• Journal of Veterinary Clinics
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• v.10 no.1
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• pp.37-46
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• 1993

This study was carried out to evaluate the effects of yohimbine on medetomidine sedation. Twenty dogs were sedated with medetomidine(0.04mg/kg, IM). Twen쇼 minutes after the injection, ten dogs were injected with saline(0.1mg/, IV)for the control group and the others were injected wi yohimbine(0.1mg/kg, IV)for the experimental group. Onset, recovery time, respiratory rate, body temperature, blood chemistry, electrocardiogram(ECG) finding were recorded. The results obtained were summarized as follows; 1. Onset of the sedation was fast and favorable. 2. Recovery time was shorted significantly by yohimbine treatment(p<0.01). 3. Respiratory rates were decreased significantly, but increased to normal level after the yohimblne treatment(p<0.01). 4. Heart rates were decreased significantly; but increased to normal level after the yohimbine treatment(p<0.01). 5. Body temperatures of dogs in the experimental group revealed higher level than those of control group(p<0.01). 6. Arrythmias were observed in both groups but relieved to normal after the yohimbine treatment. 7. Blood chemistry values were not changed significantly by medetomidine and yohimbine treatment. 8. These results showed that yohimbine is an excellent antagonist of medetomidine.

• Biomolecules & Therapeutics
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• v.6 no.2
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• pp.159-164
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• 1998

General pharmacological properties of recombinant human parathyroid hormone (hPTH) were examined. The administration of hPTH (7, 35 and 175 lU/kg sc) in mice had no effects in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazol solution. hPTH (9 and 44 lU/kg, sc) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration, and it did not influence the responses produced by injection of acetylcholine or epinephrine. It showed no direct effect at 4.4$\times$10$_{-2}$IU/ml in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also showed no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence intestinal propulsion at the doses of 7,35 and 175 lU/kg sc in mice. This drug exhibited no effect on urinary excretion at the doses of 7 and 35 lU/kg sc in rats. However, at a dose of 175 lU/kg sc, it showed a decreased urination along with decreased excretion of potassium, sodium and chloride ion. These results indicate that hPTH does not exert any of serious pharmacological effects except the inhibition of urination at a highest dose used.

• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.154-161
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• 1996

General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/kg, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/kg, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephme. The administration of LB-00014 (601, 600, 6000 IU/kg, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 lU/kg, iv). It showed no direct effect at 100 and 1000IU/m1 in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/kg, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/kg, iv. Its administration (60, 600, 6000 lU/kg, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.

• Journal of the Korean Society of Industry Convergence
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• v.5 no.4
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• pp.379-384
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• 2002

As automotive diesel engines adopt the direct injection method for a lower level of the exhaust emission and a higher fuel efficiency, the maximum temperature of engine coolant decreases. Consequently, the total available heat source from the engine coolant decreases over 35%. However, the heating source of air-conditioning system in automobiles depends on the hot engine coolant completely, so that it is nearly impossible to control air conditioning in heating season. Therefore, the present study has been carried out to develop the air conditioning system for the high efficient heat pump type using the HFC-134a. Especially, the air conditioning system of heating has been developed at a beginning stage, when it has low heat source from small and medium sized diesel recreation vehicles. To develop a control logic system for air conditioning system which is a heat pump type with a heat recovery exchanger, its cycle characteristics has been investigated according to the opening of LEV at a bench system.

• Design & Manufacturing
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• v.13 no.3
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• pp.41-47
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• 2019

In conventional machining, the use of cutting fluid is essential to reduce cutting heat and to improve machining quality. However, to increase the performance of cutting fluids, various chemical components have been added. However, these chemical components during machining have a negative impact on the health of workers and cutting environment. In current machining, environment-friendly machining is conducted using MQL (minimum quantity lubrication) or cryogenic air spraying to minimize the harmful effects. In this study, the injection nozzle that can combined injecting minimum quantity lubrication(MQL) and cryogenic gas was designed and the shape optimization was performed by using computational fluid dynamics(CFD) and design of experiment(DOE). Performance verification was performed for the designed nozzle. The diameter of the sprayed fluid at a distance of 30 mm from the nozzle was analyzed to be 21 mm. It was also analyzed to lower the aerosol temperature to about 260~270K.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.20 no.1
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• pp.75-80
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• 2008

The objective of this research was to investigate the enhancement of heat transfer by mesh in water/air direct contact air conditioning system. Mesh is inserted as a turbulent promoter in front of the water injection nozzle. The heat transfer characteristics with and without mesh and the effect of the number of inserted mesh and mesh porosity size have been studied experimentally. Inserted mesh improves heat transfer efficiency compared to non~inserted mesh system and heat transfer efficiency increased as the number of mesh is increased. Meanwhile, heat transfer efficiency decreased as the porosity of the mesh is increased. With inserted mesh, inlet and outlet temperature difference of air increased more than 50%. Heat exchange time of water/air to reach the 100% humidity decreased less than 30%. This result shows inserted mesh can enhance the performance of the water/air direct contact air conditioning system.

