• The Korean Journal of Pharmacology
• /
• v.22 no.2
• /
• pp.88-95
• /
• 1986

Clinically, subhypnotic doses of barbiturates have been known to elicit hyperalgesia. In this experiment, effect of acute or chronic phenobarital treatment on the response to pain in rat was reevaluated by hot-plate method. To elucidate its mechanism, changes of ${\beta}-endorphin$ contents and [3H]-morphine binding of the rat midbrain as well as functional opiate receptor in vas deferens were also measured. Intraperitoneal injection of sub anesthetic dose phenobarbital induced initial hyperalgesia followed by successive analgesia, while chronic phenobarbital-treatment decreased reactivity to pain. Naloxone (10mg/kg, i.p.) markedly shortened hot plate latency period, and significantly inhibited the analgesic action of phenobarbital. Single dose of phenobarbital did not affect ${\beta}-endorphin$ contents and [3H]-morphine binding in rat mid brain, but in the chronic phenobarbital-treated groups, ${\beta}-endorphin$ contents was increased, while Bmax of opiate receptor binding was decreased. Moreover, very significant correlations among responses to pain, changes of ${\beta}-endorphin$ contents and opiate receptor binding were observed. However, Kd values of opiate receptor bindings were not changed in all preparations. In the chronic phenobarbital-treated vas deferens preparations, ID50 of morphine was increased witb concomittant decrease of maximum effect. But $pA_2 $, value for naloxone was not changed. From these results, it is suggested that phenobarbital can produce analgesia due to changes of ${\beta}-endorphin$ contents as well as functional opiate receptors by receptor regulation.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.28 no.4
• /
• pp.41-48
• /
• 1986

This study was fulfilled by the weighing lysimeter method at the experimental farm of KonKuk University from April to June of 1986 to investgate the amount of evapotranspiration ( ET-lettuec )by the growing periods, evapotranspiration ratio, amount of watering per one time, days of intermission and soil moisture extraction pattern of the crisphead lettuce cultivated in the clay loam soil by different watering points of pFl.7, pF2.O, pF2.7. The results obtained are summar ized as follows : 1.The total evapotranspiration(ETlettuce) of the pFl.7 treatment plot was 358,9mm., 314.9mm in the pF2.O plot and 281.8mm in the pF2.7 plot, therefore the total ETlettuec increased with the difference of 33mm-44mm by the decrease of watering point. 2.The daily maximum ETlettuce by the watering points was 7.66mm, 6:54mm, 5.98mm, respectively in the last ten days of May, and the mean daily ETlettuce during the growing season by the watering points of pFl.7, pF2.O and pF2.7 was 5.44mm(384.5g), 4.77mm(337.2g) and 4.27mm(301.8g), respectively. 3.The evapotranspiration ratio showed maximum value in the middle of May which was the beginning of mid-season stage, and the mean evapotranspiration ratio during the total growing period was 1A7, 1.29, 1.15 by the watering points. 4.The days of watering intermission by the watering points of pFl.7, pF2.O and pF2.7 was 1.0day, 2.9days and 12.Sdays, respectively. 5.The yield of the crisphead lettuce by the watering treatments showed very high significance, and the pF2.O was confirmed as a optimum watering point. 6.The soil moisture extraction pattern(SMEP) of the pF2.0 treatment plot in the initial stage was 85.6% in the 1st and 2nd soil layer and 14.4% in the 3rd and 4th layer, and in the midseason stage, the moisture extraction proportion of the under layer accounted for 34.7%which showed that the root elongated to the lowest soil layer, and there was no difference of the SMEP between the mid-season and late-season stage. 7.The correlation coefficient between the ETlettuce and yield of lettuce by the three watering points was.739, which showed the significance of 5%.

• Fire Science and Engineering
• /
• v.23 no.6
• /
• pp.1-9
• /
• 2009

In this study, the burning behaviours of five different kinds of carpet samples covered with nylon, PP (polypropylene), PTT (poly(trimethylene terephthalate)), wool fabric and NW (nylon and wool) were evaluated by using the cone calorimeter having a radiant flux of 50kW/$m^2$. And the combustion gas toxicity was evaluated according to KS F 2271 test method. As a result of the cone calorimeter test (KS F ISO 5660-1), nylon carpet samples were ignited most easily. In ignition ability or initial flammability, NW carpet samples showed the highest value. In heat release rate (HRR), fire intensity, PP carpet samples were larger than any other samples. Nylon carpet samples were the highest smoke production rate, while N/W carpet samples the lowest. The following were in mass loss rates: NW > wool > nylon > PP > PTT. CO (carbon monoxide) was one of the most toxic gases released from the combustion. PTT carpet samples gave rise to the highest CO concentration, while NW carpet samples the lowest. In addition, PP carpet samples caused the highest $CO_2$ (carbon dioxide) concentration, while NW carpet samples the lowest. Toxicity of the gas produced from carpet samples was determined by the mouse stop motion, and it resulted in the fact that the combustion gas of PTT carpet samples was more toxic than that of any other samples.

