• Journal of Life Science
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• v.28 no.2
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• pp.216-222
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• 2018

Desmodium heterocarpon is one of vines belongs to Fabaceae family, mainly distributed in Asian countries such as Korea and Japan. This study was conducted to explore new nutraceutical resources from the plant kingdom possessing biological activities. To fulfill this purpose, the anti-oxidative and anti-inflammatory activities of D. heterocarpon ethanol extract (DHEE) were evaluated by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity assay, reactive oxygen species (ROS) scavenging activity assay, nitric oxide (NO) inhibitory activity assay, and the analysis of related protein expressions by Western blot hybridization. DHEE exhibited potent anti-oxidative activity as confirmed by DPPH radical scavenging capacity against DPPH similar with ascorbic acid, a well-known anti-oxidative agent, used as a positive control. DHEE also effectively suppressed hydrogen peroxide ($H_2O_2$)-induced ROS on RAW 264.7 murine macrophage cells. Furthermore, DHEE induced the expression of the anti-oxidative enzyme heme oxygenase 1 (HO-1), and its upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2) as a dose dependent manner. DHEE inhibited lipopolysaccharide (LPS) induced nitric oxide (NO) formation as a consequence of inducible NO synthase (iNOS) down regulation. Taken together, these results suggest that DHEE has anti-oxidative and anti-inflammatory activities and thus appears to be useful sources as potential anti-oxidant and anti-inflammatory agents. The identification of active compounds that confer biological activities of DHEE might be needed.

• Microbiology and Biotechnology Letters
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• v.42 no.3
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• pp.249-257
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• 2014

In this study, the anti-oxidative and anti-obesity activities of Amomum cardamomum L. methanol extract (ACME) were evaluated using DPPH radical scavenging activity assay, pancreatic lipase enzyme inhibition assay, and the cell culture model system. ACME exhibited DPPH radical scavenging activities dose-dependently, with $IC_{50}$ of DPPH radical scavenging activities of ACME being $25.15{\mu}g/ml$. Furthermore, ACME effectively suppressed pancreatic lipase enzyme activity dose-dependently. ACME also significantly suppressed adipocyte differentiation, lipid accumulation, triglyceride (TG) contents, and triggered lipolysis activity on 3T3-L1 preadipocytes in a dose-dependent manner, without cytotoxicity. Their anti-obesity effect was modulated by the cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$ and the peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) gene and protein expressions. Taken together, these results provide an important new insight that A. cardamomum L. possesses anti-oxidative and anti-obesity activities such as pancreatic lipase inhibition, anti-adipogenic, and lipolysis effects. There is therefore potential for its use as a promising component in the field of nutraceuticals and the identification of the active compounds that confer the anti-oxidative and anti-obesity activities of ACME might be an appropriate next step.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.156-166
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• 2019

For this study, a survey was conducted with the employees of small and medium-size enterprises (SMEs) located in Seoul and in Gyeonggi province. In the end, a total of 328 valid questionnaires were received and used in the analysis. The data of this study were analyzed using two statistics programs: SPSS Statistics 22.0 and AMOS 22.0. As for the method to verify the hypothesis, we used a structural equation model. The key findings of this study are as follows. First, the results of correlation analysis between management strategy factors, innovation activities, and business performance showed that the factors that were at a higher level of correlation were the technology differentiation strategies, marketing differentiation strategies, and the cost-driven strategy. Second, the strategic management factors that influenced innovation activities were in the following order: marketing differentiation, technology differentiation, and the cost-driven strategy, while the valid factors that affected business performance with significance were only the marketing differentiation strategy and the cost-driven strategy. Third, while the analysis showed that the technology differentiation strategy did not have a direct effect on business performance, it was shown that the relationship between the technology differentiation strategy and business performance was completely mediated by innovation activities.

• Nutrition Research and Practice
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• v.10 no.3
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• pp.359-363
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• 2016

BACKGROUND/OBJECTIVES: This study aimed to examine the association of Japanese schoolchildren's involvement in at-home meal preparation with food intake and cooking skill. SUBJECTS/METHODS: We included 1,207 fifth-grade children aged 10-11 years and one parent of each child. A cross-sectional survey was used to collect data on involvement in at-home meal preparation. Correspondence analysis was used to classify involvement in at-home meal preparation into three groups: food-related activities (cooking only or with other activities such as shopping, table-setting, clean up, and dishwashing), non-food-related activities (table-setting and/or clean up), and no (helping) activities. Food intake was assessed using a food frequency questionnaire. Logistic regression models were used to examine involvement in at-home meal preparation associations. RESULTS: The sample consisted of 1,207 fifth-grade children. Vegetable intake was lower in the no (helping) activities group than the food-related activities group (95% CI; boys: 1.2, 5.1, girls: 2.0, 8.9). Fewer children in the non-food-related activities group reported they were able to make a portion of their meals compared with the food-related activities group (95% CI; boys: 1.6, 3.5; girls: 1.5, 3.2). CONCLUSIONS: Children in the food-related activities group showed more favorable food intake and cooking skills than children in the no (helping) activities or non-food-related activities group.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.2
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• pp.11-16
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• 2015

