• 생약학회지
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• 제42권2호
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• pp.161-168
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• 2011

Advanced glycation end products (AGEs) has been shown to play an important role in the development of the diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 69 China herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 28 herbal medicines $IC_{50}$=<50 ${\mu}g/ml$) were found to have stronger AGEs inhibitory activity compared with aminoguanidine ($IC_{50}$=59.77 ${\mu}g/ml$). Particularly, 5 herbal medicines, Camptotheca acuminata (stem, leaf), Eurya groffii (stem, leaf), Cornus Capitata (leaf), Mucuna birdwoodiana (root), Nelumbo nucifera (fruit, seed) showed more potent inhibitory activity (approximately 6-27 fold) than the positive control aminoguanidine.

• International Journal of Advanced Culture Technology
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• 제9권1호
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• pp.210-217
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• 2021

In the case of an agile-based project, it was inadequate to perform a comprehensive inspection and evaluation on the establishment and operation of an information system by performing audit only with the audit and inspection elements provided by the existing information system audit and inspection system. In particular, in the case of the test activity area, it was necessary to improve the test activity audit check items to comprehensively check the agile-based development process by applying the existing audit system. To this end, a test activity improvement check model of the agile methodology audit model was presented by applying the repetition concept, a characteristic of the agile methodology. In order to empirically verify the model of this study, a survey was conducted for auditors and designers/developers who have experience in performing agile-based projects and auditing information systems. As a result of the questionnaire on the integrated test and system test in the test stage, more than 70% of the respondents were found to be suitable. More than 80% of the respondents judged that it was appropriate as a result of the questionnaire on "improvement and regression test progress according to integrated test and system test results" and "integrated test and functional actions of components and subsystems".

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2001년도 학술대회지
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• pp.406-409
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• 2001

최근 공사관리의 효율성을 제고하기 위하여 CM제도의 도입, EVMS기법의 도입 등이 추진되고 있으며 제도적, 효율적인 공정관리를 위해서 필수적인 공정관리의 운영실태와 공정관리 수행을 저해하는 전반적인 문제점과 개선방안을 모색, WBS를 포함한 기존의 건설분야 정보분류시스템들이 토목부분의 적용에 문제점을 갖고 있는 점을 고려하여 새로운 정보분류체계의 개발 둥에 대한 연구 둥이 이루어지고 있으며, 국내 건설환경에 적합한 EVMS에 의한 공정-공사비 통합관리 프로세스모델이나 건축공사 등에서 적용사례 분석을 중심으로 공정-비용 통합관리 실용화를 위한 통합모델 개선방안을 제시하고 있다. 본 논문에서는 공정 공사비 통합관리를 효율적으로 할 수 있도록 교량의 예시를 통하여 WBS(Work Breakdown Structure) 및 Activity를 구축하고, 공정관리 전산프로그램을 이용하여 성과분석을 수행하여 유사공사의 계획수립에 일조하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제26권8호
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• pp.1358-1366
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• 2016

The purpose of the present study was to investigate the immune-enhancing activity of selenizing Codonopsis pilosula polysaccharide (sCPPS₅) in nonspecific immune response. In in vitro experiment, the results showed that sCPPS₅ could promote the phagocytic uptake, NO production, and TNF-α and IL-6 secretion of RAW264.7 cells. sCPPS₅ could also strongly increase the IκB-α degradation in the cytosol and the translocation of NF-κB p65 subunit into the nucleus of RAW264.7 cells. In the vivo experiment, sCPPS₅ at medium doses could significantly improve the phagocytic index of peritoneal macrophages and induce the secretion of TNF-α and IL-6. Moreover, the effect of sCPPS₅ was significantly better than Codonopsis pilosula polysaccharide (CPPS). These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CPPS in the nonspecific immune response.

• 생약학회지
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• 제40권4호
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• pp.382-387
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• 2009

Enhanced formation and accumulation of advanced glycation end products (AGEs) have been implicated as a major pathogenesis process leading to diabetic complications, normal aging, atherosclerosis and Alzheimer's disease. In our ongoing project to discover novel treatments for diabetic complications from natural sources, we have investigated on the inhibitory activity of 67 ethanol extracts from 57 Korean herbal medicines against the formation of AGEs in vitro. Of these, 22 extracts were found to have a significant AGEs inhibitory activity ($IC_{50}$<50 ${\mu}g$/ml) compared with aminoguanidine ($IC_{50}$=75.98 ${\mu}g$/ml). Particularly, 6 extracts from 3 herbal medicines, Castanea crenata (flower, leaf, bark-twig), Acer tatarium subsp. ginnala (fruit) and Sapium japonicum (leaf, twig) showed (approximately 8-17 fold) stronger inhibitory activity than that of aminoguanidine.

• 한국미생물·생명공학회지
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• 제44권2호
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• pp.201-207
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• 2016

건강한 닭의 맹장에서 분리한 Lactobacillus sakei LAB 2와 LAB 8의 생균제로 이용을 알아보기 위해 기본적인 특성과 면역활성을 시험하였다. LAB 2와 LAB 8은 높은 내산성과 내담즙성을 가지고 있으며, 1차 대사산물인 유기산에 기인한 항균활성을 보였다. Salmonella 종을 병원성균으로 이용하여 최대 항균력을 나타내는 시간을 시험한 결과 48시간으로 나타났으며, 생성된 유기산 중 젖산의 생산량은 다른 Lactobacillus 균주보다 높게 조사되었다. In vitro 모델로 알아본 면역증진효과는 면역관련 세포의 증식과 사이토카인의 생산량 증가로 확인하였다. 이에 Lactobacillus sakei LAB 2와 LAB 8은 유용한 생균제로 개발할 수 있는 균으로 생각된다.