• Tunnel and Underground Space
• /
• v.29 no.5
• /
• pp.292-304
• /
• 2019

Limestone joint surfaces with smooth roughness were experimented by means of both the individual direct shear tests based on the KSRM standard test method and the multi-stage direct shear test to apply the stepwise vertical stresses. Changes in the roughness of the joint surfaces before and after the shear tests were examined and the difference between the two kinds of tests mentioned above was analyzed. In both tests, the shear resistance increased as the joint roughness increased and the maximum shear stress required for shearing the joint surface increased as the vertical stress increased. The peak friction angle obtained by the multi-stage direct shear tests was only 63% of that obtained by the individual direct shear tests. In the multi-stage direct shear test, the initial engagement of the concave-convex parts changes frequently during stepwise shearing process, which deforms the original roughness of a joint surface. Accordingly, the individual direct shear test is thought to be more effective when obtaining the friction angle of the rock joint surfaces. Limestone joint surfaces with smooth roughness of JRC value 4~8 were found to have peak friction angle of $47^{\circ}$, residual friction angle of $38^{\circ}$ and cohesion of 37 kPa.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.5
• /
• pp.379-386
• /
• 2021

This study was undertaken to develop a cascade-type continuous culture system (CCCS) that combines both ICT and biotechnology (BT), for the mass production of microalgae. This system is capable of maintaining the essential culture conditions of pH, temperature, carbon dioxide, and illuminance control, which are key parameters for the growth of microalgae, and is economical for producing microalgae regardless of the season or location. It has the added advantage of providing stable and high productivity. In the current study, this system was applied to culture microalgae for 71 days, with subsequent analysis of the experimental data. The initial O.D. of the culture measured from incubator 1 was 0.006. On the 71st day of culture, the O.D.s obtained were 0.399 (incubator 1), 0.961 (incubator 2), 0.795 (incubator 3), and 0.438 (incubator 4), thereby confirming the establishment of continuous culture. Thus, we present a smart-farm based on ISMC (in-situ monitoring and control) for a mass culture method. We believe that this developed technology is suitable for commercialization, and has the potential to be applied to hydroponics-based cultivation of microalgae and cultivation of high-value-added medicinal plants as well as other plants used in functional foods, cosmetics, and medical materials.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.2
• /
• pp.443-450
• /
• 2019

We studied to find the optimal manufacturing conditions of coffee grounds sludge RDF with oil drying method. We expanded the lab scale to pilot scale to compare the efficiency of the oil-drying equipment and The selection of the ratio of coffee grounds and oil, the setting temperature, and the temperature change and water content with time were measured. In order to analyze the characteristics of the research results, characteristics of solid fuels produced(Coffee grounds of oil-dried) by calorimeter, TGA, combustion equipment, and combustion gas measuring instrument were analyzed. As a result, the ratio of oil to coffee grounds was 4: 1, and when the setting temperature was set to $300^{\circ}C$, the water content reached 10wt.% or less within 20 minutes. ln addition, it showed high calorific value of 6,273kcal/kg. However, coffee grounds had a similar composition to wood and showed high luminance and produced a lot of CO in combustion gas. As a result, it is considered to be unsuitable for thermoelectric power plant and camping fuel, but the initial ignition speed is high and the heat generation is high, so it is considered that it can replace the fuels for current use.

• Korean Journal of Heritage: History & Science
• /
• v.49 no.4
• /
• pp.114-125
• /
• 2016

Lacquer is one of the most widely used natural resin in East Asia since Neolithic Age. As a major ingredient of lacquerware, lacquer is waterproof, insect-proof and rot-proof to be durable and anti-abrasion, generally utilized for mainly painting purpose. According to lacquerware excavated from several sites of Japan and China, lacquerware seems to appear in Neolithic Age. On the other hand in case of excavation research in Korea, lacquerwares are found after the Bronze Age. The initial purpose of lacquer is estimated to be adhesive, regarding the literatures mentioning bitumen(Yeoksceong ), animal glue(Kyeo) and egg alumen(Nanbaek). Especially piece of jar coffin unearthed in Pyeongtaek Daechu-ri site had trace of restoration by lacquer and hemp as an evidence of lacquer for adhesion in Pre-Three Kingdoms period. Since then a trend to restore the broken ceramics with lacquer and decorate with golden foil lasted especially in Joseon Dynasty. In the field of gold plated lacquer method, mother-of-pearl inlaying technique for lacquerware and restoration of buildings, lacquer is still used as adhesive. Due to matter of reversibility lacquer is being avoided for conservation and restoration of cultural heritage. Lacquer as a traditional material for adhesive since ancient times, however, has advantage in adhesion strength and durability. Because synthetic resin adhesive has problem of emission of volatile organic compounds and aging over time, lacquer receives attention recently. On the contrary, by combination adhesive from mixing lacquer and animal glue, already proved the possibility of applicability and chemical modification. A research to utilize lacquer as modern paint or functional material is also conducted continuously also in China and Japan. To put traditional material into practical use and modernize, chemical research from the molecular level of the lacquer is necessary in the near future.