A lot of factor effects on the enterprise's innovation and business performance, for instance CEO and members intention etc.. Niehoff et al. says, The success factors of innovation enterprise's management lead to members of vision, innovation, innovation activities and support for an aggressive attitude of the enterprise members. However, today's products consumers wanted diverse and complex needs. CEO and members of the enterprise has been the diversity effort. The increase cost savings as well as in the profit improve factors that enterprise's participated a education and training, Subgroup activities, process quality, eliminate waste, improve yields, lead time reduction, process capability increasing, ets. This paper is a report of an empirical survey performed to 277 small and medium-sized enterprise in the korea. Cronbach's alpha coefficient is employed to analyze the reliability of the data. The effect analysis of each group is performed by the SEM(structural equation model). We use the SPSS' Amos program to analyze the equation modeling and test the hypotheses of the model.

• Journal of Technology Innovation
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• v.24 no.2
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• pp.143-175
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• 2016

In this study, we have analyzed the impact of firm, innovation and industry characteristics on firm's appropriation strategy focusing of the relative preference of patents and trade secrets by using the Korea Corporate Innovation Survey 2005, 2010 and 2014 data. According to the analysis results, companies with characteristics such as venture, high-technology industry, receipt of public R&D subsidies, performing product innovation, high R&D expenditure, prefer patents to trade secrets relatively. However, firm size and R&D cooperation did not have a statistically significant effect on the relative preference. This shows that policy on appropriation system considering the industry characteristics may be more effective. Companies in the industries with a high market concentration showed that trade secrets are preferred, especially these characteristic was distinctly in small and venture companies. This means that the increase in strategic patent applications of the incumbent firms is able to restrict the patent activities in small and venture companies. Because the excessive increase in strategic patents is likely to constrain the innovation activities of small and venture firms ultimately, policy initiatives to limit the abuse of strategic patent applications is required.

• Advanced Industrial SCIence
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• v.2 no.2
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• pp.25-30
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• 2023

The purpose of this study is to empirically analyze the impact of corporate innovation activities on corporate innovation performance using data from companies participating in the smart farm project. A company's innovation activities were divided into planning capacity, R&D capacity, and commercialization capacity, and the impact of each innovation activity on the company's sales and patent creation was estimated. The moderating effect was also analyzed. Regression analysis was conducted as a research method, and as a result of the analysis, it was found that planning capacity, R&D capacity, and commercialization capacity related to innovation within a company have an impact on corporate performance creation. appeared to be In order to increase the business performance of technology commercialization, it was confirmed that planning and R&D capabilities as well as governmental technology policy support are needed.

• Proceedings of the Technology Innovation Conference
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• 1996.12a
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• pp.241-264
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• 1996

This article introduces the five functions of the national innovation system (NIS). As the national innovation system is a kind of social systems in the national level, the five generic functions of open system-production boundary spanning, maintenance, adaptation management functions-are applied to the NIS. The production function is the primary process, which produces innovative products and services of the NIS. The boundary spanning function is the function of procuring the input and disposing the innovation output or aiding in these process. Experienced R&D human resources, R&D funds, technology etc. belong to the input of the NIS. The maintenance function is responsible for the smooth operation and upkeep of the system in terms of various conditions. The adaptive function is to help the system change and adapt, scan the environment for problems, opportunities, and technological developments. It faces outward for the survival of the system from the long-term view. The management function carries out planning and controlling the overall activities for the other four functions in order to run the system. Finally it discuses implications for the diagnosis and the decision making process of S&T policy.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11a
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• pp.93-100
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• 2006

This paper deals with Government-Industry-University-Academy (G-I-U-A) collaboration mechanism in China from the perspective of National Innovation Systems (NIS) theory. The focus of the article is on the analytical and methodological issues arising from the G-I-U-A collaboration. How the O-I-U-A collaboration changes in China is identified here. After some review of academic research, the paper reveals the key roles which Government, Industry, University and Academy should play. According to the government behavior in innovation activities, a G-I-U-A collaboration mechanism with Chinese characteristics is provided in the paper.

• STI Policy Review
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• v.7 no.1
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• pp.40-65
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• 2016

Knowledge plays a more important role in promoting entrepreneurship in the current information-led society than it did during the age of industrialization. Many recent studies found that entrepreneurship stimulates and generates innovation and economic growth. In response to the issues of long-term low growth, the Japanese government implemented several policies to encourage universities initiate entrepreneurial activities. This paper examines Japanese policies since 2014 that support universities in providing various programs for developing global entrepreneurs. Thirteen academic institutes were beneficiaries of three-year funding since the fiscal year of 2014. Each university designed its own educational programs according to their own contexts, built various forms of innovation ecosystems with domestic as well as international partner organizations, and offered entrepreneurship training courses or innovation workshops for companies to sustain its programs through broadening their funding bases. Due to the interdisciplinary nature and short history in operating the programs so far, it is difficult to evaluate the effectiveness of the programs. However, each participating university accumulated knowledge and experience while carrying out their various programs, suggesting important new directions for policymakers and education program designers in facilitating entrepreneurship and innovation.