 마산항쟁으로 좁혀, 마산항쟁을 중심으로 예비분석을 수행하였다. 이어서 마산항쟁의 행위그룹의 유형과 활동을 분석하여 마산항쟁 도큐멘테이션의 영역을 정리하였다. 마지막으로 마산항쟁의 일부 행위그룹을 선정하여, 직접 기록을 조사하였다. 이를 토대로 결락기록의 현황 조사 및 분석, 수집정책 마련과 능동적 수집, 수집기록의 관리정책 수립 및 통합적 관리에 관한 세부적인 관리방안 등을 제시하였다.

• Molecules and Cells
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• 제45권6호
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• pp.365-375
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• 2022

Long non-coding RNAs (lncRNAs) may be important regulators in the progression of ankylosing spondylitis (AS). The competing endogenous RNA (ceRNA) activity of lncRNAs plays crucial roles in osteogenesis. We identified the mechanism of the differentially expressed lncRNA MALAT1 in AS using bioinformatic analysis and its ceRNA mechanism. The interaction of MALAT1, microRNA-558, and GSDMD was identified using integrated bioinformatics analysis and validated. Loss- and gain-of-function assays evaluated their effects on the viability, apoptosis, pyroptosis and inflammation of chondrocytes in AS. We found elevated MALAT1 and GSDMD but reduced miR-558 in AS cartilage tissues and chondrocytes. MALAT1 contributed to the suppression of cell viability and facilitated apoptosis and pyroptosis in AS chondrocytes. GSDMD was a potential target gene of miR-558. Depletion of MALAT1 expression elevated miR-558 by inhibiting GSDMD to enhance cell viability and inhibit inflammation, apoptosis and pyroptosis of chondrocytes in AS. In summary, our key findings demonstrated that knockdown of MALAT1 served as a potential suppressor of AS by upregulating miR-558 via the downregulation of GSDMD expression.

• 교육시설 논문지
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• 제28권6호
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• pp.3-13
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• 2021

Introduced in 2004 as an 'After-School Academy' policy, the 'After-School Care Class' has become a universal program for elementary schools over time. While the concept of public education service has expanded and changed in various ways including educational welfare, the physical environment of the care classroom has undergone fixed changes within the uniform classroom structure of a standardized school space. The purpose of this study is to identify spatial characteristics of care classroom through chasing and analysing changes in the care class space configuration from 2004 to the present. The findings are as follows. The plan of the early care classroom wasn't much different from the existing common classroom, and it was only in 2007 that the kitchen and floor heating appeared for the first time.From the 2015 standard plan, prominent differentiation of the space between learning activities and resting area was shown, but the spatial characteristics are nothing more than a division that utilizes ready-made furniture. A distinctive feature of the 2018 Seoul care classes are diversity. In the case of the care exclusive classrooms, the division between the support space and the main activity space became more clear using furniture integrated open walls and various floor levels. In the case of a shift classrooms that is used together with common classrooms, it is characterized by flexibility that allows dramatically different classroom configurations for each time period by using a convertible furnishing space.