• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3821-3824
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• 2012

Aim: SNPs of ERCC1 and ERCC2 genes have been found to be associated with response to platinum therapy in different clinical settings. In the current study, we investigated the relationship of SNPs in ERCC1 and ERCC2 to cisplain response and survival in osteosarcoma patients. Methods: 267 consecutive patients diagnosed with osteosarcoma between January 2003 to January 2005 were followed up until the end of January 2010. ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln polymorphisms were detected based upon the Sequenom MassARRAY platform.Results: For ERCC1 Asn118Asn, the variant genotype T/T was strongly significantly associated with a higher event free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.39 (0.14-0.95). ERCC2 751 A/A genotype showed increased event free survival of osteosarcoma (HR=0.44; 95%CI=0.10-0.87). However, we did not find significant association of ERCC1 Gln504Lys and ERCC2 Asp312Asn polymorphisms with prognosis of osteosarcoma. Conclusions: We first report associations of four SNPs, ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln, with risk of death from osteosarcoma in a Chinese population, indicating ERCC1 118T/T and ERCC2 A/A may be used as surrogate markers for clinical outcome of osteosarcoma treatmetn with cisplain.

• 마이크로전자및패키징학회지
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• 제11권2호
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• pp.59-66
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• 2004

본 연구에서는 유리기판을 통한 SU-8의 이중층을 후면 노광을 통하여 테이퍼지고 속이 빈 형태의 마이크로니들 배열구조물을 만드는 새로운 방법을 제안하였으며 테이퍼지고 속이 빈 형태의 원형축의 Buckling현상에 관한 해석해를 구하였다. Pyrex 7740을 유리기판으로 사용하고 이중층 구조의 SU-8 막을 후면 노광으로 금형 구조물을 제작하는 공정을 개발하였다. $200\;{\mu}m$ 높이의 SU-8기둥들에서 $4.37{\sim}5^{\circ}$범위의 테이퍼 각도를 $400\;{\mu}m$ 높이의 SU-8기둥에서는 $3.08{\sim}4.48^{\circ}$범위 내의 테이퍼 각을 보여주고 있다. 후면 유체저장소와 가로세로 각각 10개의 테이퍼 형태로 전기도금된 니켈 마이크로니들 어레이를 유리 기판을 통해 이중층 구조의 SU-8막을 후면 노광하고. 니켈을 전기도금 함으로서 실현시켰다. $200\;{\mu}m$와 $400\;{\mu}m$ 높이의 벽두께 $10{\mu}m-20{\mu}m$ 및 내경 $33.6{\mu}m-101{\mu}m$인 마이크로니들 어레이를 제작하였다. 또한 $400\;{\mu}m$ 높이의 벽두께 $20\;{\mu}m$ 및 내경 $33.6\;{\mu}m$인 $3.08^{\circ}$의 테이퍼 각 마이크로니들의 임계 버클링힘은 1.8N이었다. 이 해는 차후의 테이퍼 형태의 마이크로니들의 설계시 많은 도움을 주리라 생각한다.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 춘계학술대회 논문집
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• pp.310-313
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• 2007

This paper covers finite element simulations to evaluate the bending limit of double pipe for tube-hydroforming. The tube-hydroforming process starts with a straight precut tube. The tube is often prebent in a rotary draw bending machine to fit the hydroforming tool. During the bending the tube undergoes significant deformation. So forming defects such as wrinkling, thinning and flattening are generated in the tube. Consequently we analyzed the effect of process parameters in rotary draw bending process and searched the optimized combination of process parameters to minimize the forming defects using orthogonal arrays. The characteristic to evaluate the effects of the process parameters is the bending angle which wrinkling is generated, we define the bending angle at that time as bending limit. Of many process parameters, the process parameters of the bending process such as gab between inner and outer tube, boosting force, dimensions of mandrel were analyzed. And we observed the deformation modes of bent double pipe at specific bending angle in each parameter combination.

• 한국음향학회지
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• 제23권4호
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• pp.268-273
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• 2004

본 연구에서는 원호의 내부벽면에 1열로 배열된 어레이 트랜스듀서를 이용한 반사-투과형 생체진단용 역산란 초음파 단층화상법을 제안하였다. 제안된 방법에서는 대상 물체의 배면에 반사판을 배치하여 경면효과를 이용하였고, 유한 대역을 갖는 펄스파를 송신파로 사용하여 다중 주파수 성분을 이용함으로써 데이터 관측 범위를 줄일 수 있었다. 제안된 방법의 성능 평가를 위하여 컴퓨터 시뮬레이션을 이용한 모의 생체 조직에 대한 유효성을 검토한 격과, 트랜스듀서군의 송수신 각도 범위가 30도로 극히 좁은 범위로 제한되었음에도 불구하고 정량적인 화상재현이 가능함을 확인할 수 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1577-1580
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• 2004

This paper proposes a design and implementation of transversal adaptive digital filter using LMS (Least Mean Squares) adaptive algorithm. The filter structure is based on Distributed Arithmetic (DA) which is able to calculate the inner product by shifting and accumulating of partial products and storing in look-up table, also the desired adaptive digital filter will be multiplierless filter. In addition, the hardware implementation uses VHDL (Very high speed integrated circuit Hardware Description Language) and synthesis using FLEX10K Altera FPGA (Field Programmable Gate Array) as target technology and uses Leonardo Spectrum and MAX+plusII program for overall development. The results of this design are shown that the speed performance and used area of FPGA. The experimental results are presented to demonstrate the feasibility of the desired adaptive digital filter.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.758-761
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• 2004