• Korean Journal of Heritage: History & Science
• /
• v.51 no.2
• /
• pp.124-137
• /
• 2018

Although the evaluation system for excavation reports has been in operation for over 10 years, there has been no research on the evaluation system. First, this study examined the changes of the evaluation system, and secondly, it analyzed the evaluation factors affecting the evaluation results. As a result of institutional analysis, the present evaluation result is being utilized in PQ, and it is suggested that the evaluation subject institution is limited to the excavation institution, which may cause disadvantages to the participating museums. We also pointed out that a small number of jury members are currently evaluating the report and therefore need to reinforce it to ease the burden of assessment. As a result of evaluation factor analysis, it was confirmed that the target score was lower but the actual effect score was higher. In addition, it suggested that the indicators should be improved because the report system, headings, natural archaeological environment, scope and method of survey, and editing and printing indicators are less influential than other indicators. In addition, we conducted a regression analysis of each group by examining the appropriateness of classification amounts according to current excavation costs. As a result of the analysis, the cost of excavation in the second and third groups in 2015 and 2016 was found to affect the score. This emphasized the need for an in-depth approach to estimating the taxonomic value of the group, which is inconsistent with the initial objective of not affecting the assessment results according to excavation costs.

• The Journal of Korean Society for Radiation Therapy
• /
• v.33
• /
• pp.117-125
• /
• 2021

Purpose: To purpose of this study is to find the correlation of the Set-up error according to the couch rotation and suggest additional margin setting for the GTV. Target and Method: Each scenario treatment plan was created by making the frequency of non-coplanar beams different among all beams. The set-up error value was measured by using the Exact System and the dose accuracy was evaluated by creating a re-treatment plan. Results: When the couch was rotated by 30°, 45°, 60°, and 90°, the mean of the X-axis values was measured to be 0.29 mm, 0.26 mm, 0.51 mm, and 0.08 mm, respectively. The mean of the Y-axis values was measured to be 0.75 mm, 0.5mm, 0.35 mm, and 0.29 mm, respectively. The mean of the Z-axis values was measured to be 0.5 mm, 0.28 mm, 0.22 mm, and 0.1 mm, respectively. There were dose reductions of 0.1%, 3.1%, 1.9% in D99 for 1-NC VMAT, 2-NC VMAT, and 3-NC VMAT, respectively. Conclusion: When treating with 50% or more of non-coplanar beams among total beams, image verification is required. And it is considered to make the treatment plan by adding a 1.5 mm margin to the GTV.

• Animal Bioscience
• /
• v.35 no.2
• /
• pp.260-271
• /
• 2022

Objective: We aimed to investigate the effect of the differing amino acid (AA) release dynamics of two protein sources on the growth performance, nitrogen deposition, plasma biochemical parameters, and muscle synthesis and degradation of piglets when included in their diets at normal and low concentrations. Methods: Forty-eight piglets (Duroc×Landrace×Large White) with initial body weight of 7.45±0.58 kg were assigned to six groups and fed one of 6 diets. The 6 dietary treatments were arranged by 3×2 factorial with 3 protein sources and 2 dietary protein levels. They are NCAS (a normal protein content with casein), NBlend (a normal protein content with blend of casein and corn gluten meal), NCGM (a normal protein content with corn gluten meal), LCAS (a low protein content with casein), LBlend (a low protein content with blend of casein and corn gluten meal), LCGM (a low protein content with corn gluten meal). The release dynamics of AA in these diets were determined by in vitro digestion. The digestibility, utilization and biological value of nitrogen in piglets were determined by micro Kjeldahl method. Plasma insulin was measured by enzyme-linked immunosorbent assay kits. The protein expression of mediators of muscle synthesis and degradation was determined by western blotting. Results: Although the consumption of a low-protein diet supplemented with crystalline AA was associated with greater nitrogen digestion and utilization (p<0.05), the final body weight, growth performance, nitrogen deposition, and phosphorylation of ribosomal protein S6 kinase 1 and eIF4E binding protein 1 in the muscle of pigs in the low-protein diet-fed groups were lower than those of the normal-protein diet-fed groups (p<0.05) because of the absence of non-essential AA. Because of the more balanced release of AA, the casein (CAS) and Blend-fed groups showed superior growth performance, final body weight and nitrogen deposition, and lower expression of muscle ring finger 1 and muscle atrophy F-box than the CGM-fed groups (p<0.05). Conclusion: We conclude that the balanced release of AA from CAS containing diets and mixed diets could reduce muscle degradation, favor nitrogen retention, % intake and improve growth performance in pigs consuming either a normal- or low-protein diet.