• Asia-Pacific Journal of Business
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• v.10 no.4
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• pp.49-63
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• 2019

The export regulation of semiconductor core materials, which began with the recent revision of the export management regulations of Japan, raises the need for a new cooperation network. A hierarchical management network that was effective in the fast-follower system requires organic cooperation between the public sector and industry through a multilateral network that emphasizes horizontal co-operation among innovation actors. This study focused on the relational capital that exists among members of a business association such as an association that has been relatively marginalized from previous studies. In addition, this study aimed to analyze the effect of network activity characteristics such as industry-university linkage and informal exchange on technological innovation. Through this, I would like to draw implications for enhancing the effectiveness of the government's R & D support and innovation performance of R & D companies. Based on the results of the SMEs R & D survey, this study found that relational capital, informal exchange had a positive effect on technological innovation performance. However, if the relational capital exceeds a certain level, it is analyzed that there is a negative effect due to group think and lock-in effect. This means that informal exchange channels should be expanded for innovation and enhancement, and relational capital should be managed in consideration of the negative effects that may occur when certain levels are exceeded.

• Bulletin of the Korean Chemical Society
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• v.28 no.12
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• pp.2495-2497
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• 2007

• Journal of Life Science
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• v.28 no.2
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• pp.216-222
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• 2018

Desmodium heterocarpon is one of vines belongs to Fabaceae family, mainly distributed in Asian countries such as Korea and Japan. This study was conducted to explore new nutraceutical resources from the plant kingdom possessing biological activities. To fulfill this purpose, the anti-oxidative and anti-inflammatory activities of D. heterocarpon ethanol extract (DHEE) were evaluated by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity assay, reactive oxygen species (ROS) scavenging activity assay, nitric oxide (NO) inhibitory activity assay, and the analysis of related protein expressions by Western blot hybridization. DHEE exhibited potent anti-oxidative activity as confirmed by DPPH radical scavenging capacity against DPPH similar with ascorbic acid, a well-known anti-oxidative agent, used as a positive control. DHEE also effectively suppressed hydrogen peroxide ($H_2O_2$)-induced ROS on RAW 264.7 murine macrophage cells. Furthermore, DHEE induced the expression of the anti-oxidative enzyme heme oxygenase 1 (HO-1), and its upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2) as a dose dependent manner. DHEE inhibited lipopolysaccharide (LPS) induced nitric oxide (NO) formation as a consequence of inducible NO synthase (iNOS) down regulation. Taken together, these results suggest that DHEE has anti-oxidative and anti-inflammatory activities and thus appears to be useful sources as potential anti-oxidant and anti-inflammatory agents. The identification of active compounds that confer biological activities of DHEE might be needed.

• Microbiology and Biotechnology Letters
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• v.41 no.3
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• pp.341-349
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• 2013

In this study, the anti-oxidative and anti-obesity activities of two medicinal herb extracts, Tetrapanax papyriferus (TP) and Siegesbeckia pubescens (SP), were evaluated using DPPH radical scavenging activity assay, lipase enzyme inhibition assay, and the cell culture model system. Both methanol extracts of TP and SP showed DPPH radical scavenging activities dose-dependently, and the $IC_{50}$ of DPPH radical scavenging activities of the two medicinal herbs were 65.23 and 47.79 ${\mu}g/ml$, respectively. Furthermore, both extracts suppressed effectively lipase enzyme activity dose-dependently. Moreover, TP and SP extracts significantly suppressed adipocyte differentiation, lipid accumulation, triglyceride (TG) contents on 3T3-L1 preadipocytes in a dose-dependent manner without cytotoxicity. Their anti-obesity effect was modulated by cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$ and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) gene and protein expressions. Furthermore, TP and SP possessed a synergistic effect on anti-obesity activity. The identification of the active compounds that confer the anti-obesity activity of TP and SP might be needed.

• Microbiology and Biotechnology Letters
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• v.42 no.3
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• pp.249-257
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• 2014

In this study, the anti-oxidative and anti-obesity activities of Amomum cardamomum L. methanol extract (ACME) were evaluated using DPPH radical scavenging activity assay, pancreatic lipase enzyme inhibition assay, and the cell culture model system. ACME exhibited DPPH radical scavenging activities dose-dependently, with $IC_{50}$ of DPPH radical scavenging activities of ACME being $25.15{\mu}g/ml$. Furthermore, ACME effectively suppressed pancreatic lipase enzyme activity dose-dependently. ACME also significantly suppressed adipocyte differentiation, lipid accumulation, triglyceride (TG) contents, and triggered lipolysis activity on 3T3-L1 preadipocytes in a dose-dependent manner, without cytotoxicity. Their anti-obesity effect was modulated by the cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$ and the peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) gene and protein expressions. Taken together, these results provide an important new insight that A. cardamomum L. possesses anti-oxidative and anti-obesity activities such as pancreatic lipase inhibition, anti-adipogenic, and lipolysis effects. There is therefore potential for its use as a promising component in the field of nutraceuticals and the identification of the active compounds that confer the anti-oxidative and anti-obesity activities of ACME might be an appropriate next step.