This paper proposes a design and implementation of multiplierless digital PID (Proportional-Integral-Derivative) controller using FPGA (Field Programmable Gate Array) for controlling the speed of DC motor in digital system. The multiplierless PID structure is based on Distributed Arithmetic (DA). The DA is an efficient way to compute an inner product using partial products, each can be obtained by using look-up table. The PID controller is designed using MATLAB program to generate a set of coefficients associated with a desired controller characteristics. The controller coefficients are then included in VHDL (Very high speed integrated circuit Hardware Description Language) that implements the PID controller onto FPGA. MATLAB program is used to activate the PID controller, calculate and plot the time response of the control system. In addition, the hardware implementation uses VHDL and synthesis using FLEX10K Altera FPGA as target technology and use MAX+plusII program for overall development. Results in design are shown the speed performance and used area of FPGA. Finally, the experimental results can be shown when compared with the simulation results from MATLAB.

• 한국항해항만학회지
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• 제35권4호
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• pp.323-334
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• 2011

Suspended and sinking particles were collected in austral summer during ODP Leg 119 to the Indian Ocean sector of the Antarctic Ocean. Field work was carried out at four sampling sites in Prydz Bay. Two of these sites were located in the Outer Bay, and two in the Inner Bay. At the four locations, a total of ten deployments of a sediment trap array were made. The concentrations of chlorophylls and their degradation products both in suspended and sinking particulate matter in Prydz Bay were analyzed using HPLC. Chlorophylls a and c were the dominant algal pigments both in suspended and sinking particles. Because of the abundance of fecal pellets at Site 740, the mean fluxes at 200 m averaged 6 fold greater than that at 50 m. This implies that a dense swarm of zooplankters, presumably large copepods and/or salps, may "feed and excrete" mainly in between 100-200 m depths at this site, closest to land in Prydz Bay. Interestingly, The flux of phaeophorbide a was generally similar in magnitude to that of chlorophyll a throughout the study areas. This is an evidence that materials escaping from near-surface regions in austral summer derive mainly from the gazing of zooplankters. "New production" from sediment-trapped CHL pigment fluxes in Prydz Bay was estimated using f-ratio of 0.15, ranging from 520 to $1,605\;{\mu}gC\;m^{-2}\;day^{-1}$.

• 천문학회보
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• 제41권2호
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• pp.39.1-39.1
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• 2016

We report the discovery of a kiloparsec-size supershell in the outskirts of the Milky Way with the compact high-velocity cloud, HVC 040+01-282 (hereafter, CHVC040), at its geometrical center using the "Inner-Galaxy Arecibo L-band Feed Array" HI 21 cm survey data. Supershells are large gaseous shells, which could be produced by one of most energetic activities with an explosion energy more than $3{\times}1052erg$. The most promising origin is the explosion of multiple supernovae in OB associations, or alternatively, the impact of HVCs falling into the Galactic disk. We found the association between CHVC040 and the Galactic supershell by analysis of their morphological and physical properties. Our results imply that some compact HVCs can survive their trip through the Galactic halo and inject energy and momentum into the Milky Way disk.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1987년도 춘계학술대회논문집
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• pp.143-148
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• 1987

The Design of automotive IP must be designed for improving safety, and for satisfying the consumer's preference and for enlarging the usability of various gauges and information displaydevices. Also, these objects become more important by regarded and will be treated very sensitively for the next-generation vehicle concepts. Therefore, Automotive IP must be designed to adjust these trends, besides accord with car-inner lifestyle. One of these concept's designs is to apply Human Sensibility Ergonomics. This study suggestes the driver-centered design of the IP components that focused on the audio unit and HVAC(Heat and Ventilation Air Conditioner) through cognitive experiment. Primarily, analyzed components of IP in use, then, combined these components (especially, the number and arry of buttons, the position of LCD panel, etc.) nd designed some sample images(prototypes) the same as real size. After the subjects looked at the sam ples at the interval of 0.2/0.4/0.6 seconds, subjects should fill out the given forms from their memory. Then, the optimal prototype of IP was designed in respect to the correctness of cognition. The results will show the basic guideline of optimal design of IP that in the case of aaudio unit, the position of LCD, the array and the number of channel, in the case of HVAC, the position of LCD, TEMP button type and other button types.

• Steel and Composite Structures
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• 제23권1호
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• pp.31-40
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• 2017

This article aims at presenting multi objective optimization of parameters that affect crashworthiness characteristics of bi-tubular structures using Taguchi method with grey relational analysis. To design the experiments, the $L_9$ orthogonal array has been used and based on that, the inner tubes have been fabricated by varying the three influence factors such as reference diameter, length difference and numbers of sides of the polygon with three levels, but all the outer cylinders have the same diameter and length 90 mm and 135 mm respectively. Then, the tailor made bi-tubular steel structures were subjected into quasi static axial compression. From the test results it is found that the crushing behaviors of bi-tubular structures with different combinations were fairly significant. The important responses (crashworthiness indicators) specific energy absorption and crush force efficiency have been evaluated from load - displacement curve. Finally optimal levels of parameters were identified using grey relational analysis, and significance of parameters was determined by analysis of variance. The optimum crashworthiness parameters are reference diameter 80 mm, length difference 0 mm and number of sides of polygon is 3, i.e., triangle within the selected nine bi-tube combinations.