• Nuclear Engineering and Technology
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• v.39 no.4
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• pp.327-336
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• 2007

The influence of density differences on the mixing of the primary loop inventory and the Emergency Core Cooling (ECC) water in the downcomer of a Pressurised Water Reactor (PWR) was analyzed at the ROssendorf COolant Mixing (ROCOM) test facility. ROCOM is a 1:5 scaled model of a German PWR, and has been designed for coolant mixing studies. It is equipped with advanced instrumentation, which delivers high-resolution information for temperature or boron concentration fields. This paper presents a ROCOM experiment in which water with higher density was injected into a cold leg of the reactor model. Wire-mesh sensors measuring the tracer concentration were installed in the cold leg and upper and lower part of the downcomer. The experiment was run with 5% of the design flow rate in one loop and 10% density difference between the ECC and loop water especially for the validation of the Computational Fluid Dynamics (CFD) software ANSYS CFX. A mesh with two million control volumes was used for the calculations. The effects of turbulence on the mean flow were modelled with a Reynolds stress turbulence model. The results of the experiment and of the numerical calculations show that mixing is dominated by buoyancy effects: At higher mass flow rates (close to nominal conditions) the injected slug propagates in the circumferential direction around the core barrel. Buoyancy effects reduce this circumferential propagation. Therefore, density effects play an important role during natural convection with ECC injection in PWRs. ANSYS CFX was able to predict the observed flow patterns and mixing phenomena quite well.

• Current Optics and Photonics
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• v.5 no.4
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• pp.384-390
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• 2021

This paper presents a wide-range tunable wavelength-locking technology based on optoelectronic oscillation (OEO) loops for optical fiber sensors and microwave photonics applications, explains the theoretical fundamentals of the design, and demonstrates a method for locking the relative wavelength differences between a leader semiconductor laser and its follower lasers. The input of the OEO loop in the proposed scheme (the relative wavelength difference) determines the radio-frequency (RF) signal frequency of the oscillation output, which is quantized into an injection current signal for feedback to control the wavelength drift of follower lasers so that they follow the wavelength change of the leader laser. The results from a 10-hour continuous experiment in a field environment show that the wavelength-locking accuracy reached ±0.38 GHz with an Allan deviation of 6.1 pm over 2 hours, and the wavelength jitter between the leader and follower lasers was suppressed within 0.01 nm, even though the test equipment was not isolated from vibrations and the temperature was not controlled. Moreover, the tunable range of wavelength locking was maintained from 10 to 17 nm for nonideal electrical devices with limited bandwidth.

• Korean Journal of Materials Research
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• v.28 no.12
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• pp.685-690
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• 2018

In this study, a multifunctional ophthalmic lens material with an electromagnetic shielding effect, high oxygen permeability, and high water content is tested, and its applicability is evaluated. Metal oxide nanoparticles are applied to the ophthalmic lens material for vision correction to shield harmful electromagnetic waves; the pyridine group is used to improve the antibacterial effect; and silicone substituted with urethane and acrylate is employed to increase the oxygen permeability and water content. In addition, multifunctional tinted ophthalmic lens materials are studied using lens materials with an excellent antibacterial effect (2,6-difluoropyridine, 2-fluoro-4-pyridinecarboxylic acid) and functional (UV protection, high wettability) lens materials (2,4-dihydroxy benzophenone, 2-hydroxy-4-(methacryloyloxy)benzophenone). To solve problems such as air bubbles generated during the polymerization process for the manufacturing and turbidity of the lens surface, polymerization conditions in which the defect rate is minimized are determined. The results show that the polymerization temperature and time are most appropriate when they are $110^{\circ}C$ and 40 minutes, respectively. The optimum injection amount of the polymerization solution is 350 ms. The turbid phenomenon that appears in lens processing is improved by 10 to 95 % according to the test time and conditions.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.10
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• pp.1-7
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• 2020

In this study, a multichannel gas-liquid microextraction system is designed by integrating the automatic elution of extraction line and multichannel gas-purging liquid phase microextraction. The system uses an injection pump and inert gas to push the extraction solvent to a sample bottle of a gas-phase color autosampler and then implements multichannel gas-liquid microextraction and gas chromatography-mass spectrometry. The system also employs a three-way integrated micro-high-temperature heater, syringe pump, and microflow controller to realize the simultaneous processing of multiple groups of samples, thus improving the sample pretreatment speed and reproducibility and reducing human error. Autoinjection experiments were implemented with polycyclic aromatic hydrocarbon standard samples. The experiments show that the average recovery rate of the system exceeds 70%, and the relative standard among the channels is less than 15%.