• 농촌지도와개발
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• 제19권2호
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• pp.321-353
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• 2012

This study aims to find out ways of improving life satisfaction of rural elderly by investigating their work and leisure activity, two significant axis of the life in later life. For this purpose, researchers and one assistant researcher visited house, senior citizen's center and health center, in order to have interviews with senior citizen above 65, who are currently working in the field. The summary of the research findings are as follows; First, the average size of the farm land which each senior citizen works on is $9,237.92m^2$ and they mostly work for economic reason. During farming season, they work on average 8.62 hour per day. As primary reasons for why farming work is difficult, "insufficient income" was picked. In fact, the average annual income senior citizens earn from farming is about 15.4 million won. 49.1% of sample senior citizens work both on watered farm and farm, and they are engaged in farming 48.82 years on average, showing that most of their lives have been spent on farming. In spite of these difficulties, most senior citizens showed high intention to continue farming work further. Second, senior citizens turn out to spend their leisure time mostly on public leisure activities such as watching TV, hearing radio and gatherings with families, relatives. However, individual activities such as meditation, yoga, drawing and calligraphy turn out to be low because they require foundations to enjoy. Third, senior citizen in rural areas were divided into four groups by farm work and leisure activity: group separated from work and leisure activity(27.09%), group centered to leisure activity(24.42%), group centered to work(23.75%), and group integrated work and leisure activity(23.75%). Fourth, the groups were different depending on demographic characteristics. Namely, male senior citizen, higher educational level, living in elderly couple households, and satisfied with their economic level belonged to the group integrated work and leisure activity. But senior citizen aged above 65 years old and working for their livelihood belonged to the group centered to work, and most of female and senior citizen aged above 80 years old belonged to the group separated from work and leisure activity. Finally, as the result of analysis of differences in life satisfaction according to farm work and leisure activity of senior citizen in rural areas, the group integrated work and leisure activity, and group centered to leisure activity were higher in life satisfaction than the group separated from work and leisure activity, and group centered to work. The above result indicates that life satisfaction of senior citizen depends upon leisure activity rather than work.

• 대한가정학회지
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• 제39권4호
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• pp.121-134
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• 2001

The purpose of this paper is to analyze the service facilities and activity programs of district(Dong) office so as to develope a model of a service integrated community center Various research methods were used for this study: Field research and interviews with the managers have been done in four offices during July and August, 2000. The facilities and programs of twenty district((Dong) offices were analyzed and ninety visitors of two district(Dong) offices were surveyed. The results showed that most visitors crime to the district(Dong) office for administrative services associated with the registration for citizenships. Visitors of district(Dong) office with activity programs were more Likely to factor to the service integrated community center than were those without. The size and kinds of facilities among district(Dong) office centers were varied and contrained by the size of the building but the activity programs were very similar and mainly arts and crafts, sports, music, and health for young housewives. Several implications from the results were suggested to the model of a service integrated community center.

• 대한간호학회지
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• 제38권2호
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• pp.217-228
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• 2008

Purpose: This study was conducted to develop and to determine the effects of an integrated symptom management program for prevention of recurrent cardiac events after percutaneous coronary intervention. Methods: Subjects consisted of 58 CAD patients (experimental group: 30, control group: 28). The experimental group participated in an integrated symptom management program for 6 months which was composed of tailored education, stress management, exercise, diet, deep breathing, music therapy, periodical telephone monitoring and a daily log. The control group received the usual care. Results: The experimental group significantly decreased symptom experiences and the level of LDL compared to the control group. The experimental group significantly increased self care activity and quality of life compared to the control group. Although no significant difference was found in cardiac recurrence, the experimental group had fewer recurrences. Conclusion: These results suggest that an integrated symptom management program for prevention of recurrent cardiac events after percutaneous coronary intervention can improve symptom aggravation, recurrent rate, self care activity and quality of life. Nursing interventions are needed to maintain and further enhance the quality of life of these patients and the interventions should be implemented in the overall transition period.

• 대한화장품학회지
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• 제44권4호
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• pp.465-475
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• 2018

본 연구는 레몬밤 추출물 및 용매 분획물의 항산화 활성, 항염활성 및 미백 활성을 평가하기 위해 수행하였다. 레몬밤의 용매별 추출물의 총 폴리페놀 함량은 33.02-302.76 mg GAE/g, 총 플라보노이드 함량은 9.98-325.07 mg CE/g으로 확인되었다. 레몬밤 추출물 및 용매 분획물의 1,1-diphenyl-2-picrylhydrazyl(DPPH) 라디칼소거활성을 평가한 결과 전반적으로 레몬밤 용매별 추출물 및 물 분획물들이 대조구인 ascorbic acid ($30{\mu}M$)와 유사한 DPPH 라디칼소거능이 확인되었다. 또한 레몬밤 추출물 및 용매 분획물 중 클로로폼 분획물이 상대적으로 가장 우수한 RAW 264.7 세포의 NO생성 억제효과가 확인되었다. Tyrosinase 억제 활성은 100% 에탄올 환류 추출물의 $200{\mu}g/mL$ 농도가 통계적으로 유의한 수준에서 arbutin 처리구 보다 우수한 억제 활성을 나타내었다. 이러한 결과들은 레몬밤이 항산화, 항염 및 미백활성을 가지는 효과적인 화장품 소재로 활용 가능하다는 것을 시사한다.