• Journal of Information Technology Applications and Management
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• v.22 no.3
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• pp.115-128
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• 2015

Although the telecommunications service industry has become a basic infrastructure component of the information and communication technology (ICT) industry, it is now losing its reputation as a cash cow due to achieving a saturation of service subscribers, especially in South Korea. With the exception of improving network speeds, network operators are experiencing difficulties in creating new innovations. Therefore, new innovations for the telecommunications service industry should be identified in conjunction with government policies for industry promotion. To examine the innovative capabilities of a specific industry, innovation system theories were used as a framework for research. However, existing innovation systems are limited with regard to explaining the openness of relationships and user participation which are general properties of the ICT industry. Moreover, as sources of innovative activity, additional values such as financial support and collaboration are more appropriate. This study presents a new innovation system based on innovation values. We analyze the telecommunications service industry and prioritize the importance of telecommunication policies within South Korea. An in-depth interview with experts based on the innovation system framework is conducted first. Next, innovation factors derived from the interview are applied within an analytic hierarchy process (AHP), leading to a prioritization of innovation factors for the telecommunications service industry.

• Knowledge Management Research
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• v.17 no.3
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• pp.117-136
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• 2016

External knowledge search is critical to expand the firm's knowledge base, increasing the innovation performance. However, prior literature has paid less scholarly attention on the boundary condition of the search activity. In particular, the few literatures on the contingency factors are either conceptual or focus on the firm characteristics such as resources and capability. In this regard, this study argues the negative moderating effect of knowledge protection and environmental uncertainty of a firm on the positive relationship between external knowledge search and innovation performance, because these contingency factors hamper the reciprocity and the mutual trust between the firm and its external partner that provides knowledge needed in the innovation process. The empirical analysis is based on the sample drawn from Korean Innovation Survey, provided by STEPI in Korea. The sample consists of 1,637 respondent firms that experienced product innovation during the survey period. We could find statistically supporting results for the negative moderating effect on the positive relationship between external knowledge search and innovation performance. This study extends the academic debate on the boundary conditions of external knowledge search and provides managerial implications for successful product innovation.

• STI Policy Review
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• v.5 no.1
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• pp.112-130
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• 2014

Many actors are involved in the development of regional innovation systems (RIS) such as universities, private firms, research institutions, governments, and public agencies. In a country like Korea, where the central government takes more than 95% of the total government R&D budget, the role of regional authorities in science, technology, and innovation are fairly limited, although in recent years some regional governments have tried to promote innovation activity in their localities. This paper looks into the Gyeonggi Institute of Science and Technology Promotion (GSTEP) in Gyeonggi Province and examines its emerging role and achievements in innovation policymaking. It was found out that GSTEP engages in knowledge brokering with the purpose of helping firms participate in regional technological innovation processes. The knowledge brokering roles of this regional authority are described along with their implications for regional innovation policy. This study aims for a deeper understanding of the nature of the regional authority's role in a RIS through the case study of regional actors transitioning from being subordinators to becoming active participants with greater participation on policymaking and implementation.

• Korean System Dynamics Review
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• v.6 no.1
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• pp.71-98
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• 2005

If Korea Research & Development reinforces integrated control function, indeed would Korea Research & Development's output be increased? Truly, could Korea's competition be ultimately improved with technology innovation and accumulation of knowledge. Can reinforcement of Integrated control that reinforced efficiency of Research & Development's investment effects make Korea Research & Development's investment,itself, be decreased? I try to answer clearly that in a way to reorganize Korea technology Administration's system, introduced Korea Research & Development integrated control system's establishment is what to effect Korea innovation system's direction after answering clearly previous mentioned problems. In this study, to answer these problems view theoretical discussion about Korea innovation system, integrated control system and system dynamics. Set up analytic tools of system dynamics which includes Korea innovation system and integrated control system. Then, draw a general casual loop diagram, which includes established Korea Research & Development's integrated control system, of Korea innovation system's activity. In based these, develop situation model to analyze trend of Korea innovation system and derive a political meaning by analyzing value of Korea innovation system's major inflow, outflow and stock variations according to extent of Korea Research & Development's integrated control in the same model.

• Journal of Korean Society for Quality Management
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• v.42 no.3
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• pp.459-476
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• 2014

Purpose: This study was designed to identify whether organizational characteristics of Korean companies can make differences in innovative capability and Malcolm Baldridge management quality standard. In addition, based on the results and by verifying the influence of the innovative capability to management quality activity, it was to investigate the relations between the two factors. Methods: The subjects of this study were workers at major companies and small-and-medium sized companies. T-test was used to identify differences in innovative capabilities of industrial and age, position classifications, and regression analysis was employed to verify the influences of the innovative capability to the management quality activity. Results: The size of company caused some differences in market innovative sector regarding innovative capability. Management quality activity showed differences because of the sizes of companies and their supply types, while innovative capability influenced on all sectors of management quality activity. Conclusion: In this study Malcolm Baldridge management quality standard was applied to Korean companies. The results verified the meaningful influence of innovative capability to management quality activity. This means that the management quality activity can make a better performance when the innovative capability is good enough. Thus, the enhancement of management quality activity requires the boost of innovative capabilities of organization members.